Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions

Program

GENERAL INFORMATION

 

Accommodations

Accommodations for the conference are at the Minoa Palace Hotel.  The hotel is located in Platanias, 24 km from Chania International Airport and 12 km west of Chania town center.

 

Arrival and Check-in

It is expected that attendees will arrive/check-in on Saturday after 2:00 PM. Anyone arriving after 10:30 pm on Sunday must make alternative dinner arrangements.

 

Conference Venue

The Minoa Palace Conference Center is located at the hotel. 

 

Handicapped Accessibility

The site is fully handicapped accessible.

 

Oral Presentations

Speakers are asked to bring their USB flash drive to the reception desk at least 30 minutes prior to the session.  The allocated time for all presentations, unless otherwise indicated, includes five minutes Q&A.

 

City Tour

Buses for the city tour will depart from the hotel front lobby on Tuesday, September 30 at 3:00 pm. Badges are required for participation.

 
Breakfast

Breakfast for registered participants and registered accompanying persons will be served at the Minoa Palace Hotel main restaurant during the hours scheduled in this program.

 

Lunches/Informal Discussions

Lunches for registered participants and registered accompanying persons will be served during the times indicated in this program at the main restaurant. Badges are required for admission.

 

Dinners/Informal Discussions

Three of the dinners/informal discussion will be served during the times indicated in the program. Vegetarian entrees are available only upon request in advance of the meeting.  Please contact info@aegeanconferences.org.

 

Internet, Phone, & Computer

Wireless Internet access is located throughout the conference center free of charge during meeting hours. There are computers available in the hotel’s business center for the use of the attendees. Phone service is available for an additional charge from your hotel room.

 

Certificate of Participation

A Certificate of Participation will be distributed to a participant for those sessions that the participant has attended. A participant must attend an entire session to receive credit for that particular session. Late arrivals and early departures from a session will preclude a participant from receiving credit for that session.

 

Other Information

Animals are not permitted on site.

Badges are required for admission to all events.

All Aegean Conferences events are non-smoking.

 

No Photographs and Recording Devices

Participants are not allowed to photograph and/or record using cameras, mobile telephones and other recording devices during the slide and poster presentations.

 

 

 

 

Saturday, September 27

 

 

 

 

 

6:00-8:00 PM

Conference Registration at the Hotel Lobby

 

 

 

 

 

8:00 PM

 

Welcome Reception/Dinner

 

 

 

 

 

Sunday, September 28

 

 

 

 

 

8:00 AM

 

Breakfast

 

 

 

 

 

8:50 AM

 

Welcome / Opening Remarks

 

 

 

 

 

Session I

 

Thromboinflammation

 

 

 

Chairs: Diana Karpman and Gregory Stahl

 

9:00 AM

1

Therapeutic regulation of thromboinflammation induced by biosurfaces

 

 

 

Bo Nilsson

 

9:25 AM

2

Complement and kinin system interactions with blood cells, endothelial cells and microvesicles

 

 

 

Diana Karpman

 

9:50 AM

3

Role of complement on broken surfaces after trauma

 

 

 

Markus S Huber-Lang, S Denk, R Wiegner, S Weckbach, A Ignatius, and R Brenner

 

10:15 AM

4

Biomaterials and non-self: The complement system and beyond

 

 

 

Tom E Mollnes

 

10:40 AM

5

Bringing Mesenchymal stem cells into the clinic

 

 

 

Katarina Le Blanc

 

 

 

 

 

11:05 AM

 

Coffee Break & Poster Viewing

 

 

 

 

 

Session II

 

Host response to biomaterials

 

 

 

Chairs: Dianne Burgess and Peter Thomsen

 

11:50 AM

6

Biomaterial-associated inflammation and tissue regeneration: cell-cell communication and novel roles of exosomes and microvesicles

 

 

 

Peter Thomsen

 

12:15 PM

7

Foreign body reaction to implanted miomaterials: Disease models and inter-species differences

 

 

 

Diane Burgess, Michail Kastellorizios, Yan Wang, and Fotios Papadimitrakopoulos

 

12:40 PM

8

A novel biomarker for biocompatibility based on protein fingerprint from plasma to biomaterials in contact with human blood

 

 

 

Kristina Nilsson Ekdahl

 

1:05 PM

9

Unique macrophage polarization and NFkB activation following interaction with biomaterial surfaces

 

 

 

Laura Beth Moore, Andrew J Sawyer, Antonios Charokopos, Eleni A Skokos, and Themis R Kyriakides

 

1:30 PM

10

Tooth-associated biofilm and complement-mediated inflammatory responses in the periodontal tissue

 

 

 

Georgios Hajishengallis, Tomoki Maekawa, Toshiharu Abe, Evlambia Hajishengallis, Robert A DeAngelis, Daniel Ricklin, and John D Lambris

 

 

 

 

 

1:55 PM

 

Lunch / Informal Discussions

 

 

 

 

 

7:30 PM

 

Dinner / Informal Discussions at a local Greek Taverna

Buses depart from the hotel lobby at 7:30 PM

 

 

 

 

 

Monday, September 29

 

 

 

 

 

8:00 AM

 

Breakfast

 

 

 

 

 

Session III

 

Transplantation I

 

 

 

Chairs: Katarina LeBlanc and Ali Naji

 

9:00 AM

11

The many ways patents are used to add value

 

 

 

Janet E Reed

 

9:25 AM

12

Systemic inflammation and cardiovascular disease in renal failure

 

 

 

Bengt Fellström

 

9:50 AM

13

C5-blockade and complement monitoring for high-risk ABO-incompatible transplantations

 

 

 

Alireza Biglarnia, Erik Larsson, Kristina Nilsson-Ekdahl, and Bo Nilsson

 

10:15 AM

14

Islet transplantation and the prospect of achieving tolerance

 

 

 

Ali Naji, Malek Kamoun, Michael Rickels, and Chengyang  Liu

 

10:40 AM

15

Endothelial cell injury and complement activation

 

 

 

Gregory L Stahl

 

 

 

 

 

11:05 AM

 

Coffee Break & Poster Viewing

 

 

 

 

 

Session IV

Drugs, drug delivery systems and scaffolds

 

 

 

Chairs: Triantafillos Chavakis and Kristina N Ekdahl

 

11:50 AM

16

Cp40: a complement inhibitor getting ready for primetime

 

 

 

John D Lambris, Edimara S Reis, Alexandra Primikyri, Malvina Papanastasiou, Sophia Koutsogiannaki, Gang Chen, Markus Huber-Lang, Bo Nilsson, Alireza Biglarnia, Antonio M Risitano, George Hajishengallis, Despina Yancopoulou, Robert A DeAngelis, and Daniel Ricklin

 

12:15 PM

17

A novel bacterially inspired method for making biocompatible surfaces

 

 

 

Andrew P Herbert, Elisavet Makou, and Paul N Barlow

 

12:40 PM

18

SOBI002 - a novel complement component C5 inhibitor for efficient therapeutic targeting of the terminal complement pathway

 

 

 

Magnus M Berglund, Lotta Berghard, Per-Olof Edlund, Carina Ekholm, Jaan Hong, Susanne Lindblom, Lillemor Stenbeck Funke, Catharina Sterky, Chao Su, Charlotte Söderberg Nyhem, Kristina Nilsson Ekdahl, Bo Nilsson, and Patrik Strömberg

 

1:05 PM

19

Biopolymer mediated delivery of chemotherapeutic agents for cancer specific cytotoxicity without inducing haemotoxicity

 

 

 

Oommen P Oommen and Jöns Hilborn

 

1:20 PM

20

Nanoscale transport system for drug delivery based on amphiphilic polymers

 

 

 

Pavel Pavlovich Kulikov, Andrey Nikolaevich Kuskov, Mikhail Isaakovich Shtilman, and Aristidis Michael Tsatsakis

 

1:35 PM

21

Inflammatory and hemostatic activation induced by alginate microcapsules reveals novel mechanisms underlying their biocompatibility

 

 

 

Anne Mari Rokstad, Mathias P Ørning, Shamal Hamad, Kine Samseth Hoem, Bjørg Steinkjer, Hilde Fure, Liv Ryan, Igor Lacik, Tom Eirik Mollnes, Ole Lars Brekke, and Terje Espevik

 

1:50 PM

22

Bio-nano interface interactions between iron oxide MRI contrast agents and innate immune system

 

 

 

Nirmal K Banda, Gaurav Mehta, Ying Chao, Igor F Tsigelny, Guankui Wang, Swetha Inturi, Liliane Fossati-Jimack, Marina Botto, LinPing Wu, Seyed Moein Moghimi, and Dmitri Simberg

 

 

 

 

 

2:05 PM

 

Lunch / Informal Discussions

 

 

 

 

 

7:30 PM

 

Dinner / Informal Discussions at a local Greek Taverna

Buses depart from the hotel lobby at 7:30 PM

 

 

 

 

 

Tuesday, September 30

 

 

 

 

 

8:00 AM

 

Breakfast

 

 

 

 

 

Session V

 

Biomodulating surfaces I

 

 

Chairs: Hans Elwing and Duncan Sutherland

9:00 AM

23

The acute inflammatory responses in blood are attenuated by surface nanotopograpy

 

 

Hans Elwing

9:25 AM

24

Probing protein interactions at nanomaterials

 

 

Duncan Sutherland

9:50 AM

25

A trinity of importance: biosurfaces, the ultrastructure of complement proteins, and the nanoscience of complement activation

 

 

Thomas Vorup-Jensen

10:15 AM

26

Biomimetic materials through molecular imprinting: Fundamentals and applications

 

 

Ian A Nicholls

10:40 AM

27

Issues with protein delivery for bone regeneration

 

 

Jöns Hilborn, Oommen Varghese, Oommen P Oommen and Dmitri Ossipov

 

 

 

11:05 AM

 

Coffee Break & Poster Viewing

 

 

 

 

Session VI

Transplantation II

 

 

Chairs: Jeffrey L Platt and Bruno Reichart

11:35 AM

28

German Research Foundation, Transregio CRC 127 Xenogenic cell and organ transplantation – from the bench to the clinic

 

 

Bruno Reichart

12:00 PM

29

Inflammation and the fate of autogenous and grafted tissues

 

 

Jeffrey L Platt and Marilia Cascalho

12:25 PM

30

Preparation of immune-privileged site for all-islet transplantation by agarose-FGF2 complex

 

 

Nguyen Minh Luan and Hiroo Iwata

12:50 PM

31

Islet Xenotransplantation: are we ready for clinical islet xenotransplantation? Use of a subcutaneous monolayer cellular device containing pig islets to treat diabetic primates without Immunosupression

 

 

Pierre Gianello

1:15 PM

32

Controlling the response to allogeneic and xenogeneic surfaces in organ transplantation

 

 

Peter J Cowan and Bo Lu

1:40 PM

33

Inhibitors of leukocyte recruitment

 

 

Triantafyllos Chavakis, Ioannis Mitroulis, Rashim Pal Singh, Lan-Sun Chen, Eun Young Choi, Jong-Hyung Lim, Jindra Chmelar, Kyoung-Jin Chung, and George Hajishengallis

 

 

 

2:05 PM

 

Lunch / Informal Discussions

 

 

 

 

 

3:30 PM

 

Sightseeing and a guided walking tour in old town of Chania

Buses depart from the hotel lobby at 3:30 PM

 

 

 

 

 

7:30 PM

 

Dinner / Informal Discussions at a local Greek Taverna

Dinner to follow the tour. Buses do not return prior to dinner.

 

 

 

 

Wednesday, October 1

 

 

 

8:00 AM

 

Breakfast

 

 

 

 

 

Session VII

 

Extracorporeal circulation

 

 

Chairs: Peter Garred  and Daniel Ricklin

9:00 AM

34

Heparin coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule Ficolin-2 of the lectin complement pathway in vivo

 

 

Estrid Hein, Lea Munthe-Fog, Amrit Singh Thiara, Arnt E Fiane, Tom Eirik Mollnes, and Peter Garred

9:25 AM

35

Del-1 regulates the intravascular innate immune responses in islet xeno-transplantation

 

 

Ioannis Kourtzelis, Ioannis Mitroulis, Anaisa Ferreira, Anja Steffen, Barbara Ludwig, Claudia Waskow, and Triantafyllos Chavakis

9:40 AM

36

Role of complement in the inflammatory response to intravascular hemolysis

 

 

Per H Nilsson, Kari Otterdal, Stig Nymo, Margareta Nilsson, Pal Aukrust, and Tom Eirik Mollnes

9:55 AM

37

Calcium-containing particles induce cell toxicity and inflammation which can be reduced by the presence of citrate

 

 

Viktoria Hancock, Emma Lindeberg, and Gunilla Grundström

10:10 AM

38

A case for complement-targeted intervention in hemodialysis: Insight from in vitro studies and non-human primate models

 

 

Daniel Ricklin, Edimara S Reis, Robert A DeAngelis, Zhuoer Lin, Sophia Koutsogiannakis, Hui Chen, Ranillo RG Resuello, and John D Lambris

 

 

 

10:35 AM

 

Coffee Break & Poster Viewing

 

 

 

 

Session VIII

Biomodulating surfaces II

 

 

Chairs: George Hajishengallis and Jöns Hilborn

11:15 AM

39

Evaluation of vascular disease – a novel in vitro model for studying the interactions between human whole blood and endothelium

 

 

Peetra U Magnusson

11:40

40

Alternative pathway of complement activation on biomaterials; A role for Factor seven activating protease (FSAP)

 

 

Claudia Sperling, Sandip M Kanse, Simona Grasso, and Carsten Werner

12:05 PM

41

Cell surface engineering with biomaterials for islet transplantation

 

 

Yuji Teramura

12:30 PM

42

Protective role of PEG conjugated phospholipid in reducing ischemic reperfusion injury in an en bloc allogeneic pig kidney transplant model.

 

 

Sana Asif, Yuji Teramura, Kristina Nilsson Ekdahl, Bo Nilsson, and Alireza Biglarnia

12:45 PM

43

Improving a Factor H-binding peptide (5C6) for complement-targeted therapy

 

 

Sophia Koutsogiannaki, Zhuoer Lin, Christoph Q Schmidt, Kristina N Ekdahl, Bo Nilsson, Daniel Ricklin, and John D Lambris

1:00 PM

44

Development and application of mouse and pig complement immunoassays

 

 

Geurt Schilders, Aswin Jansen, and Jan van Binsbergen

1:15 PM

45

Modelling of a targeted nanotherapeutic "stroma" to deliver LIF, or XAV939, for use in primary human fetal dopaminergic grafts in Parkinson's disease

 

 

Su Metcalfe, Jing-Wei Zhao, Tarek M Fahmy, and Roger A Barker

 

 

 

 

1:30 PM

 

Closing Remarks

 

 

 

 

 

2:00 PM

 

Lunch / Informal Discussions

 

 

 

 

 

8:00 PM

 

Farewell Dinner

 

 

 

 

Thursday, October 2

 

 

 

8:00 AM

 

Breakfast

 

 

 

 

 

 

 

Departure

 

POSTERS

 

 

 

46

Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium

 

Ioannis Kourtzelis, Anaisa  Ferreira, Ioannis Mitroulis, John D Lambris, Claudia Waskow, and Triantafyllos Chavakis

47

Creation of an anti thrombogenic surface by incorporating heparin-binding peptides to Tri-block copolymers

 

Sana Asif, Karin Fromell, Kristina Nilsson Ekdahl, Yuji Teramura, and Bo Nilsson

48

Hemodialysis biomaterials induce complement-dependent formation of neutrophil extracellular traps

 

Ioannis Kourtzelis, Ioannis Mitroulis, Anaisa Ferreira, Konstantinos Kambas, John D Lambris, Konstantinos Ritis, and Triantafyllos Chavakis

49

Human mast cell response to nanosurfaces: balancing innate and adaptive immunity

 

Marianna Kulka

50

Material specific tissue responses: Adverse reaction to metallic debris beyond metal-on-metal hip replacement

 

Zhidao Xia, and Giorgio Perino

51

Prevention of thrombogenesis from whole human blood on hemoperfusion materials

 

Michael Thompson, Kiril Fedorov, Christophe Blaszykowski, and Sonia Sheikh

52

Seaweed myocardial regeleration: New biology of the alginate-myocardial microenvironment

 

Jay W Schneider

53

Surface modification of primary human hepatocytes with recombinant CD39 protects against thromboinflammation

 

Nina Jonsson, Asif Sana, Teramura Yuji, Kristina Ekdahl-Nilsson, Nilsson Bo, and Elisabet Gustafsson

54

The lectin complement pathway serine proteases (MASPs) represent a major crossroad between activation of the coagulation and complement systems in thromoinflammation.

 

Huda Kozarcanin, Kristina Nilsson-Ekdahl, Peetra Magnusson, and Bo Nilsson

55

Vascular repair utilizing immobilized heparin conjugate for protection against early activation of inflammation and coagulation

 

Sofia Nordling, Jaan Hong, Karin Fromell, Fredrik Edin, Johan Brännström, Rolf Larsson, Bo Nilsson, and Peetra U Magnusson

56

Validations of assays for the evaluation of C1q in inflammatory diseases and thromboinflammation

 

Kerstin Sandholm, Elisabeth Wijkström, Lillemor Skattum, Bo Nilsson, and Kristina N Ekdahl

57

Development of an in vitro test for innate immunity and blood compatibility of scaffolds and cell/scaffold constructs

 

Jaan Hong