17th International Conference on Complement Therapeutics

Authors List

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Author Abstracts
Garlanda Cecilia Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Greco Luana Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Jaillon Sebastien Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Mantovani Alberto Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Mapelli Sarah Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Marchesi Federica Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Pasqualini Fabio Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Abdurahim Saeed Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Alberici Federico Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Anstadt Robert Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Antonucci Luca A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Ariceta Gema VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Armelloni Silvia Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Armstrong Lye Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Assanelli Andrea Complement therapeutics in acute respiratory distress syndrome (ARDS) beyond SARS-CoV-2: a clinical perspective
Atanasiu Doina Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Banda Nirmal RNA profiling, protein expression and gene deletion studies in rheumatoid arthritis patient synovium and murine models identifies critical roles for activation pathway effector mechanisms as well as factor H (FH) and FH-related families in disease pathogenesis
Barbarossa Annalisa Unraveling the contribution of complement in the initial days post lung transplantation
Barr William Sex Chromosome Regulation of Complement System Activity: Evidence for Post-Transcriptional Control of C3 and C4 Levels
Bassanese Giulia Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Battaglino Cedric Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Beeckmans Hanne Unraveling the contribution of complement in the initial days post lung transplantation
Benigni Ariela In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Berthenet Kevin Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Blagojevic Aleksandra Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Blom Anna Complement factor H is a novel ligand for the inducible T cell co-stimulator (ICOS) and promotes survival or regulatory T cells in the glioma microenvironment
Bodnaruk Iryna Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Bomback Andrew VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Bongoni Anjan Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Bos Saskia Unraveling the contribution of complement in the initial days post lung transplantation
Bosàkovà Veronika Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Boudhabhay Idris Integrated complementomics reveals myeloid-mediated pro-tumoral reprogramming of ccRCC cells through intracellular C3
Cell-intrinsic complement in endothelium
Bouyain Samuel Inhibiting the Complement Classical Pathway by Blocking Activation of the C1r Zymogen
Bracke Laura Unraveling the contribution of complement in the initial days post lung transplantation
Brekke Ole- Combined complement C3 and CD14 inhibition reduce live Escherichia coli-induced inflammation, but not platelet activation in the presence and absence of antibiotics
Brenner Michael Granzyme K Activates the Entire Complement Cascade
Granzyme K-driven complement activation
Bresin Elena In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Bright Matthew Mapping complement expression in the brain: implications for neurodegenerative disease therapeutics.
Butler Samuel A Novel Tool for Complement Activation Profiling in AAV Gene Therapy
Cairns Tina Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Cappoli Andrea A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
Carriero Roberta Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Castellano Giuseppe Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Catalano Marco Contribution of complement activating anti-PLA2R1 autoantibodies in membranous nephropathy
Cedzyński Maciej Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Celik Selvi A Novel Tool for Complement Activation Profiling in AAV Gene Therapy
Cerniauskas Edvinas Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Ceulemans Laurens Unraveling the contribution of complement in the initial days post lung transplantation
Chang Nan-Shan Serum complement internalization is needed for UV-mediated nuclear bubbling cell death
Chen Xi Compstatins abolish pathogenic fibroblast function associated with inflammatory maladaptation of tissues
Ciceri Fabio Complement therapeutics in acute respiratory distress syndrome (ARDS) beyond SARS-CoV-2: a clinical perspective
Cicia Donatella Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Claes Sandra Claes Unraveling the contribution of complement in the initial days post lung transplantation
Cohen Gary Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Colombo Federico Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Connolly E. Sander Complement Activity in Emboli Retrieved During Thrombectomy for Ischemic Stroke
Cowan Peter Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Curtin Karen Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Czerwiński Marcin Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Czyszczoń Paula Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Dabrowska-Schlepp Paulina In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Dambra Monica Complement activation sustains tumor progression and invasiveness in human and mouse CRC
De Castro Deus Marina Cell-intrinsic complement in endothelium
De winter Karen Unraveling the contribution of complement in the initial days post lung transplantation
Delahaye Tim Unraveling the contribution of complement in the initial days post lung transplantation
Delmas Yahsou VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Deschatelets Pascal A novel multiplex functional assay can be utilized to elucidate the mechanisms of the complement system.
Dettner Alina Complement activation in the intensive care unit: Therapeutic approaches on the central hub?
The involvement of complement system in immune mediated platelet clearance processes
Developement team ARDA The story of empasiprubart (ARGX-117), a long acting inhibitory C2 antibody, from bench to MMN patients
Dixon Bradley VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Doherty Mary Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Donadelli Roberta In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Donado Carlos Granzyme K Activates the Entire Complement Cascade
Duan Huiquan Inhibiting the Complement Classical Pathway by Blocking Activation of the C1r Zymogen
Eikrem David Activation of native C3 without proteolytic cleavage induced by phosphatidyl serine containing membranes.
Eitel Ingo Astrocyte-Derived Complement C3 Drives Metabolic Syndrome via C3a Receptor Activation in Hypothalamic Appetite-Regulating Neurons
Therapeutic Potential of the C3aR Antagonist JR14a in Heart Failure With Preserved Ejection Fraction (HFpEF)
Emblem Åse Combined complement C3 and CD14 inhibition reduce live Escherichia coli-induced inflammation, but not platelet activation in the presence and absence of antibiotics
Emma Francesco A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
Fakhouri Fadi VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Filip-Psurska Beata Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Fisicaro Nella Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Fleckenstein Monika Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Fontana Juan Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Friščić Jasna Compstatins abolish pathogenic fibroblast function associated with inflammatory maladaptation of tissues
Fromell Karin Activation of native C3 without proteolytic cleavage induced by phosphatidyl serine containing membranes.
Fung Jenny Targeting C5a Inflammation in ALS: Ex Vivo Findings from PMX205 Phase Ib Trial
A pathogenic role of C5aR2 activation in Amyotrophic Lateral Sclerosis.
Gaboriaud Christine Complement C1 proteases as possible new therapeutic targets in diseases
Gadzinowski Mariusz Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Gajek Gabriela Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Gál Péter Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Gale Daniel VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Garcia Brandon Inhibiting the Complement Classical Pathway by Blocking Activation of the C1r Zymogen
Gargiulo Antonio A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
Garlanda Cecilia Complement therapeutics in acute respiratory distress syndrome (ARDS) beyond SARS-CoV-2: a clinical perspective
Humoral Innate Immunity and Acute Phase Proteins in COVID-19
Geisbrecht Brian Inhibiting the Complement Classical Pathway by Blocking Activation of the C1r Zymogen
Geisler Sven Compstatins abolish pathogenic fibroblast function associated with inflammatory maladaptation of tissues
Ghaboosh Hiba Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
Ghebrehiwet Berhane The C1q and gC1qR proteins as therapeutic targets in cancer
Giannini Carolina A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
Goicoechea de Jorge Elena Complement dysregulation behind the scenes in ANCA-associated vasculitis
Gragoll Carolin Therapeutic Potential of the C3aR Antagonist JR14a in Heart Failure With Preserved Ejection Fraction (HFpEF)
Astrocyte-Derived Complement C3 Drives Metabolic Syndrome via C3a Receptor Activation in Hypothalamic Appetite-Regulating Neurons
Greenbaum Larry VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Grizzi Fabio Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Grønli Renathe Combined complement C3 and CD14 inhibition reduce live Escherichia coli-induced inflammation, but not platelet activation in the presence and absence of antibiotics
Gudino Victoria Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Gumas Justin Immunostimulatory tRNA-derived RNAs in the circulation of patients with tuberculosis infection
Guse Kirsten Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Guzzo Isabella A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
Hack Erik Unraveling the contribution of complement in the initial days post lung transplantation
Hageman Jill Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Refinement of associations between age-related macular degeneration and regulators of complement activation for discovery and improved translation
Hajishengallis George Maladaptive trained immunity and chronic inflammation
Hallam Dean Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Han Seung Hyeok VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Hanack Christina A novel multiplex functional assay can be utilized to elucidate the mechanisms of the complement system.
Harris Claire Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Harvey Friedman Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Haut Nolwenn Complement C1 proteases as possible new therapeutic targets in diseases
Höchsmann Britta Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
Hoffmann Markus Compstatins abolish pathogenic fibroblast function associated with inflammatory maladaptation of tissues
Holers V RNA profiling, protein expression and gene deletion studies in rheumatoid arthritis patient synovium and murine models identifies critical roles for activation pathway effector mechanisms as well as factor H (FH) and FH-related families in disease pathogenesis
Hook Lauren Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Hoxha Elion Contribution of complement activating anti-PLA2R1 autoantibodies in membranous nephropathy
Huber-Lang Markus Complement activation in the intensive care unit: Therapeutic approaches on the central hub?
Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
The involvement of complement system in immune mediated platelet clearance processes
Ikehata Masami Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Imanifard Zahra In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Isbel Nicole VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Iuzzolino Lucia A novel multiplex functional assay can be utilized to elucidate the mechanisms of the complement system.
Jarych Dariusz Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Jin Xin Unraveling the contribution of complement in the initial days post lung transplantation
Joakimsen Ingrid Combined complement C3 and CD14 inhibition reduce live Escherichia coli-induced inflammation, but not platelet activation in the presence and absence of antibiotics
Jonsson A. Helena Granzyme K Activates the Entire Complement Cascade
Julianisya Alana A pathogenic role of C5aR2 activation in Amyotrophic Lateral Sclerosis.
Kaes Janne Unraveling the contribution of complement in the initial days post lung transplantation
Karlsen Bård Combined complement C3 and CD14 inhibition reduce live Escherichia coli-induced inflammation, but not platelet activation in the presence and absence of antibiotics
Kasperkiewicz Katarzyna Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Kavanagh David Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Kawamura Takuya Immunostimulatory tRNA-derived RNAs in the circulation of patients with tuberculosis infection
Ke BoJun Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
King Ben Complement and Diabetes in rodent models: complement controls metabolism, and metabolism controls complement
Kirino Yohei Immunostimulatory tRNA-derived RNAs in the circulation of patients with tuberculosis infection
Kiss Bence Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Klint Cecilia A Novel Tool for Complement Activation Profiling in AAV Gene Therapy
Kocsis Andrea Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Koehl Joerg Astrocyte-Derived Complement C3 Drives Metabolic Syndrome via C3a Receptor Activation in Hypothalamic Appetite-Regulating Neurons
Köhl Jörg Therapeutic Potential of the C3aR Antagonist JR14a in Heart Failure With Preserved Ejection Fraction (HFpEF)
Kolev Martin A novel multiplex functional assay can be utilized to elucidate the mechanisms of the complement system.
Kor Viktor Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Kortleven Pheline Unraveling the contribution of complement in the initial days post lung transplantation
Kozma Viktoria A Novel Tool for Complement Activation Profiling in AAV Gene Therapy
Kulak Klaudia A Novel Tool for Complement Activation Profiling in AAV Gene Therapy
Kurzawa Marzena Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Lako Majlinda Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Lambris John Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Therapeutic complement modulation at the forefront of novel immunotherapies: Misconceptions, myths, and novel insights
The involvement of complement system in immune mediated platelet clearance processes
Compstatins abolish pathogenic fibroblast function associated with inflammatory maladaptation of tissues
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Lee John Targeting C5a Inflammation in ALS: Ex Vivo Findings from PMX205 Phase Ib Trial
A pathogenic role of C5aR2 activation in Amyotrophic Lateral Sclerosis.
Li Min Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Inhibiting the Complement Classical Pathway by Blocking Activation of the C1r Zymogen
VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Licht Christoph VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Lill Markus Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Link-Lenczowski Paweł Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Liu Jin Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
López Lázaro Luis VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Łukasiewicz Jolanta Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Maciejewska Anna Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Magrini Elena Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Makhkamova Munisakhon Asymmetric dimethylarginine: a biomarker bridging coronary heart disease and metabolical associated steatotic liver disease
Malik Kamil Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Mannes Marco Complement activation in the intensive care unit: Therapeutic approaches on the central hub?
Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
The involvement of complement system in immune mediated platelet clearance processes
Marasà Maddalena Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Maritati Federica Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Martynowski Dariusz Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Mastaglio Sara Complement therapeutics in acute respiratory distress syndrome (ARDS) beyond SARS-CoV-2: a clinical perspective
Mastellos Dimitris TBA - Mastellos
Compstatins abolish pathogenic fibroblast function associated with inflammatory maladaptation of tissues
Mastrangelo Antonio VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Matteoli Gianluca Targeting Fibroblast-Derived C3: A Potential Therapeutic Strategy to Halt Chronic Inflammation in IBD.
Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Mattinzoli Deborah Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
McRae Jennifer Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Meyer Florian Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Mikołajczyk Krzysztof Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Mizuno Masashi VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Mohler Jennifer Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Mollnes Tom Combined complement C3 and CD14 inhibition reduce live Escherichia coli-induced inflammation, but not platelet activation in the presence and absence of antibiotics
Montagner Sara Contribution of complement activating anti-PLA2R1 autoantibodies in membranous nephropathy
Morgan B. Paul Mapping complement expression in the brain: implications for neurodegenerative disease therapeutics.
Targeting complement in brain diseases.
Moro Marc Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Muntz Fenella Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Nagy Zoltán Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Németh Bálint Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Nester Carla VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Neves de Holanda Maria Izabel VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Nguyen Van Dien Mapping complement expression in the brain: implications for neurodegenerative disease therapeutics.
Nilsson Bo Activation of native C3 without proteolytic cleavage induced by phosphatidyl serine containing membranes.
A Novel Tool for Complement Activation Profiling in AAV Gene Therapy
Nilsson Ekdahl Kristina Activation of native C3 without proteolytic cleavage induced by phosphatidyl serine containing membranes.
Noris Marina In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Novysedlak Rene Unraveling the contribution of complement in the initial days post lung transplantation
Olcina Monica Selective pressures driving altered complement protein expression in the tumour microenvironment
Padoa Sofia In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Pál Gábor Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Pappas Chris Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Refinement of associations between age-related macular degeneration and regulators of complement activation for discovery and improved translation
Penati Francesca In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Pettersen Kristin Combined complement C3 and CD14 inhibition reduce live Escherichia coli-induced inflammation, but not platelet activation in the presence and absence of antibiotics
Pezone Giovanni Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Pickering Matthew VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Pinheiro Sofia Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Pio Ruben Targeting complement in immunosuppressive tumor microenvironments
Piras Rossella In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
Podestà Manuel Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Poppelaars Felix RNA profiling, protein expression and gene deletion studies in rheumatoid arthritis patient synovium and murine models identifies critical roles for activation pathway effector mechanisms as well as factor H (FH) and FH-related families in disease pathogenesis
Pouw Richard Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Quintana Porras Luis Fernando Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Rabbani Said Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Design and Evaluation of Glycomimetics as Ficolin-1 Antagonists
Ranson Neil Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Ratajczak Mariusz The different responsiveness of C3- and C5-deficient murine BM cells to oxidative stress explains why C3 deficiency, in contrast to C5 deficiency, correlates with better pharmacological mobilization and engraftment of hematopoietic stem cells.
Rawish Elias Astrocyte-Derived Complement C3 Drives Metabolic Syndrome via C3a Receptor Activation in Hypothalamic Appetite-Regulating Neurons
Therapeutic Potential of the C3aR Antagonist JR14a in Heart Failure With Preserved Ejection Fraction (HFpEF)
Read Austin A pathogenic role of C5aR2 activation in Amyotrophic Lateral Sclerosis.
Redissi Alaeddine Integrated complementomics reveals myeloid-mediated pro-tumoral reprogramming of ccRCC cells through intracellular C3
Remuzzi Giuseppe In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
In vitro efficacy of recombinant Factor H, CPV-104, to antagonize alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy (C3G)
Rezola Artero Mikel Integrated complementomics reveals myeloid-mediated pro-tumoral reprogramming of ccRCC cells through intracellular C3
Richards Burt Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Refinement of associations between age-related macular degeneration and regulators of complement activation for discovery and improved translation
Ricklin Daniel Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
Design and Evaluation of Glycomimetics as Ficolin-1 Antagonists
Risitano Antonio Maria Complement therapeutics in acute respiratory distress syndrome (ARDS) beyond SARS-CoV-2: a clinical perspective
Rodo Jordi A Novel Tool for Complement Activation Profiling in AAV Gene Therapy
Rojas Rechy Moises Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Rossi Véronique Complement C1 proteases as possible new therapeutic targets in diseases
Roumenina Lubka Integrated complementomics reveals myeloid-mediated pro-tumoral reprogramming of ccRCC cells through intracellular C3
Complement in Sickle Cell Disease
Cell-intrinsic complement in endothelium
Ruggeri Annalisa Complement therapeutics in acute respiratory distress syndrome (ARDS) beyond SARS-CoV-2: a clinical perspective
Rusack Timo Astrocyte-Derived Complement C3 Drives Metabolic Syndrome via C3a Receptor Activation in Hypothalamic Appetite-Regulating Neurons
Therapeutic Potential of the C3aR Antagonist JR14a in Heart Failure With Preserved Ejection Fraction (HFpEF)
Rüthemann Peter Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Sahu Arvind Viral teachings on complement regulation
Salas Azucena Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Salvaris Evelyn Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
Santhosh Sneha Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Savukoski Susa Complement activation in the intensive care unit: Therapeutic approaches on the central hub?
The involvement of complement system in immune mediated platelet clearance processes
Saw Wan Ting Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b
Schaefer Franz Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Schmidt Christoph Complement activation in the intensive care unit: Therapeutic approaches on the central hub?
Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
Schmitz-Valckenberg Steffen Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Schneider Michael Astrocyte-Derived Complement C3 Drives Metabolic Syndrome via C3a Receptor Activation in Hypothalamic Appetite-Regulating Neurons
Therapeutic Potential of the C3aR Antagonist JR14a in Heart Failure With Preserved Ejection Fraction (HFpEF)
Schols Dominique Unraveling the contribution of complement in the initial days post lung transplantation
Schrezenmeier Hubert Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
Schubart Anna Iptacopan (Fabhalta) for the treatment of complement-mediated diseases
In vitro effect of FB inhibitor in patients with primary Immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN).
Schwaeble Wilhelm Augmenting cytotoxicity of pathogen-specific antibodies that initiate complement activation independent of the classical pathway
Schwardt Oliver Design and Evaluation of Glycomimetics as Ficolin-1 Antagonists
Seager Nathan Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Shigematsu Megumi Immunostimulatory tRNA-derived RNAs in the circulation of patients with tuberculosis infection
Sichau Jannik Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherence
Simberg Dmitri Complement Alternative Pathway Inhibitors for Hemocompatibility of Nanoparticles in Multiple Animal Species.
Skurnik Mikael Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Smiesko Martin Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Design and Evaluation of Glycomimetics as Ficolin-1 Antagonists
Sobała Łukasz Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Spirig Rolf Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Steel David Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Stravalaci Matteo Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Subramaniam and collaborators Shankar A spatial and tissue digital landscape of triple negative breast cancer and complement pathways
Świerzko Anna Dissecting the role of bacterial outer membrane vesicle- (OMV)-dependent complement activation in systemic inflammatory response syndrome (SIRS)
Influence of N-glycosylation of the SARS-CoV-2 Spike protein on its interaction with collectins and complement activation
Szamosi Johan VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Tenner Andrea Knowing the Enemy: Selectively targeting complement to treat Alzheimer disease and related dementias
Theisen Erin Granzyme K Activates the Entire Complement Cascade
Thielens Nicole Complement C1 proteases as possible new therapeutic targets in diseases
Thomas Julie Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Thurman Joshua RNA profiling, protein expression and gene deletion studies in rheumatoid arthritis patient synovium and murine models identifies critical roles for activation pathway effector mechanisms as well as factor H (FH) and FH-related families in disease pathogenesis
Toso Marc Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Traggiai Elisabetta Contribution of complement activating anti-PLA2R1 autoantibodies in membranous nephropathy
Trombetta Elena Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Tsai Cheng-Chang Serum complement internalization is needed for UV-mediated nuclear bubbling cell death
Van De Kar Nicole VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
van de Logt Anne-Els Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
Van de Sompel Ariella Unraveling the contribution of complement in the initial days post lung transplantation
Van de Walle Inge The story of empasiprubart (ARGX-117), a long acting inhibitory C2 antibody, from bench to MMN patients
Unraveling the contribution of complement in the initial days post lung transplantation
Van Slambrouck Jan Unraveling the contribution of complement in the initial days post lung transplantation
Vanaudenaerde Bart Unraveling the contribution of complement in the initial days post lung transplantation
Vermeire Severine Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Verstockt Bram Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Veuskens Bert Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Viatore Marika Complement activation sustains tumor progression and invasiveness in human and mouse CRC
Vivarelli Marina Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)
VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
A case of a young C3G patient with a multifactorial genetic background, treated with pegcetacoplan
Vos Robin Unraveling the contribution of complement in the initial days post lung transplantation
Walker Patrick VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Wallace Dean VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Wang Zhongshen VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Whitfield Phil Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Widmer Kevin Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulators
Williams Brandi Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry
Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Woodruff Trent Targeting C5a Inflammation in ALS: Ex Vivo Findings from PMX205 Phase Ib Trial
A pathogenic role of C5aR2 activation in Amyotrophic Lateral Sclerosis.
Wu Wei Inhibiting the Complement Classical Pathway by Blocking Activation of the C1r Zymogen
Xiao Junyu Structural insights into IgM and complement activation
Xie Long Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function
Zanella Gaia Activated fibroblasts produce high level of complement component 3 during intestinal inflammation
Zanoni Francesca Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitors
Zecher Daniel VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN
Zelek Wioleta Mapping complement expression in the brain: implications for neurodegenerative disease therapeutics.
Targeting complement in brain diseases.
Zouace Moussa Refinement of associations between age-related macular degeneration and regulators of complement activation for discovery and improved translation
Zouache Moussa Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-driven
Chromosome 1q32 Haplotypes Define a Fundamental Complement Factor H Protein Family Complotype That Modulates Susceptibility to Age-related Macular Degeneration in Individuals of European Ancestry