8th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets

Program

Important: The program online is copyrighted to each author and should not be copied and pasted!
  • Code of conduct

    Aegean Conferences is committed to making its meetings an inclusive space for sharing ideas and knowledge. The code of conduct can be found at:https://www.aegeanconferences.org/src/App/pages/view/AegeanCodeofConduct 

    Accommodations

    Accommodations for the conference are at the Sheraton Hotel. The Hotel is located in Ixia, Rhodes, 14.5 km from the airport.

    Arrival and Check-in 

    Attendees are expected to arrive/check-in after 3:00 PM local time. Registered participants arriving after 10:00 PM should make alternative dinner arrangements.  

    Conference Venue

    The Sheraton Conference Center is located at the hotel.  

    Handicapped Accessibility 

    The site is fully handicapped accessible. 

    Oral Presentations

    Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A. 

    City Tour

    Buses for the city tour will depart from the hotel front lobby 3:00 PM. Badges are required for participation. 

    Breakfast

    Breakfast for registered participants and registered accompanying persons will be served at the Sheraton Hotel main restaurant during the hours scheduled in this program.

    Lunches/Informal Discussions

    Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant. Badges are required for admission.

    Dinners/Informal Discussions

    Three of the dinners/informal discussions will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting. 

    Internet, Phone, & Computer 

    Wireless internet access is available throughout the conference center free of charge during meeting hours. 

    Certificate of Participation

    A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session.

    Meeting Room Policy

    Mask Recommendation

    Face masks are recommended indoors.

    No Photographs and Recording Devices 

    Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations. 

    Other Information

    Animals are not permitted on site. 

    Badges are required for admission to all events. 

    All Aegean Conferences events are non-smoking. 

     

    Aegean Conferences expects attendees to conform their conduct at these meetings to the policies and procedures of their employing institution or company. If we learn of improper conduct by an attendee, we will take appropriate action, including reporting such conduct to the attendee's employing institution or company and barring the attendee from participation in our meetings.

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Monday, September 26

06:00 PM - 07:00 PM
Conference Registration
07:00 PM - 10:00 PM
Welcome Reception and Dinner

Tuesday, September 27

07:30 AM - 09:00 AM
Breakfast
09:00 AM - 09:05 AM
Welcome and Opening Remarks - Kostas Coumenis
TME, Metastasis and Tumor Dormancy
Chairs: Costas Koumenis and Ashi Weeratna
09:05 AM - 09:30 AM
Age against the machine: how aging impacts tumor progression
Ashani Weeraratna
09:30 AM - 09:55 AM
Origins and Behavior of Disseminated Tumor Cells during Minimal Residual Disease
Maria Sosa, Carolina Rodriguez-Tirado, and Alcina Rodrigues
09:55 AM - 10:20 AM
The Integrated Stress response in tumor progression and metastasis
Constantinos Koumenis
Keynote Lecture
Chair: Sandra Ryeom
10:45 AM - 11:30 AM
Oxygen Sensing
William Kaelin
11:10 AM - 12:00 PM
Coffee Break and Poster Viewing
Hypoxia, HIF and the TME
Chair: Sandra Ryeom
12:00 PM - 12:25 PM
Regulation of the HIF response at the level of chromatin
James Nathan
12:25 PM - 12:50 PM
The oncogenic role and therapeutic potential of targeting the RNA demethylase FTO in VHL deficient renal cell carcinoma.
Man Zhao1, Dalin Zhang, Haowen Jiang1, Suchitra Natarajan1, Hongjuan Zhao, Jim Brooks, Donna Peehl, Amato Giaccia1,, and Erinn Rankin1
12:50 PM - 01:15 PM
Hypoxia-derived extracellular vesicles metabolically reprogram endothelial cells to induce angiogenesis
Tom Keulers, Joel Beaumont, Kim Kampen, and Kasper Rouschop
01:15 PM - 02:45 PM
Lunch and Informal Discussions
02:45 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Dinner and Informal Discussions (Buses Depart from Hotel Lobby)

Wednesday, September 28

07:30 AM - 08:30 AM
Breakfast
Therapeutic Targeting, Immune Evasion and Plasticity
Chair: Soledad Sosa
08:30 AM - 08:55 AM
Novel Strategies for In-Situ Tumor Vaccination - Reprograming TIME Evolution via Compartmental Targeting
Amir Abdollahi
08:55 AM - 09:20 AM
Optimizing the interaction between immunotherapy and treatments that both directly and indirectly target tumour cells
Michael Horsman1, Priyanshu Sinha1, Folefac Asonganyi1, Søren Nygaard1, Mateusz Sitarz2, Brita Sørensen2, and Pernille Elming1
09:20 AM - 09:45 AM
Mechanistic understanding of response and resistance to lysosomal inhibition
Monika Bhardwaj 1, Jennifer Lee1, Amanda Versace 1, Sandra Harper 2, Aaron Goldman 2, Mary Crissey 1, Vaibhav Jain 1, Mahendra Rathore 1, megane vernon 3, Andrew Aplin 3, Jeffrey Winkler 1, Qin Liu 2, David Speicher 2, and Ravi Amaravadi 1
09:45 AM - 10:10 AM
Cell-extrinsic and –intrinsic mechanisms in pancreatic cancer subtype identity and therapy response
Niklas Krebs1, Lukas Klein1, Florian Wegwitz1, Elisa Espinet2, Carlo Maurer3, Mengyu Tu1, Frederike Penz1, Stefan Küffer4, Elisabeth Hessmann1, Andreas Trumpp2, Philipp Ströbel4, Rolf Brekken5, Volker Ellenrieder1, and Shiv Singh1
10:10 AM - 10:25 AM
Identification of a deubiquitination module essential for Treg fitness in the tumor microenvironment
Deyu Fang
10:25 AM - 11:10 AM
Coffee Break and Poster Viewing
Genome Integrity
Chair: Ester Hammond
11:10 AM - 11:35 AM
Hypoxia Tumour Biology and Tumour Genomics-CoDrivers of Tumour Evolution
Robert Bristow
11:35 AM - 12:00 PM
Sensing aberrant transcription by MYC oncoproteins
Dimtrios Papadopoulos, Daniel Solvie, Leonie Uhl, Stefanie Ha, and Martin Eilers
12:00 PM - 12:15 PM
Quantifying Poly(ADP-Ribose) Polymerase (PARP) in vivo using a non-invasive PARP1 PET tracer
Lilie Lin
Novel Targets in the TME
Chair: Natasha Kyprianou
12:15 PM - 12:40 PM
Nerve Growth Factor Regulation of the Gastric Cancer Tumor Microenvironment
Jin Cho, Xiaofei Zhi, Timothy Wang, and Sandra Ryeom
12:40 PM - 01:05 PM
Pathway analysis including miRNA functional analysis in tissue and cell type contexts
Artemis Hatzigeorgoiu
01:05 PM - 01:20 PM
Cancer-associated bacteria as a novel component of the tumor microenvironment affecting breast cancer proliferation, metabolism, and immunity
Alana Arnone, Yu-Ting Tsai, Adam Wilson, David Soto-Pantoja, and Katherine Cook
01:20 PM - 01:40 PM
Special Session: Alexia-Ileana Zaromytidou, Nature Cancer Editor
01:40 PM - 03:00 PM
Lunch and Informal Discussions
03:00 PM - 06:30 PM
Informal Discussions
06:45 PM - 10:30 PM
Dinner and Informal Discussions (Buses depart from Hotel Lobby)

Thursday, September 29

07:30 AM - 08:30 AM
Breakfast
UPR and Stress Responses
Chair: Ravi Amaravadi
08:30 AM - 08:55 AM
Identifying a conserved molecular signature for pediatric osteosarcoma
Linda Hendershot
08:55 AM - 09:20 AM
Mechanisms and functions of eIF2 kinase GCN2 in translational control and stress adaptation
Ronald Wek1 and Tracy Anthony2
09:20 AM - 09:45 AM
Uncovering cross-talk between mediators of the Unfolded Protein Response
Gideon Ong, Wafa Kammouni, and Susan Logue
09:45 AM - 10:10 AM
Prostate cancer is addicted to GCN2 to preserve amino acid homeostasis
Ricardo Cordova1, Jagannath Misra1, Tracy Anthony2, Roberto Pili3, Ronald Wek1, and Kirk Staschke1
10:10 AM - 10:35 AM
Microenvironmental and cancer cell intrinsic mechanisms of early dissemination reveal a new dormancy program and a vulnerability to target dormant cancer cells.
Julio Aguirre-Ghiso
10:35 AM - 11:20 AM
Coffee Break and Poster Viewing
Metabolism, Epigenetics and the TME
Chair: Susan Logue
11:20 AM - 11:45 AM
Therapeutic vulnerabilities in cancer stemming from metabolic heterogeneity
Ben Stanger
11:45 AM - 12:10 PM
The drivers and effectors of phenotype switching
Colin Goding
12:10 PM - 12:35 PM
KMT2C loss is associated with an aggressive tumor phenotype in bladder cancer
Apostolos Klinakis
12:35 PM - 01:00 PM
Phenotypic reprogramming of the prostate tumor microenvironment overcomes therapeutic resistance
Natasha Kyprianou and Maddison Archer
01:00 PM - 01:15 PM
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Dennis Vitkup
01:15 PM - 02:45 PM
Lunch and Informal Discussions
03:00 PM - 07:30 PM
City Tour (Buses Depart from Hotel Lobby)
07:30 PM - 10:30 PM
Dinner and Informal Discussions (Buses do not return to the hotel prior to dinner)

Friday, September 30

07:30 AM - 08:30 AM
Breakfast
Radiation Resistance and Sensitization
Chair: Michele Kim
08:30 AM - 08:55 AM
A phase II study of nelfinavir plus concurrent chemoradiation for advanced, HPV-negative squamous cell carcinoma of the head and neck
William Su1, Amit Maity1, Daniel Pryma2, David Mankoff2, Roger Cohen3, John Lukens1, and Alexander Lin1
08:55 AM - 09:20 AM
Hypoxia-induced ROS leads to the accumulation of R-loops independently of DNA damage
Ester Hammond
09:20 AM - 09:45 AM
Radiation and immune-modulation in lung cancer: perspective from a clinical and translational lens
Ramesh Rengan
09:45 AM - 10:10 AM
Immune Priming using low energy focused ultrasound (LOFU)
Chandan Guha
10:10 AM - 10:25 AM
Prediction of inter-fractional motion in lung cancer and impact on proton therapy delivery
Kyriakos Fotiou and Eirik Malinel
10:25 AM - 11:20 AM
Coffee Break and Poster Viewing
Latest developments in Radiotherapy-FLASH Radiation
Chair: Alex Lin
11:20 AM - 11:45 AM
Defining the future of FLASH radiation in the clinical setting
James Metz
11:45 AM - 12:10 PM
Physics considerations for commissioning an experimental beam line for in vivo proton FLASH experiments
Michele Kim
12:10 PM - 12:35 PM
Mechanistic insights on the increased therapeutic index of FLASH abdominal irradiation in mice, and technological path to clinical translation of FLASH therapy
Billy Loo1, Erinn Rankin1, Vignesh Viswanathan1, Stavros Melemenidis1, Rakesh Manjappa1, M Ashraf1, Luis Soto1, Suparna Dut1, Brendan Whelan2, Brianna Lau1, Murat Surucu1, Amy Yu1, G-One Ahn4, Joel Greenberger5, Michael Epperly5, Kerriann Casey3, Edward Graves1, Peter Maxim6, and Sami Tantawi7
12:35 PM - 01:00 PM
FLASH in murine and 3D spheroid models – Vancouver experience
Alastair Kyle1, Jennifer Baker1, Judit Banath1, Taixiang Wang1, Anam Liu1, Tania Karan2, Claudia Mendez2, Alanah Bergman2, Peter Petric2, Cheryl Duzenli2, and Andrew Minchinton1
01:00 PM - 01:10 PM
Closing Remarks: Ester Hammond
01:10 PM - 02:30 PM
Lunch and Informal Discussions
02:30 PM - 07:00 PM
Informal Discussions
07:30 PM - 11:00 PM
Farewell Dinner

Saturday, October 01

08:00 AM - 10:00 AM
Breakfast
10:00 AM - 12:00 PM
Departure