6th International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism

Posters

Important: The program online is copyrighted to each author and should not be copied and pasted!
37 Restoring Gut-Brain-Immune Axis Homeostasis: The Role of Microbial-Based Interventions in the Management of Gastrointestinal and Systemic Symptoms in ME/CFS and Long COVID
Joanna Michalina Jurek1 and Jesus Castro-Marrero2
38 Metabolic plasticity in neutrophil immunometabolism: The critical role of the pentose phosphate pathway in effector functions of iPSC-derived neutrophils
Sebastian Sigl1, Christoph Klein1, Monika Linder1, and Maria Veiga-da-Cunha2
39 Role of intestinal Glucose Transporter 2 in atherosclerosis.
Nirmala Mouttoulingam and Soraya Taleb
40 Uncovering the Osteoimmunmetabolic Landscape of Osteoclasts: The Role of the nuclear respiratory factor 1 (NRF1) and Mitochondrial Dynamics in Bone Resorption and Disease
Carina Scholtysek1,2, Thea Hofmann1,2, Katrin Palumbo-Zerr1,2, Jean-Philippe Auger3, Agnus Monica Davis1,2, Gerhard Krönke3, and Georg Schett1,2
41 Acute exposure to Interleukin-1β Blocks Gluconeogenesis leading to Prolonged Hypoglycemia
Marc Y. Donath, Daniel T. Zeman-Meier, and Pia Neubert
42 Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells
Ignacio Heras-Murillo1, Diego Mañanes1, Annalaura Mastrangelo1, Josep Calafell-Segura2, Pablo Hernansanz-Agustín10, Marten Szibor3,4, Ignacio Melero5,6, José Antonio Enríquez10, Navdeep S Chandel7, Esteban Ballestar2,8, Stefanie K Wculek1,9, and David Sancho1
43 Determining the Regulation of IRG1 and the Impact of Itaconate on Vascular Inflammation
Priyanka Patel1, Marina Diotallevi2, and Mark Crabtree1,2
44 GLUT3 promotes stemness and survival of activated CD8 T cells through ROS detoxification
Martin Vaeth
45 Induction of trained immunity through dietary supplementation with beta-glucan boosts myeloid anti-tumour immunity in diet induced obesity
Anna Ledwith1, Hannah Prendeville2, Cian Horneck Johnston2, John McGrath2, Stephen Cunningham2, Helen Roche1, and Frederick Sheedy2
46 Trained Immunity—Going Viral: β-Glucan Immunometabolic Rewiring Enhances Antiviral Immunity via Interferon-Dependent Antiviral Training (IDAT)
Cian Horneck Johnston, Anna Ledwith, John McGrath, Hannah Prendiville, Jamie Murphy, and Vasile Mihai Sularea
47 Phenotyping metabolic dysfunction-associated steatotic liver disease from an immunological, metabolic, and gut microbiome perspective
Méabh B Ní Chathail1, Christopher E Shannon1,2, Sinéad M Mullin1, Sarah Lawler1, Pamla Singh3, Suzanne Norris3, Frederick J Sheedy4, and Helen M Roche1,4,5
48 EVs from glycolytic MSCs: a promising therapy for osteoarthritis
Maria Jesus Araya1, Yeimi Herrera-Luna1, Eliana Lara-Barba1, Cynthia García-Guerrero1, César Merino1, José Matas2, Maximiliano Barahona3, Alexander Ortloff4, Ana María Vega-Letter5, and Patricia Luz-Crawford1
49 The metabolic adaptations and requirements of tissue-resident Th2 cells
Anna K Kania, David E Sanin, Mia Gidley, Eryk Kokosinski, and Edward Pearce
50 Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system
Jamie Frankish
51 Enhancing the mitochondrial metabolism improves sepsis outcomes in a preterm piglet model of neonatal sepsis.
Björn Klabunde1, Ole Bæk1,2, Karoline Aasmul-Olsen1, and Duc Ninh Nguyen1
52 Macrophage oxidative capacity and mitochondrial membrane dynamics are associated with IRF5-linked inflammatory polarization under metabolic stress.
Dorothy Tonui1, Lucie Orliaguet4, Jennifer Rieusset3, Nicolas Venteclef1, and Fawaz Alzaid1,2
53 Interrogating metabolic effects of the antimicrobial peptide cathelicidin in conventional CD4+ T cells
Zachary Lim1, Jessica Anania1, Victoria Stavrou2, Sarah Dimeloe2, and Emily Gwyer Findlay1
54 Human cytomegalovirus induces metabolic rewiring via mitochondrial modulation to facilitate replication
Mohammad Pirouzfar1,2,4, Hatem Abouguendia1,2,4, Tong Liu3, Leah Cui3, and Cecilia Söderberg-Nauclér1,2,3,4
55 Metabolic dysregulation in resident macrophages: the key to inflammaging?
Eugenia V Diez1,2, Maria Dzamukova1,2, and Gerhard Krönke1
56 Pancreatic alpha cells integrate neuronal and immune stimuli for insulin secretion
Kelly Alexa Trimigliozzi1, Sophia Julia Wiedemann1, Leila Rachid1, Hélène Mereau1, Giada Ostinelli2, Guy A Rutter2,4,5,, Marianne Böni-Schnetzler1, Daniel Thomas Meier1, and Marc Yves Donath1
57 MARCO is an IFN-restricted immunometabolic decoy LPS receptor
Fiachra Humphries
58 Exploring thymic involution with aging and metabolic disease at a single-cell resolution
Niedson Correia de Lima Junior1, Leticia Souza Figueiredo1, Gabriel Palermo Ruiz1, Henrique Camara2, Raissa Guimarães Ludwig1, Deisi Braga Shimo1, Diogo de Moraes1, Henry David Mogollon Garcia1, Yu-Hua Tseng2, Alessandro dos Santos Farias1, and Marcelo Alves da Silva Mori1
59 Mitochondrial mass defines human CD4+ effector T cell subsets
Hisashi Hashimoto, Fadi Issa, and Joanna Hester
60 Fish Oil Metabolites and Early-Life Immunity against Infection: Evidence from Children and Preterm Pigs
Ole Bæk1,2, Bo Chawes2, and Duc N Nguyen1
61 MCMV vaccination decreases the metastatic potential of colon cancer in the lungs
Shaghayegh Hasanpour
62 Elucidating the role of PYCR1 during metabolic rewiring in viral infection and cancer
Iqra Anam Khawaja
63 Insights relating to heterogeneous innate immune training in monocytes from older individuals
Sive Duncan1,2, Christopher E Shannon1,3, Anna Quinn2, Brian Mullen1,2, Katy Horner2, Martina Wallace4, and Helen M Roche1,2,5,6
64 Modulation of T cell signaling pathways to mitigate age-associated (CAR) T cell dysfunction
Nadine Brückner1,3, Philip Bucher2,3, Melanie Grimm2,3, Judith Feucht2,3, and Josef Leibold1,3
65 Epigenomic reprogramming of adipose tissue macrophages governed by Histone DeMethylase 6B (KDM6B) influences adipose tissue expansion and metabolic health
Bastien AZNAR, Amine Toubal, and Nicolas Venteclef
66 Adipocyte-derived extracellular vesicles drive adipose tissue macrophage identity.
Akeem J Pinnock, Xiaoyuan Xu, Stephen Flaherty, Ethan Edwin, and Anthony W Ferrante
67 Metabolic rewiring of mast cells in obesity and diabetes augments dengue disease severity.
Monica Palanichamy Kala1, Abhay P.S. Rathore2, Manouri Senanayake3,4, Annelies Wilder-Smith5,6,7, and Ashley Lauren St. John1,2,8,9
68 Investigating the link between colon hypoxia loss and dysbiosis
Joanna A Olivas and Mariana Byndloss
69 Transient dietary changes modulate inflammatory disease trajectory in the lean state.
Zewen Jiang and Sagar Bapat
70 SDHA activity regulates anti-tumor CD8+ T cell function
Erin Tanaka1, Braden Kersey1, Monika Maneva1, Juhee Oh1, Liam Johnston1, Anne-Sophie Archambault1, Rachel Cederberg2, Meredith Clark2, Annette Patterson1, Kevin Bennewith2, Will Bailis3, and Ramon Klein Geltink1
71 Cyp27a1-driven metabolic control in macrophages subverts tumor immunity
Piyal Saha, Paul Ettel, Lovro Davidoski, Roko Sango, Jayne Louise Wilson, and Thomas Weichhart
72 Marginal zone B cell-specific AKT and NOTCH signaling causes spontaneous Liver Cancer in Female Mice
Leonie Schroers and Thomas Wunderlich
73 Does immune control of cytomegalovirus reactivation improve glioblastoma outcome?
Maedeh Alipour1,2,3, Nerea Martín Almazán4,5, Mattia Russel Pantalone5,6, Giuseppe Stragliotto6, and Cecilia Söderberg Nauclér1,2,3,7
74 Cell type resolved glucocorticoid signaling in adipose tissue of patients with Cushing’s syndrome
Ulrich Stifel1, Frederick Vogel2, Hanna Meid1, Paul Knoop1, Julia Kühlwein3, Petra Zimmermann6, Jan Tuckermann5, Karin Danzer3,4, Martin Reincke2, and Pamela Fischer-Posovszky1
75 Menage a trois: Neuro-endocrine-immune regulation of metabolic homeostasis
Marko Šestan
76 Metabolic and functional diversity of tumor-infiltrating NK cells
Cristhiane Favero de Aguiar, Maxim Nosenko, Carrie Corkish, Cathal Keane, Simon O’Shaughnessy, and David Finlay
77 The IL-17A and IFN-γ dichotomy in MASLD compromises the immune response to mCMV infection
Karlo Mladenić, Felix M Wensveen, and Bojan Polić
78 The autophagy enhancer spermidine promotes expansion of human regulatory T cells under mTOR-inhibited conditions
Emina Voss1, Hisashi Hashimoto1, Quan Yao Ho1,2, Fadi Issa1, and Joanna Hester1
79 Conserved Crosstalk of NIK/STAT5 signaling axis in Kupffer cells during metabolic NASH progression
Patricia Schmidt, F. Thomas Wunderlich, and Anne Juliane Vesting
80 Mitochondrial rewiring essentially contributes to the anti-inflammatory effects of glucocorticoids
Jean-Philippe Auger1,2, Max Zimmermann1, Maria Faas1, Ulrich Stifel3, David Chambers1, Brenda Krishnacoumar4, R. Verena Taudte5, Charlotte Grund1, Carina Scholtysek1, Stefan Uderhardt1, Mónica Pascual Maté1, Cornelia Stoll1, Martin Böttcher6, Katrin Palumbo-Zerr1, Maria Dzamukova2, Markus Kieler7, Melanie Hofmann7, Stephan Blüml8, Dimitrios Mougiakakos6, Uwe Sonnewald9, David Simon1,2, Arnd Kleyer1,2, Eicke Latz10, Jörg Hofmann9, Georg Schett1, Jan Tuckermann3, and Gerhard Krönke1,2,10
81 Apoptotic cell clearance induces epigenetic reprogramming of inflammatory macrophages resulting in mitochondrial rewiring promoting a tissue repairing phenotype
Jean-Philippe Auger1,2, Katrin Palumbo-Zerr1, David Chambers1, Rossella Mancuso1, Mónica Pascual Maté1, Georg Schett1, and Gerhard Krönke1,2,3
82 Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity
Chantal Wientjens1, Maria Dovermann1, Jelena Zurkovic2, Jayagopi Surendar1, Svetozar Nesic3,4, Timon D. Utecht1, Carola Sarici1, Christoph Thiele2, and Christoph Wilhelm1
83 Unravelling the metabolic properties of tissue resident macrophages in skeletal muscle
Katharina Miriam Schönberger1, Vincen Wu2, Jörg Büscher3, Nicola Zamboni2, and Katrien De Bock1
84 Glutathione regulates natural killer cell immunity and mediates tumor control
Melanie Grusdat-Pozdeev1, Dirk Brenner1, and Luana Guerra1
85 Elevated succinate levels in heart failure with preserved ejection fraction
Rongling Wang1,3,4, Ashraf Abdelhamid Hamouda1, Sarah Valentina Liévano Contreras1, Martin Forbes2, Stefan Kempa2, Alexandra Maria Chitroceanu3, and Gabriele Schiattarella1,3,4
86 METABOLIC MODULATION OF ILC2S: HOW PARASITIC INFECTION REPROGRAMS IMMUNITY AGAINST ASTHMA
Maria Doverman, Chantal Wientjens, and Christoph Wilhelm
87 Hepatic IL-6 Resistance reprograms infiltrating Macrophages in the Tumormicroenvironment of Hepatocellular Carcinoma
Peter Wienand, F. Thomas Wunderlich, and Philipp Hammerschmidt
88 Energetic adaptation of resident macrophages in metabolic dysfunction-associated steatotic liver disease
Joanna Razafiarison1, Dorothy Tonui1, Nicolas Venteclef1, Fawaz Alzaid1, and Camille Blériot2
89 Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release.
Anne-Sophie Archambault1,2, Lauar de Brito Monteiro1,3, Lucas F Starchuk1,2, Armando Alcazar4, Oh Juhee1,2, Joshua Dubland1,2,5, Bojana Rakic1,2,5, Annette E Patterson1,2, C. Bruce Verchere1,3, and Ramon I Klein Geltink1,2,6
90 A multi-omic approach to profiling cytokine-induced memory-like NK cell metabolic reprogramming
Gearóid C Conlon, David K Finlay, Clair M Gardiner, and Aisling Dunne
91 Metabolic modulation with 2-deoxy-D-glucose alters T lymphocyte functions
Tjaša Frlic, Tadeja Snedec, and Mojca Pavlin
92 early BCG vaccination is potentially beneficial for preterm infant immune systems
Ausra Pranevicius and Ole Bæk
93 Gut hormone GIP facilitates APOE production by adipose tissue macrophages to support adipogenesis during obesity
Irina Efimova1,2, Shani Ben Shlomo-Zidovetzki2, Anat Neumann1,2, Isabel Zvibel2, Sigal Fishman2, and Chen Varol1,2
94 Using 3H-AdExos to investigate local lipid cycling in adipose tissue
Brianna E Brooks1 and Anthony W Ferrante2
95 Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress
Michael Scaglione1,2, Montana Knight3, Krittin Trihemasava1,2, Kelly Rome1,2, Anne-Sophie Archambault4, Juhee Oh4, Erin Tanaka4, Elise Hall1,2, Van Le1,2, Caleb Lines5, Brian Goldspiel1,2, Hossein Fazelinia7, Clemence Queriault1,2, Lucien Turner1,2, Tanay Parnaik6, Jimmy Xu6, Lynn Spruce7, Caroline Bartman6, Clementina Mesaros6, Ramon Klein Geltink4,8,9, Crystal Conn5, and Will Bailis1,2
96 Methionine restriction induces ATF4 expression and anti-tumor activity in macrophages
Kendra A Libby1,2 and Alison Ringel1,2
97 Macrophage handling of non-degradable particulates contained within cell corpses
Stephanie Bersie1, Alexandra McCubbrey2, and Shannon Hott2
98 ACC1 regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health
Maria Rafailia Theodorou1, Fabian Nikolka2, Karsten Hiller2, and Christoph Wilhelm1
99 Single-cell profiling of hepatic dendritic cells in Metabolic-associated Steatotic Liver Disease
Camilla Klaimi1, Pauline Jacquemain1, Kevin Ory1, Anne-sophie Jenequin1, Charlene Pourpe1, Ghania Kara-Ali1, Zouriatou Gouda1, Marine Huillet1, Nathalie Hennuyer1, Arnaud Carrier2, Alexandre Pelletier2, Fabien Delahaye2, Amelie Bonnefond1, David Dombrowicz1, Bart Staels1, and Joel Haas1
100 A PHGDH-dependent mechanism regulates dendritic cell functions
Ebenezer Asiedu, Matthew Weiland, and Connie M Krawczyk
101 Metabolic secretome of macrophages maintain tissue homeostasis.
Alishan Sahu1, Antra Gaur1, Thomas Köcher2, and Thomas Weichhart1
102 Restoring Gut-Brain-Immune Axis Homeostasis: The Role of Microbial-Based Interventions in the Management of Gastrointestinal and Systemic Symptoms in ME/CFS and Long COVID
Joanna Michalina Jurek and Jesus Castro-Marrero
103 Regulation of Myeloid Multinucleation by specific metabolic adaptations
Gernot Schabbauer
104 Mitochondria Transfer in Oral Cancer impairs CD4+ T cell metabolism and functional responses by promoting exhaustion via hypoxic stress
Barbara Antilef1, Sergio Sanhueza1, Romina Quiroga1, Solange Cisterna 1, Camila Muñoz-Grez1, Liliana Lamperti1, Agustin Vera1, Patricia Luz-Crawford3, Andres Caicedo 4, Luciano Ferrada2, Mauricio Hernandez5, and Estefania Nova-Lamperti1
105 Adiponectin increases CD8 memory cell function by promoting mitochondrial metabolism
Marko Šestan
106 Loss of metabolic plasticity and decreased nutrient availability leads to the generation of cytotoxic T cells during aging
Francesc Baixauli1, Nadia Schlauri1, Sarah Roffeis1, Jasmin Grählert1, Erta Xhafa1, Joy Edwards-Hicks2, Fredrik Trulsson1, and Christoph Hess1,2
107 Standardizing immunometabolic respirometry: a comparative analysis of Oroboros and Seahorse
Paul Knoop1,2, Pamela Fischer-Posovszky1,2, Iris-Tatjana Kolassa2,3, Matthias Mack3, and Daniel Tews1,2
108 Deciphering the Metabolic Control of Treg Function
Janika Härm1, Henry Kurniawan1, Takumi Kobayashi1,, Veronika Horkova1, Melanie Grusdat, Joseph Longworth1,, and Dirk Brenner1,
109 Macrophage glucocorticoid receptor shapes the immune response to obesity associated hepatocellular carcinoma
Tim Schaffranek1, Giorgio Caratti1, Jun-Min Lee1, Pamela Fischer-Posovszky2, Jan Tuckermann1, and Ulrich Stifel2
110 Local and systemic lipid metabolism dictate granuloma development and associated atherosclerosis disease progression
Jayne Louise Wilson1, Stephan Forisch1, Vivien Vankann1, Manuela Träger1, Anja Wagner2, Cécile Philippe3, Paul Ettel1, Nyamdelger Sukhbaatar1, Piyal Saha1, Maximilian Krisch3, Chrysoula Vraka3, Marion Mußbacher4, Markus Hengstschläger1, Marcus Hacker3, Andreas Bergthaler5,8, Tarek Moustafa6, Klaus Kratochwill2,7, and Thomas Weichhart1
111 Defining the metabolic requirements of CD8+ Tc2 cells indicates serotonin degradation as an important metabolic switch
Sabrina Ferreira1,2, Lisa Holla1,2, Lorenz Wirth1,2, Jenny Mjösberg1,2, and Chris Tibbitt1,2
112 Profiling metabolic reprogramming of CD4+ T cell activation by 1,2 13C-Glucose and U-13C-Glutamine parallel tracing platform and lipidomics
Ziyu Yang1, Alex Dickens2, Matilda Kråkström3, and Matej Orešič3
113 Mitochondrial dysfunctions dictate sensitivity to pathobiont infections and colitis by impairing regulatory T cell function
Mauro Corrado
114 Decoding Obesity-Induced Inflammation: The Critical Role of TNFAIP3
John G Scanlan1, David Finlay1, and Lydia Lynch2
115 Insulin receptor signalling regulates B cell metabolism and function
Paulo Jose Basso, Mengyi Zhu, and Sue Tsai
116 Targeting T cell metabolism to bolster anti-viral response in type 2 diabetes
Weixin Chen, Victor Gray, Rachael Julia Yuenyinn Tan, Jia Ming Nickolas Teo, Zhihao Huang, Carol Ho Yi Fong, Tommy Wing Hang Law, Zi-Wei Ye, Shuofeng Yuan, Xiucong Bao, Ivan Fan-Ngai Hung, Kathryn Choon-Beng Tan, Chi-Ho Lee, and Guang Sheng Ling
117 Neutrophil-derived activin A mediates cancer-associated cardioskeletal wasting through mitochondrial dysfunction
Amro Soliman, Kasia Dzierlega, Ali Jaafar, and Xavier Clemente-Casares
118 Tumour-infiltrating regulatory T cells engage Nrf2 signalling to support their metabolic adaptation in hepatocellular carcinoma
Elena Perpinan Mas1, Nicolas Sompairac2,3, Erik Ramon Gil4,16, Chi Man5, Leonard Bellersheim1, Marianna Maddaloni6, Christian Schmidl6, Diana Marin Correa 1, Celio Xavier da costa Santos7, Elisavet Kodela 1, Juan José Lozano8, David Camell-Raventos9, Ana Hernández de Sande9, Roser Pinyol9, Cheng Zhang1, Xinmeng Liao17, Emmanuelle Landmann1, Jorge Yaguana Torres1, Marwa Elgosbi1, Ada Sera Kurt1, Vrinda Sharma 1, Maegen Fleming1, Thomas Dowe1, Marwo Habarwaa1, Ziyu Liu5, Yoh Zen1, Rosa Raquel1, Debashis Sarker1,10, Albena Dinkova-Kostova 11, Shahram Kordasti2,3, Timothy Tree12, Josep M. Llovet9,13,14, Ajay Shah7, Gilbert Fruhwirth5, Erika Pearce15, Jack Leslie4,16, Alberto Sanchez-Fueyo1, and Niloufar Safinia1
119 Short-Term Microbial Exposure Induces Long-Lasting Immune Cell Reprogramming
Aline Ignacio1, Marcela Davoli Ferreira1, Larisa Kovtonyuk1, Lauar Monteiro3, Ramon Klein Geltink, and Kathy McCoy1
120 Lipid droplet biogenesis regulates human NK cell function
Susanna NG1, Philipp Strobl1, Natalia Pietrosemoli2, Claudia Chica2, and Laura Surace1
121 Single cell immune metabolism to measure vaccine efficacy
Kendra K Reynaud1, Ana Delgado2, Magali Sarafian3, and Laurent Beloeil1
122 Memory SalvAge: how autophagy-dependent mitochondrial inheritance controls T cell fate decisions.
Mariana Borsa1, Ana Victoria Lechuga-Vieco1, Amir H Kayvanjoo2, Edward Jenkins1, Yavuz Yazicioglu1, Ewoud B Compeer1, Felix C Richter1, Simon C Rapp2, Robert Mitchell1, Tom Youdale3, Hien Bui4,5, Emilia Kuuluvainen4,5, Michael L Dustin1, Linda V Sinclair3, Pekka Katajisto4,5,6, and Katja Simon1,2
123 Association of Neutrophil Cytosolic Factor 2 with Tuberculosis in blood and lung.
Pumla Majozi1,2, Thabo Mpotje1,2, Antony Rapulana1,2, Welcome Setjie3, Tamia Lawrance1,2, Hlumani Ndlovu3, and Jackson Marakalala1,2,4
124 Molecular and Cellular Signatures of Hepatocellular Carcinoma Development in Patients with Metabolic Dysfunction-associated Steatotic Liver Disease
Lillian I Dolapchiev, Suet-Ying Kwan, and Laura Beretta