19th International Conference on Innate Immunity

Posters

Important: The program online is copyrighted to each author and should not be copied and pasted!
48 Development of novel NLRP3 PET radiotracers and their application
Shijun Zhang, Yiming Xu, and Savannah Biby
49 The dual role of IL-6 in intestinal epithelial integrity and health during Mycobacterium avium paratuberculosis infection in Crohn’s disease
SALEH NASER and Ala' Alhendi
50 Features of Gene Regulation in Violation of the Inflammatory Response
Alexander N. Orekhov and Tatiana I. Kovyanova
51 New, intracellular roles of the alarmin HMGB1 in monocytes revealed by identifying its interactome.
Rebecka Heinbäck1, Marit van der Zijde1, Choi Tsang1, Alexander Espinosa1, Cecilia Aulin1, and Helena Erlandsson Harris1,2
52 Molecular studies of the inflammatory properties of HMGB1
Xingzhao Wen
53 Multifaceted HEV ORF2 capsid protein modulates pDC response
Garima Joshi1, Elodie Decembre1, Marlene Dreux1, Claire Montpellier4, Jacques Brocard3, Laurence Cocquerel4, Martin Ferrie4, Nolwenn Jouvenet5, Omran Allatif1, Viet Loan Dao-Thi2, and Delphine Galiana1
54 PGI2 Deficiency Augments Memory ILC2 Responses in Allergic Inflammation
Weisong Zhou1, Jian Zhang1, Shinji Toki1, Allison E Norlander2, Dawn C Newcomb1, and Stokes Peebles1
55 Caloric restriction enhances anti-mycobacterial capacity of systemic immune cells regardless the differences due to host genetic background
Claudia La Rocca1, Maria Teresa Lepore1, Carla Bromuro2, Cristiana Barbati2, Giuseppe Matarese1, and Carla Palma2
56 Effect of Cadmium exposure on coelomocytes, the cellular part of the earthworms’ innate immune system, using single-cell RNAseq and live cell imaging techniques
Martina Höckner and Adolf Sandbichler
57 COVID-19-derived insulin resistance confuses neutrophils, promoting higher NETosis and miR-21-5p upregulation.
Camilo Cabrera1, Romina Quiroga1, Sergio Sahueza1, Bárbara Antilef1, Camila Muñoz1, Mario Henriquez-Beltrán2,3, Gonzalo Labarca1,4, María C Garcia-Hidalgo3,5, David De Gonzalo-Calvo3,5, Fernando Valiente-Echeverría6, José Luis Garrido7, María Inés Barría8, Mauricio Hernández9, Luciano Ferrada10, and Estefania Nova-Lamperti1
58 Glycolysis-stimulated lactate production by tumor-associated macrophages promotes their M2-like phenotype
Katarzyna Kurylowicz1, Kasturi Chakraborty2, Chang Cui2, Gustavo Gastão Davanzo3, Guolin Zhou2, Xu Anna Tang2, Kelly Q. Schoenfelt2, Natalie Pulliam4, Catherine A. Reardon2, Swati Kulkarni4, Tomas Vaisar5, Pedro M. Moraes-Vieira3, Yingming Zhao2, and Lev Becker2
59 Analysis of mechanisms of immune evasion in liver cancer
Camilla Volponi, Aurora Gazzillo, and Eduardo Bonavita
60 The Bone Marrow Endothelial Progenitor Cell Response in Mice with Septic Infection
Xin Shi, Kevin J Simms, and Ping Zhang
61 The need for Notch ensures that CD8 T cells wait for help from CD4 T cells
Adrien Laurent1, Nikolina Babala1, Julien Karrich1, Astrid Bovens1, and Jannie Borst2
62 Additive STING activation shifts cisplatin toxicity from kidney injury to liver failure
Wulf Tonnus, Karolin Flade, and Andreas Linkermann
63 TGFβ-1-Thrombospondin-1 axis regulates neutrophil infiltration into the urothelium during urinary tract infection
Lars Christian Widera1, Sebstian Beßler2, Philippa Spangenberg1, Jenny Dick1, Devon Siemes1, Olga Shevchuk1, Jens Soltwisch2, Klaus Dreisewerd2, and Daniel Robtert Engel1
64 Discovery of an Interferon-Independent Innate Immunity Pathway Using Poxvirus Proteins
Don B Gammon1, Emily Rex1, Sabrynna Brito Oliveira2, and Flavio G da Fonseca2
65 Alternative Organ-Selective Leukocyte Recruitment Receptors
Donna L Senger and Stephen M Robbins
66 Enhanced alternative splicing of transcripts encoding the innate immune, stress-activated protein kinase PKR is a prevalent presence in osteosarcoma.
William L Blalock1,4, Enrico Focaccia1,4, Manuela Piazzi1, Alberto Bavelloni2, Elisa Belloni1, Davide Pradella1, Claudia Ghigna1, and Karyna Volkava3
67 Comparison of the relative number of ILCs in normal conditions and in rheumatoid arthritis and bronchial asthma
Olga Boeva, Maria Berishvili, Ekaterina Pashkina, and Vladimir Kozlov
68 Macrophage-induced silencing of insulin signaling is an adaptive strategy for lipoprotein mobilization upon bacterial infection
Gabriela Krejčová1, Cecilia Morgantini2, Myriam Aouadi2, and Adam Bajgar1
69 Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks
Quen J Cheng1, Kylie Farrell1, Jeffrey Fenn1, Zuchao Ma2, Sara K Makanani1, and Jonathan Siemsen1
70 Interleukin 6 Polymorphisms 174 and 597: Impact on Graft-versus-Host Disease after allogeneic hematopoietic Stem Cell Transplantation in Childhood
Bernd Gruhn, Susan Wittig, and Laura Wetzel
71 Macrophages recycle nutrients from dying cells
Adam Bajgar and Gabriela Krejčová
72 Complement-activating Multimeric immunotherapeutic compleXes (CoMiX) elicit killing of Pseudomonas aeruginosa
Bianca Brandus1, Gilles Iserentant 1, Aubin Pitiot1, Xavier Dervillez1, Delphine Fouquenet2, Benoit Briard2, Mustapha Si-Tahar2, Guillaume Desoubeaux2, and Carole Devaux1
73 The role of antioxidant defense mechanisms in regulating the trained immunity-induced anti-tumor functions of neutrophils
Panagiotis Sidiropoulos, Lydia Kalafati, and Triantafyllos Chavakis
74 Innate immune response of the kidneys to trauma
Rebecca Halbgebauer1, Lena Schuette1, Karin Danzer2, and Markus Huber-Lang1
75 The role of ZNF598 in translational stress in inflammatory macrophages
Rodrigo D Requião, Pedro MM Moraes-Vieira, Mario H Bengtson, Lincon F Lima-Silva, Heloisa Prado, Monara Angelim, Webster Leonardo Costa, and Paulo EF Macêdo
76 Human monocyte derived macrophages evade ferroptosis via GCH1 pathway
Julia Sauer1, Patricia Pia Ogger2, Carolin Kirstin Watson1, Meshal Ansari1, Eva Griesser1, Katrin Fundel-Clemens1, Katja Köppen3, Alina Nessensohn1, Matthew James Thomas1, Karim Christian El Kasmi3, and Peter Murray2
77 Inhibitors of Bruton’s tyrosine kinase interfere with neutrophil functions in vitro
Mirre De Bondt1, Janne Renders1, Paloma Petit de Prado1, Gayel Duran2, Paulien Baeten2, Bieke Broux2, Mieke Gouwy1, Patrick Matthys1, Niels Hellings2, and Sofie Struyf1
78 The role of adaptor protein Mal/TIRAP in transducing TLR signaling
Gabrielle C McClymont1, Prasanna Suresh2, David Klenerman2, and Clare E Bryant3
79 Activation of ATF3 and IL-6 related transcription factors by candidalysin
Emily L Priest, Julian R Naglik, and Jonathan P Richardson
80 Calling for dendritic cell backup: interplay between CCR2 and CXCR4 drives bone marrow egress of cDC progenitors
Mariana Pereira da Costa1, Carlos M Minutti1, Cécile Piot1, Margarida Bonifacio1, Evangelos Giampazolias1, Ana Cardoso1, Mar Cabeza-Cabrerizo1, Neil C. Rogers1, Marta Lebrusant-Fernandez3, Chrysante S. Iliakis2, Andreas Wack2, and Caetano Reis e Sousa1
81 A novel E3 ligase of GILZ, which represents a target to suppress multiple cytokine pathways and bypass the metabolic adverse effects of glucocorticoids in autoimmune disease treatment
Iolanda Miceli, Rochelle Sherlock, Lily (IanIan) Cheang, Akshay D'Cruz, Taylah Bennett, Terry Lim Kan Sian, Trevor Wilson, Rangi Kandane-Rathnayake, Eric Morand, and Sarah A. Jones
82 PTX3 is expressed in terminal lymphatics and shapes their organization and function
Andrea Doni1, Marina Sironi2, Annalisa Del Prete 3, Fabio Pasqualini 2, Sonia Valentino2, Ivan Cuccovillo2, Michela Calvi 4, Antonella Tosoni 5, Gianluca Vago 5, Manuela Nebuloni5, Cecilia Garlanda6, Annunciata Vecchi 2, Barbara Bottazzi 2, and Alberto Mantovani 2
83 The interaction of complement-activating collectins CL-K1 and CL-L1 with bacterial isolates from preterm neonates.
Gabriela Gajek 1, Karolina Chojnacka 2, Maciej Cedzyński 1, Tomasz Szczapa 2, Katarzyna Kasperkiewicz3, Marta Majchrzak 4, Soren W. K. Hansen5, and Anna St. Świerzko 1
84 hnRNPA3 as an organizing RNA regulator in inflammatory responses relevant to intestinal homeostasis
Fotis Ioakeimidis2, Panagiotis Mavrommatis-Parasidis1, Sofia Gargani1,2, Dimitris Tzanos2, Margarita Andreadou2, Dimitra Palioura2, Vasileios Ntafis2, Martina Samiotaki2, Pantelis Hatzis2, and Dimitris L. Kontoyiannis1,2
85 Outer membrane vesicles secreted by Yersinia enterocolitica O:3 as a target for complement system
Cédric Battaglino1, Irina Bodnaruk 2, Paula Czyszczoń3, Katarzyna Kasperkiewicz 2, Jolanta Łukasiewicz 3, Mariusz Gadzinowski 4, Gabriela Gajek 1, Mikael Skurnik 5,6, Maciej Cedzyński 1, Teresa Basińska 4, and Anna St. Świerzko 1
86 Clinical associations of complement-activating collectins CL-K1 and CL-L1 in preterm neonates
Gabriela Gajek1, Soren W. K. Hansen2, Anna St. Świerzko 1, Dariusz Jarych1,3, Maja Kufetnicka-Babout4, Paulina Kobiela 5, Agnieszka Szala-Poździej 1, Karolina Chojnacka 6, Katarzyna Sobczuk 4, Iwona Domżalska-Popadiuk5, Jan Mazela 6, Jarosław Kalinka 4, Steffen Thiel7, and Maciej Cedzyńki 1
87 Aryl hydrocarbon receptor is necessary to restrain tissue macrophage inflammatory tonus and systemic glucose homeostasis during obesity
Bianca Castelucci Bataglioli1, Gisele De Castro1, João Víctor Virgílio da Silva1, Gustavo Gastão Davanzo1, Guilherme Ribeiro1, Larissa Menezes dos Reis1, Marcelo Rodrigues Berçot1, Ana Julia Estumano Martins1, Helder Takashi Imoto Nakaya2, Sílvio Roberto Consonni3, Lev Becker4, and Pedro Manoel Mendes de Moraes Vieira1
88 Breast Cancer Remodels Lymphatics in Human Sentinel Lymph Nodes
Sirpa Jalkanen
89 Clonal haematopoiesis shapes the immune system: the case of the preleukemic neutrophil
Hector Huerga Encabo
90 Microglia derived extracellular mitochondria modulate neuronal survival and function
Monara K S C Angelim, Gisele Castro, Willias S Santos, and Pedro M M M Vieira
91 Primed monocytes in gammaherpesvirus-induced EAE exacerbation
Annet van de Waterweg Berends1,2, Xiang Du 2, Justine Javaux2, Remy Sandor2, Malyvanh Pathammavong2, Bieke Broux1, Bénédicte Machiels2, Niels Hellings1, and Laurent Gillet2
92 Natural antibodies and complement are required for clearance of necrotic cell debris by neutrophils
Sofie Vandendriessche, Matheus Mattos, Emilia Laura Bialek, Sara Schuermans, and Pedro Elias Marques
93 Genome-wide CRISPR/Cas9 screen reveals CCDC134 as a new regulator of Toll-like receptor signaling
Léa Bernaleau1, Michaela Drobek1, Ales Drobek1, Fenja Blank2, Maeva Delacrétaz1, Olivia Majer2, and Manuele Rebsamen1
94 Innate immunity affected by sepsis showed the features of long-lasting immunosuppression in pediatric patients.
Marcela Hortova-Kohoutkova1,2, Lukas Homola3, Gabriela Blazkova1, Rafael Arguello4, and Jan Fric1,2,5
95 The alarmin HMGB1 is released in different forms from cancer cell lines – potential impact on function
HARINI PECHIAPPAN1, Rebecka Heinbäck2, Sigrid Stråtveit Gravning1, Kjerstin Jakobsen1, Cecilia Aulin2, and Helena Erlandsson Harris1
96 Targeting Tumour-Infiltrating Regulatory T Cells: A Nanobody Approach
Neema . A. Jumapili, Sana Arnouk, and Jo A. Van Ginderacter
97 Microglia derived extracellular mitochondria modulate neuronal survival and function
Monara Angelim, Gisele Castro, Willias Silva Santos, and Pedro Manoel Mendes de Moraes Vieira
98 ICOS and 4-1BB as promising targets for immunostimulation in exhausted NK cells from cervical cancer patients
Jose Manuel Rojas Diaz1, Jesse Haramati2, Pablo Cesar Ortiz Lazareno3, Fabiola Solorzano Ibarra1, Nadia Tatiana Garcia Barrientos1, Ksenia Klimov Kravtchenko1, Pedro Ivan Urciaga Gutierrez1, Marcela Sofia Guitron Aviña2, Alexia Paola Dominguez Hernandez2, Martha Cecilia Tellez Bañuelos2, and Susana del Toro Arreola1
99 Leukocyte recruitment in Usutu virus-induced encephalitis
Emily Slowikowski1, Céleste Willems1, Sara Schuermans1, Leen Delang1, Rafael Elias Marques2, and Pedro Elias Marques1
100 Mechanisms of necrotic cell debris clearance from injury sites in vivo
Pedro Elias Marques
101 Targeting Innate Immune Memory in Age-Related Macular Degeneration
Guillaume Blot, Frédérik Fournier, Jeffrey Sullivan, Vera Guber, Ariel Wilson, Masayuki Hata, and Przemyslaw Sapieha
102 Obesity renders poorly immunogenic malignancies amenable to senolysis
Frederik Fournier1, Roberto Diaz-Marin1, Frederique Pilon3, Gabrielle Girouard4, Ariel Wilson3, Bruno Larrivée3, Mathieu Neault1, Frederick Antoine Mallette1, Sergio Crespo Garcia1, and Przemyslaw Sapieha1
103 Identification of effectors of innate immunity
Jeffrey Sullivan1, Frédérik Fournier2, Guillaume Blot2, Vera Guber 2, Agnieszka Dejda 2, Masayuki Hata2, Ariel Wilson2, and Przemyslaw Sapieha2
104 Dissecting the impact of enteric viral-bacterial co-infection on the host innate immune response and its implications for pathogenicity
Philipp Darius Konstantin DK Walch and Petr Broz
105 Necrophagy, DaNGeRous indigestion, defecation and immunity to cancer
Caetano Reis e Sousa
106 Evasins inhibit chemokine activity by affecting multiple chemokine proteoforms and preventing binding to GAGs
Emilia Bialek1,2, Roos Budts1, Mieke Gouwy1, Luna Dillemans1, Fabio Beretta1, Paul Proost1, Ingrid Dijkgraaf2, and Pedro Marques1
107 Innate Immune Training of Osteoclastogenesis promotes Inflammatory Bone Loss
Nora Haacke1, Hui Wang3, Shu Yan1, Marko Barovic1, Xiaofei Li3, Kosuke Nagai1, Lydia Kalafati1, George Hajishengallis3, and Triantafyllos Chavakis1
108 Neutrophils sense extracellular nutrients via mTORC1 and AMPK with consequences for lysosomal activity
Emily R Watts1, Patricia Coelho1, Ailiang Zhang1, Ryan D Huff2, Chris F Rider2, Christopher Carlsten2, and Sarah R Walmsley1
109 Candidalysin drives Candida albicans induced-IL-1β expression and release during oral infection
Alexander Kempf, Giorgio Camilli, James S Griffiths, and Julian R Naglik
110 Identification of macaque dendritic cell precursors (pre-DC) in blood and tissue reveals their dysregulation in early SIV infection
Benoit FAVIER
111 Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis.
Rishi Rajesh1, Reham Atallah1, Ilse Lanz1, Wolfgang Platzer1, Svetlana Pahernik1, Agnes A Mooslechner1, Stefano Angiarí2, Leigh Marsh3, Thomas Bärnthaler1, and Akos Heinemann1
112 The role of JAK/STAT signaling in neutrophilic airway inflammation
Barsha Nayak, Julia Teppan, Iris Red, Juliana Schwanzer, Akos Heinemann, and Eva Böhm
113 Aging eosinophils: from transcriptome to target
Svetlana Pahernik, Thomas Bärnthaler, Rishi Rajesh, Agnes Mooslechner, Ilse Lanz, Kathrin Rohrer, and Akos Heinemann
114 Rewiring of lipid metabolism upon sensing of fungal melanin is an essential host defense mechanism in alveolar macrophages
Vassilis Nidris, Ioannis Morianos, Electra Nenedaki, Evangelia Intze, and Georgios Chamilos
115 Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells
Sofia C. Khouili1, Elena Priego1, Annalaura Mastrangelo1, Sarai Martínez-Cano3, Johan Garaude2, Salvador Iborra3, Michel Enamorado4, and David Sancho1
116 Bacterial polyphosphates impede the macrophage response to infection
Frano Malinarich1, Julian Röwe1, Kevin Brueck1,2, Archana Jayaraman2, Johannes Platten1, Viola Krenzlin1, Foruzandeh Samangan1, Marcel Strüve1, Asala Al-Janabi1, Claudius Witzler1, Dilraj Kaur1, Mahil Lambert3, Verena K Raker4, Sabrina Muecklich5, Amrit Mann1, Madhusudhan Thati1, Volker Dötsch3, Wolfram Ruf1, Frank Bloos6, Michael Bauer6, Stefan Tenzer1, Christoph Reinhardt1, and Markus Bosmann1,2
117 β-glucan induces trained immunity hallmarks in dendritic cells
Ana Redondo-Urzainqui1, Dieke Dieke van Dinther2, Paola Brando3, Elena Priego1, Aitor Jarit-Cabanillas5, Elena Hernández-García5, Manuel Rodrigo-Tapias6, Sarai Martínez-Cano6, Ana Quintas7, Ana Dopazo7, Manuel J Gómez8, Fátima Sánchez-Cabo8, Carlos del Fresno4, and David Sancho1
118 Translocation of gut Enterococcus faecalis trains myeloid bone marrow progenitors via the C-type lectin receptor Mincle.
Iñaki Robles-Vera1, Aitor Jarit-Cabanillas1, Paola Brandi1, Maria Martinez-Lopez5, Sarai Martinez-Cano1,3, Cristina Gonzalez-Correa2, Javier Moleon2, Juan Duarte2, Laura Conejero3, Pablo Mata4, Carmen Maria Diez-Rivero3, Marta Bergon-Gutierrez4, Ivan Fernandez-Lopez1, Manuel J. Gomez6, Ana Quintas7, Ana Dopazo7, Fatima Sanchez-Cabo6, Esther Pariente8, Carlos del Fresno4, Jose Luis Zubiza3, Salvador Iborra3, and David Sancho1
119 Jak-Stat signaling maintains homeostasis in T cells and macrophages
Nikolaus Fortelny1,2, Matthias Farlik1,3, Thomas Decker5, Mathias Mueller4, and Christoph Bock1,6
120 In vivo CRISPR screen reveals essential cytokines regulating macrophage phenotypes in neuroinflammation
Clara de la Rosa, Arek Kendirli, and Martin Kerschensteiner
121 An AZIN2-acetylspermidine axis required for resolution of inflammation
Kosuke Nagai1, Kyoung-Jin Chung1, Hui Wang2, Lydia Kalafati1, Peter J Murray3, Vasileia-Ismini Alexaki1, George Hajishengallis2, and Triantafyllos Chavakis1
122 Colony-stimulating factor 1 receptor (CSF1R) inhibition reprograms tumor associated macrophages and impairs mesothelioma growth
Rosanna Mezzapelle1,2, Alessandro Mesaglio1, Angela Antonia Rilievo1, Andrea Lamarca1, Caprioglio Francesca1,2, Liam Colley1, Anna Mondino3, Massimo Crippa1, and Marco Emilio Bianchi1,2
123 ImmunoGenic Surrender: a new mechanism of immune surveillance
Marco E Bianchi1,2, Rosanna Mezzapelle1,2, Francesca Caprioglio1,2, Liam S Colley3,4, and Massimo P Crippa2
124 Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory
Athanasios Ziogas1 and Mihai G. Netea1