October 22
6:30 PM – Conference Registration
7:30 PM – Welcome Reception and Dinner
October 23
8:00 AM Breakfast
Session 1. Fibrosis across organs and organisms
9:00 AM Rafael Kramann- Common mechanisms of fibrosis in kidney and heart
9:25 AM Paul Martin - investigating skin repair and scarring in various model organisms
9:50 AM Paul Noble - Anger Management: Targeting Invasive Fibroblasts in Progressive Pulmonary Fibrosis (It’s more than matrix production)
9:50 AM Short Talk - TBA
10:05 AM Short Talk - TBA
10:20 AM First poster flash presentations (1 slide / presentation / 1 minute each)
10:30 AM Coffee Break and Poster Presentation
Session 2. Cellular orchestras controlling health and disease
11: 30 AM Sabine Werner- Stromal-epithelial communication in tissue repair and cancer
11: 55 AM Boris Hinz- The stressed relationship between macrophages and fibroblasts
12:20 PM Tatiana Kisseleva- IL-17 signaling regulates TNF-TNFR1 responses in steatotic hepatocytes in mice
12:55 PM Robert Schwabe - Regulation of liver zonation, metabolism, injury and regeneration by hepatic stellate cells
1:20 PM Second poster flash presentations (1 slide / presentation / 1 minute each)
1:45 PM Lunch and Informal Discussions
3:00 PM Informal Discussions
7:30 PM Dinner and Informal Discussions (Buses Depart from Hotel Lobby)
October 24
8:00 AM Breakfast
Session 3. Teasing out and validating novel targets for fibrosis
9:00 AM Timothy Mckinsey- Phenotypic Screening, Machine Learning and New Therapeutic Targets for Cardiac Fibrosis
9:25 AM Jelena Mann- Using Human Liver Slices to Assess Efficacy of New Compounds and Illuminate the Biology of Fibrosis
9:50 AM Peter Olinga – Precision-Cut Tissue Slices: A Cutting-Edge Tool for Studying and Advancing the Treatment of Fibrotic Diseases
10:15 AM Scott Lowe - Cell therapy approaches to remove excessive senescent cells from tissues
10:40 AM Short Talk - TBA
10:55 AM Third poster flash presentations (1 slide / presentation / 1 minute each)
11:10 AM Coffee Break and Poster Presentation
Session 4. Assessment of putative antifibrotics: the state-of-the-art
12:00 PM Geoff Teixeira - Targeting Claudin-1 as a novel therapeutic approach to reverse organ fibrosis
12:25 PM Reginald Brys - AGMB-101, a full agonistic antibody of MET, achieves deep suppression of liver fibrosis through a pleiotropic mechanism of action
12:50 PM Paul Yaworsky – A neutralizing antibody to EphrinB2 suppresses fibrosis in preclinical in vitro and in vivo models
1:15 PM Grant Budas - Combination strategies for MASH
1:40 PM Short Talk - TBA
1:55 PM Fourth poster flash presentations (1 slide / presentation / 1 minute each)
2:00 PM Lunch and Informal Discussions
3:00 PM Informal Discussions
7:30 PM Dinner and Informal Discussions (Buses Depart from Hotel Lobby)
October 25
8:00 AM Breakfast
Session 5. Innovations in clinical trial design
9:00 AM Florian Rieder- Mechanisms and clinical trial endpoints of intestinal fibrosis
9:25 AM Gisli Jenkins - A Scar is Born: The molecular pathology of pulmonary fibrosis.
9:50 AM Tim Van Kaem- A New Frontier in IBD - Towards the prevention of structural bowel damage in Crohn’s disease
10:15 AM Short Talk - TBA
10:30 AM Short Talk - TBA
10:45 AM Short Talk - TBA
11:00 AM Coffee Break and Poster Presentation
Session 6. Immune mechanisms of injury, repair, and fibrosis
12:00 PM Valerie Horsely - Inside out: Mechanisms of tissue fibrosis
12:25 PM Naglaa Shoukry- The Dual Role of Neutrophils during Liver Injury
12:50 PM Kevin Hart- Cross regulatory cytokine networks and rebound inflammation in fibrotic disease
1:15 PM Oliver Eikelberg- The role of B cells and plasma cells in the pathogenesis of fibrosis
1:40 PM Short Talk - TBA
1:55 PM Lunch and Informal Discussions
3:00 PM Tour of Knossos Archaeological Site and Archaeological Museum (Buses Depart from Hotel Lobby)
7:30 PM Dinner and Informal Discussions (Buses do not return to hotel prior to dinner)
October 26
8:00 AM Breakfast
Session 7. Maps, atlases and all things single cell
9:00 AM Rebekka Schneider-Kramann -Mapping fibrosis progression and reversal in the bone marrow
9:25 AM Neil Henderson- Using single cell and spatial genomics to decode human liver regeneration and repair
9:50 AM Chris Buckley- A therapeutic cell atlas focusing on fibroblasts
10:15 AM Lee Borthwick - Using human tissue models to illuminate the biology of fibrosis and unlock new drug targets
10:40 AM Short Talk - TBA
10:55 AM Coffee Break and Poster Presentation
Session 8. The mighty macrophage in fibrosis
12:00 PM David Brenner- Macrophage Heterogeneity during NASH Regression Unveils Multifaceted TREM2 Dependent Mechanisms that Facilitate NASH and Fibrosis Resolution
12:25 PM Bob Lafyatis- "Single nucleotide resolution of altered transcription factor binding in profibrotic macrophages from patients with interstitial lung disease"
12:50 PM Thomas Fabre- Making sense of the myeloid mess: defining and targeting functional myeloid subsets.
1:15 PM Short Talk - TBA
1:30 PM Lunch and Informal Discussions
3:00 PM Informal Discussions
7:30 PM Farewell Dinner
October 27
8:00 AM Breakfast
11:00 AM Departure