4th International Conference on Tissue Repair, Regeneration, and Fibrosis

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 
    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport
    Please note that Crete has two airports. You want to arrive at the Heraklion International Airport (code: HER) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively Chania International Airport (CHQ) is a two-hour drive to the Conference Center.

    Accommodation Tax
    An accommodation tax of € 10.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

    Accommodations
    Accommodations for the conference are at the Aldemar Hotel.  The hotel is located in Hersonissos, 27 km from Heraklion International Airport.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in 
    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:00 pm on the first day should make alternative dinner arrangements.

    Conference Venue
    The Aldemar Conference Center is located at the hotel. 

    Handicapped Accessibility
    The site is fully handicapped accessible.

    Oral Presentations
    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    Archaeological Site of Knossos and City Tour
    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast
    Breakfast for registered participants and registered accompanying persons will be served at the Aldemar Knossos Royal Village main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions
    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions
    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer 
    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation
    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information
    Animals are not permitted on site.
    Badges are required for admission to all events.
    All Aegean Conferences events are no smoking, no e-cigarretes, no vaping, etc. 

    No Photographs and Recording Devices 
    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 
    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

     

Tuesday, October 22

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:00 PM
Welcome Reception and Dinner

Wednesday, October 23

08:00 AM - 08:50 AM
Breakfast
08:50 AM - 09:00 AM
Welcome and Opening Remarks
Session I. Fibrosis across organs and organisms
09:00 AM - 09:25 AM
1
Common mechanisms of fibrosis in kidney and heart
Rafael Kramann
09:25 AM - 09:50 AM
2
Investigation inflammation and skin repair in various model organisms
Paul Martin
09:50 AM - 10:05 AM
3
Targeting Fibrosis to Change Cancer Outcomes
Therese Suchoski1, Hailey Doerflein1, Paul Lembicz1, Garrison Dell1, Hope Steele1, Elizabeth Kato1, Rima Zgheib1, Mitchell Kronenberg, Hilde Cheroutre, and Rana Herro1
10:05 AM - 10:20 AM
4
3DPROFIB: an in vitro 3D assay in synthetic hydrogels to quantify extracellular matrix remodeling in fibrosis
Maria Mitsi1, Federica Genovese2, Benjamin Simona3, and Martin Ehrbar1
10:20 AM - 10:40 AM
First poster flash presentations (1 slide / presentation / 1 minute each)
10:40 AM - 11:20 AM
Coffee Break and Poster Viewing
Session ΙΙ. Cellular orchestras controlling health and disease
11:30 AM - 11:55 AM
5
Stromal-epithelial communication in tissue repair and cancer
Sabine Werner
11:55 AM - 12:20 PM
6
The stressed relationship between macrophages and fibroblasts
Boris Hinz
12:20 PM - 12:45 PM
7
IL-17 signaling regulates TNF-TNFR1 responses in steatotic hepatocytes in mice.
Tatiana Kisseleva
12:45 PM - 01:10 PM
8
Regulation of liver zonation, metabolism, injury and regeneration by hepatic stellate cells
Robert F Schwabe
01:10 PM - 01:30 PM
Second poster flash presentations (1 slide / presentation / 1 minute each)
01:30 PM - 02:45 PM
Lunch and Informal Discussions
02:45 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Thursday, October 24

08:00 AM - 09:00 AM
Breakfast
Session III. Teasing out and validating novel targets for fibrosis
09:00 AM - 09:25 AM
9
Anger Management: Targeting Invasive Fibroblasts in Progressive Pulmonary Fibrosis (It’s more than matrix production)
Paul Noble
09:25 AM - 09:50 AM
10
Using Human Liver Slices to Assess Efficacy of New Compounds and Illuminate the Biology of Fibrosis
Jelena Mann
09:50 AM - 10:15 AM
11
Precision-Cut Tissue Slices: A Cutting-Edge Tool for Studying and Advancing the Treatment of Fibrotic Diseases
Peter Olinga
10:15 AM - 10:40 AM
12
The origin and TGFb dependency of fibrosis and inflammation associated fibroblasts
Justin Shyer
10:40 AM - 10:55 AM
13
Species-specific anti-fibrotic effects of bile acids in human and mouse precision-cut kidney slices
Henricus A.M. Mutsaers, Sandra M. Hansen, Rianne van Dekken , and Rikke Nørregaard
10:55 AM - 11:10 AM
Third poster flash presentations (1 slide / presentation / 1 minute each)
11:10 AM - 11:40 AM
Coffee Break and Poster Viewing
Session IV. Assessment of putative antifibrotics: the state-of-the-art
11:40 AM - 12:05 PM
14
Targeting Claudin-1 as a novel therapeutic approach to reverse organ fibrosis
Geoffrey Teixeira
12:05 PM - 12:30 PM
15
AGMB-101, a full agonistic antibody of MET, achieves deep suppression of liver fibrosis through a pleiotropic mechanism of action
Virginia Morello, Damiana sattanino, Manuela Cazzanti, Torsten Dreier, Caroline Meers, Maarten Van Roy, Paolo Michieli, and Reginald Brys
12:30 PM - 12:55 PM
16
A neutralizing antibody to EphrinB2 suppresses fibrosis in preclinical in vitro and in vivo models
Paul Yaworsky
12:55 PM - 01:20 PM
17
Combination strategies for MASH
Grant Budas
01:20 PM - 01:35 PM
18
CCN3-Derived Peptide BLR-200 has Anti-Fibrotic Properties in Systemic Sclerosis
Andrew Leask
01:35 PM - 02:00 PM
Fourth poster flash presentations (1 slide / presentation / 1 minute each)
02:00 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Friday, October 25

08:00 AM - 09:00 AM
Breakfast
Session V. Innovative approaches to disease treatment and clinical trial design
09:00 AM - 09:25 AM
19
Role and Therapeutic Potential of the Long Non-Coding RNA DNM3OS in Liver Fibrosis
Nihad Boukrout, Sandy Fellah, Cynthia Van der Hauwaert, Wendy Arondal, Romain Larrue, Bruno Lefebvre, Michael Perrais, François Glowacki, Nicolas Pottier, and Christelle Cauffiez
09:25 AM - 09:50 AM
20
A Scar is Born: The molecular pathology of pulmonary fibrosis
Gisli Jenkins
09:50 AM - 10:15 AM
21
A New Frontier in IBD - Towards the prevention of structural bowel damage in Crohn’s disease
Tim Van Kaem
10:15 AM - 10:30 AM
22
Cdc42 small GTPase is a novel regulator of the fibrogenic activation of human intestinal myofibroblasts
Atif Zafar1, Yan Wang1, Armando Marino-Melendez1, Florian Rieder2, and Andrei I. Ivanov1
10:30 AM - 10:45 AM
23
Combination therapy blocking TNF superfamily members 14 and 15 reverses pulmonary fibrosis
Hope Steele1,3, Ashley Willicut4, Garrison Dell1,3, Andrew Ghastine1, Xinh-Xinh Nguyen 5, Paul Lembicz1, Hailey Doerflein1, Therese Suchowski1, Elizabeth Kato1, Rima Zgheib1, Carol Feghali-Bostwick 5, Michael Croft6, and Rana Herro1
10:45 AM - 11:00 AM
24
Mechanically regulated transcription factors balance between regenerative and fibrotic cell memory
Fereshteh Sadat Younesi1,2, Andrew Miller3, Thomas H. Barker3, and Boris Hinz1,2
11:00 AM - 12:00 PM
Coffee Break and Poster Viewing
Session VI. Immune mechanisms of injury, repair, and fibrosis
12:00 PM - 12:25 PM
25
Starts and stops: Adipocytes in tissue repair and fibrosis
Valerie Horsley1, Elizabeth Caves1, Maria Forni1, Radhika Atit, and Monique Hinchcliff1
12:25 PM - 12:50 PM
26
The dual role of neutrophils during liver injury
Yousef Maali1,2, Manuel Flores Molina1,2, Omar Khedr1, Mohamed N Abdelnabi1,2, Jessica Dion1, Ghada S Hassan1, and Naglaa Shoukry1
12:50 PM - 01:15 PM
27
Cross regulatory cytokine networks and rebound inflammation in fibrotic disease
Kevin Hart
01:15 PM - 01:40 PM
28
The role of B cells and plasma cells in the pathogenesis of fibrosis
Oliver Eickelberg
01:40 PM - 01:55 PM
29
How Th2 specific cytokines: interleukin (IL)-4 and IL-13 affect cellular metabolism and reactive oxygen species production in mare endometrial fibroblasts?
Anna Wójtowicz1, Agnieszka Sadowska1, Kamil Myszczyński2, Monika Kaczmarek2, Graca Ferreira-Dias3,4, and Anna Szóstek-Mioduchowska1
01:55 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 08:00 PM
Tour of Knossos Archaeological Site and Archaeological Museum (Buses Depart from Hotel Lobby)
08:00 PM - 11:00 PM
Dinner and Informal Discussions (Buses do not return to hotel prior to dinner)

Saturday, October 26

08:00 AM - 09:00 AM
Breakfast
Session VII. The mighty macrophage in fibrosis
09:00 AM - 09:25 AM
30
Macrophage Heterogeneity during NASH Regression Unveils Multifaceted TREM2 Dependent Mechanisms that Facilitate NASH and Fibrosis Resolution
David A Brenner
09:25 AM - 09:50 AM
31
Single nucleotide resolution of altered transcription factor binding in profibrotic macrophages from patients with interstitial lung disease
Bob Lafyatis
09:50 AM - 10:15 AM
32
Fab5 macrophage expression of GPNMB promote fibrosis across organs
Thomas Fabre1, Alexander Barron1, Saurav De1, Stephen Christensen1, Marc Wadsworth1, Kathryn Bound1, Franklin Schlerman1, Ju Wang1, Thomas Wynn1, Ken Dower1, kevin Hart1, and lee borthwick2
10:15 AM - 10:40 AM
33
Using human tissue models to illuminate the biology of fibrosis and unlock new drug targets
Lee Borthwick
10:40 AM - 10:55 AM
34
Leveraging Single Cell Genomics to Resolve Macrophage Heterogeneity across Tissue and Disease: Mapping in vitro to in vivo Profiles
Marc H. Wadsworth II, Kathryn Bound, Roxanne Martino, Stephen M. Christensen, Saurav De, Matthew P. Lech, Iana Garcia, David Logan, Alexander M.S. Barron, Ken Dower, Kevin M. Hart, Kellie M. Kravarik, Thomas Wynn, and Thomas Fabre
10:55 AM - 12:00 PM
Coffee Break and Poster Viewing
Session VIII. Maps, atlases and all things single cell
12:00 PM - 12:25 PM
35
Mapping fibrosis progression and reversal in the bone marrow
Rebekka Schneider-Kramann
12:25 PM - 12:50 PM
36
Using single cell and spatial genomics to decode human liver regeneration and repair
Neil Henderson
12:50 PM - 01:15 PM
37
A therapeutic cell atlas focusing on fibroblasts
Christopher Buckley
01:15 PM - 01:30 PM
38
Myeloid cells contribute to bystander CD8 T-cell accumulation in MASH and are sufficient for fibrosis
Stephen M Christensen, Marc Wadsworth II, James McMahon, Kathryn Bound, Xiao Chen, Kellie M Kravarik, Tom Wynn, Ken Dower, Kevin Hart, Alexander Barron, and Thomas Fabre
01:30 PM - 01:35 PM
Closing Remarks
01:35 PM - 02:45 PM
Lunch and Informal Discussions
02:45 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner