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Monday, September 20 |
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7:00 PM |
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Conference Registration |
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8:00 PM |
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Welcome Reception and Dinner |
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Tuesday, September 21 |
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8:00 AM |
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Breakfast |
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9:00 AM |
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Welcome and Opening Remarks |
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Keynote Lecture Chair: Costas Koumenis |
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9:10 AM |
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Optical and Optoacoustic imaging: the revolution of label free observations. Vasilis Ntziachristos |
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SESSION I |
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Tumor Stroma Chair: Andrew Thorburn |
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10:00 AM |
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Implications of spatiotemporal heterogeneity of stromal cells and matrix remodeling for pancreatic cancer progression and therapy Ellen Puré |
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10:30 AM |
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Regulation of a pre-metastatic niche in the lung by endothelial cells Sandra Ryeom |
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11:00 AM |
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ATF4 regulates fibroblast activation, angiogenesis and metastasis Costas Koumenis and Ioannis Verginadis |
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11:30 AM |
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Coffee Break and Poster Viewing |
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SESSION II |
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TME-Immune System & Inflammation Chair: Ioanna Papandreou |
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12:15 PM |
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Enhancer Reprogramming Links TNFα-producing Macrophages Surveillance and Subtype Identity in Pancreatic Cancer Shiv Singh, Mengyu Tu, Lukas Klein, Elisa Espinet, Theodoros Georgomanolis, Florian Wegwitz, Xiaojuan Li, Uday Kishore, Philipp Ströbel, Elisabeth Hessmann, Stephan Hahn, Andreas Trumpp, Argyris Papantonis, Volker Ellenrieder, and Shiv Singh |
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12:45 PM |
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Reprogram the vascular microenvironment for solid tumor immunotherapy Yi Fan |
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1:15 PM |
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Blockade of p38 kinase impedes the mobilization of myeloid populations that promote breast cancer metastasis Justin Zonneville, Priyanka Rajan, Scott Abrams, and Andrei Bakin |
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1:45 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Wednesday, September 22 |
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7:30 AM |
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Breakfast |
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SESSION III |
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Tumor Hypoxia I Chair: Amit Maity |
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8:30 AM |
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Studying Novel VHL Regulatory Signaling Pathways in Kidney Cancer Qing Zhang |
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9:00 AM |
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The Multiple Facets of LincNORS: From O2 Sensing in Cancer Cells to Human Phenotypes Mircea Ivan |
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9:30 AM |
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Metabolic targeting in lung cancer: What did we learn from pre-clinical and clinical metformin trials, what is next? Theos Tsakiridis |
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Keynote Lecture Chair: Sandra Ryeom |
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10:00 AM |
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A telomere-to-mitochondria axis regulates inflammation in replicative crisis Joe Nassour, Lucia Gutierrez, Tobias Scvhmidt, Adriana Correia, Gerald Shadel, and Jan Karlseder |
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10:50 AM |
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Coffee Break and Poster Viewing |
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SESSION IV |
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Tumor Hypoxia II Chair: Crystal Conn |
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11:45 AM |
12 |
Targeting Clear Cell Ovarian Cancer by targeting Glutaminase-1 Othon Illiopoulos |
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12:15 PM |
13 |
Reciprocal regulation of HIF-1α by two kinases, ERK1/2 and CK1δ, creates a gradient of HIF-1α subcellular distribution and transcriptional activity Christina Arseni, Kreon Koukoulas, George Simos, and Ilias Mylonis |
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12:30 PM |
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Hypoxia-induced FAM13A modulates growth, metastatic potential and actin cytoskeleton organization of lung cancer cells Iwona Ziółkowska-Suchanek, Marta Podralska, Magdalena Żurawek, Katarzyna Iżykowska, Agnieszka Dzikiewicz-Krawczyk, and Natalia Rozwadowska |
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12:45 PM |
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Hypoxia-induced alternative splicing of the VEGFA transcript is mediated by ROS-driven and HIF-independent subcellular re-distribution of SAFB1/2 and SRPK1 Chrysa Taze, Sotiria Drakouli, George Simos, Eleni Georgatsou, and Ilias Mylonis |
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1:00 PM |
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The metabolic enzyme pyruvate dehydrogenase phosphatase 1 (PDP1) is a positive regulator of HIF activity during the hypoxic response. Angeliki Karagiota, Amalia Kanoura, George Simos, Efrosyni Paraskeva, and Georgia Chachami |
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1:30 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Thursday, September 23 |
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7:30 AM |
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Breakfast |
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SESSION V |
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Radiation, normal tissue damage and fibrosis Chair: Ioanna Papandreou |
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9:00 AM |
17 |
Normal tissues responses of the adult and juvenile mouse brain to FLASH-Radiotherapy Charles Limoli, Yasaman Alaghband, Barrett Allen, Benoit Petit, Pierre Montay-Gruel, and Marie-Catherine Vozenin |
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9:30 AM |
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FLASH proton radiotherapy reduces toxicities in skin, muscle and bone tissues while maintaining an equipotent efficacy against sarcoma as compared to standard proton radiotherapy Anastasia Velalopoulou, Ilias Karagounis, Gwendolyn Cramer, Michele Kim, Giorgos Skoufos , Denisa Goia, Sarah Hagan, Ioannis Verginadis, Khayrullo Shoniyozov, Lutian Yao, Ling Qin, Artemis Hatzigeorgiou, Andy Minn, Mary Putt, Matthew Lanza, Charles-Antoine Assenmacher, Enrico Radaelli, Jennifer Huck, Eric Diffenderfer, Lei Dong, James Metz, Constantinos Koumenis, Keith Cengel, Theresa Busch, and Amit Maity |
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10:00 AM |
19 |
Strong dependence of repair pathway choice on the load of DSBs in the genome George Iliakis, Emil Mladenov, Aashish Soni, Veronika Mladenova, and Martin Stuschke |
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10:30 AM |
20 |
Effective metabolic targeting and suppression of hypoxia, survival and radio-resistance pathways in non-small cell lung cancer (NSCLC) by canagliflozin mediates tumor suppression alone and in combination with radiotherapy Olga-Demetra Biziotis, Evangelia Tsakiridis, Jianhan Wu, Amr Ali, Elham Ahmadi, Aruz Mesci, Tobias Berg, Gregory Steinberg, and Theodoros Tsakiridis |
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10:45 AM |
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Coffee Break and Poster Viewing |
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SESSION VI |
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GI and GU cancers Chair: Ellen Pure |
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11:30 AM |
21 |
Hemojuvelin protects against hepatocellular carcinoma by iron-dependent and independent mechanisms Kostas Pantopoulos |
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12:00 PM |
22 |
TBA Amato Giaccia |
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12:30 PM |
23 |
Notch signaling in therapy resistance in aggressive breast cancer Rumela Chakrabarti |
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1:00 PM |
24 |
V-set and immunoglobulin domain containing 1 – an enigmatic marker of hepatoid carcinomas of the stomach and gastric-type carcinoma of the liver Simona Gurzu, Raluca van Staden Stefan, Haruhiko Sugimura, and Ioan Jung |
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1:15 PM |
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De novo steroidogenesis in osteotropic tumor cells drives bone metastasis formation Peter Benko, Simon Nagy, Toru Hiraga, and David Gyori |
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1:30 PM |
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Lunch and Informal Discussions |
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3:30 PM |
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City Tour Depart from hotel lobby at 3:30 PM |
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8:00 PM |
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Dinner and Informal Discussions Please note that buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour |
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Friday, September 24 |
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7:30 AM |
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Breakfast |
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SESSION VII |
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ER stress, translational regulation in cancer Chair: Ravi Amaravadi |
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8:30 AM |
26 |
Crosstalk between Oncogenic Stress and ER stress in Cancer Xi Chen |
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9:00 AM |
27 |
Dual ribosome profiling uncovers metabolic limitations in distinct cellular populations of the tumor microenvironment Fabricio Loayza-Puch |
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9:30 AM |
28 |
A protein synthesis-dependent adaptive response shapes aggressive prostate cancer Crystal Conn |
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10:00 AM |
29 |
DIANA microRNA analysis suite: Towards identification of non-coding RNAs as cancer biomarkers Artemis Hatzigeorgiou |
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10:30 AM |
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Coffee Break and Poster Viewing |
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SESSION VIII |
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Autophagy & Metabolic Stress Chair: Yi Fan |
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11:15 AM |
30 |
Autophagy as a moving target in cancer. Andrew Thorburn |
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11:45 AM |
31 |
Lysosomal autophagy inhibition: mechanism and clinical translation updates Ravi Amaravadi, Monika Bhardwaj, Vaibhav Jain, Amanda Versace, Mary Ann Crissey , and Jennifer Lee |
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12:15 PM |
32 |
Oncogenic and microenvironmental control of lipid droplet dynamics supports malignant progression Ioanna Papandreou |
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12:45 PM |
33 |
Mitochondrial targeting with clinically used complex I inhibitors in prostate cancer. Metabolic regulation and anti-tumor efficacy in combination with radiotherapy Evangelia Tsakiridis, Lindsay Broadfield, Katarina Marcinko, Amr Ali, Elham Ahmadi, Olga-Dimitra Biziotis, Aruz Mesci, Tobias Berg, Gregory Steinberg, and Theodoros Tsakiridis |
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1:00 PM |
34 |
Rosemary Extract Inhibits Cell Survival and Proliferation and Activates Apoptosis in PC-3 and 22Rv1 Prostate Cancer Cells Deborah Termini, Filip Vlavcheski and Evangelia Tsiani |
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1:30 PM |
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Closing Remarks |
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1:35 PM |
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Lunch and Informal Discussions |
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8:00 PM |
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Farewell Dinner |
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Saturday, September 25 |
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8:00 AM |
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Breakfast |
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Departure |
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POSTERS |
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35 |
Single-Cell RNA Sequencing Unravels Heterogeneity of the Stromal Niche in Cutaneous Melanoma Heterogeneous Spheroids Jiri Novotny, Karolina Strnadova, Barbora Dvorankova, Sarka Kocourkova, Radek Jaksa, Pavel Dundr, Vaclav Paces, Karel Smetana, Jr., Michal Kolar, and Lukas Lacina |
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36 |
Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts Karolina Strnadová, Lucie Pfeiferová, Petr Přikryl, Barbora Dvořánková, Erik Vlčák, Jana Frýdlová, Martin Vokurka, Jiří Novotný, Jana Šáchová, Miluše Hradilová, Jan Brábek, Jana Šmigová, Daniel Rosel, Karel Smetana, Jr., Michal Kolář, and Lukáš Lacina |
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37 |
Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2 Jana Šáchová, Jiří Novotný, Michal Kolář, Miluše Hradilová, Martina Krausová, Hynek Strnad, Karel Smetana Jr., Jan Plzák, and Tomáš Vomastek |
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38 |
Interplay between hypoxia and sumoylation in transcriptional regulation: the role of TFAP2A Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, and Georgia Chachami |
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39 |
Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity and subsequent adaptation of cells to hypoxia by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism. Ioanna Maria Gkotinakou, Eleni Kechagia, Kalliopi Pazaitou-Panayiotou, Ilias Mylonis, Panagiotis Liakos, and Andreas Tsakalof |
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40 |
The Effect of Cannabis on Myeloid-derived Suppressor Cells Iris Wyrobnik, Hila Noval-Kotzer, and David Meiri |
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41 |
Significance of maspin expression in gastric carcinomas Ioan Jung, Raluca van Staden Stefan, and Simona Gurzu |
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42 |
Carnosic acid, a rosemary polyphenol, activates ERK and induces apoptosis in NSCLC cells Eric O'Neill and Evangelia Tsiani |
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43 |
Sustained inflammatory signaling through Stat1/Stat2/IRF9 is associated with amoeboid phenotype of melanoma cells Aneta Škarková, Anna-Marie Šůchová, Vladimír Čermák, Ladislav Merta, Daniel Rosel, and Jan Brabek |
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The Effect of Cannabis on Myeloid-derived Suppressor Cells Iris Wyrobnik, Hila Novak-Kotzer, and David Meiri |