Thursday, September 24

6:00 PM

Conference Registration

8:00 PM

Welcome Reception / Dinner

Friday, September 25

7:30 AM

Breakfast

8:20 AM

Welcome and Opening Remarks

Session I

Immunometabolism and disease

Chair: Steve Shoelson

8:30 AM

1

Immunopathogenesis of non-alcoholic fatty liver disease

Daniel A Giles and Senad Divanovic

9:05 AM

2

Thermoneutrality promotes mature myeloid cell retention in bone marrow and reduces circulating monocytes and neutrophils

Andrew F Elvington, Stoyan Ivanov, Jesse Williams, Bernd Zinselmeyer, Brian Saunders, Michael Johnson, Yongjian Lui, Clarissa Craft, and Gwendalyn J Randolph

9:40 AM

3

Metabolic interactions in the tumor microenvironment

Erika Pearce, Jing Qiu and Chih-Hao Chang

10:15 AM

4

Lipid metabolism affects regulatory T cell dynamics in cancer

Ilenia Pacella, Chiara Focaccetti, Eleonora Timperi, Vincenzo Barnaba and Silvia Piconese

10:30 AM

Coffee Break & Poster Viewing

Session II

Energetics & Immunometabolism

Chair: Randy Levinson

11:30 AM

5

Macrophage retention inhibits beige adipogenesis in obesity

Kyoung-Jin Chung, Antonios Chatzigeorgiou, Ioannis Mitroulis, George Hajishengallis, Vasileia Alexaki and Triantafyllos Chavakis

12:05 PM

6

Lymphocyte-specific effects in beige adipogenesis

Katia Karalis, T Chavakis, M Moisidou, S Karaliota, and E Kodela

12:40 PM

7

Intrinsic Anti-Inflammatory Actions of AMPK Activation

Steven Shoelson

1:15 PM

8

Adipocyte, but not macrophage or endothelial HIF2 protects from whitening of the brown adipose tissue and metabolic dysregulation in the course of diet-induced obesity

Ruben Garcia-Martin, Kyoung-Jin Chung, Nan Qin, Maria Rubin de Celis, Bettina Gercken, Vasileia Alexaki and Triantafyllos Chavakis

1:30 PM

Lunch/Informal Discussions

7:30 PM

Dinner/Informal Discussions at a local Greek restaurant

Saturday, September 26

7:30 AM

Breakfast

Session III

Adaptive & Innate Immunity

Chair: Gwendolyn Randolph

8:30 AM

9

The immune regulation of adipose tissue function

Xaioyuan Xu, Eleanor Ables, Ambar Grijalva, and Anthony W Ferrante Jr

9:05 AM

10

Innate immune cells in Type 1 and Type 2 diabetes

Isabelle Magalhaes, Ophélie Roussel, Badr Kiaf, Jennifer Da Silva, Lucie Beaudoin, and Agnes Lehuen

9:40 AM

11

Fatty acid-induced macrophage inflammation: when the bells don't always Toll!!!

Graeme Lancaster, Katherine Langley and Mark Febbraio

10:15 AM

12

Mannose receptor deficiency protects against high-fat diet-induced insulin resistance by reducing classical activation of liver and adipose tissue macrophages in obese mice

Leonie Hussaarts, Noemi Garcia Tardon, Simone Haeberlein, Karin de Ruiter, Lisa Hoving, Arifa Ozir-Fazalalikhan, Gerard van der Zon, Vanessa van Harmelen, Sven Burgdorf, Maria Yazdanbakhsh and Bruno Guigas

10:30 AM

Coffee Break & Poster Viewing

Session IV

Cytokines & Metabolism

Chair: Erika Pearce

11:30 AM

13

De-stressing the beta cell with IL-22 in diabetes

Michael McGuckin

12:05 PM

14

IL22 links mucosal immunity to metabolic syndromes

Wenjun Ouyeng

12:40 PM

15

Physiology of pro-inflammatory cytokines in metabolism

Marc Donath

1:15 PM

16

IL-33 induces insulin secretion via intra-islet innate lymphoid cells 2

Elise Dalmas, Frank Lehmann, Erez Dror, Constanze Thienel, Marcela Borsigova, Jean-Philippe Girard, Marianne Boeni-Schnetzler, Daniela   Finke and Marc Donath

1:30 PM

Lunch/Informal Discussions

7:30 PM

Dinner/Informal Discussions at a local Greek restaurant

Sunday, September 27

7:30 AM

Breakfast

Session V

Intracellular immunometabolism

Chair: Janelle Ayres

8:30 AM

17

mTOR and metabolic control of T cell fate decisions

Hongbo Chi

9:05 AM

18

Metabolic control of human Treg cell generation in health and autoimmunity

Giuseppe Matarese, Veronica De Rosa and Mario Galgani

9:40 AM

19

Understanding the impact of flux through the cholesterol biosynthesis pathway in host defense

Steven J Bensinger

10:15 AM

20

A role for Peroxisome Proliferator-Activated Receptor Beta in T cell development

Isabelle Mothe-Satney, Joseph Murdaca, Raphaelle Squillace, Akila Rekima, Brigitte Sibille, Anne-Sophie Rousseau, Frederic Labret, Valerie Verhasselt, Paul Grimaldi and Jaap Neels

10:30 AM

Coffee Break & Poster Viewing

Session VI

Microbiome and Infectious disease

Chair: Triantafyllos Chavakis

11:30 AM

21

The intestinal immune system as a new therapeutic target in obesity related insulin resistance

Daniel Winer

12:05 PM

22

The intestinal microbiota protects against infection-induced metabolic pathologies

Janelle Ayres

12:40 PM

23

Metabolic regulation of hepatic immunity and immunopathology

Mala Maini

1:15 PM

24

Early antiretroviral therapy in HIV infection normalizes perturbations in CD8+ T cell metabolism

A K M Nur ur Rahman, Leanne Wybenga-Groot and Mario Ostrowski

1:30 PM

Lunch/Informal Discussions

3:30 PM

City Tour

7:30 PM

Dinner/Informal Discussions at a local Greek restaurant

Monday, September 28

7:30 AM

Breakfast

Session VII

Hot Topics

Chair: Marc Donath

8:30 AM

25

Loss of GPS2 sensitizes macrophage activation upon metabolic stress in obesity and type-2 diabetes

Nicolas Venteclef and Eckardt Treuter

9:05 AM

26

Immunometabolism of obesity and diabetes

Gokhan Hotamisligil

9:40 AM

27

Hypothalamic Inflammation - a Therapeutic Target

Matthias Tschoep

10:15 AM

28

Diet composition affects hypothalamic T-cell presence

Stefanie Kälin, Isabelle Serr, Maike Becker, Verena Ott, Matthias Tschöp and Carolin Daniel

10:30 AM

29

The immunoregulatory of the incretin glucose dependent insulinotrophic polypeptide (GIP)in adipose tissue and bone marrow hematopoiesis

Isabel Zvibel, Ferananda Mantelmacher, Or Touval, Sigal Fishman and Chen Varol

10:45 AM

Coffee Break & Poster Viewing

Session VIII

Student talks

Chair: Giuseppe Matarese

11:30 AM

30

Metabolic Enzyme Histocytometry: A novel tool to investigate the metabolic microenvironment of intact tissue

Anne Miller, Arvand Haschemi, Johannes Laengle, Michael Bergmann, Oswald Wagner and Marion Groeger

11:45 AM

31

PPARg Regulates Tolerogenic And Metabolic Potential Of CD11c+ Cells Ensuring Immune Tolerance In The Airways

Mahesh Raundhal, Anupriya Khare, Krishnendu Chakraborty, Catherine Corey, Rachael Huff, Christina Morse, Sruti Shiva, Prabir Ray and Anuradha Ray

12:15 PM

32

S. Typhimurium evades macrophage defense by downregulating insulin signaling mediated glycolysis

Saray Gutierrez, Julia Fischer, Raja Ganesan, Nirmal Robinson, Martin Krönke, Vidya Velagapudi and Jens Brüning

12:30 PM

33

SIRT1 gain-of-function mutation leads to imbalance of the immune system and exhaustion of beta cells

Constanze Thienel, Elise Dalmas, Erez Dror, Marianne Böni-Schnetzler and Marc Donath

12:45 PM

34

Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1

Yusuke Endo and Toshinori Nakayama

1:00 PM

35

Deletion of PKCε in islet-associated macrophages improves β-cell function

Liam O'Reilly, Carsten Schmitz-Pieffer, James Cantley, Vivian Turner, Robert Brink and Trevor Biden

1:15 PM

Closing Remarks

1:30 PM

Lunch/Informal Discussions

8:00 PM

Farewell Dinner

Tuesday, September 29

7:30 AM

Breakfast

9:30 AM

Departure

POSTERS

36

The impact of acute peripheral lipopolysaccharide administration on the mitochondrial proteins expression in the brain of adult rat- a preliminary study

Agnieszka Basta-Kaim, Ewa Trojan, Joanna Ślusarczyk, Katarzyna Głombik, Monika Leśkiewicz, Marta Kubera and Bogusława Budziszewska

37

1 Physiological synergy between IL‐1β and insulin on glucose disposal and macrophage activity

Erez Dror

38

A novel Tsc2-mTORC1-CDK4 axis controls tissue homeostasis by regulating polarization, proliferation, and metabolism in macrophages

Monika Linke, Ha Pham, Thomas Schnöller, Karl Katholnig, Maria Schöller, Martin Hirtl, Andrea Preitschopf, Mario Mikula, Markus Hengstschläger, Martin Susani and Thomas Weichhart

39

Acetylation Control of MAT IIα in Human Hepatocellular Cancer

Qun-Ying Lei

40

Activation of macroautophagy following TCR engagement regulates T helper cell fate

Enric  Mocholi, Ross Gruber, Bridget Shafit-Zagardo and Fernando Macian

41

Analysis of urate transporters in hyperuricemia

Blanka Stiburkova, Pavel Simek, Pavel Cepek, Vladimir Krylov, Andrea Mancikova and Karel Pavelka

42

Antipsychotic Olanzapine treatment causes alteration in metabolic parameters and gut microbiota of male mice

Francine Mittestainer, Angélica Camacho, Kelly Calisto, Fernanda Pace, Dioze Guadagnini, Andrey Santos, Maria Carolina Mendes and Mario Saad

43

Calcium sensing receptor-mediated elevation in proinflammatory cytokine expression via increased autophagy in human LS14 preadipocytes

Pamela  Mattar, Cecilia Fuentes, Marcela  Reyes and Mariana Cifuentes

44

Deciphering the molecular mechanisms underlying NLRP3 inflammasome activation by saturated fatty acids

Marco Gianfrancesco, Katarzyna Bloch, Jonas  Dehairs, Laurent L'homme, Johan Swinnen, Jacques Piette, Nicolas Paquot, Nathalie Esser and Sylvie Legrand-Poels

45

Differential expression of autophagic genes in adipose tissue in short term of high fat diet

Carla Nunez, Rafaela Marineli, Joseane Morari, Guilherme Prado, Natália Ribeiro, Andressa Baseggio and Mario Maróstica

46

Distinct metabolic requirements for T helper 1 and 2 polarization by dendritic cells

Leonard Pelgrom, Alwin van der Ham, Leonie Hussaarts, Bruno Guigas, Maria Yazdanbakhsh and Bart Everts

47

Does leptin stimulate degranulation and respiratory burst in isolated human neutrophils?

Natalia Rebolledo, Mariana Cifuentes, Camila Corvalan, María Victoria Ramos, Marina Palermo and Marcela  Reyes

48

Enhanced T dependent IgA response in the small intestine results in impaired glucose metabolism by altered microbiota

Fabio Grassi

49

Evaluation of phosphorylation of Akt and content of glucose transporter protein GLUT4 in skeletal muscle of rats with periapical lesion

Doris Sumida, Fernando Chiba, Maria Mattera, Mariana Benites, Amanda Pereira, Thaís Tsosura, Natalia Scaramele and Renato Pereira

50

Expression and Function of Regulatory T Cells Subsets in Adipose Tissue from Overweight Subjects

Aleida Núñez-Ruiz , Juan Cortes-García, Nancy Cortez-Espinosa , Paola Herrera-Rojas , Víctor Ruíz-Rodríguez, Mariana Salgado-Bustamante, Mariana García-Hernández , Elizabeth Reynaga-Hernández and Diana Portales-Pérez

51

Glucose-dependent insulinotrophic polypeptide (GIP) reduces adipose tissue inflammation via enhanced lipid droplet protein expression

Fernanda Mantelmacher, Chen Varol, Sigal Fishman and Isabel Zvibel

52

Glucose-dependent insulinotropic peptide (GIP) plays a direct anti-inflammatory role in immune cells during diet-induced obesity

Fernanda mantelmacher, Chen Varol, Or Touval, Isabel Zvibel and Sigal Fishman

53

HDAC inhibition improves atherogenic macrophage function and affects cellular metabolism

Jan Van den Bossche, Annette Neele, Marten Hoeksema, Jeroen Baardman and Menno de Winther

54

High glucose induces donors-specific cytokine and TLR profiles in primary human M1 and M2 macrophages

Julia Kzhyshkowska Kzhyshkowska, Kondaiah Moganti, Michael Balduff, Harald Klüter, Alexei Gratchev and Martin Harmsen

55

Low-grade inflammatory status is inversely associated to the duration of obesity in a sample of young children.

Magel Costa, Camila Corvalan and Marcela Reyes

56

Mice fed a diet rich in omega-3 fatty acid have a higher frequency of phagocytosing neutrophils in circulation

Sara Svahn, Marcus Ulleryd, Louise Grahnemo, Staffan Nilsson, Jonh-Olov Jansson and Maria Johansson

57

Modulating Immunometabolism of Mouse and Human Tumor-Infiltrating Lymphocytes to Enhance T cell Based Therapy for Cancer

Madhusudhanan Sukumar, Jie Liu, Shashank Patel, Pawel Muranski and Toren Finkel

58

Myeloid-specific SOCS3 deletion induces insulin sensitivity and thermogenesis

Vasileia Ismini Alexaki, Kyoung-Jin Chung, Antonios Chatzigeorgiou, Ales Neuwirth, Christine Mund, Sylvia Grossklaus, Bradford Hamilton and Triantafyllos Chavakis

59

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization

Maxim Artyomov, Abhishek Jha, Stan (Ching-Cheng) Huang, Alexei Sergushichev, Yulia Ivanova, Vicky Lampropoulou, Karina Chmielewski, Kelly Marsh, Juliet Ashall, Edward Pearce, Edward Driggers, Ekaterina Loginicheva and Bart Everts

60

Neuroprotective effect of different types of Nanocurcumin on hydrogen peroxide-induced damage in SH-SY5Y

Monika Leśkiewicz, Magdalena Regulska, Danuta Jantas, Agnieszka Basta-Kaim, Bogusława Budziszewska and Władysław Lasoń

61

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

Felix Wensveen, Vedrana Jelenčić, Sonja Valentić, Marko Šestan, Tamara Turk Wensveen, Sebastian Theurich, Ariella Glasner, Davor Mendrila, Davor Štimac, Thomas Wunderlich, Jens Bruening, Ofer Mandelboim and Bojan Polić

62

Novel Insulin Degrading Enzyme Inhibitor Ameliorates insulin autoimmunity in Type I Diabetic Mouse Model

Dan Frenkel

63

Nucleic acid sensing receptors promote inflammation in obesity related insulin resistance

Xavier Revelo, Magar Ghazarian, Melissa  Chng, Helen Luck, Helena  Lei, Sue Tsai, Minna Woo, Edgar Engleman, Shawn Winer and Daniel Winer

64

Optimistic expectancies are associated with elevated production of interleukin-2 in rats

Marta Kubera, Katarzyna Curzytek, Rafał Ryguła, Jakub Kręgiel, Weronika Duda, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Barbara Korzeniak, Agnieszka Basta-Kaim, Bogusława Budziszewska and Władysław Lasoń

65

The amino acid sensor GCN2 drives a metabolic stress response inhibiting proinflammatory responses to apoptotic cells that promotes tolerance and suppresses systemic autoimmunity

Buvana Ravishankar, Haiyun Liu, Rahul Shinde, Marianne Kortzinsky and Tracy McGaha

66

The AMPK-interacting protein Fnip1 regulates peripheral B lymphocyte development and survival

Heon Park, Julita Ramirez, Mark Tsang, Terri Iwata, Daciana Margineantu, David Hockenbery and Brian Iritani

67

The effect of diet-induced hyperlipidemia on CD4+ T cell metabolism

Jacob Amersfoort, Jan van den Bossche, Hidde Douna, Frank Schaftenaar, Maxime Lagraauw, Daniël van der Velden, Ilze Bot, Gijs van Puijvelde and Johan Kuiper

68

The fate of oleic in human activated CD4+ T cells

Andreea Ioan-Facsinay, Anja de Jong, Marieke Heijink, Anna Hoekstra, Joanneke Kwekkeboom, Celia Berkers, Martin Giera, Bart Everts, Tom Huizinga, Margreet Kloppenburg and Rene Toes

69

The role of sortilin on adipose tissue immune cells in diet-induced obesity

Sigal Fishman, Chen Varol, Fernanda Mantelmacher, Or Touval and Isabel Zvibel

70

TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders

Chun-Pyo  Hong, Chang Ho Yun, You-Me  Kim and Myoung Ho  Jang

71

Treatment with α7nAChR agonist reduces atherosclerosis and modulates immune responses in ApoE-/- mice

Marcus Ulleryd, Li Jin Yang, Sara Svahn, Annica Andersson, Sansan Hua, Ulrika Islander, Erik Michaëlsson and Maria Johansson

72

Upregulation of nutrient transporters in the metabolic reprogramming of antiviral T cells

Laura Pallett, Anna Schurich, Linda Sinclair, Upkar Gill, Danyal Jajbhay, Sian Henson, Jessica Wijngaarden, Patrick Kennedy, Doreen Cantrell and Mala Maini