16th International Conference on Complement Therapeutics

Program - Wednesday, June 12

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 

    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport

    You want to arrive at the Athens International Airport (code: ATH). You can take a taxi from the airport to the hotel (~100 EUR). You may also rent a car at the airport and drive to the conference center. 

    Accommodation Tax

    An accommodation tax of € 10.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

    Accommodations

    Accommodations for the conference are at the Wyndham Loutraki Hotel.  The hotel is located in Loutraki, 114 km from the Athens International Airport

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Wyndham Loutraki Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast

    Breakfast for registered participants and registered accompanying persons will be served at the Wyndham Loutraki Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Wednesday, June 12

08:00 AM - 08:50 AM
Breakfast
08:50 AM - 09:00 AM
Welcome and Opening Remarks - Dimitrios Mastellos (on behalf of the Organizing Committee)
SESSION I: Structural insights and mechanisms of activation and regulation
Chairs: Gregers Andersen and Doryen Bubeck
09:00 AM - 09:20 AM
1
Structure determination of complement initiation ‘caught in the act’
Thomas H Sharp
09:20 AM - 09:40 AM
2
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring
Gregers R Andersen, Martin H Jørgensen, and Trine AF Gadeberg
09:40 AM - 10:00 AM
3
Molecular insights into activation and signaling of the complement anaphylatoxin receptors
Arun K Shukla
10:00 AM - 10:15 AM
4
The complex complement modulatory role of the human factor H-related proteins
Barbara Uzonyi1,2, Alexandra T. Matola1,2, Alexandra Papp1, Marcell Cserhalmi1, Hani H. Hammad1, Dániel Bencze1, Dávid Szakács1, Veronika H. Barbai1, Ádám I. Csincsi1, Andrea E. Schneider1, and Mihály Józsi1,2
10:15 AM - 10:35 AM
5
Regulating the complement membrane attack complex
Doryen Bubeck
10:35 AM - 11:15 AM
Coffee Break and Poster Viewing
SESSION II: Therapeutic development: novel complement inhibitors
Chairs: Christina Lamers and Brian Geisbrecht
11:15 AM - 11:35 AM
6
Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide and Chemical Analogs
Xin Xu1, Timothy J. Herdendorf1, Huiquan Duan1, Denise L. Rohlik3, Sourav Roy3, Hinman Zhou4, Haya Alkhateeb4, Sanjay Khandelwal5, Qilong Zhou2, Ashley Wilkinson1, Ping Li2, Gowthami M. Arepally5, John K. Walker4, Brandon L. Garcia3, and Brian V Geisbrecht1
11:35 AM - 11:55 AM
7
Insights into the molecular basis for inhibition of the classical pathway by C1 esterase inhibitor
Ryan J. Garrigues, Matthew P. Garrison, and Brandon L. Garcia
11:55 AM - 12:15 PM
8
Decommissioning the initiators: Therapeutic Interference in the early activation steps of the complement response
Daniel Ricklin
12:15 PM - 12:35 PM
9
History of a success: setting proximal complement inhibitors as new treatment paradigm for Paroxysmal Nocturnal Hemoglobinuria
Antonio M Risitano
12:35 PM - 12:55 PM
10
Therapeutic inhibition of complement C5aR1 is neuroprotective in Parkinson’s disease preclincal models
Eduardo A Albornoz and Trent M Woodruff
12:55 PM - 01:15 PM
11
Towards cyclic peptides targeting the complement system
Christina Lamers1, Bekas Alo1, Max Beining1, Stephanie Vogt2, Lorella Ciullo2, Carla Plüss2, and Daniel Ricklin2
01:15 PM - 01:30 PM
12
The story of empasiprubart (ARGX-117), an inhibitory C2 antibody with sweeping properties, from healthy volunteers to three phase 2 proof-of-concept studies
Laura Bracke, Tim Delahaye, Jolien Delaere, Karen De Winter, Emma K Persson, Eline Haspeslagh, Ans Rombaut, and Inge Van de Walle
01:30 PM - 01:50 PM
13
Expanding the therapeutic scope of complement C3 inhibition: new paradigms and opportunities
Dimitrios C. Mastellos3, Rebecca Lee1, Georgia Sfyroera1, Despina Yancopoulou2, and John D. Lambris1
01:50 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses depart from hotel lobby)