2nd International Meeting of Clearance of Dying Cells and Debris in Healthy and Diseased Immune System

Program

GENERAL INFORMATION

Accommodations

The conference participants will be staying at the Sheraton Hotel, which is located in Ixia, Rhodes, 14.5 km from the airport.

 

Arrival and Check-in

Attendees are expected to arrive/check-in on Sunday after 2:00 pm local time. Registered participants arriving after 10:30 pm Sunday night should make alternative dinner arrangements.

 

Conference Venue

The Sheraton Conference Center is located at the hotel.

 

Handicapped Accessibility

The site is fully handicapped accessible.

 

Oral Presentations

Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session. The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

 

City Tour

Buses for the city tour will depart from the hotel front lobby on Wednesday, October 8 at 3:00 PM. Badges are required for participation.

 
Breakfast

Breakfast for registered participants and registered accompanying persons will be served at the Sheraton Hotel main restaurant during the hours scheduled in this program.

 

Lunches/Informal Discussions

Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant. Badges are required for admission.

 

Dinners/Informal Discussions

Three of the dinners/informal discussions will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting. Please contact info@aegeanconferences.org.

 

Internet, Phone, & Computer

Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

 

Certificate of Participation

A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session.

 

Other Information

Animals are not permitted on site.

Badges are required for admission to all events.

All Aegean Conferences events are non-smoking.

 

No Photographs and Recording Devices

Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations.

 

Sunday, October 5

 

 

 

Registration

 

7:00-8:00 PM

Hotel Lobby

 

 

 

 

Welcome Reception/Dinner

8:00 PM

Main Restaurant

 

 

 

Monday, October 6

 

 

 

8:00 AM

 

Breakfast

 

 

 

9:00 AM

 

Welcome & Opening Remarks

Dror Mevorach

 

 

 

Session I

 

Introduction to Clearance of Apoptotic Cells

 

 

Chairs: Shigekazu Nagata and Dror Mevorach

9:15 AM

1

Macrophage receptors and cell activation

 

 

Siamon Gordon

10:15 AM

2

Stages of apoptotic cell clearance and their relevance to disease

 

 

Kodi S Ravichandran

 

 

 

11:00 AM

 

Coffee Break

 

 

 

Session II

 

Innate Immunity

 

 

Chairs: Kodi Ravichandran and Siamon Gordon

11:30 AM

3

Exposure of phosphatidylserine during apoptosis

 

 

Shigekazu Nagata

12:15 PM

4

Macrophages-tissue specific ontogeny and functions: Intestinal lamina propria and liver as a model

 

 

Chen Varol

1:00 PM

5

The role of CD169 macrophages in dead cell clearance and inflammatory regulation

 

 

Masato Tanaka, Kenichi Asano, and Kazunori Karasawa

1:45 PM

6

The role of phosphatidylserine receptor, T-cell Immunoglobulin Mucin domain-4 (TIM-4), in Filovirus Entry

 

 

Bethany Rhein and Wendy Maury

 

 

 

2:00 PM

 

Lunch / Informal Discussions

 

 

 

7:30 PM

 

Dinner / Informal Discussions at a Local Greek Restaurant

Buses depart from the hotel lobby at 7:30 PM

 

 

 

Tuesday, October 7

 

 

 

8:00 AM

 

Breakfast

 

 

 

Session III

Specific patterns: receptors/ligands and tolerance

 

 

Chairs: Keith Elkon and Philippe Saas

9:00 AM

7

TAM receptor diversification in the phagocytosis of apoptotic cells

 

 

Anna Zagórska, Erin D Lew, Paqui G Través, and Greg Lemke

9:45 AM

8

Clearing aged neutrophils

 

 

Andres Hidalgo, María Casanova-Acebes, Linnea A Weiss, Noelia A-González, and Jose M Adrover

10:30 AM

9

The satiated macrophage: a key player in the resolution of inflammation

 

 

Amiram Ariel, Senthil Kumaran Sathyanarayanan, and Sagie Schif-Zuck

10:45 AM

10

PIKfyve-mediated membrane fission regulates dead cell clearance during phagocytosis and entosis

 

 

Shefali Krishna, Oliver Florey, Yongchan Lee, and Michael Overholtzer

 

 

 

11:00 AM

 

Coffee Break

 

 

 

Session IV

Inflammation and autoimmunity

 

 

Chair: TBA

11:30 AM

11

Complement: more than a “guard” against invading pathogens

 

 

John D Lambris

12:15 PM

12

Distinct contributions of C1q and C3 in preventing immunogenicity of apoptotic cells in lupus

 

 

Keith Elkon, C Sontheimer, L Colonna, Y Nguyen, and YF Peng

1:00 PM

13

Sialylation of anti-histone IgG autoantibodies modulates inflammatory responses during clearance of apoptotic cells in SLE

 

 

Luis E Muñoz and Martin Herrmann

1:45 PM

14

The oxidative burst mediates anti-inflammatory clearance of dead cells in a mouse model of Systemic lupus Erythematosus and inflammatory arthritis

 

 

Deborah Kienhöfer, Jonas Hahn, Luis Munoz, Rikard Holmdahl, Georg Schett, and Markus H Hoffmann

 

 

 

2:00 PM

 

Lunch / Informal Discussions

 

 

 

7:30 PM

 

Dinner / Informal Discussions at a Local Greek Restaurant

Buses depart from the hotel lobby at 7:30 PM

 

 

 

Wednesday, October 8

 

 

 

8:00 AM

 

Breakfast

 

 

 

Session V

Therapeutic potential of apoptotic cells

 

 

Chairs: TBA

9:00 AM

15

Apoptotic cell infusion induces self-tolerance

 

 

Philippe Saas

9:45 AM

16

Retinoids mediate the liver X and the glucocorticoid receptor-induced enhancement in apoptotic cell clearance: Therapeutic implications

 

 

Zsuzsa Szondy, Zsolt Sarang, Gergely Joós, Ralph Rühl, and Éva Garbuczi

10:15 AM

17

Apoptotic cell prevent human high grade graft versus host disease

 

 

Dror Mevorach

10:45 AM

18

A novel mechanism in the induction of cytokine production and Th17 differentiation by apoptotic cells during their phagocytosis, and its implication in autoimmune diseases

 

 

Xiaojing Ma and Hajeong Kim

 

 

 

11:00 AM

 

Coffee Break

 

 

 

Session VI

Clearance mechanisms and cancer

 

 

Chairs: TBA

11:30 AM

19

Autophagy protein targeting of phagosomes and entotic vacuoles

 

 

Oliver Florey, Noor Gammoh, Sung Eun Kim, Xuejun Jiang, and Michael Overholtzer

12:15 PM

20

Dying tumor cell clearance and its impact on the outcome of cancer radiotherapy

 

 

Kisten Lauber

1:00 PM

21

Entosis in injured androgen-independent human prostate carcinoma (DU145) cells as a result of anticancer Apatone® pro-oxidant treatment and during remodelling of their xenotransplanted carcinomas in nude mice

 

 

Jacques Gilloteaux, James M Jamison, Jack L Summers, and Tom Miller

1:20 PM

22

Formation of defective autophagosomes in p53 negative colorectal cancer cells reinforces the crocin-induced apoptosis

 

 

Amr Amin, K Bajbouj, M Gandesiri, and R Schneider-Stock

1:40 PM

23

The role of apoptotic blebbing in tissue homeostasis and tumour growth

 

 

Michael F Olson, Linda Julian, and Katerina Mardilovich

 

 

 

2:00 PM

 

Lunch / Informal Discussions

 

 

 

3:00 PM

 

City Tour

Buses depart from the hotel lobby at 3:00 PM

 

 

 

7:30 PM

 

Dinner / Informal Discussions at a Local Greek Restaurant

Please note buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour

 

 

 

Thursday, October 9

 

 

 

8:00 AM

 

Breakfast

 

 

 

Session VII

Specific organs

 

 

Chairs: TBA

9:00 AM

24

TAM signaling in Homeostatic Regulation:  From phagocytosis of photoreceptors onto identifying new roles for Protein S

 

 

Tal Burstyn-Cohen

9:45 AM

25

Apoptotic cells induce NF-κB and inflammasome negative signaling

 

 

Adi Tabib and Dror Mevorach

10:15 AM

26

Engulfment of dead cells by cardiac myofibroblasts limits tissue damage and promotes recovery after myocardial infarction

 

 

Michio Nakaya

10:30 AM

27

Hypoxic-induced Proteolysis of MERTK and CD36 by ADAMs Suppresses CD47-dependent Cardiomyocyte and HIF2 Efferocytosis by Macrophages during Fibrotic Cardiac Repair

 

 

Edward B Thorp

10:45 AM

28

Neuronal eat-me and don’t-eat-me signals in synaptic pruning by microglial phagocytosis

 

 

Urte Neniskyte, Eva Haas, and Cornelius Gross

11:00 AM

29

Peripheral blood neutrophils treated with sphingolipid analogue drug FTY720 expose an untypical molecular pattern and are extensively cleared by scavenger receptors

 

 

Malgorzata Bzowska, Joanna SkrzeczyƄska-Moncznik, Aneta Sroka, and Krzysztof Guzik

 

 

 

11:15 AM

 

Closing Remarks

 

 

 

1:00 PM

 

Lunch / Informal Discussions

 

 

 

8:00 PM

 

Farewell Dinner

 

 

 

Friday, October 10

 

 

 

8:00 AM

 

Breakfast

 

 

 

Departure