Wednesday, September 21

6:00 PM

Conference Registration

8:00 PM

Welcome Reception/Dinner

Thursday, September 22

7:30 AM

Breakfast

8:25 AM

Welcome and Opening Remarks

SESSION I

Chronic tissue Injury and repair

Chairs: Thomas Wynn and Stefan Wollin

8:30 AM

1

Myeloid cell regulation of adult lung alveologenesis post-pneumonectomy

Andrew Lechner and Jason Rock

8:55 AM

2

TBA

Paul Noble

9:20 AM

3

Immunoregulation of liver fibrosis: novel pathways

Sophie Lotersztajn

9:45 AM

4

Contribution of hepatic stellate cells to hepatic wound healing and carcinogenesis

Robert Schwabe

10:10 AM

5

Novel pharmacological approaches for the treatment of Non-Alcoholic Steatohepatitis (NASH)

James Trevaskis, Silvia Guionaud, Hani Jouihan, Michelle  Beaton, Peter Ravn, Sarah Will, Michael Feigh, Sanne Skovgaard Veidal, Matthew Coghlan, Joseph Grimsby, Anish Konkar, Cristina Rondinone, and Lutz Jermutus

10:35 AM

6

Type 2 immunity protects against obesity-induced metabolic disease but exacerbates NAFLD collaboratively with TGF-β1

Kevin Hart, Thomas Fabre, Richard Gieseck, Lee Borthwick, Kevin Vannella, Robert Thompson, Sandra White, Genevieve Soucy, Marc Bilodeau, Thirumalai Ramalingam, Naglaa Shoukry, and Thomas Wynn

10:50 AM

7

Anti-LOXL2 treatment paves the way for macrophage-mediated collagen degradation in liver fibrosis

Mordehay Klepfish, Milena Vugman, Chen Varol, and Irit Sagi

11:05 AM

Coffee Break/Poster Viewing

SESSION II

Focus on liver regeneration and fibrosis

Chairs: Ludovic Vallier and Lee A Borthwick

12:00 PM

8

Targeting rebound inflammation to improve anti-fibrotic therapy

Thiru Ramalingam, Richard (Trey) Gieseck, Tommy Acciani, Kevin Hart, Allen Cheever, Margaret Mentink-Kane, Kevin Vannella, and Thomas A Wynn

12:25 PM

9

Intravital imaging of liver regeneration and repair

Neil Henderson

12:50 PM

10

Epigenetic control of wound healing and tissue fibrosis

Derek Mann

1:15 PM

11

Hepatic stellate cells, hedgehog and hepatocyte reprogramming

Ana Mae Diehl

1:40 PM

12

Interleukin-13 drives distinct cellular pathways directing regeneration and fibrosis

Richard Gieseck, Thirumulai Ramalingam, Kevin Hart, Kevin Vannella, David Cantu, Wei-Yu Lu, Sofia Ferreira-Gonzalez, Stuart Forbes, Ludovic Vallier, and Thomas Wynn

1:55 PM

13

Sortilin deficiency attenuates ductular reaction and bile duct morphogenesis following cholestasis-induced liver injury

Einav Hubel, Elise Lavoie, Roy Avraham, Sigal Fishman, Jonathan Dranoff, Oren Shibolet, and Isabel Zvibel

2:10 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

Friday, September 23

7:30 AM

Breakfast

SESSION III

Progenitor cells and regeneration

Chairs: Neil Henderson and Paola Romagnani

8:30 AM

14

Human induced pluripotent stem cells to model inherited metabolic disorders

Ludovic Vallier

8:55 AM

15

Liver regeneration from hepatic progenitor cells

Stuart Forbes

9:20 AM

16

Generation of functional islets of langerhans from human exocrine pancreas

Kevin Docherty

9:45 AM

17

Dissecting the molecular and cellular mechanisms responsible for tissue repair in inflammatory bowel disease

Shiro Yui, Jordi  Guiu, Pawel Schweiger, and Kim Jensen

10:10 AM

18

Regeneration of the biliary tree using primary extra-hepatic cholangiocyte organoids

Fotios Sampaziotis, Richard Gieseck, Natalie Lie Berntsen, Miguel Cardoso de Brito, Steve Sawiak, María Gómez-Vázquez, Olivia Tysoe, Daniel Ortmann, Alessandro Bertero, Johannes Bargehr, Mariëlle  Zonneveld, Loukia Yiangou, Negar Pirmadjid, Marianne   Pedersen, Matthias  Pawlowski, Nikitas Georgakopoulos, Edmund  Godfrey, Sara Upponi, Casey  Rimland, Ingrid  Simonic, Susan Davies, Kim Jensen, William Gelson, Sanjay Sinha, Graeme Alexander, Nicholas Hannan, Espen Melum, Tom Wynn, Kourosh Saeb-Parsy, and Ludovic Vallier

10:25 AM

19

Type I, III collagen and elastin remodeling is elevated in the precision-cut lung slice model of IPF and can be restored back to vehicle levels using a PDE inhibitor

Niels Hansen, Morten Karsdal, Sarah Brockbank, Simon Cruwys, Alan Young, Puneeta Nath, and Diana Leeming

10:40 AM

Coffee Break/Poster Viewing

SESSION IV

Myofibroblasts and Biomarkers

Chairs: Joseph Arron and Bryan Fuchs

11:40 AM

20

Biomarkers of fibrosis progression; a route to shorter and smaller clinical trials

Toby Maher

12:00 PM

21

Novel biomarkers and mechanisms of lung fibrosis

Oliver Eickelberg

12:25 PM

22

Periplakin: a target for autoimmunity in lung fibrosis

Bruno Crestani

12:50 PM

23

Myofibroblast mechanical memory

Boris Hinz

1:15 PM

24

Alveolar regulation of TGFβ activation

Gisli Jenkins

1:40 PM

25

Redox regulation of cardiomyocyte renewal

Hesham Sadek

2:05 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

Saturday, September 24

7:30 AM

Breakfast

SESSION V

Therapeutic strategies

Chairs: Stuart Forbes and Paul Noble

8:30 AM

26

Fingerprints of Fibrosis: Tracing pathogenic mechanisms in human tissue

Carmel Nanthakumar, Adam Taylor, Lindsay Edwards, Susan Boyce, Richard Marshall, Andrew Fisher, Toby Maher, Gino Miele, Hannah Woodcock, Rachel Chambers, and Andy Blanchard

8:55 AM

27

Biomarker-Guided Therapeutic Strategies in IPF

Joseph Arron

9:20 AM

28

Anti-inflammatory, anti-angiogenic, anti-fibrotic! The mode of action of nintedanib in fibrosing interstitial lung diseases.

Lutz Wollin, Elizabeth Redente, David Riches, Joerg Distler, and Cara Williams

9:45 AM

29

Molecular pathways in kidney fibrosis

Carol Moreno Quinn

10:10 AM

30

TBA

Lynne Murray

10:35 AM

Coffee Break/Poster Viewing

SESSION VI

Immune mechanisms of repair and fibrosis

Chairs: Sophie Lotersztajn and Jason Rock

11:30 AM

31

Myeloid cells in regeneration and fibrosis: dynamics, regulation and function

Sabine Eming

11:55 AM

32

Translating scleroderma: pathogenic mechanisms and recent clinical trials

Christopher Denton

12:20 PM

33

Purinergic Signaling in Fibrosis

Bruce Cronstein and Gibran Sheikh

12:45 PM

34

From vasculopathy to immune activation and fibrosis - A Fli1 Odyssey

Maria Trojanowska

1:10 PM

35

A retinoic acid dependent stroma-leukemia crosstalk promotes tissue remodeling and chronic lymphocytic leukemia progression

Andrea Brendolan

1:35 PM

Lunch and Informal Discussions

3:30 PM

City Tour

7:30 PM

Dinner and Informal Discussions

Sunday, September 25

7:30 AM

Breakfast

SESSION VII

Fibrosis and regeneration across organ systems I

Chairs: Lynne Murray and Sabine Eming

8:30 AM

36

Molecular magnetic resonance imaging of fibrosis in animal models

Bryan Fuchs, Christian  Farrar, Philip  Waghorn, Lan Wei, Pauline Desogere, Bo Zhu, Michael  Lanuti, Kenneth Tanabe, and Peter Caravan

8:55 AM

37

The renal progenitor system in kidney homeostasis, injury and regeneration

Paola Romagnani

9:20 AM

38

Causes and effects of fibrosis in chronic muscle damage

Marcela Low, Christine Eisner, Farshad Babaijhandagi, and Fabio Rossi

9:45 AM

39

Autotaxin distorts lipid homeostasis promoting and interconnecting fibrosis and cancer

Vassilis Aidinis

10:10 AM

40

A Recombinant Antibody to Siglec-8 Inhibits Lung and Skin Fibrosis

Rustom Falahati, Bradford Youngblood, John Leung, Alejandro Dorenbaum, Leonard Shultz, Dale Greiner, Michael Brehm, Christopher Bebbington, and Nenad  Tomasevic

10:25 AM

41

c-Rel is a master regulator of innate immunity and multi-organ fibrosis.

Jack Leslie, Saimir Luli, Julie Worrell, Jonathan Scott, John Simpson, Neil Sheerin, Lee Borthwick, Derek Mann, and Fiona Oakley

10:40 AM

42

The role of p21 activated kinase 1 (PAK1) in liver fibrosis

Aoibheann Mullan, James Pritchett, Katherine Martin, Jessica Llewellyn, Varinder Athwal, Neil Hanley, and Karen Piper Hanley

10:55 AM

Coffee Break/Poster Viewing

SESSION VIII

Fibrosis and regeneration across organ systems II

Chairs: Derek Mann and Carol Moreno Quinn

12:00 PM

43

Immune Surveillance, Wound Repair and Fibrosis of the Salivary Gland

Maria Kukuruzinska

12:25 PM

44

Muscle stem cell regenerative decline in aging

Laura García-Prat, Marta  Martinez-Vicente, Marta Flandez, Sonia Alonso-Martín, Javier Rodríguez-Ubreva, Esteban  Ballestar, Antonio Serrano, Marco Sandri, and Pura Muñoz-Cánoves

12:50 PM

45

Building Better Bone: Biologic and Engineering Strategies for Managing Traumatic Bone Loss

Robert Guldberg, Albert Cheng, Nick Willett, Mara Schenker, and Laxminarayanan Krishnan

1:15 PM

46

Organ specific roles for FPR-1 in fibrosis

Benjamin Millar, Jack Leslie, Alan Carruthers, John Ferguson, Matthew Sleeman, Saimir Luli, Rachel Howarth, Chris Fox, Lynne Murray, Donna Finch, Derek Mann, Andrew  Fisher, and Lee A Borthwick

1:40 PM

47

Yes Associated Protein 1 (YAP1) and Integrin α 11 β1 promote organ fibrosis

James Pritchett, Katherine Martin, Jessica Llewellyn, Aoibheann Mullan, Emma Harvey, Sayyid Raza, Varinder Athwal, Neil Hanley, and Karen Piper Hanley

1:55 PM

48

Rhamm deficiency impairs normal liver wound healing after acute hepatotoxin exposure

Michele Pritchard and Jennifer McCracken

2:10 PM

Closing Remarks

2:15 PM

Lunch and Informal Discussions

8:00 PM

Farewell Dinner

Monday, September 26

7:30 AM

Breakfast

10:30 AM

Departure