11th International Conference on Autoimmunity: Mechanisms and Novel Treatments

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Aegean Conferences Communication  

    Please note that our registration fees include hotel accommodations and therefore no additional reservations are required. The only communication you should receive is from Aegean Conferences and if your paying by credit card, payment receipts from Conferex LLC. SCAM Alert: Beware of any third party companies calling and/or emailing you to reserve hotel accommodations for you during our conferences

    Registration 
    In completing the online registration form you are not automatically accepted to attend the conference nor are you automatically registered for the conference. Final registration to the conference shall occur after you have been accepted and notified by the conference chair of your acceptance to the conference. If you have been charged the registration fee but your attendance has been declined you will be reimbursed in full.

    Airport
    Please note that Crete has two airports. You want to arrive at the Heraklion International Airport (code: HER) and take a taxi from the airport to the hotel (~60 EUR). You may also rent a car at the airport and drive to the conference center. Alternatively Chania International Airport (CHQ) is a two-hour drive to the Conference Center.

    Accommodation Tax
    An accommodation tax of € 10.00 per room night will apply, and will be charged automatically to the individual guest’s extras accounts. 

    Accommodations
    Accommodations for the conference are at the Aldemar Hotel.  The hotel is located in Hersonissos, 27 km from Heraklion International Airport.  Please take a taxi from the airport to the conference venue. 

    Arrival and Check-in 
    It is expected that attendees will arrive/check-in after 3:00 PM. Anyone arriving after 10:00 pm on the first day should make alternative dinner arrangements.

    Conference Venue
    The Aldemar Conference Center is located at the hotel. 

    Handicapped Accessibility
    The site is fully handicapped accessible.

    Oral Presentations
    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

    Archaeological Site of Knossos and City Tour
    Buses for the city tour will depart from the hotel front lobby at 3:30 pm. Badges are required for participation. 

    Breakfast
    Breakfast for registered participants and registered accompanying persons will be served at the Aldemar Knossos Royal Village main restaurant during the hours scheduled in this program. 

    Lunches/Informal Discussions
    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant and only after the session has finished. Badges are required for admission.

    Dinners/Informal Discussions
    Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org. 

    Internet, Phone, & Computer 
    Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

    Certificate of Participation
    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session. 

    Passports and Visa
    Participants are advised to check on their individual requirements before attending any Aegean Conference meeting. Visa applications should be filed at the nearest Greek Embassy in the country in which you are resident, at least three months prior to the anticipated departure date.

    Letters of Invitation
    Letters of invitation to attend an Aegean Conference meeting will be issued only to:

    • Authors of accepted abstracts
    • Fully paid registrants

    Note: Invitations are issued at the discretion of Aegean Conferences, and requests for letters will be accepted only 60 days prior to the conference start date.

    Liability and Insurance
    Neither the organizers, nor the Aegean Conferences will assume any responsibility whatsoever for damage or injury to persons or property during meeting period. Participants are advised to arrange their own personal travel and health insurance.  

    Other Information
    Animals are not permitted on site.
    Badges are required for admission to all events.
    All Aegean Conferences events are no smoking, no e-cigarretes, no vaping, etc. 

    No Photographs and Recording Devices 
    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Code of Conduct Policy 
    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be viewed here. 

     

Thursday, October 17

06:30 PM - 07:30 PM
Conference Registration
07:30 PM - 10:00 PM
Welcome Reception and Dinner

Friday, October 18

08:00 AM - 08:25 AM
Breakfast
08:25 AM - 08:30 AM
Welcome and Opening Remarks
Session I - T cell development (and unconventional T cells)
Chairs: Jen Gommerman and Steven Ziegler
08:30 AM - 08:55 AM
1
Thymic B cells in central T cell tolerance
Ludger Klein and Iliana Siamishi
08:55 AM - 09:20 AM
2
Stem-like lymphocytes at the origin of adaptive immune responses to infection and cancer
Veit Buchholz
09:20 AM - 09:45 AM
3
Restraining Autoimmune T Cells
Dario Vignali
09:45 AM - 10:10 AM
4
Metabolic checkpoints for the treatment of autoimmune disease
Tim D Sparwasser
10:10 AM - 10:25 AM
5
Chromatin organizer ASCL1 regulates thymic epithelial cell gene expression for self-tolerance induction
Nobuko Akiyama1,2, Kano Namiki1,2, Kenta Horie1, Takahisa Miyao1, Maki Miyauchi1,2, and Taishin Akiyama1,2
10:25 AM - 10:55 AM
Coffee Break and Poster Viewing
Session II - T-B interactions
Chairs: Ludger Klein and Nicole Joller
10:55 AM - 11:20 AM
6
Non-linear effects of graded B cell hyperreactivity in autoimmunity
Carina Diehl, Valeria Soberon, Seren Baygün, Yuanyuan Chu, and Marc Schmidt-Supprian
11:20 AM - 11:45 AM
7
New roles for FOXP3: Isoforms and Translation
Steven Ziegler
11:45 AM - 12:10 PM
8
Function of B Cells in murine Cytomegalovirus (MCMV) infection
Ari Waisman
12:10 PM - 12:35 PM
9
New insights into the biology of regulatory plasma cells
Simon Fillatreau
12:35 PM - 12:50 PM
10
Glutaminase 1 (GLS1) regulates T and B cell responses
Oezen Sercan Alp1, Darya Malko2,3, Thomas Kreutzberg1, Stefan Müller1, Hanna Kandler1, Sven Ruf4, Christoph Potting4, Matthias Herrmann1, and Nadine Biesemann1
12:50 PM - 01:05 PM
11
CLN-978, a CD19/CD3-directed T cell-engaging antibody construct, leads to rapid and deep B cell depletion and has broad potential for development in autoimmune diseases
Patrick A. Baeuerle1, Maire F. Quigley1, Jennifer S. Michaelson1, Jeffrey Jones1, Farrukh T. Awan3, Geoffrey P. Shouse2, Yue Zhang1, Todd Shearer1, Judy Inumerable1, Irina M. Shapiro1, and Stephen Wax1
01:05 PM - 02:30 PM
Lunch and Informal Discussions
02:30 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Saturday, October 19

08:00 AM - 08:30 AM
Breakfast
Session III - Effector T cells
Chairs: Marc Schmidt-Supprian and Ari Waisman
08:30 AM - 08:55 AM
12
Genome-wide perturbation of autoimmune-associated genetic variants to define their effects on T cell biology
John P Ray1, Alex Ho1, Max Dippel1, Arpit Mishra6, Stephan Pribitzer1, LeAnn Nguyen1, Samantha Hardy1, Harshpreet Chandock2, Florence Chardon3, Troy McDiarmid3, Hannah DeBerg1, Jane Buckner6, Jay Shendure3, Carl de Boer4, Michael Guo5, and Ryan Tewhey2
08:55 AM - 09:20 AM
13
The co-inhibitory receptor TIGIT induces tissue protective functions in T cells
Camilla Panetti and Nicole Joller
09:20 AM - 09:45 AM
14
A look at the gut-eye axis in retinal autoimmunity
Rachel R Caspi
09:45 AM - 10:10 AM
15
A new checkpoint in the control of T cell responses in CNS autoimmunity
Thomas Korn
10:10 AM - 10:25 AM
16
IL-10 producing regulatory T-cells in multiple sclerosis
Jens Geginat
10:25 AM - 11:25 AM
Coffee Break and Poster Viewing
Session IV - Regulation of autoimmunity
Chairs: Simone Mader and Thomas Korn
11:25 AM - 11:50 AM
17
X-Chromosome Inactivation & Female-bias of Systemic Lupus Erythematosus
Claudia Lovell and Montserrat Anguera
11:50 AM - 12:15 PM
18
Control of regulatory T cell stability and function during inflammation
Jose Carlos F Alves-Filho and Daniele B Nascimento
12:15 PM - 12:40 PM
19
Regulation of T cell costimulation by CTLA-4-dependent transendocytosis
Lucy S.K. Walker
12:40 PM - 01:05 PM
20
IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation
Betsy J Barnes
01:05 PM - 01:30 PM
21
Genome organization and multi-layered transcriptional circuitries regulate the differentiation of effector regulatory T cells
David Chisanga1,3, Hannah D Coughlan4, Timothy M Johanson4, Jian Wu1,3, Alexandra Garnham4, Santiago Valle de Torre5,6, Brendan E Russ6, Renee Gloury5,6, Stephen Turner6, Gordon Smyth4, Wei Shi6, Rhys S Allan4, Axel Kallies5,6, and Ajithkumar Vasanthakumar1,3,5
01:30 PM - 02:45 PM
Lunch and Informal Discussions
02:45 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Sunday, October 20

08:00 AM - 08:30 AM
Breakfast
Session V - Tissue resident T cells and local environment
Chairs: Francesca Odoardi and Ari Waisman
08:30 AM - 08:55 AM
22
Mapping TCR microrepertoires and spatial distribution of tissue-infiltrating T cell clones
Cedric Ly2, Darius Schaub2, Robin Khatri2, Eva Tolosa4, Christian Krebs3, Stefan Bonn2, and Immo Prinz1
08:55 AM - 09:20 AM
23
Tissue-resident memory CD4+ T cells sustain chronic CNS autoimmunity
Aurora Pignata1, Davis Frieser1, Cheng-Chih Cheng-Chih2, Hendrik Engelenburg2, Marine Alis1, Carmen Gonzalez-Fierro1, Vincent Cazaentre1, Romain Miranda-Capet1, Eloise Dufourd1, Thais Vermeulen1, Amel Aida1, Klaas Van Gisbergen4, Nicolas Blanchard1, Jörg Hamann2, Joost Smolders3, Roland S Liblau1, and Frederick Masson1
09:20 AM - 09:45 AM
24
Dysregulated T cells in skin cancer associated with recessive dystrophic Epidermolysis bullosa
Iris K Gratz
09:45 AM - 10:00 AM
25
The role of NFκB inducing kinase in regulatory T cells
Zeynep Ergün and Ari Waisman
10:00 AM - 10:15 AM
26
Microbiota-induced T cell stimulation in the ileal lamina propria
Naoto Kawakami, Isabel J Bauer, and Ping Fang
10:15 AM - 10:45 AM
Coffee Break and Poster Viewing
Session VI - Neuroinflammation
Chairs: Melanie Greter and Burkhard Becher
10:45 AM - 11:10 AM
27
Astrocyte memory
Francisco J Quintana
11:10 AM - 11:35 AM
28
The role of the lung in CNS autoimmunity
Alexander Flügel
11:35 AM - 12:00 PM
29
Novel insights into inflammatory diseases of the central nervous system
Simone Mader
12:00 PM - 12:25 PM
30
Visualization of autoantibody entry into the CNS tissue
Francesca Odoardi
12:25 PM - 12:40 PM
31
Cross-reactive peptides: A mechanistic link between multiple sclerosis and EBV
Philipp Nawrath1,2, Valentina Ferrari1, Antonio Lanzavecchia3, and Federica Sallusto1,2
12:40 PM - 12:55 PM
32
Dissecting autoreactive T cell immunity in Guillain–Barré syndrome.
Christophe Capelle1, Lenka Súkeníková1, Piffaretti Pietro1, Sam G Edalat1, Paolo Ripellino3, Bettina Schreiner 2, and Daniela Latorre1
12:55 PM - 02:30 PM
Lunch and Informal Discussions
03:00 PM - 08:00 PM
Archaeological Tour of Knossos and the Museum (Buses Depart Hotel Lobby)
08:00 PM - 11:00 PM
Dinner and Informal Discussions (Buses do not return to the hotel prior to dinner)

Monday, October 21

08:00 AM - 08:30 AM
Breakfast
Session VII - Myeloid cells
Chairs: Francisco Quintana and Montserrat Anguera
08:30 AM - 08:55 AM
33
Adenophages: a distinct macrophage population in exocrine glands that is maintained by ILC derived GM-CSF
Burkhard Becher
08:55 AM - 09:20 AM
34
The role of embryonic macrophages at the maternal-fetal interface
Melanie Greter
09:20 AM - 09:45 AM
35
Monocyte IRF5 in TLR7 driven Macrophage Activation Syndrome
Jessica Hamerman
09:45 AM - 10:15 AM
36
Temporal roadmap of progressive neuroinflammation reveals chronic phagocyte differentiation sustained within the CNS
Florian Ingelfinger1,2,3, Juan Villar-Vesga1, Donatella De Feo1, Pauline Clément1, Hendrik J Engelenburg5, Joost Smolders5,6, Daniel Kirschenbaum4, Bettina Schreiner3, Burkhard Becher1, Sarah Mundt1, Cheng-Chih Hsiao5, and Jörg Hamann5
10:15 AM - 10:30 AM
37
In vivo CRISPR screen reveals essential cytokines regulating macrophage phenotypes in neuroinflammation
Arek Kendirli1, Clara de la Rosa1, Seren Baygün, Martin Kerschensteiner1, and Marc Schmidt-Supprian
10:30 AM - 11:00 AM
Coffee Break and Poster Viewing
Session VIII - Environmental basis of autoimmunity
Chairs: Jessica Hamerman and Sergio Baranzini
11:00 AM - 11:25 AM
38
The role of gut microbiome in EAE and MS
Sergio Baranzini
11:25 AM - 11:50 AM
39
Priming of commensal-specific regulatory T cells protects from colitis
Markus Geuking
11:50 AM - 12:15 PM
40
Identifying Intestinal Microbes that Modulate Neurodevelopmental Disorders
Kathy McCoy
12:15 PM - 12:40 PM
41
Molecular requirements for priming a T-dependent gut IgA response
Jen Gommerman
12:40 PM - 12:55 PM
42
Multiple Sclerosis and Gut Microbiota: Lachnospiraceae from the Ileum of MS Twins trigger MS-like Disease in Germfree Transgenic Mice
Hongsup Yoon1,2,3, Lisa A Gerdes1,2, Florian Beigel4, Yihui Sun5, Janine Kövilein1,2, Jiancheng Wang1,2, Tanja Kuhlmann6, Andrea Flierl-Hecht1, Dirk Haller7, Reinhard Hohlfeld1, Sergio E Baranzini5, Hartmut Wekerle1,3, and Anneli Peters1,2
12:55 PM - 01:00 PM
Closing Remarks
01:00 PM - 02:30 PM
Lunch and Informal Discussions
02:30 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner

Tuesday, October 22

08:00 AM - 10:00 AM
Breakfast
10:00 AM - 11:00 AM
Departure