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Aegean Conferences Communication
Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences
Registration
In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.
Airport
Please note that Crete has two airports. You want to arrive at the Heraklion International Airport (code: HER) and take a taxi from the airport to the hotel (~80 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively Chania International Airport (CHQ) is a two-hour drive to the Conference Center.
Accommodation Tax
An accommodation tax of € 10.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts.
Accommodations
Accommodations for the conference are at the Kalimera Kriti Hotel. The hotel is located in Sissi, 40 km from Heraklion International Airport. Please take a taxi from the airport to the conference venue.
Arrival and Check-in
It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:00 pm on the first day should make alternative dinner arrangements.
Conference Venue
The Kalimera Kriti Conference Center is located at the hotel.
Handicapped Accessibility
The site is fully handicapped accessible.
Oral Presentations
Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.
Archaeological Site of Knossos and City Tour
Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation.
Breakfast
Breakfast for registered participants and registered accompanying persons will be served at the Kalimera Kriti main restaurant during the hours scheduled in this program.
Lunches/Informal Discussions
Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.
Dinners/Informal Discussions
Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting. Please contact info@aegeanconferences.org.
Internet, Phone, & Computer
Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.
Certificate of Participation
A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session.
Passports and Visa/ETIAS
Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date. Starting 2025 you may need to apply for an ETIAS.
https://www.etiaseu.com/us-citizens/etias-greece
Letters of Invitation
Letters of invitation to attend an Aegean Conference meeting will be issued only to:
- Authors of accepted abstracts
- Fully paid registrants
Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.
Liability and Insurance
Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.
Other Information
Animals are not permitted on site.
Badges are required for admission to all events.
All Aegean Conferences events are no smoking, no e-cigarretes, no vaping, etc.
No Photographs and Recording Devices
Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations.
Code of Conduct Policy
Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here.
Saturday, May 10
06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:30 PM
Welcome Dinner (networking and informal discussions)
Sunday, May 11
08:00 AM - 08:50 AM
Breakfast
08:50 AM - 09:00 AM
Welcome and Opening Remarks - John Lambris (on behalf of the Organizing Committee)
SESSION I Structural insights - mechanisms of activation and regulation
Chairs: Christine Gaboriaud and Brian Geisbrecht
09:00 AM - 09:20 AM
1
Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3bMoises H Rojas Rechy1, Doina Atanasiu2, Lauren M Hook3, Tina M Cairns2, Wan Ting Saw2, Neil A Ranson1, Friedman M Harvey3, Gary H Cohen2, and Juan Fontana4
09:20 AM - 09:40 AM
2
Viral teachings on complement regulationArvind K Sahu
09:40 AM - 10:00 AM
3
Activation of native C3 without proteolytic cleavage induced by phosphatidyl serine containing membranes.David Eikrem1, Kristina Nilsson Ekdahl,, Karin Fromell1, and Bo Nilsson1
10:00 AM - 10:20 AM
4
Complement C1 proteases as possible new therapeutic targets in diseasesVéronique Rossi1, Nolwenn Haut3, Nicole M Thielens1, and Christine Gaboriaud2
10:20 AM - 10:35 AM
5
Sex Chromosome Regulation of Complement System Activity: Evidence for Post-Transcriptional Control of C3 and C4 LevelsWilliam A Barr
10:35 AM - 11:15 AM
Coffee Break and Poster Viewing (Odd Numbers)
SESSION II Therapeutic complement inhibitors: from bench to bedside
Chairs: Anna Schubart Wellensiek and Daniel Ricklin
11:15 AM - 11:35 AM
6
Therapeutic complement modulation at the forefront of novel immunotherapies: Misconceptions, myths, and novel insightsJohn D Lambris
11:35 AM - 11:55 AM
7
Inhibiting the Complement Classical Pathway by Blocking Activation of the C1r Zymogen Huiquan Duan1, Wei Wu2, Ping Li2, Samuel Bouyain3, Brandon L Garcia1, and Brian V Geisbrecht1
11:55 AM - 12:15 PM
8
Keeping host defense on a leech: Gigastasin as a versatile template for designing complement and coagulation system modulatorsAleksandra Blagojevic1, Peter Rüthemann1, Kevin Widmer1, Florian Meyer1, Sofia Pinheiro1, Said Rabbani1, Rolf Spirig2, Kirsten Guse2, Martin Smiesko1, Markus Lill1, and Daniel Ricklin1
12:15 PM - 12:35 PM
9
Complement Alternative Pathway Inhibitors for Hemocompatibility of Nanoparticles in Multiple Animal Species.Dmitri Simberg
12:35 PM - 12:50 PM
10
The story of empasiprubart (ARGX-117), a long acting inhibitory C2 antibody, from bench to MMN patientsInge Van de Walle and ARDA Developement team
12:50 PM - 01:10 PM
11
Iptacopan (Fabhalta) for the treatment of complement-mediated diseasesAnna Schubart
01:10 PM - 01:25 PM
12
Augmenting cytotoxicity of pathogen-specific antibodies that initiate complement activation independent of the classical pathwayWilhelm J Schwaeble
01:25 PM - 01:40 PM
13
TBA - MastellosDimitris Mastellos
01:40 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 10:30 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)
Monday, May 12
08:00 AM - 09:00 AM
Breakfast
SESSION III Novel therapeutic concepts and mechanisms of inflammation
Chairs: Anna Blom and George Hajishengallis
09:00 AM - 09:20 AM
14
Maladaptive trained immunity and chronic inflammationGeorge Hajishengallis
09:20 AM - 09:40 AM
15
Compstatins abolish pathogenic fibroblast function associated with inflammatory maladaptation of tissues
Jasna Friščić1, Xi Chen2, Sven Geisler3, Dimitrios C Mastellos5, John D Lambris4, and Markus H Hoffmann1
09:40 AM - 10:00 AM
16
Targeting Fibroblast-Derived C3: A Potential Therapeutic Strategy to Halt Chronic Inflammation in IBD.Gianluca Matteoli
10:00 AM - 10:20 AM
17
The different responsiveness of C3- and C5-deficient murine BM cells to oxidative stress explains why C3 deficiency, in contrast to C5 deficiency, correlates with better pharmacological mobilization and engraftment of hematopoietic stem cells. Mariusz Z Ratajczak
10:20 AM - 10:40 AM
18
Granzyme K-driven complement activationMichael Brenner
10:40 AM - 10:55 AM
19
Activated fibroblasts produce high level of complement component 3 during intestinal inflammation Gaia Zanella1, BoJun Ke1, Donatella Cicia1, Veronika Bosàkovà1, Saeed Abdurahim1, Sneha Santhosh1, Victoria Gudino3, Marc Moro3, Azucena Salas3, Bram Verstockt2, Severine Vermeire2, and Gianluca Matteoli1
10:55 AM - 11:15 AM
20
RNA profiling, protein expression and gene deletion studies in rheumatoid arthritis patient synovium and murine models identifies critical roles for activation pathway effector mechanisms as well as factor H (FH) and FH-related families in disease pathogenesis V Michael Holers, Felix Poppelaars, Nirmal Banda, and Joshua M Thurman
11:15 AM - 11:35 AM
21
Complement activation in the intensive care unit: Therapeutic approaches on the central hub?Markus Huber-Lang1, Alina Dettner1, Christoph Q Schmidt2, Susa Savukoski1, and Marco Mannes1
11:35 AM - 12:15 PM
Coffee Break and Poster Viewing (Even Numbers)
SESSION IV Complement in hemolytic disease and metabolism
Chairs: Lubka Roumenina and Benjamin King
12:15 PM - 12:35 PM
22
Complement therapeutics in acute respiratory distress syndrome (ARDS) beyond SARS-CoV-2: a clinical perspectiveFabio Ciceri1, Sara Mastaglio1, Andrea Assanelli1, Cecilia Garlanda2, Antonio Maria Risitano3, and Annalisa Ruggeri1
12:35 PM - 12:55 PM
23
Breakthrough haemolysis in PNH patients on C3 inhibition: a role for immune adherenceHiba Ghaboosh1, Marco Mannes2, Jannik Sichau1, Britta Höchsmann2, Markus Huber-Lang2, Daniel Ricklin3, Hubert Schrezenmeier2, and Christoph Q Schmidt1
12:55 PM - 01:15 PM
24
Complement in Sickle Cell DiseaseLubka T Roumenina
01:15 PM - 01:30 PM
25
The involvement of complement system in immune mediated platelet clearance processesSusa Savukoski1, Alina Dettner1, John D Lambris2, Markus Huber-Lang1, and Marco Mannes1
01:30 PM - 01:50 PM
26
Complement and Diabetes in rodent models: complement controls metabolism, and metabolism controls complement Ben C King
01:50 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)
Tuesday, May 13
08:00 AM - 09:00 AM
Breakfast
SESSION V Complement in cancer Immunity and immunotherapy
Chairs: Elena Magrini and Ruben Pio
09:00 AM - 09:20 AM
27
Selective pressures driving altered complement protein expression in the tumour microenvironmentMonica M Olcina
09:20 AM - 09:40 AM
28
Targeting complement in immunosuppressive tumor microenvironmentsRuben Pio
09:40 AM - 10:00 AM
29
Complement activation sustains tumor progression and invasiveness in human and mouse CRC Elena Magrini1, Kevin Berthenet1, Monica Dambra2, Marika Viatore1, Giovanni Pezone1, Fabio Grizzi1, Luana Greco1, Roberta Carriero1, Fabio Pasqualini2, Sarah Mapelli1, Alberto Mantovani1,2,3, Sebastien Jaillon1,2, Federica Marchesi1,4, and Cecilia Garlanda1,2
10:00 AM - 10:20 AM
30
Complement factor H is a novel ligand for the inducible T cell co-stimulator (ICOS) and promotes survival or regulatory T cells in the glioma microenvironmentAnna M Blom
10:20 AM - 10:40 AM
31
A spatial and tissue digital landscape of triple negative breast cancer and complement pathwaysShankar Subramaniam and collaborators
10:40 AM - 10:55 AM
32
Integrated complementomics reveals myeloid-mediated pro-tumoral reprogramming of ccRCC cells through intracellular C3Mikel Rezola Artero, Alaeddine Redissi, Lubka Roumenina, and Idris Boudhabhay
10:55 AM - 11:40 AM
Coffee Break and Poster Viewing (Odd Numbers)
SESSION VI Complement in ocular inflammation: genetic drivers and mechanistic insights
Chairs: Majlinda Lako and Kip Connor
11:40 AM - 12:00 PM
33
Age-related macular degeneration: a tale of two RPE/choroid-centric diseases, of which only one is complement-drivenGregory S Hageman, Brandi L Williams, Jin Liu, Chris M Pappas, Robert A Anstadt, Nathan A Seager, Jennifer Mohler, Julie Thomas, Marc Toso, Jill L Hageman, Steffen Schmitz-Valckenberg, Monika Fleckenstein, Karen Curtin, Moussa Zouache, and Burt T Richards
12:00 PM - 12:20 PM
34
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal functionEdvinas Cerniauskas 1, Marzena Kurzawa1, Long Xie2, Dean Hallam1, David H Steel1, Mary Doherty3, Phil Whitfield3, Lye Armstrong1, David Kavanagh4, John D Lambris5, Viktor I Kor1, Claire Harris2, and Majlinda Lako1
12:20 PM - 12:35 PM
35
Refinement of associations between age-related macular degeneration and regulators of complement activation for discovery and improved translationMoussa A Zouace, Chris M Pappas, Burt Richards, and Gregory S Hageman
12:35 PM - 12:55 PM
36
The C1q and gC1qR proteins as therapeutic targets in cancerBerhane Ghebrehiwet
12:55 PM - 01:15 PM
Flash Poster Session A (up to 20 min). The conference will include a live poster sessions during which registered presenters will be able to give a 3-min ‘flash’ poster talk highlighting the main findings of their study.
01:15 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 08:00 PM
Archaeological Tour of Knossos and the Museum (Buses Depart Hotel Lobby)
08:00 PM - 11:00 PM
Dinner and Informal Discussions (Buses do not return or pickup from the hotel prior to dinner)
Wednesday, May 14
08:00 AM - 09:00 AM
Breakfast
SESSION VII Targeting Complement in kidney and infectious diseases
Chairs: Elena Goicoechea De Jorge and Tom Eirik Mollnes
09:00 AM - 09:20 AM
37
Complement dysregulation behind the scenes in ANCA-associated vasculitisElena Goicoechea de Jorge
09:20 AM - 09:40 AM
38
Cell-intrinsic complement system activation mediates reprogramming of human Podocytes: role of SGLT2 inhibitorsMatteo Stravalaci1, Min Li1, Manuel A. Podestà1, Deborah Mattinzoli1, Masami Ikehata1, Francesca Zanoni1, Silvia Armelloni1, Federico S. Colombo4, Elena Trombetta4, John D. Lambris2, and Giuseppe Castellano1
09:40 AM - 10:00 AM
39
Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injuryGábor Pál1,6, Anjan K. Bongoni2, Bence Kiss1,6, Jennifer L. McRae2, Evelyn J. Salvaris2, Nella Fisicaro2, Fenella Muntz3, Bálint Zoltán Németh1,6, Zoltán Attila Nagy1,6, Andrea Kocsis1,4, Peter J. Cowan1,5, and Péter Gál1,4
10:00 AM - 10:15 AM
40
Real-world evidence for efficacy and safety of Iptacopan and Pegcetacoplan in patients with primary membranoproliferative glomerulonephritis (MPGN)Luca Antonucci1,2, Giulia Bassanese3, Maddalena Marasà4,5, Federica Maritati6, Luis Fernando Quintana Porras7, Federico Alberici8, Anne-Els van de Logt9, Franz Schaefer3, and Marina Vivarelli10
10:15 AM - 10:35 AM
41
Humoral Innate Immunity and Acute Phase Proteins in COVID-19Cecilia Garlanda
10:35 AM - 11:15 AM
Coffee Break and Poster Viewing (Even Numbers)
SESSION VIII Complement: driver of neuroinflammation in neurodegenerative diseases
Chairs: Andrea Tenner and Zelek Wioleta
11:15 AM - 11:35 AM
42
Knowing the Enemy: Selectively targeting complement to treat Alzheimer disease and related dementiasAndrea J Tenner
11:35 AM - 11:55 AM
43
Targeting complement in brain diseases.Paul Morgan and Wioleta M Zelek
11:55 AM - 12:15 PM
44
Mapping complement expression in the brain: implications for neurodegenerative disease therapeutics.Matthew Bright, Van Dien Nguyen, B. Paul Morgan, and Wioleta M Zelek
12:15 PM - 12:35 PM
45
A pathogenic role of C5aR2 activation in Amyotrophic Lateral Sclerosis.John D Lee, Jenny N Fung, Alana Julianisya, Austin Read, and Trent M Woodruff
12:35 PM - 12:55 PM
46
Complement Activity in Emboli Retrieved During Thrombectomy for Ischemic StrokeE. Sander Connolly
12:55 PM - 01:10 PM
47
Targeting C5a Inflammation in ALS: Ex Vivo Findings from PMX205 Phase Ib TrialJenny Fung, John Lee, and Trent Woodruff
01:10 PM - 01:30 PM
Flash poster session B (up to 20 min). The conference will include a live poster sessions during which registered presenters will be able to give a 3-min ‘flash’ poster talk highlighting the main findings of their study.
01:30 PM - 01:35 PM
Closing Remarks - Lubka Roumenina and Dimitris Mastellos (On behalf of the organizing committee)
01:35 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner
Thursday, May 15
08:00 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure