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06:00 PM |
Conference Registration |
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08:00 PM |
Welcome Reception/Dinner |
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07:30 AM |
Breakfast |
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08:30 AM |
Welcome and Opening Remarks Shankar Subramaniam |
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Session I |
Chair: Joe Nadeau |
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08:45 AM |
1 |
Systems Biology of Stem Cells NG H |
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09:15 AM |
2 |
Adaptive Systems Biology of Mammalian Chromosome Rearrangements in Evolution Harris Lewin, Jaebum Kim, Jian Ma, Denis Larkin and Marta Farre |
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09:45 AM |
3 |
High altitude hypoxia adaptation may provide answers for sea level diseases Gabriel Haddad, Tsering Stobdan, Roy Ronen, Vineet Bafna, Pedro Cabrales and Dan Zhou |
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10:15 AM |
4 |
Systems Biology of Cellular Stress Sindhu Raghunandan, Srini Ramachandran, Eugene Ke, Ratnesh Lal, Shu Chien, John Shyy, Zhen Chen, Julie Li, Mark Wang, Traci Marin, Mano Maurya, Mano Maurya, Shakti Gupta and Shankar Subramaniam |
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10:45 AM |
5 |
Systems Medicine in Oncology: Signaling-networks dynamic modeling, a possible tool for a better prediction of the behavior of associations of inhibitors of different pathways in colorectal cancer Silvio Parodi, Nicoletta Castagnino, Lorenzo Tortolina, Massimo Maffei, Gabriele Zoppoli, Alessio Nencioni, Alberto Ballestrero and Franco Patrone Franco Patrone |
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11:10 AM |
Coffee Break & Poster Viewing |
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Session II |
Chair: Harris Lewin |
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12:00 PM |
6 |
A 'complement-ary' view on the human complement system in host defense, disease and therapy Daniel Ricklin and John Lambris |
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12:30 PM |
7 |
Molecular Identifier Clustering based Immune Repertoire Sequencing and Its Application in Studying Human Antibody Repertoire in Malaria Ning Jiang |
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01:00 PM |
8 |
RNA exosome regulation of noncoding transcripts and AID activity in the B cell genome Evangelos Pefanis, Jiguang Wang, Gerson Rothschild, Junghyun Lim, Raul Rabadan, Aris Economides and Uttiya Basu |
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01:30 PM |
9 |
Sensitive mapping of chromatin-altering polymorphisms reveals molecular drivers of autoimmune diseases Shyam Prabhakar |
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02:00 PM |
Lunch/Informal Discussions |
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07:30 PM |
Dinner/Informal Discussions at a local Greek Restaurant |
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07:30 AM |
Breakfast |
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Session III |
Chair: Christian Metallo |
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08:30 AM |
10 |
High throughput, functional genomics yields minimal sets of factors that can program cells into skeletal and cardiac muscle Alexandre Colas, Michael Yu, Matthew Tierney, Wesley McKeithan, Peter Andersen, Emily Berry, Sole Gatto, Thomas Cunningham, Sean Spiering, Florent Carrette, Trish Tran, Chun-Teng Huang, Jean-Francois Riou, Muriel Umbhauer, Giovanni Paternostro, Deepak Srivastava, Dimitrios Zisoulis, Gregg Duester, Alessandra Sacco and Mark Mercola |
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09:00 AM |
11 |
The Diversity and Complexity of Calcium Signaling in Cardiac Muscle Raimond Winslow |
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09:30 AM |
12 |
Engineered Cell-free Epicardium Activates Regeneration in the Adult Mammalian Heart Pilar Ruiz-Lozano |
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10:00 AM |
13 |
A computational infrastructure for multi-scale modelling Peter Hunter, David Nickerson, Alan Garny and Tommy Yu |
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10:30 AM |
14 |
Acetyl Co-A: a Metabolic Junction Linking Metabolism and Cell Identity in Pluripotent Cells Arieh Moussaieff, Eran Meshorer, Benedicte Herrmann, Daniel Aberdam and Yaakov Nahmias |
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11:00 AM |
Coffee Break & Poster Viewing |
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Session IV |
Chair: Peter Hunter |
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12:00 PM |
15 |
Flow modulation of endothelial function: a multi-level regulation by AMPK/SIRT1 Zhen Chen, John Shyy, Shankar Subramaniam and Shu Chien |
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12:30 PM |
16 |
The pathway of collagen secretion Vivek Malhotra |
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01:00 PM |
17 |
Historeceptomics signatures to represent pharmacologic perturbations of biological systems Sergey Shmelkov, Klara Felsovalyi, James Swetnam and Timothy Cardozo |
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01:30 PM |
18 |
Significant Alterations in Gene Expression Within the Wnt Pathway Contribute to the Natural Variation in Bone Mechanical Function Stephen Schlecht, Lauren Smith, Yueqin Yang, Erin Bigelow, Amber Cathey, Bonnie Nolan, Melissa Ramcharan, Eugene Manley Jr, Maureen Devlin, Joseph Nadeau and Karl Jepsen |
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02:00 PM |
Lunch/Informal Discussions |
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07:30 PM |
Dinner/Informal Discussions at a local Greek Restaurant |
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07:30 AM |
Breakfast |
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Session V |
Chair: Dina Petranovic |
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08:30 AM |
19 |
Probing cell metabolism using isotope tracers to understand disease mechanisms Christian Metallo |
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09:00 AM |
20 |
Studies of Metabolic Diseases and Cancer through Genome Scale Modeling of Human Metabolism Jens Nielsen |
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09:30 AM |
21 |
Re-wiring of mitochondrial metabolic pathways in response to genetic and environmental perturbations Daniel Tennant |
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10:00 AM |
22 |
Fatty acid metabolism in cancer cells: Are we looking at the right pathway? Daniel Weindl, Xiangyi Dong, Thekla Cordes and Karsten Hiller |
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10:30 AM |
23 |
Mechanistic modeling of metabolism and the Warburg effect in Hepatocellular carcinoma, using multi level -omics data and enzyme kinetics Avlant Nilsson, Adil Mardinoglu and Jens Nielsen |
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10:45 AM |
24 |
Temporal transcriptional response to insulin stimulation of myocytes: Impact of type 2 diabetes and obesity Leif Väremo, Camilla Scheele, Christa Broholm, Adil Mardinoglu, Intawat Nookaew, Mathias Uhlén, Bente Klarlund Pedersen and Jens Nielsen |
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11:00 AM |
Coffee Break & Poster Viewing |
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Session VI |
Chair: Aris Economides |
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11:30 AM |
25 |
Using iPSCs to identify brain specific developmental gene regulatory pathways Merril Gersten, Graham Cocks, Akshay Bhinge, Lawrence Stanton, Shankar Subramaniam and Noel Buckley |
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12:00 PM |
26 |
Identification of Therapeutic Targets for Glioblastoma by Transcriptional Network Analysis Vipul Bhargava |
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12:30 PM |
27 |
In search of a common pathway for folic acid-responsive neural tube defects, neurodegeneration and cancer. Patrick Stover, Martha Field, Elena Kamynina and Ashley Palmer |
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01:00 PM |
28 |
Role of Mutant Ubiquitin (UBB+1) in the yeast model of Alzheimer’s disease Xin Chen, Ana Joyce Munoz, Andrea Molt and Dina Petranovic |
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01:30 PM |
Lunch/Informal Discussions |
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03:00 PM |
City Tour (depart from the hotel lobby at 3:00PM) |
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07:30 PM |
Dinner/Informal Discussions at a local Greek Restaurant |
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07:30 AM |
Breakfast |
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Session VII |
Chair: Gabriel Haddad |
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08:30 AM |
29 |
Quantifying acetate metabolism in hypoxic cancer cells Vinay Bulusu, Sergey Tumanov and Jurre Kamphorst |
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09:00 AM |
30 |
Integrating Genomic Layers to Understand Phenotypic Variation across Populations Philip Awadalla |
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09:30 AM |
31 |
Unraveling CRISPR-Cas9 genome engineering parameters in mammalian cells via a library-on-library approach Prashant Mali |
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10:00 AM |
32 |
Mendel 2.0: Revisiting genome organization and evolution, with epistasis, epigenetics and systems properties Joseph Nadeau |
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10:30 AM |
33 |
Research and Resource opportunities at the Heart, Lung and Blood Institute Pankaj Qasba |
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11:00 AM |
34 |
Gene correlation networks for the study of the hematopoietic stem cell niches Charles Durand and Pierre Charbord |
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11:15 AM |
Coffee Break & Poster Viewing |
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Session VIII |
Chair: Shankar Subramaniam |
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12:00 PM |
35 |
Enantiostasis rewiring of cellular networks & depigmenting disorder Vitiligo Rajesh Gokhale |
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12:30 PM |
36 |
Rapid, broad-based sequence profiling with digital PCR, High Resolution Melt, and Machine Learning Stephanie Fraley |
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01:00 PM |
37 |
Integrating multi-omic data analytics and health coaching to optimize wellness and minimize disease Nathan Price |
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01:30 PM |
38 |
Computational framework for elucidating the 3D spatial organization of chromatin from Hi-C experiments Gaurav Arya |
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02:00 PM |
Closing Remarks |
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02:15 PM |
Lunch/Informal Discussions |
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08:00 PM |
Farewell Dinner |
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07:30 AM |
Breakfast |
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09:30 AM |
Departure |
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POSTER SESSION Chair: Meghana Hemphill |
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39 |
A network-based scoring function for predicting protein complex structures Edward Shih and Ming-Jing Hwang |
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40 |
Archetypal signatures of biological activities Sergei Makarov, Alexander Medvedeva, Lioubov Medvedeva, Matt Moeser, Elena Martsen, Alexander Granick and Ming Zeng |
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41 |
Border-based quantification of molecule distribution in cell volume Mikhail Paveliev, Agne Velthut-Meikas, Marko Crivaro, Mart Saarma and Heikki Rauvala |
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42 |
Calcium signaling pathway contributes to hypoxia adaptation in Tibetans Changqing Zeng, Tianzi Liu and Basangzhuoma Basangzhuoma |
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43 |
Cancer mutations converge in the selection of deregulated arachidonate and xenobiotics metabolism Francesco Gatto, Almut Schulze and Jens Nielsen |
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44 |
Dysregulated signaling hubs of lipid metabolism unravel mechanism underlying hepatocellular carcinoma Sunjae Lee, Adil Mardinoglu, and Jens Nielsen |
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45 |
Exploring regulatory networks and interactions of the miR-96 cluster in the inner ear Morag Lewis, Annalisa Buniello, Jennifer Hilton, Stijn van Dongen, Anton Enright and Karen Steel |
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46 |
FastGeneSL based on Logical Transformation of Genome-scale Model for Rapid Identification of Oncogenes as Targets for Cancer Treatment Cheng Zhang, Boyang Ji, Adil Mardinoglu, Jens Nielsen and Qiang Hua |
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47 |
HCSD: the human cancer secretome database Amir Feizi and Jens Nielsen |
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48 |
Highly parallel intracellular inhibition of protein-protein interaction networks identifies novel cancer drug leads Philip Kim |
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49 |
Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling Pouyan Ghaffari, Adil Mardinoglu and Jens Nielsen |
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50 |
MalaCards - essential biomedical research tool Noa Rappaport, Michal Twik, Noam Nativ, Ella Buzhor, Tsippi Iny Stein, Iris Bahir, Marilyn Safran and Doron Lancet |
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51 |
Quantitative analysis of CXCR3-ligand mediated cell-cell communication Sarah Schrier, Abby Hill and Douglas Lauffenburger |
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52 |
Reconciling proteomic data into genome scale models Benjamin Sanchez and Jens Nielsen |
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53 |
The Landscape of Metabolic Interactions in Human Gut Ecosystem Boyang Ji and Jens Nielsen |
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54 |
Towards a Multi-scale Systems Biology Model of the Developing Heart. Nazanin Ebrahimi, Gib Bogle, Christopher Bradley, Michael Cooling and Peter Hunter |