15th International Conference on Genomics and Systems Biology of Human Disease and Aging

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 

    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport

    Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~65 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.

    Accommodation Tax

    An accommodation tax of € 10.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

     Accommodations

    Accommodations for the conference are at the Avra Imperial Hotel.  The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Avra Imperial Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast

    Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Saturday, June 22

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception and Dinner

Sunday, June 23

07:30 AM - 08:25 AM
Breakfast
08:25 AM - 08:30 AM
Welcome and Opening Remarks
Cancer
Chair: Bing Ren
08:30 AM - 08:55 AM
1
Hippo Signaling and Cancer
Kun-Liang Guan
08:55 AM - 09:20 AM
2
Spatial transcriptomic analysis of triple-negative breast cancer occurring during pregnancy and post-involution.
Dasha Veraksa1, Kavitha Mukund1, Jerneja Tomsic2, David Frankhouser2, Augusto Ochoa3, Lucio Miele3, Shankar Subramaniam1, and Victoria Seewaldt2
09:20 AM - 09:45 AM
3
A Spatial and cellular landscape of triple negative breast cancer
Shankar Subramaniam1, Kavitha Mukund1, Zahra Mesrizadeh1, Darya Veraksa1, Jerneja Tomsic2, David Frankhouser2, Augusto Ochoa3, Jovanny Zabaleta3, and Victoria Seewaldt2
09:45 AM - 10:10 AM
4
A genome-wide single-cell 3D genome atlas of lung cancer progression
Miao Liu1, Shengyan Jin1, Sherry S Agabiti1, Tyler B Jensen1, Tianqi Yang1, Jonathan SD Radda1, Christian F Ruiz1, Gabriel Baldissera1, Mandar D Muzumdar1, and Siyuan Wang1
10:10 AM - 10:35 AM
5
GATA6, a novel regulator of 3D genome organization in colorectal cancer
Feng Yue
10:35 AM - 11:00 AM
6
Novel strategies to enhance the efficacy of CAR T cell immunotherapy in brain tumors
Dinorah Friedmann-Morvinski1, Alina Brosque1, Dana Tarab4, Shani Nahmias2, Yarden Engel3, Dan Peer4, Marcelle Machluf2, Michael Berger3, and Dinorah Friedmann-Morvinski1
11:00 AM - 11:40 AM
Coffee Break and Poster Viewing
Senescence and Aging (I)
Chair: Ana Pombo
11:40 AM - 12:05 PM
7
The Epigenomic Landscape of Retrotransposon Expression in Cellular Senescence and Neurodegeneration
John M Sedivy
12:05 PM - 12:30 PM
8
Reactivation of neurogenic niches in aged mammalian brain
Bogdan Bintu
12:30 PM - 12:55 PM
9
Augmented R-loops as the Underlying Mechanism for Cockayne Syndrome-associated Neurological Disorder and Premature Aging
Xiang-Dong Fu
12:55 PM - 01:20 PM
10
Stem Cell-Mediated Mechanisms of Functional Neuromusculoskeletal Restoration in Naturally Aged Mice
Seth Thompson1, Chelsea Rugel1, Kavitha Mukund 4, Tanvi Potluri5, Rajeswari Pichika 6, Richard Lieber1, Scott Budinger3, Shankar Subramaniam4, and Mitra Lavasani1
01:20 PM - 01:45 PM
11
The Ying Yang of retrotransposons activity in the soma: from junk to RNA tools for antiaging and tissue regeneration
Valerio Orlando
01:45 PM - 02:00 PM
12
Single-Cell Analysis of Aging-Associated Gene Regulatory Programs in the Human Hippocampus
Nathan R Zemke1, Sainath Mamde1, Seoyeon Lee1, Nicole Berchtold2, Hannah Indralingam1, Weronika Bartosik1, Pik Ki Lau1, Keyi Dong1, Bing Yang1, Amanda Yang1, Yasmine Tani1, Chumo Chen1, Qiurui Zeng1, Carl W Cotman2, Xiangmin Xu3, and Bing Ren1
02:00 PM - 03:10 PM
Lunch and Informal Discussions
Epigenetics (1st session)
Chair: Hemali Phatnani
03:10 PM - 03:35 PM
13
Extensive folding variability between homologous chromosomes in mammalian cells
Ibai Irastorza-Azcarate1, Alexander Kukalev1, Rieke Kempfer1,4, Christoph Thieme1, Julia Markowski1,4, Roland Schwarz1, Stefan Kempa1, Guido Mastrobuoni1, Bing Ren3,4, and Ana Pombo1,4
03:35 PM - 04:00 PM
14
3D chromatin structure at the intersection of Toxicology and Disease
Yvonne Fondufe-Mittendorf
04:00 PM - 04:25 PM
15
Chromatin Regulation and Cancer
Yang Shi
04:25 PM - 04:50 PM
16
Genome organization in and around the nucleolus
Raffaella Santoro
04:50 PM - 05:15 PM
17
TEM-seq: ultra-sensitive multiomics link chromatin features and DNA methylation
Bryan J Venters1, Vishnu U. Sunitha Kumary1, Allison Hickman1, Anup Vaidya1, James Anderson1, Ryan J Ezell1, Jonathan M Burg1, Louise Williams2, Chaithanya Ponnaluri2, Hang Geong Chin2, Pierre Esteve2, Isaac Meek2, Zu-Wen Sun1, Martis W. Cowles1, Sriharsa Pradhan2, and Michael-Christopher Keogh1
05:15 PM - 05:30 PM
18
Global regulation of Heterochromatin Landscape and Gene expression in pediatric Leukemia
Sinisa Dovat, Yali Ding, Bing He, Daniel Bogush, and Joseph Schramm
05:30 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions

Monday, June 24

08:00 AM - 08:30 AM
Breakfast
Epigenetics (2nd session)
Chair: Jian Ma
08:30 AM - 08:55 AM
19
Epigenetic regulation by histone acetylation
Asifa Akhtar
08:55 AM - 09:20 AM
20
Nuclear Organization of Gene Expression by Nuclear Speckles, Surrounding Structures, and Active Gene Motion
Andrew S Belmont
09:20 AM - 09:45 AM
21
Bifunctional Effectors that Switch from Activators to Repressors: Dynamics and Mechanisms
Lacramioara Bintu, Cecilia Andrews, and Eli Costa
09:45 AM - 10:00 AM
22
Genome and epigenome interactions in the maintenance of traces of past life experiences
Rodrigo Arzate and Isabelle Mansuy
10:00 AM - 10:25 AM
23
Epigenetic etiology of intellectual disability
Angel Barco
10:25 AM - 10:40 AM
24
Fish(ing) in the Hi(gh)-C(sea)
Tathagata Biswas1, Hua Li2, and Nicolas Rohner1,3
10:40 AM - 11:40 AM
Coffee Break and Poster Viewing
Senescence and Aging (II)
Chair: Hongkui Zeng
11:40 AM - 12:05 PM
25
Single cell multi-omics landscape of development and ageing
Wolf Reik
12:05 PM - 12:30 PM
26
Epigenetics of senescence and aging: from mechanisms to interventions
Peter Adams
12:30 PM - 12:55 PM
27
Optical Metabolic Imaging in Aging and Diseases
Lingyan Shi
12:55 PM - 01:20 PM
28
Using Spatial Genomics to Study the Central Nervous System in Health and Disease
Hemali Phatnani
01:20 PM - 01:35 PM
29
Time to Wake Up: Regulation of Neural Stem Cell Quiescence
Andrea Brand
01:35 PM - 01:50 PM
30
Uncovering the single-cell RNA isoform dynamics of the aging mouse brain using long-read nanopore sequencing
Emmanouil Maragkakis
02:00 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions

Tuesday, June 25

08:00 AM - 08:30 AM
Breakfast
Brain Cell Census and Neural Circuits
Chair: Shankar Subramaniam
08:30 AM - 08:55 AM
31
Cell type organization of the mammalian brain
Hongkui Zeng
08:55 AM - 09:20 AM
32
Brain cell diversity: Insights from single cell 3D epigenomics
Joe Ecker
09:20 AM - 09:45 AM
33
Understanding cellular vulnerabilities and disease trajectories in Alzheimer's disease
Ed Lein
09:45 AM - 10:10 AM
34
Understanding the interaction between sleep and transcriptional regulation in Autism
Lucia Peixoto
10:10 AM - 10:35 AM
35
Neural circuit organization and function, and applications of single-cell genomics and epigenomics
Xiangmin Xu
10:35 AM - 10:50 AM
36
The impact of sleep deprivation on genome regulation in dorsal CA1 region of hippocampus
Dominika Vojtasova1,2, Alexander Kukalev1, Dario Righelli4, Christoph Thieme1, Dominik Szabó1,2, Ibai Irastorza-Azcarate1, Elizabeth Medina3, Kaitlyn Ford3, Kristan Singletary3, Izabela Harabula1,2, Davide Risso4, Lucia Peixoto3, and Ana Pombo1,2
10:50 AM - 11:40 AM
Coffee Break and Poster Viewing
A system's biology approach to organ pathologies
Chair: Gabriel Haddad
11:40 AM - 12:05 PM
37
Assessing regulatory variation in the normal human population
Jim Hughes
12:05 PM - 12:30 PM
38
Addressing the cardiovascular toxicity of small molecule oncology drugs
Mark Mercola
12:30 PM - 12:55 PM
39
Parsing disease complexity: A phenotype-guided perspective
Joe Nadeau and J. Andrew Pospisilik
12:55 PM - 01:20 PM
40
A multi-omics cell atlas of kidney
Kun Zhang
01:20 PM - 01:45 PM
41
scRNAsequencing characterization of human pluripotent stem cell-derived hepatocytes
Abigail Leinroth 1, Jessica Goebel 1, Neirwantee Misir1, Heera Choe1, Zhe Li 2, Marisa Carbonaro 2, Ge Zhou 1, Chris Schoenherr1, and Aris Economides1
01:45 PM - 02:00 PM
42
Integrative single-cell analyses reveal a spatial organization program directing the formation of cellular communities in the developing human heart
Quan Zhu, Colin Kern, Bogdan Bintu, and Bing Ren
02:00 PM - 03:00 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
Guided Tour of Old Town Chania (Buses Depart from Hotel Lobby)
07:00 PM - 11:00 PM
Dinner and Informal Discussions (Buses do not return or pickup from the hotel prior to dinner)

Wednesday, June 26

08:00 AM - 08:30 AM
Breakfast
Systems Biology Approaches to Human Diseases
Chair: Prashant Mali
08:55 AM - 09:20 AM
43
High-throughput and high-dimensional profiling of single antigen-specific T cells
Jenny Jiang
09:20 AM - 09:45 AM
44
Screening for variable drug responses using human iPSC cohorts
Jason Swedlow
09:45 AM - 10:10 AM
45
The Role of CCAAT/Enhancer Binding Protein beta (CEBPB) in Type 2 Diabetes
Jian Yan1,2, Yong-Qiang Ning2, Linbu Liao2, and Li-Jun Zhang3
10:10 AM - 10:35 AM
46
A high altitude experiment-in-nature in humans: role of non-coding RNA
Priti Azad, Dan Zhou, and Gabriel G Haddad
10:35 AM - 10:50 AM
47
Distinct structural and functional heterochromatin partitioning of lamin B1 and B2 in mammalian cells
Sriharsa Pradhan1, Sagnik Sen1, Pierre-Olivier Esteve1, Karthikeyan Raman1, Julie Beaulieu1, George R. Feehery1, Shuang-yong Xu1, James C. Samuelson 1, Udayakumar S. Vishnu2, and Hang Gyeong Chin3
10:50 AM - 11:05 AM
48
Bridging the gap between genetic mutations, molecular mechanisms of disease, and personalized therapeutics
Francesca Briganti and Mark Mercola
11:05 AM - 11:40 AM
Coffee Break and Poster Viewing
Nextgen omics methods
Chair: Lingyan Shi
11:40 AM - 12:05 PM
49
Genetics of mammlian chromatin interactome
Ming Hu
12:05 PM - 12:30 PM
50
Machine Learning for Single-Cell Spatial Epigenome
Jian Ma
12:30 PM - 12:55 PM
51
Towards predicting gene expression from sequence
Jussi Taipale
12:55 PM - 01:20 PM
52
At scale functional mapping, targeting, and repurposing of protein interactions via PepTile
Prashant Mali
01:20 PM - 01:45 PM
53
A general framework for inferring progenitor state hierarchy and dynamics from retrospective lineage barcoding
Weixiang Fang1, Claire M Bell1, Abel Sapirstein1, Soichiro Asami1, Donald J Zack3, Hongkai Ji2, and Reza Kalhor1
01:45 PM - 02:10 PM
54
Functional genomics in the pangenome era
Ting Wang
02:10 PM - 02:15 PM
Closing Remarks
02:15 PM - 03:30 PM
Lunch and Informal Discussions
03:30 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:30 PM
Farewell Dinner and Travel Awardsll

Thursday, June 27

08:00 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure