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Aegean Conferences Communication
Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences
Registration
In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.
Airport
Please note that Crete has two airports. You want to arrive at the Chania International Airport (code: CHQ) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively the other airport (HER) is a two-hour drive to the Conference Center.
Accommodation Tax
An accommodation tax of € 4.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts.
Accommodations
Accommodations for the conference are at the Avra Imperial Hotel. The hotel is located in Kolymbari, 39 km from Chania International Airport, 23 km from the Souda Harbor, and 23 km west of Chania town center. Please take a taxi from the airport to the conference venue.
Arrival and Check-in
It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:30 pm on the first day should make alternative dinner arrangements.
Conference Venue
The Avra Imperial Conference Center is located at the hotel.
Handicapped Accessibility
The site is fully handicapped accessible.
Oral Presentations
Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.
City Tour
Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation.
Breakfast
Breakfast for registered participants and registered accompanying persons will be served at the Avra Imperial Hotel main restaurant during the hours scheduled in this program.
Lunches/Informal Discussions
Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.
Dinners/Informal Discussions
Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting. Please contact info@aegeanconferences.org.
Internet, Phone, & Computer
Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.
Certificate of Participation
A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session.
Passports and Visa
Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.
Letters of Invitation
Letters of invitation to attend an Aegean Conference meeting will be issued only to:
- Authors of accepted abstracts
- Fully paid registrants
Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.
Liability and Insurance
Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.
Other Information
Animals are not permitted on site.
Badges are required for admission to all events.
All Aegean Conferences events are non-smoking.
No Photographs and Recording Devices
Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations.
Code of Conduct Policy
Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here.
Friday, May 26
06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Reception & Dinner
Saturday, May 27
08:00 AM - 08:50 AM
Breakfast
08:50 AM - 09:00 AM
Welcome & Opening Remarks - John Lambris (on behalf of the Organizing Committee)
Structural insights and mechanisms of activation, regulation and crosstalk
Chairs: Anna Blom and Brian Geisbrecht
09:00 AM - 09:20 AM
1
structural insight on the function of properdin in the alternative pathwayJosefine Lorentzen, Dennis V Pedersen, Trine AF Gadeberg, and Gregers R Andersen
09:20 AM - 09:40 AM
2
A review of the double inhibition of complement and TLRs - from the origin on the bench through animal studies and possible clinical applications.Tom E Mollnes
09:40 AM - 10:00 AM
3
FcγR-mediated Trogocytosis 2.0: Revisiting History gives rise to a Unifying Hypothesis Ronald P Taylor
10:00 AM - 10:20 AM
4
Cytosolic C3 in cellular homeostasis and defenceBen C King
10:20 AM - 10:35 AM
5
Granzyme K activates a new complement pathwayCarlos Donado1,2, Helena Jonsson1,2, and Erin Theisen1,2
10:35 AM - 11:15 AM
Coffee Break and Poster Viewing
Therapeutic development: novel complement inhibitors
Chairs: Monica Olcina and Daniel Ricklin
11:15 AM - 11:35 AM
6
The dawn of clinical C3 inhibition: the story, its milestones and what lies aheadJohn D Lambris & collaborators
11:35 AM - 11:55 AM
7
Mechanistic and therapeutic aspects in complement-driven periodontal diseaseGeorge Hajishengallis1, Hatice Hasturk2, Dimitrios Mastellos3, Despina Yancopoulou4, and John D Lambris5
11:55 AM - 12:15 PM
8
A new treatment paradigm for Paroxysmal Nocturnal Hemoglobinuria: the era of proximal complement inhibitorsAntonio M. Risitano1,2, Camilla Frieri1, Luana Marano1, Despina Yancopoulou3, Dimitris Mastellos5, and John D. Lambris4
12:15 PM - 12:35 PM
9
Drug and Druggability: A new era in complement-targeted therapeutics and novel approaches off the conventional pathDaniel Ricklin1, Said Rabbani1, Oliver Schwardt1, Rachel Hevey1, Ekaterina Umnyakova1, Peter Rüthemann1, Clément Bechtler1, Kevin Widmer1, Aleksandra Blagojevic1, Stephanie Vogt1, Jannes Felsch1, Murielle Golomingi2, Christina Lamers1, Richard B Pouw1, Martin Smiesko1, Markus Lill1, Verena Schroeder2, Christoph Q Schmidt3, and John D Lambris4
12:35 PM - 12:55 PM
10
Continued investigations of modified DNA aptamers
as inhibitors of complement proteins and their complexes
Brian V Geisbrecht, Huiquan Duan, and Ying Zhang
12:55 PM - 01:10 PM
11
An Oral C5aR receptor antagonist blocks disease in the C3 gain-of-function mouse model of aHUS.Kate Smith-Jackson1,3, Isabel Y. Pappworth1,3, Beth G. Gibson1,3, Thomas Hoyler2, Marianne Martinic2, Mark Murphy 2, and Kevin J Marchbank1,3
01:10 PM - 01:25 PM
12
Complement inhibition prevents paranodal loop injury in an anti-GM1 antibody-mediated paranodal demyelinating mouse model.Inge Van de Walle1, Clare I Campbell2, Rhona McGonigal2, Jennifer A Barrie2, Jolien Delaere1, Laura Bracke1, Madelaine E Cunningham2, Denggao Yao2, Tim Delahaye2, and Hugh J Willison2
01:25 PM - 01:40 PM
13
Probing C3 modulation in the intracellular space: Cellular internalization of compstatin-based C3 inhibitors and its functional implicationsDimitrios C. Mastellos1, Rebecca Lee2, Merita Rumano2, George Hajishengallis3, Despina Yancopoulou4, and John D. Lambris2
01:40 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions
Sunday, May 28
08:00 AM - 09:00 AM
Breakfast
Targeting complement in neurological diseases
Chairs: Andrea Tenner and Wioleta Zelek
09:00 AM - 09:20 AM
14
Complement in neuroinflammatory and neurodegenerative diseases.Paul Morgan
09:20 AM - 09:40 AM
15
progressive neurological injury, early neurological deterioration and microvascular dysfunction following endovascular thrombectomy for larger vessel stroke: a target for anti-complement therapeuticsE Sander Connolly
09:40 AM - 10:00 AM
16
A detrimental role for complement C5aR1 activation in Huntington’s diseaseJohn D Lee, Jenny N Fung, Jianina Marallag, Ning Liu, and Trent M Woodruff
10:00 AM - 10:20 AM
17
New Shot on Goal: Targeting Inflammation and Synapse Loss to Suppress Alzheimer’s DiseaseAndrea J Tenner1,2, Nicole D. Schartz1, Heidi Y. Liang3, Shu-Hui Chu1, Angela Gomez-Arboledas1, and Ali Mortazavi3
10:20 AM - 10:40 AM
18
Generation and characterization of C3 inducible conditional KO Alzheimer’s-like miceBrijendra Singh1, Andre F Batista1, Maren K Schroeder1, Khyrul Khan1, Emma T Spooner1, Takashi Saito5, Hiroki Sasaguri4, Takaomi C Saido4, Michael C Carroll3, and Cynthia A Lemere1
10:40 AM - 11:00 AM
19
The therapeutic potential of C3aR agonists in the post-acute phase after stroke Marcela Pekna
11:00 AM - 11:20 AM
20
The role of terminal pathway in driving pathology in dementia.Wioleta M Zelek, Ryan J Bevan, and Paul Morgan
11:20 AM - 11:40 AM
21
Aberrant protein S-nitrosylation of C3 activates phagocytosis of neuronal synapses by microglia in Alzheimer's diseaseHongmei Yang1,2, Chang-ki Oh1,2, Haitham Amal1,2, John S. Wishnok1,2, Sarah Lewis1,2, Emily Schahrer1,2, Dorit Trudler1,2, Tomohiro Nakamura1,2, Steven R. Tannenbaum1,2, and Stuart A. Lipton1,2
11:40 AM - 12:15 PM
Coffee Break and Poster Viewing
Complement in thromboinflammation
Chairs: Lubka Roumenina and Mikkel-Ole Skjoedt
12:15 PM - 12:35 PM
22
The complement regulator MAP-1 interacts with activated FXII and attenuates the coagulation systemMikkel-Ole Skjoedt
12:35 PM - 12:55 PM
23
An alternative binding and activation mechanism of native C3 induced by contact with biosurfaces without involvement of the thioesterBo Nilsson, Anna Adler, Osama Hamad, Claudia Dührkop, Roland Ebert, Yuji Teramura, Kristina N Ekdahl, and Karin Fromell
12:55 PM - 01:10 PM
24
The Escherichia coli-induced platelet aggregation in human whole blood is inhibited by compstatin and is C3b dependentAnne Landsem1, Åse Emblem1, Corinna Lau1, Dorte Christiansen1, Alexandra Gerogianni2, Bård O. Karlsen1, Tom E. Mollnes1,3, Per H. Nilsson2, and Ole L. Brekke1,4
01:10 PM - 01:25 PM
25
A MaGical cASe:
a story on the cell-specific effects of C3-mediated neurodegeneration
Maria-Tzousi Papavergi1,2, Brijendra Singh1,3, Andre Felipe Batista1,3, Praveen Bathini1,3, Emma Spooner1, Shaomin Li1,3, and Cynthia Ann Lemere1,3
01:25 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions
Monday, May 29
08:00 AM - 09:00 AM
Breakfast
Targeting Complement in cancer and kidney diseases
Chairs: sophie Chauvet and Ruben Pio
09:00 AM - 09:20 AM
26
The C5a/C5aR1 axis in tumor-associated myeloid cells Ruben Pio
09:20 AM - 09:35 AM
27
Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapyCarsten Krieg1, Lukas M Weber2, Bruno Fosso3, Marinella Marzano3, Monica M Olcina5, Enric Domingo5, Mark D Robinson4, and Silvia Guglietta6
09:35 AM - 09:55 AM
28
Understanding the role of C5aR1 in tumours with immunosuppressive microenvironmentsMonica M Olcina
09:55 AM - 10:15 AM
29
Intracellular Functions of Complement proteins in health and in Diseases affecting
the KidneyLubka T Roumenina
10:15 AM - 10:30 AM
30
In situ Complementomics in kidney diseases and cancer Idris Boudhabhay, Margot Revel, Marie Sophie Meuleman, Amine Majdi, Antonin Bourdin, Sophie Chauvet, and Lubka T Roumenina
10:30 AM - 10:45 AM
31
Impact of C3 and soluble C5b-9 levels on renal outcomes in C3 glomerulopathy : results from a national-wide retrospective cohortSophie Chauvet
10:45 AM - 11:00 AM
32
Evaluation of minimal factor H therapy administered to kidneys during ex vivo normothermic perfusion as a treatment to improve ischaemia reperfusion injuryChloe M Connelly, Beth Gibson, Balaji Mahendran, Samuel J Tingle, Lucy Bates, Madison Cooper, Emily Thompson, Colin Wilson, Neil Sheerin, and Kevin Marchbank
11:00 AM - 11:40 AM
Coffee Break and Poster Viewing
Complement in ocular inflammation and infectious diseases
Chairs: Cecilia Garlanda and Ben King
11:40 AM - 12:00 PM
33
Age-related Macular Degeneration: a Tale of Two RPE-centric Diseases, of Which Only One is Complement-drivenGregory S Hageman, Brandi L Williams, Jin Liu, Robert A Anstadt, Nathan A Seager, Julie Thomas, Jill L Hageman, Steffen Schmitz-Valckenberg, Monika Fleckenstein, Karen Curtin, Chris M Pappas, Moussa Zouache, and Burt T Richards
12:00 PM - 12:20 PM
34
Bacterial evasion strategy as basis for novel antimicrobial treatment.Anna Blom
12:20 PM - 12:40 PM
35
The mannose-binding lectin (MBL) in MIS-C: relationship between MBL genotype, levels, and functional activity against SARS-CoV-2Matteo Stravalaci1,2, Isabel Pagani3, Hang Zhong1, Marina Sironi1, Simone Bondesan6, Federica Barzaghi6, Paola Carrera6, Francesca Izzo9, Elena Zoia9, Elisa Vicenzi3, Barbara Bottazzi1, Rosanna Asselta2, Giorgio Casari4,7, Alessandro Aiuti4,5, Alberto Mantovani1,2,8, and Cecilia Garlanda1,2
12:40 PM - 12:55 PM
(15 min) ‘Flash’ poster session A
12:55 PM - 03:00 PM
Lunch and Informal Discussions
03:30 PM - 07:30 PM
City Tour
07:30 PM - 11:00 PM
Dinner and Informal Discussions
Tuesday, May 30
08:00 AM - 09:00 AM
Breakfast
Mechanisms and therapeutic targets in immune-mediated and inflammatory diseases
Chairs: Silvia Guglietta and Paul Morgan
09:00 AM - 09:20 AM
36
Modulation of lung injury by tissue-specific C3 expressionHrishikesh S Kulkarni
09:20 AM - 09:40 AM
37
RNA Profiling and protein expression studies in the synovium of both rheumatoid arthritis and post-traumatic injury identify causal pathogenic mechanisms for complement activation in both diseasesV Michael Holers and Nirmal Banda
09:40 AM - 10:00 AM
38
Compstatins abolish pathogenic fibroblast function associated with inflammatory tissue primingJasna Friscic1, Xi Chen1,2, John D Lambris3, and Markus H Hoffmann1
10:00 AM - 10:20 AM
39
C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infectionJigar V Desai1, Claudia Kemper2, Ben Afzali4, Jörg Köhl4, and Michail S Lionakis1
10:20 AM - 10:40 AM
40
Both liver-derived and intracellular complement modulate hematopoietic stem/progenitor cell metabolism and stress response.MARIUSZ Z RATAJCZAK
10:40 AM - 11:00 AM
41
Xenotransplantation: Using Genome Editing to Overcome Pig-to-Human Incompatibilities.Robert Montgomery, Brendan Keating, Alexander Loupy, Nader Moazami, Jeffrey M Stern, Jacqueline I Kim, Massimo Mangiola, Adam Griesemer, Sapna A Mehta, Deane E Smith, and Jef D Boeke
11:00 AM - 11:15 AM
‘Flash’ poster session B
11:15 AM - 11:55 AM
Coffee Break and Poster Viewing
Disease biomarkers and complement diagnostics
Chairs: Veronique Fremeaux-Bacchi and Zoltan Prohaszka
11:55 AM - 12:15 PM
42
Stratification of patients with complement mediated diseases for complement targeted therapies: the perspective from the diagnostic complement laboratoryAshley Frazer-Abel 1, Michael Kirschfink 2, and Zoltán Prohászka3
12:15 PM - 12:35 PM
43
Comprehensive genetic evaluation for the diagnosis of complement alternative pathway-mediated kidney diseasesveronique fremeaux-Bacchi
12:35 PM - 12:50 PM
44
Ex vivo complement activation on endothelial cells: set up of a new functional tool to explore complement dysregulationAnna Duval1,3, Marie-Sophie Meuleman1, Lubka Roumenina1, Sophie Caillard2, and Véronique Frémeaux-Bacchi1,3
12:50 PM - 01:05 PM
45
Identification of genes involved in the protective response of C3aR in amyotrophic lateral sclerosis pathologyJenny N.T. Fung, John D Lee, and Trent M Woodruff
01:05 PM - 01:20 PM
46
Distinct cell-bound complement activation products associate with disease activity and immune transcriptional programs in systemic lupus erythematosusGabriel R Arguelles, Lynne M Mitchell, Dennis E Hourcade, John P Atkinson, Elisha DO Roberson, and Alfred HJ Kim
01:20 PM - 01:40 PM
47
Natural antibody targeted complement inhibitor ameliorates the development of chronic heart and lung transplant rejectionZhenxiao Tu, Changhai Li, Kunal Patel, Stephen Tomlinson, and Carl Atkinson
01:40 PM - 01:50 PM
Closing Remarks - Lubka Roumenina, Dimitrios Mastellos (On behalf of the organizing committee)
01:50 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner
Wednesday, May 31
08:00 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure