6th International Conference on Cytokines in Cancer

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 

    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport

    You want to arrive at the Athens International Airport (code: ATH). You can take a taxi from the airport to the hotel (~100 EUR). You may also rent a car at the airport and drive to the conference center. 

    Accommodation Tax

    An accommodation tax of € 10.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

    Accommodations

    Accommodations for the conference are at the Wyndham Loutraki Hotel.  The hotel is located in Loutraki, 114 km from the Athens International Airport

    Arrival and Check-in

    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.

    Conference Venue

    The Wyndham Loutraki Conference Center is located at the hotel. 

    Handicapped Accessibility

    The site is fully handicapped accessible.

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    City Tour

    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast

    Breakfast for registered participants and registered accompanying persons will be served at the Wyndham Loutraki Hotel main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer

    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information

    Animals are not permitted on site.

    Badges are required for admission to all events.

    All Aegean Conferences events are non-smoking.

    No Photographs and Recording Devices

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

Saturday, June 01

06:00 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception / Dinner

Sunday, June 02

07:30 AM - 08:00 AM
Breakfast
08:00 AM - 08:10 AM
Welcome and Opening Remarks - Mathias Müller
(Session 1) One Health: lessons from other diseases and species
Chairs: Ana Gamero and Jun Gui
08:10 AM - 08:30 AM
1
Gut Microbiome and Immune/Metabolic Perturbations in Obesity-driven Cancer
Lopa Mishra
08:30 AM - 08:50 AM
2
STING agonist immunotherapy and cytokine release syndrome in dogs with spontaneously occurring cancer
Jennifer A Lenz1, June DiBona1, Matthew J Atherton1, Timothy Hart3, Michael Ringenberg3, Hank Schmidt3, Sumita Roy-Ghanta3, and Jong Yu3
08:50 AM - 09:10 AM
3
Type I Interferon accelerates tumor progression in a mouse model of chronic lymphocytic leukemia.
Daniel Harari3, Eyal David1, Shlomit Reich-Zeliger1, Alona Dov3, Mathumathi Krishnamohan3, Vladislav Volchinsky3, Ido Amit1, David Spaner2, and Gideon Schreiber3
09:10 AM - 09:30 AM
4
Lessons learned from interferons and viruses
Eleanor Fish
09:30 AM - 09:50 AM
5
Comparative studies of osteopontin as a candidate immune suppressor in histiocytic sarcoma
Jennifer A Lenz1, Brandon Peng1, Charles-Antoine Assenmacher2, Enrico Radaelli2, and Matthew J Atherton1
09:50 AM - 10:10 AM
6
The role of type I IFN in the regulation of KSHV infection
Zelmira Nunez del Prado, Christian Matthew McDonald, Richard Bradford, Clarice Noussi Djouwoug, Alexandra Moutafis, and Noula Shembade
10:10 AM - 10:30 AM
7
A new Look at Macrophage Activation
Thomas Decker1, Aarathy R. S. J. Geetha1, Katrin Fischer1, Olga Babadei1, Matthias Farlik2, and Mathias Müller3
10:30 AM - 10:50 AM
Coffee Break
(Session 2) Microenvironment and metabolism
Chairs: Eleanor Fish and Jennifer Lenz
10:50 AM - 11:10 AM
8
Targeting stroma to normalize the tumor microenvironment
Ellen Puré
11:10 AM - 11:30 AM
9
Stressing Out Immune-Cold Triple-negative Breast Cancers
Xi Chen
11:30 AM - 11:50 AM
10
Restoring cytokine signalling in bone metastases to enhance therapeutic sensitivity
Belinda Parker
11:50 AM - 12:10 PM
11
Multifaceted Function of IL-37 in the Tumor Microenvironment
Haiyan Liu
12:10 PM - 12:30 PM
12
The crosstalk between FGF21 and T cell lipid metabolism
Jun Gui
12:30 PM - 12:50 PM
13
Defining the estrogen signaling in breast tumor microenvironment
Chistoforos Thomas
12:50 PM - 01:10 PM
14
Tumor-secreted PTHrP drives pancreatic cancer cachexia
Nikita Bhalerao1,2, Jessica Peura1,2, Yamini Ogoti1,2, Calvin Johnson1,2, Qingbo Chen3, Ekaterina Korobkina3, Faith Keller4, Maximilian Wengyn5, Robert J Norgard5, Richard Kremer6, Emma Watson4, Marcus Ruscetti2, David Guertin3, and Jason R Pitarresi2,3
01:10 PM - 01:30 PM
15
The microbiome and regulation of immunity in pancreatic cancer
Tracy McGaha
01:30 PM - 02:50 PM
Lunch and Informal Discussions
02:50 PM - 04:00 PM
Poster Session #1
04:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses depart from hotel lobby)

Monday, June 03

07:30 AM - 08:00 AM
Breakfast
08:00 AM - 08:10 AM
Housekeeping Notes
(Session 3) Senescence & adverse effects
Chairs: Ellen Pure and Lisa Mielke
08:10 AM - 08:30 AM
16
Understanding host-microbiome communication affecting checkpoint blockade response and toxicity
Elizabeth M Park, Sarah M Schneider, and Stephanie S Watowich
08:30 AM - 08:50 AM
17
Applying lessons learned from senescence-mediated cytokine signaling mechanisms to cancer therapy
Marcus Ruscetti
08:50 AM - 09:10 AM
18
Therapeutics targeting the CD80:PD-L1 duplex modulate T cell immunity
Ross A Dickins
09:10 AM - 09:30 AM
19
Differential Activation of Interferon Signaling Pathways Underlies Improved Preservation of Intestinal Normal Tissues following FLASH Radiotherapy
Tristan L Lim, Clara Morral, Ioannis I Verginadis, Kyle Kim, Leo Luo, Caitlin J Foley, Michele M Kim, Mary Putt, Seyyedeh Azar Oliaei Motlagh, Anastasia Velalopoulou, Priyanka Chowdhury, Denisa Goia, Andy J Minn, and Constantinos Koumenis
09:30 AM - 09:50 AM
20
Interplay between genetics and inflammation in the initiation of oesophageal cancer
Francesca Ciccarelli
09:50 AM - 10:10 AM
21
Chromosome 9p21.3 coordinates cell intrinsic and cell extrinsic tumor suppression
Francisco M Barriga1,2, Kaloyan M Tsanov2, Yu-Jui Ho2, Noor Sohail3, Amy Zhang4, Timour Baslan2, Alexandra N Wuest2, Isabella Del Priore2,5, and Brigita Brigita1
10:10 AM - 10:30 AM
22
Role of Interferon-gamma-induced glycosylation in melanoma
M. Raza Zaidi
10:30 AM - 10:50 AM
23
PP2C Phosphatases - Terminators of Suicidal Thoughts
BOGDANOVA DARIA2 and Oleg NIKOLAEVICH Demidov3
10:50 AM - 11:10 AM
Coffee Break
(Session 4) Immunology and immunotherapy
Chairs: Donna Senger and Margaret Chou
11:10 AM - 11:30 AM
24
Mechanisms of resistance against gd T cell mediated tumor cell killing
Andreas Behren1,2, KokFei Chan1, Andrew Li1, Conor Kearney1, and Jessica Da Gama Duarte1
11:30 AM - 11:50 AM
25
Cytokines and Intraepithelial Lymphocyte Function in Colorectal Cancer
Lisa Mielke
11:50 AM - 12:10 PM
26
Ikaros family transcription factors cooperatively enforce T cell exhaustion and restrain CAR T cell efficacy
Ian Parish
12:10 PM - 12:30 PM
27
Targeting JAK/STAT phosphatases in CAR T cell therapy
Tony Tiganis
12:10 PM - 12:30 PM
28
Dual role of trogocytosis mediated by human tumor-associated macrophages and neutrophils in the regulation of anti-tumor antibody efficacy
Evgeniy Eruslanov
12:50 PM - 01:10 PM
29
Stat3 deficient neutrophils hinder the growth and dissemination of tumors
Jadwiga Jablonska
01:10 PM - 01:30 PM
30
Dissemination routes of diffuse large B cell lymphoma shape differently the immune response to cancer invasion in secondary lymphoid organs.
Kamil Chahine, Daniel Molina Romero, Tommaso Virgilio, and Santiago F. Gonzalez
01:30 PM - 01:50 PM
31
Role of the dual function cytokine IL-33 in glioma progression and control.
Donna L Senger and Stephen M Robbins
01:50 PM - 02:50 PM
Lunch and Informal Discussions
02:50 PM - 04:00 PM
Poster Session #2
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses depart from hotel lobby)

Tuesday, June 04

07:30 AM - 08:00 AM
Breakfast
08:00 AM - 08:10 AM
Housekeeping Notes
(Session 5) Pathogenesis
Chairs: Jadwiga Jablonska and Anna Bielawska
08:10 AM - 08:30 AM
32
The metastatic microenvironment of melanoma brain metastasis
Isaac P. Witz
08:30 AM - 08:50 AM
33
Intracellular GTP gradients is a major mechanism regulating G-proteins activity in cancer
Mikhail Nikiforov
08:50 AM - 09:10 AM
34
Krupple-like Factor 5 (KLF5) Transcription Factor Promotes Basal Type Breast Cancer through Cytokines FGF-BP1 and IGFL1
Ceshi Chen
09:10 AM - 09:30 AM
35
Ubiquitin-dependent degradation of cyclin D3 is a barrier for myeloproliferative neoplasms
J. Alan Diehl
09:30 AM - 09:50 AM
36
Forward genetic screening incolorectal cancer organoids identifies novel regulators of metastasis
Andreas Blanco
09:50 AM - 10:10 AM
37
Disrupted RNA metabolism in Cancer
Katherine Borden
10:10 AM - 10:30 AM
38
Targeting integrin-linked kinase in colon tumorigenesis
Bryan R.G Williams, Saleh Almasabi, and Afsar U Ahmed
10:30 AM - 10:50 AM
39
Jekyll or Hyde: Leveraging the Ubiquitin-specific protease 6 (USP6) Oncogene for Therapeutic Benefit
Margaret Chou
10:50 AM - 11:10 AM
Coffee Break
(Session 6) Synthetic biology and therapeutics
Chairs: Stephanie Watowich and Katherine Borden
11:10 AM - 11:30 AM
40
CRISPR to target oncogenic fusion gene with precision and efficiency in vitro and in vivo
Hua Yu
11:30 AM - 11:50 AM
41
Targeting elements of the interferon pathway in the treatment of malignancies
Leonidas Platanias
11:50 AM - 12:10 PM
42
A novel monocyte-based cell therapy for the tumour targeted delivery of IFN-alpha
Roberta Mazzieri
12:10 PM - 12:30 PM
43
Oligonucleotide-based glioma immunotherapy: the Goldilock’s dilemma
Marcin Kortylewski
12:30 PM - 12:50 PM
44
Cytokine-based approaches to normalizing the tumor microenvironment
Serge Fuchs
12:50 PM - 01:10 PM
45
Therapeutic potential of long-acting c-type natriuretic peptide cytokines
Zhen Lu2, Ioannis Verginadis3, Motofumi Kumazoe4, Gerardo M Castillo1, Yao Yao1, Sandra Bicher3, Menghao You2, Takashi Nojiri5, Yasutake Tanaka4, Yoshinori Fujimura4, Hiroaki Onda4, Yui Hatakeyama4, Akiko Nishimoto-Ashfield1, Katrina Bykova1, Nikolay M Buynov1, Hirofumi Tachibana4, Constantinos Koumenis3, Elijah M Bolotin1, Serge Y Fuchs2, and Rebecca E Guerra1
01:10 PM - 01:30 PM
46
Endothelial cell-derived cytokines and cancer immunotherapy
Yi Fan
01:30 PM - 01:50 PM
47
Cytokine release differentiates responses to CAR T cells or BiTEs targeting melanoma
Rohan S Shivde1, Aditi Thakur2, Serena Gacek1, Dinesh Jaishankar1, Cormac Cosgrove1, Silpol Dhiantravan2, Meghan Cholak4, Surya Pandey4,6, Irina Balyasnikova2,3, and I. Caroline Le Poole1,5
01:50 PM - 03:00 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
Guided Tour of Ancient Corinth (Buses Depart from Hotel Lobby)
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses do not return or pickup from the hotel prior to dinner)

Wednesday, June 05

07:30 AM - 08:00 AM
Breakfast
08:00 AM - 08:10 AM
Housekeeping Notes
(Session 7) Inter/intracellular communications
Chairs: Elena Voronov and Hua Yu
08:10 AM - 08:30 AM
48
Exosomes in Immune Suppression and Tumor Progression
Wei Guo
08:30 AM - 08:50 AM
49
Cytokine Receptor Stoichiometry Regulates Cell Fate
Winnie L Kan1, Urmi Dhagat3, Kerstin B Kaufmann4, Timothy R Hercus1, Tracy L Nero3, Andy GX Zeng4, Sophie E Broughton3, Daniel Thomas, Denis Tvorogov1, Richard D Andrea1, John E Dick4, Michael W Parker3, and Angel F Lopez1
08:50 AM - 09:10 AM
50
The role of tumour intrinsic inflammasome mutations in lung adenocarcinoma.
Daniel J Gough
09:10 AM - 09:30 AM
51
Plasma Membrane Nano-partitioning, Endosomal Sorting, and Mechanical Stress: Key Players in the Selectivity of JAK/STAT Signaling by Interferons.
Christophe Lamaze
09:30 AM - 09:50 AM
52
Therapeutic targeting of JAK kinases
Olli Silvennoinen
09:50 AM - 10:10 AM
53
Regulation of immune cell responses through cytokines and extracellular vesicles
Andreas Möller
10:10 AM - 10:30 AM
54
Metabolic and pro-survival functions of Stat1 in mutant KRAS cancers
Antonis E Koromilas
10:30 AM - 10:50 AM
55
Mechanisms of extracellular vesicles-mediated neuroblastoma metastasis
Mayura R. Dhamdhere1, Chethana P. Gowda1, Vikash Singh1, Zhenqiu Liu1, Nicholas Carruthers2, Christa N. Grant1, Arati Sharma1, Sinisa Dovat1, Jeffrey M. Sundstrom3, Hong-Gang Wang1, and Vladimir S. Spiegelman1
10:50 AM - 11:10 AM
Coffee Break
(Session 8) Inflammation and cancer
Chairs: Francesca Ciccarelli and Lopa Mishra
11:10 AM - 11:30 AM
56
The role of dietary carbohydrates and insulin in hepatic inflammation
Igor Astsaturov
11:30 AM - 11:50 AM
57
Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines
Matthias Ernst, Moritz F Eissmann, and Anne Huber
11:50 AM - 12:10 PM
58
Inflammatory role of STAT2 in Hepatocellular Carcinoma
Ana Gamero
12:10 PM - 12:30 PM
59
Inhibition of IL-1β induced inflammation improves prognosis of CRC-bearing mice
Esther Noy Machluf-Katz1, Sami Stalin1, Gay Barsky, Oron Goldshtein1, Mathumathi Krishnamohan1, Marina Bersudsky1, Tomer Cooks1, Anton Osinzov, and Voronov Elena1
12:30 PM - 12:50 PM
60
Cytokines and T lymphocytes in chronic inflammation associated cancers
Julien C. Marie
12:50 PM - 01:10 PM
61
Inflammatory stress promotes the progression of TP53-mutant clonal hematopoiesis to myeloid neoplasms during aging
Yan Liu
01:10 PM - 01:30 PM
62
Increasing the metabolic fitness of TILs by IL15 to treat tumors and metastatic disease
George Pavlakis
01:30 PM - 01:45 PM
Final Remarks - Serge Fuchs
01:45 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:30 PM
Farewell Dinner and Travel Awards - Belinda Parker and Leon Platanias

Thursday, June 06

08:00 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure