10th International Conference on Autoimmunity: Mechanisms and Novel Treatments

Posters

Important: The program online is copyrighted to each author and should not be copied and pasted!
40 Unveiling autoimmune adrenal disease with imaging mass cytometry
André Sulen1, Kathrine Skarstein2, Bergithe Oftedal1, Eystein S Husebye1,3, and Eirik Bratland1
41 Meningeal lymphatics and immunity in brain function and dysfunction
Jonathan Kipnis
42 IL-12-driven intrinsic neuroepithelial cells attenuate CNS inflammation
Myrto Andreadou1, Ekaterina Friebel1, Teresa Cramer2, Pascale Eede3, Donatella De Feo1, Selma Tuzlak1, Christina Welsh1, Shirin Schneeberger3, Shiva Tyagarajan2, Melanie Greter1, Frank L Heppner3, Sarah Mundt1, and Burkhard Becher1
43 IL-17 regulates EAE severity through the intestinal environment
Katlynn L Carter, Tommy Regen, and Ari Waisman
44 Role of the phosphate exporter Xpr1 in myeloid cell development
Sebastian A Stifter1, Ekaterina Petrova1, Selma Tuzlak2, Annika Keller3, Burkhard Becher2, and Melanie Greter1
45 New molecular methods in the diagnosis of rheumatoid arthritis
Randa M.T Issa
46 Does cancer masquerade as sarcoidosis
Daniel Albert
47 Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Dana L.E. Vergoossen1, Annabel M. Ruiter2, Kevin R. Keene2, Erik H. Niks2, Martijn R. Tannemaat2, Ellen Strijbos2, Alexander F Lipka2, Els C. Jol-van der Zijde3, Jaap A. Bakker4, Brigitte A. Wevers4, Maarten J.D. van Tol3, Elisabet Westerberg5, Lucia S. Borges6, Olivia C. Tong6, David P. Richman6, Isabel Illa7, Anna R Punga5, Amelia Evoli8, Silvere M van der Maarel1, Jan J.G.M. Verschuuren2, and Maartje G.M. Huijbers1
48 Uncovering how GM-CSF rejuvenates the Alzheimer brain
Rachel Lindemann1, Maria Geesdorf2, Wiebke Mildenberger1, Elsa Roussel1, Myrto Andreadou1, Philipp Häne1, Frank Heppner2, Donatella De Feo1, and Burkhard Becher1
49 Constitutive RIG-I Activation Causes Skin Lesion Resembling Psoriasis in Mice
Ahmed Abu Tayeh and Takashi Fujita
50 Nrf2 regulates redox metabolism of CD4+T cells in chronic inflammatory conditions like childhood arthritis
Anandhi Rajendiran, Sudheendra Hebbar Subramanyam, Klaus Tenbrock, and Kim Ohl
51 PD-1/PD-L1 co-inhibition and its multiplexed impact on neuroinflammation
Christian Thomas Ashworth1, Florian Ingelfinger1, Lothar Dieterich3, Bettina Schreiner3, Burkhard Becher1, and Sarah Mundt1
52 Joint-tissue sensing drives TLR4+ Tfh-like cells cytotoxic activity
Daniela Amaral-Silva, Jaime C Branco, and Helena Soares
53 Single cell sequencing of antigen-specific autoreactive B cells in MuSK myasthenia gravis
Laurent M Paardekooper1, Jessica M van Bokkum1, Yvonne E Fillié-Grijpma1, Theresa Kissel3, Susan L Kloet1, Martijn R Tannemaat2, Jan J Verschuuren2, Silvère M van der Maarel1, and Maartje G Huijbers1
54 Macrophage-derived human resistin promotes perivascular adipose tissue (PVAT) dysfunction in a rheumatoid arthritis mouse model.
Aline G. Fedoce1, Marcos H. Rosa1, Flávio P. Veras1, Ayda H. Schnaider1, Josiane F. Silva1, Isadora M. Paiva1, Mirele R. Machado1, Leandra N. Ramalho2, José Carlos F. Alves-Filho1, Fernando Q. Cunha1, Anthony Bonavia3, Mitchell A. Lazar3, and Rita C. Tostes1
55 NCF1-dependent low induction of reactive oxygen species in plasmacytoid dendritic cells exacerbates lupus
Huqiao Luo1, Vilma Urbonaviciute1, Amir Ata Saei1,2, and Rikard Holmdahl1
56 Foxp3 expression on regulatory T cells is regulated by acetyl-coa availability
Philipp Stueve2, Janet G Godoy2, Tim D Sparwasser2, and Luciana Berod1
57 An animal model of cortical grey matter inflammation resembling progressive MS pathology
Emily M Ullrich Gavilanes1,2,3, Aleksandra Mezydlo1,2, Clara de la Rosa del Val1,2,3, Nils Treiber1,2, Virag Kocsis-Jutka1,2, and Martin Kerschensteiner1,2
58 Astrocyte-derived HB-EGF promotes recovery from autoimmune CNS inflammation and is a potential target in progressive disease
Mathias Linnerbauer
59 The RNA sensor TLR7 mediates immune cells, promoting autoimmunity and kidney disease during chronic RNA-viral infection in mouse and human
Christabel Celia Kho1, Sümeyye Ertugrul1, Patrick Droste2, Alexandra Brand1, Satoru Kudose3, Konstantinos Symeonidis1, Sara Khorasani1, Hella Luksch4, Claudia Günther5, Vivette D'Agati3, Peter Boor2, Christian Kurts1, and Zeinab Abdullah1
60 The role of cytokine-producing B cells in initiation of EAE
Anna S Thomann1, Courtney A McQuade1, Katarina Pinjušić2, and Anneli Peters1,2
61 The role of MMP-12 in MS-associated neuroinflammation
Laura M Oberbichler, Sara da Costa Pereira, Rachel Lindemann, Donatella de Feo, and Burkhard Becher
62 Neutrophil extracellular traps (NET) trigger an enhanced pro-inflammatory response in macrophage subpopulations in rheumatoid arthritis patients via the aryl hydrocarbon receptor (AhR) pathway
Dyhia Melbouci1, Sarra Seninet1, Marie-Christophe Boissier1,2, Elodie Segura3, and Patrice Decker1
63 Intranasal delivery of TGFα – a novel therapeutic approach for lesion resolution in Multiple Sclerosis?
Lena Loesslein
64 Role of CNS-infiltrating immune cells in mice undergoing experimental autoimmune encephalomyelitis after asymptomatic HSV-1 infection
Luisa F. Duarte1, Mónica A. Farías2, Almendra Castillo 1, Felipe Cancino2, Claudia A. Riedel1, and Pablo A. González2
65 The T cell HECT type ubiquitin ligase HECTd1 is a potential therapeutic target for multiple sclerosis
Amy Tang and Deyu Fang
66 TRAF6 counteracts MALT1 protease function to prevent autoimmune inflammation
Thomas J. O'Neill, Andreas Gewies, Carina Graß, Thomas Seeholzer, and Daniel Krappmann
67 Serum and CSF protein profiles associated with severity of relapsing-remitting multiple sclerosis
Carolina Moraes-Cabe1, Vincent Bondet1, Darragh Duffy1, Priyanka Devi-Marulkar1, Caroline Papeix2, Sandra Pellegrini1, and Frédérique Michel1
68 Antigen-specific nanoparticle tolerance treatment actively induces regulatory mechanisms via the STING pathway
Joseph R Podojil1,2, Tobias Neef1, Tushar Murthy2, Michael T Boyne1,2, Ming-Yi Chiang1, Andrew C Cogswell1, Adam Elhofy2, and Stephen D. Miller1
69 GM-CSF drives multi-organ autoimmunity upon loss of peripheral tolerance
Sara A Costa Pereira1, Margit Lanzinger2, Dona de Feo1, Nico Nunez1, Myrto Andreadou1, Sinduya Krishnarajah1, Elsa Roussel1, Frederike Ridder1, Juan Villar-Vesga1, Philipp Häne1, Rachel Lindemann1, Aakriti Sethi1, André Fonseca da Silva1, Mirjam Lutz1, Andrew L Croxford3, Melanie Greter1, and Burkhard Becher1
70 Identification of BPT264 - a potent alpha-enhanced/beta-dead and half-life-extended IL-2 Treg enhancer for treatment of autoimmune diseases
Adrian R Walmsley, Magali Muller, Ruben Alvarez, Fabian Junker, Benoit Hornsperger, Roy Meoded, Jean-Philippe Carralot, Vijay Pattabiraman, and Bertolt Kreft
71 Active translation control of CD4 T cell activation by regulatory T cells
Steven F Ziegler1, Lomon So1, Kazushige Obata-Ninomiya1, Alex Hu1, and Ram Savan2
72 Retroviral glycoprotein-mediated immune suppression via the potassium Channel KCa3.1- A new strategy for amelioration of Inflammatory Bowel Diseases (IBD).
Magdalena Janina Laska1, Jesper Bonnet Møller2, Jonas Heilskov Graversen3, Dorthe Strøbæk4, Linda Blomster5, Palle Christophersen4, and Shervin Bahrami6
73 A minimal intracellular domain of CD5 allows a negative regulator of T cell activation to operate positively
Zachary Fasana1, Courtney Matson1, Erika Carmody1, Paul E Love2, and Nevil J Singh1
74 Recent thymic emigrants require Notch signaling to transition into functionally mature naïve T cells
JC Zuniga-Pflucker
75 Microglia ontogeny and phenotype is influenced by the unique micro-environment of the circumventricular organs
Hannah Van Hove1,2,3,5, Jonathan Bastos1,2,3, Isabelle Scheyltjens1,2,3, Karen De Vlaminck1,2,3, Ana Rita Pombo Antunes1,2,3, Daliya Kancheva1,2,3, Lukas Amann4, Wiebke Mildenberger5, Diego Gomez-Nicola6, Ilse Smolders7, Luc Bouwens8, Marco Prinz4,9,10, Melanie Greter5, Jo A Van Ginderachter1,2, and Kiavash Movahedi1,2,3
76 Identification of essential modules regulating T cell migration to the central nervous system in multiple sclerosis
Arek Kendirli, Clara de la Rosa, Katrin Franziska Lämmle, Isabel Julia Bauer , Martin Kerschensteiner, and Naoto Kawakami
77 Deficiency of NIK in CX3CR1 expressing cells protects from autoimmune neuroinflammation
Nishada S. Ramphal and Ari Waisman
78 The emerging role of autoreactive T cells in Guillain-Barré syndrome
Lenka Súkeníková1, Anna Mallone1, Federica Sallusto1,2, Paolo Ripellino3, Bettina Schreiner4, and Daniela Latorre1
79 B cells contribute to splenic CD8 T cell response through communication with marginal metallophilic macrophages and splenic cDC1 in murine Cytomegalovirus infection
Xinyuan Liu, Ronald Backer, and Ari Waisman
80 Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis
Dana L.E. Vergoossen1, Jaap J. Plomp2, Christoph Gstöttner3, Yvonne E. Fillié-Grijpma1, Roy Augustinus1, Robyn Verpalen1, Manfred Wuhrer3, Paul W.H.I. Parren4,5, Elena Dominguez-Vega3, Silvère M. van der Maarel1, Jan J. Verschuuren2, and Maartje G. Huijbers2
81 Identification of BPT323 - An immunocytokine for treatment of autoimmune diseases combining orthogonal modes of action of TNFa blockade and selective Treg expansion
Adrian Walmsley, Magali Muller, Natalie Wickli, Sandra Klein, Ruben Alvarez, Robert Tam, Vijay Pattabiraman, and Bertolt Kreft