16th International Conference on Complement Therapeutics

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 

    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport

    You want to arrive at the Athens International Airport (code: ATH). You can take a taxi from the airport to the hotel (~100 EUR). You may also rent a car at the airport and drive to the conference center. 

    Accommodation Tax

    An accommodation tax of € 10.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

    Accommodations

    Accommodations for the conference are at the Wyndham Loutraki Hotel.  The hotel is located in Loutraki, 114 km from the Athens International Airport

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Wyndham Loutraki Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast

    Breakfast for registered participants and registered accompanying persons will be served at the Wyndham Loutraki Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Tuesday, June 11

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception and Dinner

Wednesday, June 12

08:00 AM - 08:50 AM
Breakfast
08:50 AM - 09:00 AM
Welcome and Opening Remarks - Dimitrios Mastellos (on behalf of the Organizing Committee)
SESSION I: Structural insights and mechanisms of activation and regulation
Chairs: Gregers Andersen and Doryen Bubeck
09:00 AM - 09:20 AM
1
Structure determination of complement initiation ‘caught in the act’
Thomas H Sharp
09:20 AM - 09:40 AM
2
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring
Gregers R Andersen, Martin H Jørgensen, and Trine AF Gadeberg
09:40 AM - 10:00 AM
3
Molecular insights into activation and signaling of the complement anaphylatoxin receptors
Arun K Shukla
10:00 AM - 10:15 AM
4
The complex complement modulatory role of the human factor H-related proteins
Barbara Uzonyi1,2, Alexandra T. Matola1,2, Alexandra Papp1, Marcell Cserhalmi1, Hani H. Hammad1, Dániel Bencze1, Dávid Szakács1, Veronika H. Barbai1, Ádám I. Csincsi1, Andrea E. Schneider1, and Mihály Józsi1,2
10:15 AM - 10:35 AM
5
Regulating the complement membrane attack complex
Doryen Bubeck
10:35 AM - 11:15 AM
Coffee Break and Poster Viewing
SESSION II: Therapeutic development: novel complement inhibitors
Chairs: Christina Lamers and Brian Geisbrecht
11:15 AM - 11:35 AM
6
Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide and Chemical Analogs
Xin Xu1, Timothy J. Herdendorf1, Huiquan Duan1, Denise L. Rohlik3, Sourav Roy3, Hinman Zhou4, Haya Alkhateeb4, Sanjay Khandelwal5, Qilong Zhou2, Ashley Wilkinson1, Ping Li2, Gowthami M. Arepally5, John K. Walker4, Brandon L. Garcia3, and Brian V Geisbrecht1
11:35 AM - 11:55 AM
7
Insights into the molecular basis for inhibition of the classical pathway by C1 esterase inhibitor
Ryan J. Garrigues, Matthew P. Garrison, and Brandon L. Garcia
11:55 AM - 12:15 PM
8
Decommissioning the initiators: Therapeutic Interference in the early activation steps of the complement response
Daniel Ricklin
12:15 PM - 12:35 PM
9
History of a success: setting proximal complement inhibitors as new treatment paradigm for Paroxysmal Nocturnal Hemoglobinuria
Antonio M Risitano
12:35 PM - 12:55 PM
10
Therapeutic inhibition of complement C5aR1 is neuroprotective in Parkinson’s disease preclincal models
Eduardo A Albornoz and Trent M Woodruff
12:55 PM - 01:15 PM
11
Towards cyclic peptides targeting the complement system
Christina Lamers1, Bekas Alo1, Max Beining1, Stephanie Vogt2, Lorella Ciullo2, Carla Plüss2, and Daniel Ricklin2
01:15 PM - 01:30 PM
12
The story of empasiprubart (ARGX-117), an inhibitory C2 antibody with sweeping properties, from healthy volunteers to three phase 2 proof-of-concept studies
Laura Bracke, Tim Delahaye, Jolien Delaere, Karen De Winter, Emma K Persson, Eline Haspeslagh, Ans Rombaut, and Inge Van de Walle
01:30 PM - 01:50 PM
13
Expanding the therapeutic scope of complement C3 inhibition: new paradigms and opportunities
Dimitrios C. Mastellos3, Rebecca Lee1, Georgia Sfyroera1, Despina Yancopoulou2, and John D. Lambris1
01:50 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses depart from hotel lobby)

Thursday, June 13

08:00 AM - 09:00 AM
Breakfast
SESSION III: Novel therapeutic concepts and mechanisms of inflammation
Chairs: Anna Blom and George Hajishengallis
09:00 AM - 09:20 AM
14
Maladaptive trained immunity and chronic inflammation
George Hajishengallis
09:20 AM - 09:40 AM
15
Bone-marrow mediated trained immunity
Triantafyllos Chavakis
09:40 AM - 10:00 AM
16
Expression and activation of intracellular complement (complosome) in human and murine stem cells – novel view on the biology of stem cells.
MARIUSZ Z RATAJCZAK
10:00 AM - 10:20 AM
17
Protective functions of cytosolic C3 in pancreatic beta cells.
Klaudia Kulak, Katarzyna Kuska, Lucie Colineau, Marina McKay, Karolina Maziarz, Julia Slaby, Ben King, and Anna M Blom
10:20 AM - 10:35 AM
18
Does C2b have a role in inflammation?
Marco Mannes, Alina Dettner, Susa Savukoski, Christoph Q. Schmidt, and Markus Huber-Lang
10:35 AM - 10:55 AM
19
Analysing and targeting complement activity in age related macula degeneration of the eye
Marius Ueffing, Angela Armento, Simon J. Clark, David Merle, and Merve Sen
10:55 AM - 11:30 AM
Flash Poster session-A (35 min)
11:30 AM - 12:15 PM
Coffee Break and Poster Viewing
SESSION IV: Preclinical models and interventions exploiting complement regulators
Chairs: Inge Van de Walle and Gregory Hageman
12:15 PM - 12:35 PM
20
Development of C3 humanized rats as preclinical models for evaluating novel human C3-targeted therapeutics
Feng Lin
12:35 PM - 12:55 PM
21
The crystal structure of the Factor H-recruiting peptide 5C6 in complex with Factor H domains 8-14 demonstrates an unprecedented domain arrangement in Factor H and allows for rational optimisation of the 5C6 peptide
Christoph Q Schmidt1, Clément Bechtler2, Jannik Sichau1, Ekaterina Umnyakova2, Jannes Felsch2, Arthur Dopler1, Daniel Ricklin2, Dierk Niessing3, and Thomas Monecke3
12:55 PM - 01:10 PM
22
Anti-FHR-1 antibodies reacting against domain 18 of complement factor H have opposing effects on its function; implications for therapeutic enhancement of FH
Mieke C. Brouwer1,3, Anna E. van Beek1,3, Gerard van Mierlo1,3, Gillian Dekkers1,3, Ilse Jongerius1,2,3, Diana Wouters1,3, Taco W. Kuijpers1,2,3, and Richard B. Pouw1,3,4
01:10 PM - 01:25 PM
23
Nonclinical evaluation of CTx001, a gene therapy for the treatment of geographic atrophy in aged-related macular degeneration
Dennis Keefe1, Mustafa Munye1, Athanasios Didangelos1, Sofiya Pisarenka1, Suhnrita Chaudhuri1, Rachel Green1, Peter Emery-Billcliff1, Nakul Patel1, Pamela Whalley1, Parisa Zamiri1, Simon Clark 1, and Paul Bishop1
01:25 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions

Friday, June 14

08:00 AM - 08:45 AM
Breakfast
SESSION V: Targeting Complement in Cancer
Chairs: Elena Magrini and Lubka Roumenina
08:45 AM - 09:05 AM
24
Complement signaling as an immune checkpoint in the ovarian cancer microenvironment
Thejaswini Giridharan1, Sora Suzuki1, ANM Nazmul Khan1, AJ Robert McGray1, Martin Kolev2, Pascal Deschatelets2, Claudia Kemper3, Emese Zsiros4, and Brahm H. Segal5
09:05 AM - 09:25 AM
25
The role of C1q and gC1qR as a novel checkpoint in cancer
Berhane Ghebrehiwet
09:25 AM - 09:45 AM
26
Complement-related proteins for diagnosis, prognosis and prediction of response in cancer
Ruben Pio
09:45 AM - 10:00 AM
27
Intracellular C1r promotes kidney cancer progression
Nicolas S Merle1, Mikel Rezola Artero1, Alessandra Zarantonello1, Artemis Angelidou11, Margot Revel1, Idris Boudhabhay1, Christine Gaboriaud2, and Lubka T Roumenina1
10:00 AM - 10:15 AM
28
The role of complement in pancreatic cancer: from complement activation triggering and effector mechanism/s to combination with classical therapies
Monica Dambra1, Giovanni Pezone1, Alberto Mantovani1,2,3, Elena Magrini1, and Cecilia Garlanda1,2
10:15 AM - 10:30 AM
29
The Role of Complement Receptor C5aR1 in a Murine Glioblastoma Model
Jad RW Farouqa1, Stefan E Sonderegger 1, Chelsea Stewart1, Eduardo Albornoz2, Nadya Panagides1, Jamileh Nabizadeh1, and Barbara Rolfe1
10:30 AM - 10:45 AM
30
Intracellular complement FH promotes renal cancer by modulation of the cell cycle and energy metabolism in fibroblasts and tumour cells
Mikel Rezola Artero1,2, Margot Revel1, Alessandra Zarantonello1, Andrea Minery Berenguer1, Idris Boudhabhay1, Jordan Dimitrov4, Angela Armento3, Mohamed Ali Jarboui3, Marius Ueffing3, and Lubka Roumenina1
10:45 AM - 11:00 AM
31
Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Elena Magrini1, Kevin Berthenet1, Luna Minute2, Monica Dambra2, Fabio Grizzi1, Roberta Carriero1, Fabio Pasqualini2, Sarah Mapelli1, Sebastien Jaillon1,2, Alberto Mantovani1,2,3, and Cecilia Garlanda1,2
11:00 AM - 11:45 AM
Coffee Break and Poster Viewing
SESSION VI: Complement in inflammatory and autoimmune diseases
Chairs: Peter Garred and Despina Yancopoulou
11:45 AM - 12:05 PM
32
The inflammatory landscape in peri-implantitis and host modulation therapeutic opportunities
Georgios Kotsakis
12:05 PM - 12:25 PM
33
Complement Activity in Emboli Retrieved During Thrombectomy for Ischemic Stroke
E. Sander Connolly
12:25 PM - 12:45 PM
34
Complement control in chronic inflammation and atherosclerosis
Christoph J. Binder
12:45 PM - 01:05 PM
35
Is there a bright side of complement after trauma?
Markus Huber-Lang, Rebecca Halbgebauer, Lisa Wohlgemuth, and Marco Mannes
01:05 PM - 01:20 PM
36
C1q-mimiking scFv fragments binding anti-C1q autoantibodies modulate disease progression in MRL/lpr mouse model of Systemic Lupus Erythematosus
Andrey Tchorbanov1, Silviya Bradyanova1, Nikolina Mihaylova1, Nikola Ralchev1, and Ivanka Tsacheva2
01:20 PM - 03:00 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
Guided Tour of Ancient Corinth (Buses Depart from Hotel Lobby)
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses do not return or pickup from the hotel prior to dinner)

Saturday, June 15

08:00 AM - 09:00 AM
Breakfast
SESSION VII: Complement in organ transplantation and infectious diseases
Chairs: Tom Mollnes and Matteo Stravalaci
09:00 AM - 09:20 AM
37
Complement in chronic allograft dysfunction after lung transplantation
Hrishikesh S Kulkarni
09:20 AM - 09:40 AM
38
The Roles of Complement C3 and C5 in Pulmonary Antifungal Immunity
Jigar V Desai1 and Michail S Lionakis2
09:40 AM - 10:00 AM
39
Development of mannose binding lectin as therapeutic agent in COVID-19
Matteo Stravalaci1,2, Isabel Pagani3, Virginia Cianchi2,5, Hang Zhong5, Mattia Pedotti6, Luca Varani6, Marina Sironi4, Barbara Bottazzi4, Elisa Vicenzi3, Alberto Mantovani2,4,7, and Cecilia Garlanda2,5
10:00 AM - 10:15 AM
40
C3 targeting with AMY-101 diminishes IL-8-driven neutrophil chemotaxis in severe COVID-19
Christina Antoniadou1, Anastasia-Maria Natsi1, Dimitrios C Mastellos2, Evangelos Papadimitriou1, Efstratios Gavriilidis1, Victoria Tsironidou1, Markus Huber-Lang3, Antonio M Risitano4,5, Despina Yancopoulou6, Georgios Germanidis7, Panagiotis Skendros1, Konstantinos Ritis1, and John D Lambris8
10:15 AM - 10:30 AM
41
Concomitant deficiency of C5aR1 and C5aR2 drives neutrophil dysregulation resulting in increased susceptibility to pneumococcal infection
Sarah Walachowski1,2, Archana Jayaraman1, Markus Dudek1,2, Joshua D Campbell3, Joseph P Mizgerd1, and Markus Bosmann1,2
10:30 AM - 10:45 AM
42
Complement C5b-C8 and C5b-C9 membrane attack complexes differentially potentiate antimicrobial activity against drug-resistant Neisseria gonorrhoeae
Evan R Lamb and Alison K Criss
10:45 AM - 11:00 AM
Flash Poster session-B (15 min)
11:00 AM - 11:30 AM
Coffee Break and Poster Viewing
SESSION VIII: Kidney disease, biomarkers and complement diagnostics
Chairs: Ashley Frazer-Abel and Hrishikesh Kulkarni
11:30 AM - 11:50 AM
43
In situ Complementomics reveals pathological intracellular action of complement C3 in diseases affecting the kidney
Lubka T Roumenina, Idris Boudhabhay, Margot Revel, Mikel Rezola Artero, and Idris Boudhabhay
11:50 AM - 12:10 PM
44
Immune complex glomerulonephritis and C3 glomerulopathy in 2024 – state of the art
Richard J Smith, Yuzhou Zhang, Nicolo G. Borsa, Amanda O. Taylor, and Carla M. Nester
12:10 PM - 12:30 PM
45
The association of the complotype with on long-term outcome in kidney transplantation
Felix Poppelaars1,3, Michael Holers3, Mohamed R. Daha11,, Joshua M. Thurman3, and Marc A. Seelen1
12:30 PM - 12:45 PM
46
Renin in C3 Glomerulopathy by SomaScan
Yuzhou Zhang and Richard J.H. Smith
12:45 PM - 01:00 PM
47
Genome-wide association screening of complement activation – data from a general population study
Damia Noce2, Luisa Foco2, Florian Kronenberg1, Reinhard Würzner1, and Cristian Pattaro2
01:00 PM - 01:15 PM
48
Elucidating Complement Activation Mechanisms in AAV Gene Therapy: Development of a Novel ELISA-Based Assay for Enhanced Safety and Efficacy 
Klaudia Kulak, Viktoria Kozma, Cecilia Klint, Camilla Nilsson, Jordi Rodo, Samuel Butler, Ali Qamar, and Michael Schwenkert
01:15 PM - 01:30 PM
Closing Remarks - Lubka Roumenina, Dimitrios Mastellos (On behalf of the organizing committee)
01:30 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:30 PM
Farewell Dinner

Sunday, June 16

08:00 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure