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Sunday, June 14 |
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6:00 PM |
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Conference Registration |
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8:00 PM |
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Welcome Reception/Dinner |
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Monday, June 15 |
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7:30 AM |
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Breakfast |
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8:30 AM |
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Welcome and Opening Remarks |
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Session 1
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Germline and non-mammalian ncRNAs Chair: Joan Steitz |
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8:45 AM |
1 |
Biogenesis of germline small RNAs Radha Raman Pandey, David Homolka and Ramesh Pillar |
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9:15 AM |
2 |
Male Infertility Caused by Ubiquitination-deficient Mutations in Human Piwi (Hiwi) Lan-Tao Gou, Jun-Yan Kang, Peng Dai, Xin Wang, Feng Li and Mo-Fang Liu |
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9:45 AM |
3 |
Uniting Major Constituents of the Genome: The Role of piRNAs in the Germline Toshiaki Watanabe, Ee-chun Cheng, Mei Zhong and Haifan Lin |
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10:15 AM |
4 |
Embryonic Piwi expression is required for the heterochromatic germinal piRNA production in the Drosophila adult female Abdou Akkouche, Bruno Mugat, Blaise LI, Carolina Varela-Chavez, Alain Pélisson and Severine Chambeyron |
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10:30 AM |
5 |
Protein-guided elimination of specific lncRNAs controls sexual differentiation and heterochromatin gene silencing in fission yeast Leila Touat-Todeschini, Mathieu Dangin, Yuichi Schichino, Edwige Hiriart, Benoit Gilquin, Akira Yamashita, Ravi Sachidanandam, Nicolas Thierry-Mieg, Jan Kadlec, Ramesh Pillai, Masayuki Yamamoto and Andre Verdel |
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10:45 AM |
6 |
5′ non-coding end of La Crosse orthobunyavirus RNA genome allosterically structures and activates the polymerase catalytic site Piotr Gerlach, Helene Malet, Stephen Cusack and Juan Reguera |
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11:00 AM |
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Coffee break and poster viewing |
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Session 2
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Genome Editing and RNA Therapeutics Chair: Andrei Thomas Tikhonenko |
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12:00 PM |
7 |
CRISPR-Cas9: an ancient bacterial immune system harnessed for genome engineering Emmanuelle Charpentier |
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12:30 PM |
8 |
Systematic exploration of LincRNAs in the immune system using the CRISPR/Cas9 system Jorge Henao-Mejia |
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1:00 PM |
9 |
Targeted gene knockdown using aptamer-siRNA chimeras Judy Lieberman |
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1:30 PM |
10 |
Somatic genome editing as a novel tool to model human cancers in mice Andrea Ventura |
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2:00 PM |
11 |
3’UTR SNPs that are targets for A-I RNA editing control IGF1R mRNA expression levels in high-risk neuroblastoma Danika Johnston, Elena Sotillo-Piñeiro, Linh Le, Lee McDaniel, Pichai Raman, Ariella Sasson, Liu Xu, Travis Laver, Edward Attiyeh, Kristina Cole, John Maris, Sharon Diskin and Andrei Thomas-Tikhonenko |
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2:15 PM |
12 |
Molecular mechanism and therapeutic activity of modified U1 snRNAs Franco Pagani |
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2:30 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions at a Local Greek Restaurant |
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Tuesday, June 16 |
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7:30 AM |
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Breakfast |
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Session 3 |
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RNA Metabolism |
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8:30 AM |
13 |
hnRNPs and snRNPs: the instruments of post-transcriptional gene regulation Gideon Dreyfuss |
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9:00 AM |
14 |
New RNA metabolic enzymes: mechanisms, biology and disease Javier Martinez |
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9:30 AM |
15 |
small RNAs and RNPs Zissimos Mourelatos |
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10:00 AM |
16 |
The role of alternative splicing in leukemia immunoediting Andrei Thomas-Tikhonenko |
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10:30 AM |
17 |
Spliceosomal snRNA targeting to Cajal bodies Adriana Roithova and David Stanek |
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10:45 AM |
18 |
RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation Prathamesh Thangaraj Nadar Ponniah, Muhammad Zoabi, Hanan Khoury-Haddad, Marko Usaj, Inbal Budowski-Tal, Tali Haran, Arnon Henn, Yael Mandel-Gutreund and Nabieh Ayoub |
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11:00 AM |
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Coffee break and poster viewing |
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Session 4 |
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microRNA Biogenesis and Regulation Chair: Gideon Dreyfuss |
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12:00 PM |
19 |
Regulation of microRNA biogenesis Javier Caceres |
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12:30 PM |
21 |
Regulation of miRNA repression and miRNA metabolism in mammalian cells Witold Filipowicz |
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1:00 PM |
22 |
Target-induced microRNA degradation by DIS3L2 and TUT1 Gabrielle Haas, Semih Cetin, Mélanie Messmer, Béatrice Chane-Woon-Ming, Johana Chicher, Lauriane Kuhn, Philippe Hammann and Sébastien Pfeffer |
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1:15 PM |
23 |
Mature microRNA 3' non-templated nucleotide additions during T cell activation Cristina Gutiérrez-Vázquez, Anton Enright, Vladimir Benes, Joseph Mizgerd, Maria Mittelbrunn and Francisco Sánchez-Madrid |
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1:30 PM |
24 |
Uncovering microRNA dynamic degradation in cancer through metabolic labeling Matteo Marzi, Francesco Ghini, Heiko Muller, Benedetta Cerruti and Francesco Nicassio |
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1:45 PM |
25 |
Multiple distinct mechanisms disrupt let-7 microRNA biogenesis and function in neuroblastoma John Powers, Kaloyan Tsanov, Frederik Roels, Richard Ebright, Marc Seligson, T de Soysa, Patrick Cahan, Jessica Theissen, Grace LaPier, Daniel Pearson, Frank Berthold and George Daley |
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2:00 PM |
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Lunch and Informal Discussions |
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3:30 PM |
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Meet 'AAA' Editors Angela Eggleston (Nature)
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7:30 PM |
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Dinner and Informal Discussions at a Local Greek Restaurant |
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Wednesday, June 17 |
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7:30 AM |
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Breakfast |
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Session 5 |
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lncRNAs in Development & Disease Chair: Witold Filipowicz |
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8:30 AM |
26 |
Genome regulation by long noncoding RNAs Howard Chang |
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9:00 AM |
27 |
Senescence LncRNPs Myriam Gorospe |
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9:30 AM |
28 |
A new class of long non-coding RNAs directly regulating signal transduction pathways Erwei Song |
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10:00 AM |
29 |
About Noam Chomsky, DNA motifs, non-codingRNAs and cancer patients George Calin |
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10:30 AM |
30 |
An mRNA-derived ncRNA targets and regulates the ribosome Andreas Pircher and Norbert Polacek |
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10:45 AM |
31 |
The long noncoding RNA SPRY4-IT1 regulates cell proliferation and apoptosis in human melanocytes. Wei Zhao, Joseph Mazar, Bongyong Lee, John Shelley, Subramaniam Govindarajan, Dwight Towler, Marcel Dinger and Ranjan Perera |
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11:00 AM |
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Coffee break |
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Session 6 |
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Long and Short ncRNAs in Cancer Chair: Judy Lieberman |
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11:30 AM |
32 |
Regulation and function of non-coding RNAs in colorectal cancer Ashish Lal |
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12:00 PM |
33 |
Long non-coding RNAs in Cancer Sven Diederichs |
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12:30 PM |
34 |
Regulation of acute leukemia progression by non coding (lnc/enhancer) RNAs Iannis Aifantis |
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1:00 PM |
35 |
The lncRNA CASC15 is a target of the the 6p22 neuroblastoma GWAS susceptibility locus Kristina Cole |
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1:30 PM |
36 |
A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel Or Bida, Moriah Gidoni, Sol Efroni and Doron Ginsberg |
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1:45 PM |
37 |
Role of NEAT1 long non coding RNA in therapy resistant prostate cancer Dimple Chakravarty |
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2:00 PM |
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Lunch/Informal Discussions |
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3:30 PM |
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City Tour (depart from the hotel lobby at 3:30PM) |
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7:30 PM |
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Dinner/Informal Discussions at a local Greek Restaurant |
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Thursday, June 18 |
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7:30 AM |
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Breakfast |
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Session 7 |
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microRNAs in Development Chair: Zissimos Mourelatos |
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8:30 AM |
38 |
MicroRNA Regulation of Mammalian Embryonic Development Robert Blelloch |
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9:00 AM |
39 |
Mechanisms of microRNA regulation in stem cells and cancer Richard Gregory |
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9:30 AM |
40 |
Role of microRNA processing enzyme Drosha in vascular development Akiko Hata, Xuan Jiang, Daniel Hart, Mai Baalbaki, Pinar Bayrak-Toydemir and Whitney Donahue |
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10:00 AM |
41 |
Regulation of Dicer1 Expression by Microprocessor Complexes and SnaR ncRNA Jerome Barbier, Gabriel Sanchez, Xin Chen, Celine Elie, Marion Helsmoortel, Anne Coleno-Costes, Xavier Contreras and Rosemary Kiernan |
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10:15 AM |
42 |
Functional analysis of the miR-CLIP defined potential multi-miRNA sponge lncRNA H19 Jochen Imig, Andreas Brunschweiger, Alexander Kanitz, Anneke Brümmer, Nitish Mittal, Jonathan Hall and Mihaela Zavolan |
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10:30 AM |
43 |
Mir-17~92 Governs Motor Neuron Subtype Survival Intrinsically by Mediating Nuclear PTEN Jun-An Chen |
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10:45 AM |
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Coffee break and poster viewing |
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Session 8 |
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Systems biology of ncRNAs Chair: Howard Chang |
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12:00 PM |
44 |
Viral Noncodings RNAs: Insights into Evolution Joan Steitz |
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12:30 PM |
45 |
The regulation of the regulators: The identification of miRNA promoters and their targets through an experimental computational approach Artemis Hatzigeorgiou |
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1:00 PM |
46 |
Regulatory RNAs Nikolaus Rajewsky |
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1:30 PM |
47 |
MicroRNAs, MicroRNA isoforms, and their Targets Isidore Rigoutsos |
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2:00 PM |
48 |
The first wave of transcription in mouse zygotes produces mainly non-coding transcripts Ken-ichiro Abe, Ryoma Yamamoto, Vedran Franke, Minjun Cao, Yutaka Suzuki, Masataka Suzuki, Kristian Vlahovicek, Petr Svoboda, Richard Schultz and Fugaku Aoki |
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2:15 PM |
49 |
RNA interference pathways regulate genome integrity and early mouse development programs Constance Ciaudo |
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2:30 PM |
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Lunch/Informal Discussions |
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8:00 PM |
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Farewell Dinner |
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Friday, June 19 |
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7:30 AM |
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Breakfast |
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8:30 AM |
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Departure |
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Posters |
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50 |
A role for DNA methylation in expression and function of activating ncRNAs Ulf Ørom |
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51 |
An emerging player NKILA is a modulator of Activation Induced Cell Death in T lymphocytes Di Huang, Shicheng Su and Bodu Liu |
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52 |
Analysis of RNP structure of long non-coding RNAs with a relevant function in muscle differentiation Sama Shamloo, Julie Martone, Monica Ballarino and Irene Bozzoni |
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53 |
Antisense lncRNAs regulate mutually exclusive expression of virulence genes in malaria parasites Inbar Amit-Avraham, Guy Pozner, Shiri Eshar, Yair Fastman, Netanel Kolevzon, Eylon Yavin and Ron Dzikowski |
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54 |
Artificial biocompatible linkage for long synthetic modified nucleic acid constructs Afaf El-Sagheer and Tom Brown |
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55 |
Characterization of a cold-associated non-coding RNA signature in natural models of hypometabolism Pier Jr Morin |
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56 |
Characterization of extreme non-coding element conservation in mycobacteria Mmakamohelo Direko and Alan Christoffels |
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57 |
Collecting and Indexing experimentally supported microRNA targets in coding and non-coding transcripts Maria Paraskevopoulou, Ioannis Vlachos, Dimitra Karagkouni, Georgios Georgakilas, Thanasis Vergoulis, Theodore Dalamagas and Artemis Hatzigeorgiou |
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58 |
Critical factors that determine silencing efficiency of miRNA-like siRNAs in targeting CAG repeats within translated regions. Anna Stroynowska-Czerwinska, Agnieszka Fiszer and Wlodziemierz Krzyzosiak |
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59 |
Cross-species comparative analysis of Dicer proteins during Sindbis virus infection Erika Girardi, Mathieu Lefèvre, Béatrice Chane-Woon-Ming, Simona Paro, Jean-Luc Imler, Carine Meignin and Sébastien Pfeffer |
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60 |
Crosstalk between CTCF and HOXA10 in human breast cancer: possible application of shRNA Muhammad Mustafa, Ji-Yeon Lee and Myoung Hee Kim |
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61 |
microRNAs regulating CD8 T cell responses to chronic viral infections Erietta Stelekati, Jennifer Hope, Donald Gracias, Adam Fike, Daniel Beiting, Mohammed-Alkhatim Ali, Peter Katsikis and E. John Wherry |
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62 |
Delivery of miR-146a mimics with PepFect6 inhibits inflammatory responses in keratinocytes and skin Annely Lorents, Egon Urgard Urgard, Mariliis Klaas Klaas, Janeli Viil, Toomas Runnel, Ülo Langel, Viljar Jaks, Margus Pooga and Ana Rebane |
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63 |
Differential expression of circulating microRNAs in breast cancer patients and individuals carrying BRCA1 mutation Dana Jurkovičová, Monika Magyerková, Lucia Copáková, Vladimír Bella, Michal Konečný, Mária Krivjanská, Ľudovít Kulcsár and Miroslav Chovanec |
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64 |
Differentially secreted miRNAs in stress induced premature senescence Lucia Terlecki-Zaniewicz, Ingo Lämmermann, Hanna Dellago and Johannes Grillari |
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65 |
Discovery of protein-RNA networks Gian Gaetano Tartaglia |
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66 |
Evaluation of in silico miRNA target prediction algorithms Dimitra Karagkouni, Maria Paraskevopoulou, Ioannis Vlachos, Georgios Georgakilas and Artemis Hatzigeorgiou |
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67 |
Exosomal microRNAs as biomarkers of bipolar disorder and schizophrenia Jason Choi, Andre Fischer, Farahnaz Sananbenesi and Ivana Delalle |
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68 |
Ezh2 silences tumor suppressor miR-34a expression in human pancreatic ductal adenocarcinoma by inducing heterochromatin formation Yangchao Chen |
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69 |
Flexible motif discovery in ranked sequence lists. Morten Nielsen, Paula Tataru, Tobias Madsen, Asger Hobolth and Jakob Pedersen |
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70 |
Heterogeneity of miR-10b expression in circulating tumor cells Albert Mellick, Christin Gasch, Prue Plummer, Sabine Riethdorf, Klaus Pantel and David Wescott |
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71 |
Highly sensitive TaqMan®-based microRNA detection for translational research Shoulian Dong, Linda Wong, Thomas Gulham, Bonnie Moy, Pak Wah Tsang, Chunmei Liu, Cora Woo and Junko Stevens |
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72 |
Identification of microRNA transcription start sites by combining high-throughput experimental techniques and Machine Learning Georgios Georgakilas, Ioannis Vlachos, Maria Paraskevopoulou, Peter Yang, Yuhong Zhang, Aris Economides and Artemis Hatzigeorgiou |
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73 |
Inhibition of the PI3K/mTOR pathway activates extensive transcriptome changes in Ewing Sarcoma cells Paola Frisone, Elisa de Paola, Marco Fidaleo and Maria Paola Paronetto |
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74 |
Insights into miRNA functions and regulation by decoding miRNA degradation dynamics Matteo Marzi, Francesco Ghini, Benedetta Cerruti and Francesco Nicassio |
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75 |
Interplay between the dengue non structural proteins and the human RNA silencing machinery Pavan Kumar Kakumani, K S Rajgokul, Akhil Banerjea, Guruprasad Medigeshi, Pawan Malhotra, Sunil Mukherjee and Raj Bhatnagar |
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76 |
Interstrand cross-link induced miR-139-3p and mi-R199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation Stefan Erkeland |
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77 |
lncRNAs regulate the tumorigenesis of breast cancer cells by autophagy Chang Gong, Xin Jing and Erwei Song |
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78 |
Long non-coding RNA expression patterns in Hodgkin lymphoma Masoumeh Tayari, Klaas Kok, Gertrud Kortman, Jantine Sietzema, Debora de Jong , Martijn Terpstra, Lydia Visser, Arjan Diepstra , Anke van den Berg and Joost Kluiver |
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79 |
Long noncoding RNAs as a novel component of the Myc transcriptional network Melanie Winkle, Anke van den Berg, Masoumeh Tayari, Jantine Sietzema, Martijn Terpstra, Gertrud Kortman, Debora de Jong, Lydia Visser, Arjan Diepstra, Klaas Kok and Joost Kluiver |
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80 |
Maternal LncRNA during Oocyte to Embryo transition Sravya Ganesh |
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81 |
Micro RNA mimics the biological effects of canonical CBF-AML leukemia fusion proteins Nicoletta Sacchi |
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82 |
MicroRNA-mediated control of hippocampal maturation Laura Guajardo, Rodrigo Aguilar, Fernando Bustos, Rodrigo Gutierrez, Brigitte van Zundert and Martin Montecino |
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83 |
MicroRNAs: posttranscriptional modulators of cellular and extracellular cartilage compartments Bjoern Bluhm, Julia Etich, Harald Ehlen, Tatjana Holzer, Lena Pitzler, Christian Frie and Bent Brachvogel |
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84 |
miR-142-3p is silenced by mutant p53 to induces invasion in a mouse model of pancreatic cancer Jack Godfrey and Martin Bushell |
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85 |
miR-211 functions as a metabolic switch in human melanoma cells Joseph Mazar, Feng Qi, Bongyong Lee, John Marchica, Subramaniam Govindarajan, John Shelley, Jian-Liang Li and Ranjan Perera |
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86 |
miRNA detection by ligation and amplification of complementary DNA oligos using SplintR® ligase Larry McReynolds , Alexander Zhelkovsky and Jingmin Jin |
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87 |
NEAT1/paraspeckles as novel players in pathogenesis of amyotrophic lateral sclerosis Tatyana Shelkovnikova, Michail Kukharsky, Annamaria Quintiero and Vladimir Buchman |
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88 |
Neuroblastoma transcriptome sequencing reveals a risk associated long noncoding RNA NBAT-1 that controls tumor progression via regulating cell proliferation and neuronal differentiation GK Pandey, S Mitra, S Subhash, F Hertwig , M Kanduri , K Mishra , S Fransson , A Ganeshram , T Mondal , S Bandaru , M Östensson , L M Akyürek , J Abrahamsson , S Pfeifer , E Larsson , M Fischer , T Martinsson , F Hedborg , P Kogner and C Kanduri |
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89 |
Oxidized RNA in Systemic Lupus Erythematosus Andreas Koenig, Ralph Budd, Andras Perl and Iwona Buskiewicz |
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90 |
Recent advances in analysis of DicerO Eliška Svobodová, Jana Urbanová and Petr Svoboda |
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92 |
Regulation of Interleukin-8 expression in Cystic Fibrosis lung epithelial cells by HuR and miR-16 Motohiro Tsuchiya, Sharmistha Bhattacharyya, Parameet Kumar, Shobha Vasudevan, Jennifer Martindale, Myriam Gorospe and Roopa Biswas |
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93 |
Revealing microRNA function with DIANA-miRPath v3.0 Ioannis Vlachos, Konstantinos Zagganas, Maria Paraskevopoulou, Georgios Georgakilas, Dimitra Karagkouni, Thanasis Vergoulis, Theodore Dalamagas and Artemis Hatzigeorgiou |
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94 |
Roles of miR-338-5p in downregulating Id1 and inhibiting chemoresistance Liang Han, B Li, SW Tsao and ALM Cheung |
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95 |
Signature of circulating microRNAs in patients with acute heart failure Ekaterina Ovchinnikova, Daniela Schmitter, Eline Vegter, Christopher O'Connor, Daniel Bloomfield, Gadi Cotter, Alexandre Mebazaa, Piotr Ponikowski, Adriaan Voors and Eugene Berezikov |
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96 |
Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple Negative Breast Cancer Zheng-Rong Lu, Jenny Parvani, Maneesh Gujrati and William Schiemann |
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97 |
Smart way to die: Cross-talk between autophagy and apoptosis of tumor cells by knockdown of antisense long non-coding mitocondrial RNAs (ASncmtRNAs). Soledad Vidaurre, Karen Villota, Maximiliano Bendek, Veronica Burzio and Luis Burzio |
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98 |
Sphingolipids regulate the activation of dendritic cells upon virus infections or TLR stimulation Young-Jin Seo, Curtis Pritzl and Bumsuk Hahm |
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99 |
Targeted labeling of small RNAs for imaging and enrichment Giedrius Vilkaitis, Alexandra Plotnikova, Aleksandr Osipenko, Viktoras Masevicius and Saulius Klimasauskas |
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100 |
Targeting lncRNA HOTAIR with peptide nucleic acids in breast and ovarian cancers Ali Ozes, Nick Pulliam and Kenneth Nephew |
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101 |
Targeting the melanoma-specific long non-coding RNA linc01212 as an effective antimelanoma strategy Eleonora Leucci, Pieter Mestdagh, Roberto Vendramin, Arturo Orjalo, Sven Eyckerman , Kris Gevart, Irwin davidson, Jo Vandesompele and Jean-Christophe Marine |
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102 |
The immature phenotype T-ALL long noncoding RNAome as a prelude to novel therapeutic targeting Annelynn Wallaert, Kaat Durinck, Filip Matthijssens, Wouter Vanloocke, Pieter-Jan Volders, Inge Van De Walle, Yves Benoit, Bruce Poppe, Pieter Mestdagh, Jo Vandesompele, Tom Taghon, Jean Soulier, Pieter Rondou, Pieter Van Vlierberghe and Frank Speleman |
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103 |
The influence of heat stress conditions on small RNAs levels in Drosophila. Sergey Funikov, Sergey Ryazanskii, David Garbuz, Helen Zelentsova, Michail Evgen’ev, Olga Zatsepina and Alexander Kanapin |
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104 |
The Landscape of Driver Long Noncoding RNAs Across 1104 Cancer Genomes Andrés Lanzós, Roderic Guigó, Nuria López-Bigas and Rory Johnson |
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105 |
The Long Noncoding Mitochondrial RNAs Induce Tumor Cell Death Through a MicroRNA-based Pathway Veronica Burzio, Christopher Fitzpatrick, Macarena Briones, Oliveira-Cruz Luciana, Soledad Vidaurre and Luis Burzio |
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106 |
The long noncoding RNA induced by pathogenic infections Nobuyoshi Akimitsu and Katsutoshi Imamura |
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107 |
The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression Xinna Zhang and Xiongbin Lu |
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108 |
The role of long noncoding RNAs in normal hematopoiesis and malignant transformation Leah Sabin, Joaquina Delas, Emily Lee, David Kelley, John Rinn and Gregory Hannon |
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109 |
The human pericardial fluid is enriched with cardiovascular-expressed microRNAs and exosomes able to elicit therapeutic responses Cristina Beltrami, Saran Shantikumar, Andrew Shearn, Cha Rajakaruna, Gianni Angelini and Costanza Emanueli |
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110 |
The role of microRNAs in the malignant evolution of squamous cell carcinoma of the skin (SCC) Adi Mizrahi, Aviv Barzilai, Iddo Ben-Dov, Yechezkel Sidi and Dror Avni |
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111 |
Tools4miRs – one place to gather all tools for miRNA analysis Anna Lukasik, Maciej Wojcikowski and Piotr Zielenkiewicz |
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112 |
tRNA-derived fragments target the small ribosomal subunit to fine-tune translation Jennifer Gebetsberger and Norbert Polacek |
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113 |
Y chromosome-linked long non-coding RNAs: Function and involvement in coronary artery disease Elsa Molina, Guat Chew, Stephen Myers and Fadi Charchar |
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114 |
Y-RNA-derived small RNAs as biomarkers and effectors of atherosclerosis Michele Trabucchi and Emanuela Repetto |
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115 |
The Wnt-regulated long non-coding RNA WNTRLINC1 interacts with TCF4/β-catenin to control the expression of the intestinal stem-cell factor ASCL2 Antonis Giakountis, Panagiotis Moulos, Vasiliki Zarkou, Christina Oikonomou, Vaggelis Harokopos, Artemis G. Hatzigeorgiou, Martin Reczko, Pantelis Hatzis |