Aegean Conferences

2nd International Conference on Mesenchymal Cells in Health & Disease

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!

General Information

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Thursday, June 27

06:30 PM - 07:30 PM

Conference Registration

07:30 PM - 10:30 PM

Welcome Reception and Dinner

Friday, June 28

08:00 AM - 09:00 AM

Breakfast

09:00 AM - 09:10 AM

Welcome - Opening Remarks

Session I: Chronic Inflammatory Disease

Chairs: George Kollias and Christopher Buckley

09:10 AM - 09:30 AM

Inflammation, damage or pain: Fibroblasts decide
Christopher D Buckley

09:30 AM - 09:50 AM

Regulators of fibroblast-mediated inflammation
Michael Brenner

09:50 AM - 10:10 AM

Fibroblast lineage structure in health and disease
Matthew Buechler

10:10 AM - 10:30 AM

Fibroblast driven causalities in chronic inflammation
George Kollias

10:30 AM - 11:30 AM

Coffee Break and Poster Viewing (Odd Numbers)

SESSION Ib: Chronic Inflammatory Disease

Chairs: George Kollias and Christopher Buckley

11:30 AM - 11:50 AM

Computational inference of metabolic tissue zonation and metabolic crosstalk in inflammatory disease
Allon Wagner

11:50 AM - 12:00 PM

Single-cell characterisation of synovial fibroblasts in systemic sclerosis
Celina Geiss¹, Miranda Houtman¹, Raphael Micheroli¹, Yannis Djeffal², Mojca Frank Bertoncelj¹, Sam G Edalat¹, Kristina Bürki¹, Chantal Pauli³, Michael Bonelli⁴, Thomas Karonitsch⁴, Oliver Distler¹, Caroline Ospelt¹, and Muriel Elhai¹

12:00 PM - 12:10 PM

Regulation of synovial fibroblast activation and expansion in arthritis
Fani Roumelioti¹, Christos Tzaferis^1,², and George Kollias^1,^2,³

SESSION II: Fibrosis

Chairs: Fiona Oakley and Yuval Rinkevich

12:10 PM - 12:30 PM

Organ dependency on its surrounding (fascia) connective tissues
Yuval Rinkevich

12:30 PM - 12:50 PM

Immunotherapeutical targeting of mesenchymal cells in fibrotic disease
Christian Stockmann

12:50 PM - 01:10 PM

TBA - Fiona Oakley
Fiona Oakley

01:10 PM - 01:20 PM

A possible profibrotic role of tissue iron in Systemic Sclerosis
Nikolaos I Vlachogiannis¹, Artemis Galani², Kleio-Maria Verrou^1,³, Panagiotis A. Ntouros¹, Thomas G. Maris^4,⁵, Vassilis L. Souliotis⁶, Apostolos Karantanas^4,⁵, Lia Angela Moulopoulos², and Petros P. Sfikakis^1,³

01:20 PM - 01:30 PM

Selective inhibition of myofibroblast phenotype by blood pressure drug telmisartan
Che-Min Lee¹, Henry Li¹, Nikita Telkar¹, Wan Lam¹, and Kevin Bennewith¹

01:30 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Saturday, June 29

08:00 AM - 09:00 AM

Breakfast

SESSION III: ECM and mechanotransduction

Chairs: Sophie Acton and Miguel A del Pozo

09:00 AM - 09:20 AM

THE EMBO LECTURE: Cell and tissue mechanoadaption: molecular mechanisms and physiopathological relevance
Miguel A del Pozo

09:20 AM - 09:40 AM

Role of the YAP/TAZ mechanotransducers in aging and cancer. A tissue-level perspective
Stefano Piccolo

09:40 AM - 10:00 AM

Mechanisms maintaining lymph node structure and function
Sophie Acton

10:00 AM - 10:10 AM

Mechanosensitive and metabolic pathways regulate plasma membrane ATP synthase trafficking in mouse embryonic fibroblasts
Aleksandra Norczyk-Simón¹, Laura Sotodosos-Alonso¹, María García-García⁴, Enrique Calvo², Asier Echarri³, and Miguel A. del Pozo ¹

10:10 AM - 10:20 AM

Metabolic reprogramming of Lymph node FRCs govern their proliferation, and function
Nital Sumaria², Emily Bessell⁴, Premkumar Palanisamy¹, Burkhard Ludewig³, Louisa K James², Daniel J Pennington², and Lalit Kumar Dubey¹

SESSION IV: Contextually-specified stromal niches

Chairs: Theresa Lu and Roni Nowarski

10:20 AM - 10:40 AM

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling
Roni Nowarski

10:40 AM - 11:00 AM

Fibroblast diversity within human Gut-Associated Lymphoid Tissues in health and inflammatory bowel disease
William W Agace

11:00 AM - 12:00 PM

Coffee Break and Poster Viewing (Even Numbers)

SESSION IVb: Contextually-specified stromal niches

Chairs: Theresa Lu and Roni Nowarski

12:00 PM - 12:20 PM

Immunotherapeutical targeting of cardiac fibroblasts
Burkhard Ludewig

12:20 PM - 12:40 PM

Lymphatic dysfunction of the skin and immune dysregulation
Theresa Lu

12:40 PM - 01:00 PM

Mesenchymal engagements in Psoriatic Arthritis
Maria Armaka

01:20 PM - 01:40 PM

Genetic and epigenetic activation of synovial fibroblasts in rheumatoid arthritis
Caroline Ospelt

01:40 PM - 01:50 PM

IL-33-mediated fibroblast-myeloid cell crosstalk controls intestinal granuloma formation
Angelina De Martin¹, Elke Scandella¹, Mechthild Lütge¹, Christian Perez-Shibayama¹, Cristina Gil-Cruz¹, Nicola Harris², Franca Ronchese³, Graham Le Gros³, and Burkhard Ludewig¹

01:50 PM - 02:00 PM

SEPTIN 8 regulates mitochondrial function in fibroblasts
Huan Liu, Xiaoyu Wu, Sabine Werner, and Michael Cangkrama

02:00 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

03:00 PM - 05:00 PM

Early Career Researcher (ECR) Session

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Sunday, June 30

08:00 AM - 09:00 AM

Breakfast

SESSION V: Lymphoid organs and Immunity

Chairs: Sanjiv A. Luther and Scott Mueller

09:00 AM - 09:20 AM

Neuroimmune interactions in lymphoid tissues
Scott Mueller

09:20 AM - 09:40 AM

Unravelling stromal cell regulation of the humoral response in lymphoid tissue and beyond
Alice E Denton

09:40 AM - 10:00 AM

Multi-tier coordination of antiviral immunity by fibroblasts
Natalia B Pikor

10:00 AM - 10:20 AM

Characterization of fibroblast subsets and function within secondary lymphoid organs
Sanjiv A Luther

10:20 AM - 10:40 AM

Linking lymphatics to mesenchymal cells in the developing lymph node
Christopher G. Mueller and Zinaida Igamberdieva

10:40 AM - 10:50 AM

Spatially resolving fibroblast-tumour interactions in melanoma metastatic lymph nodes
Harry L Horsnell, Yannick O Alexandre, Cameron G Williams, Shihan Li, Jan Schroeder, Ashraful Haque, and Scott N Mueller

10:50 AM - 11:00 AM

Pericardial fat-associated lymphoid clusters control T cell activation and differentiation during autoimmune myocarditis
Nadine Cadosch¹, Christian Perez Shibayama¹, Cristina Gil Cruz^1,², Hung-Wei Cheng¹, Anna Joachimbauer^1,², Frank Ruschitzka², Dörthe Schmidt², and Burkhard Ludewig^1,²

11:00 AM - 11:50 AM

Coffee Break and Poster Viewing (Odd Numbers)

SESSION VI: Stem Cell function and Tissue Regeneration

Chairs: Sabine Werner and Omer Yilmaz

11:50 AM - 12:10 PM

Dietary control of intestinal stem cells in physiology and disease
Omer Yilmaz

12:10 PM - 12:30 PM

Mesenchymal regulation of intestinal epithelial self-renewal
Ramesh A Shivdasani

12:30 PM - 12:50 PM

Functional Role of Tissue Damage & Regenerative Response in Cancer Progression & Metastasis
Raghu Kalluri

12:50 PM - 01:10 PM

Parallels between wound healing and cancer: A fibroblast perspective
Sabine Werner

01:10 PM - 01:30 PM

Age-related stromal change drive tumor progression
Sheila Stewart

01:30 PM - 01:50 PM

Multiple facets of androgen receptor signaling in fibroblast senescence and pro-tumorigenic functions
Gian-Paolo Dotto

01:50 PM - 02:00 PM

Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection
Lucas F Loffredo and Nicholas Arpaia

02:00 PM - 03:00 PM

Lunch and Informal Discussions

03:30 PM - 07:30 PM

Guided Tour of Old Town Chania (Buses Depart from Hotel Lobby)

07:30 PM - 11:00 PM

Dinner and Informal Discussions (Buses do not return to the hotel prior to dinner)

Monday, July 01

08:00 AM - 09:00 AM

Breakfast

SESSION VII: From Fibroblast States to Tumor Programs

Chairs: Maria Tsoumakidou and Ruth Scherz-Shouval

09:00 AM - 09:20 AM

Evolution of mesenchymal cell in carcinomas
Ruth Scherz-Shouval

09:20 AM - 09:40 AM

Stromal and immune plasticity shape the metastatic microenvironment
Neta Erez

09:40 AM - 10:00 AM

Mechanisms and consequences of pancreatic cancer stromal evolution
Mara Sherman

10:00 AM - 10:20 AM

Development and underlying mechanisms of fibroblastic states within the antigen-presenting cell landscape in cancer
Maria Tsoumakidou

10:20 AM - 10:30 AM

Cancer-associated fibroblasts influence Treg cell dynamics in lung cancer
Olivia R. Ringham, Lucas F Loffredo, and Nicholas Arpaia

10:30 AM - 10:40 AM

Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
Benedetta Apollonio¹, Christian Klein², Alexander Deutsch³, and Alan G. Ramsay¹

10:40 AM - 10:50 AM

DRAFT - High-fat Western diet supports colorectal cancer progression by promoting mucin secretion and infiltration of cancer-associated fibroblasts
Giulia Rizzo¹, Samuel Elias Pineda Chavez², Marek Wozny², Giada Mori¹, Faris Hrvat², Alejandra Carriles Linares², Annalisa Maroli³, Paola Spaggiari⁴, Michele Carvello³, Alessandro Repici^2,⁵, Antonino Spinelli^2,³, Alessandro Armuzzi^2,⁶, and Stefania Vetrano^1,²

10:50 AM - 11:50 AM

Coffee Break and Poster Viewing (Even Numbers)

SESSION VIII: Molecular Basis of Fibroblast-Dependent Tumor Processes

Chairs: Vasiliki Koliaraki and Anne Fletcher

11:50 AM - 12:10 PM

Identifying conserved, targetable pathways of immune suppression in the tumour microenvironment
Anne Fletcher

12:10 PM - 12:30 PM

Dynamics of tumour immune microenvironments
Mark Coles

12:30 PM - 12:50 PM

Mesenchymal activation and functions in intestinal carcinogenesis
Vasiliki Koliaraki

12:50 PM - 01:10 PM

Cell plasticity in pathogenesis and therapy of colorectal cancer
Florian Greten

01:10 PM - 01:40 PM

Round table “The future of mesenchymal research” Chair: Laurie Dempsey

01:40 PM - 01:45 PM

Closing Remarks

01:45 PM - 03:00 PM

Lunch and Informal Discussions

03:00 PM - 07:00 PM

Informal Discussions

07:30 PM - 11:00 PM

Farewell Dinner

Tuesday, July 02

08:00 AM - 10:00 AM

Breakfast

10:00 AM - 12:00 PM

Departure