5th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets

Preliminary Program

Friday, June 8

     

6:00 PM

 

Conference Registration

     

8:00 PM

 

Welcome Reception and Dinner

     

Saturday, June 9

     

7:30 AM

 

Breakfast

     

8:30 AM

 

Welcome & Opening Remarks

     

SESSION I

Tumor Immunology and Immunotherapy I

Chair: Costas Koumenis

     
   

Keynote Speaker

8:35 AM

1

Immunogenic therapies targeting specific organelles or molecules within cancer cells

Guido Kroemer

     

9:30 AM

2

Inactivation of the type I interferon responses in the tumor microenvironment engenders the immune privileged niche and desmoplasia

Serge Fuchs

9:55 AM

3

ΔNp63/CXCL2/CCL22-mediated recruitment of myeloid-derived suppressor cells promotes metastasis in triple negative breast cancer

Rumela Chakrabarti and Sushil Kumar

10:20 AM

4

Targeting Immune Evasion in Cancer to Improve Radiation Sensitivity

Todd Aguilera, Amato  Giaccia, Hussein  Shehade, Marjan  Rafat, Laura Castenelli, Lesley  Ellies, Edward  Graves, and Eslam Elghonaimy

     

10:30 AM

 

Coffee Break and Poster Viewing

     

SESSION II

Tumor Immunology and Immunotherapy II

Chair: Ravi Amaravadi

11:15 AM

5

Targeting the innate immune response in brain metastasis

Nicola Sibson

11:40 AM

6

Radiation as an immunomodulatory drug

Chandan Guha

12:05 PM

7

Using radiation to augment the effects of immunomodulatory agents

Amit Maity

12:30 PM

8

“Instituting Molecular Precision in Localised Prostate Cancer - Marrying the Tumor Micro-environment to Genomics”

Robert Bristow

     

SESSION III

Oncogenic stress, tumor metabolism and targeting metabolic vulnerabilities

Chair: Ester Hammond

12:55 PM

9

How and Why Ras and Myc cooperate

Gerard Evan, Trevor Littlewood, Nicole Sodir, Roderik Kortlever, Luca Pellegrinet, and Tania Campos

1:20 PM

10

MYC, lipid metabolism and calcium signaling in breast cancer

Zachary Schug

1:45 PM

11

Targeting the metabolic vulnerability of metastatic cancer

Jiangbin Ye

     

2:00 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

     

Sunday, June 10

     

7:30 AM

 

Breakfast

     

SESSION IV

Stress resistance & cancer: Targeting organelle-specific stress responses

Chair: Eric Chevet

     
   

Keynote Speaker

8:30 AM

12

Targeting LAP:  LC3-associated phagocytosis and anti-cancer immunity

Douglas Green

     

9:25 AM

13

Leveraging the mechanism of autophagy regulation of tumor cell apoptosis to improve cancer therapies

Andrew Thorburn

9:50 AM

14

RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells.

Zachary Schafer

10:15 AM

15

ER translocation of the entire MAPK pathway is required for ERK reactivation and  autophagy, driving therapy resistance in BRAF mutant cancers

Rani  Ojha , Nektaria  Leli , Angelique  Onorati , Ioannis  Verginadis, Shengfu  Piao , Feven  Tameire, Cynthia  Chude , Costas  Koumenis, and Ravi  Amaravadi

10:40 AM

16

Critical role of Beclin 2 in innate immune signaling and tumor development through non-canonical autophagy and metabolic pathways

Helen Yicheng Wang

     

10:50 AM

 

Coffee Break and Poster Viewing

     

SESSION V

Tumor stroma and impact on tumor response to treatment

Chair: J. Alan Diehl

11:35 AM

17

Exploiting the Biology of Tumor Stroma and Exosomes for Diagnosis and Treatment of Cancer

Raghu Kalluri

12:00 PM

18

Shifting Fibroblasts between Catabolism and Anabolism through Metabolic Regulation Governs Extracellular Matrix Homeostasis

Xiao Zhao, Laleh Soltan-Ghoraie, Pamela Psarianos, Kenneth Yip, David Goldstein, Ralph Gilbert, Ian Witterick, Hilary Pang, Ali Hussain, Ju Hee Lee, Justin Williams, Scott Bratman, Laurie Ailles, Benjamin Haibe-Kains, and Fei-Fei Liu

12:25 PM

19

Lung Endothelial Cells Promote Epithelial to Mesenchymal Transition

Sandra Ryeom

12:50 PM

20

Molecular imaging of an oncoprotein in tumor ECM for cancer detection and risk-stratification

Zheng-Rong  Lu

     

1:00 PM

 

Lunch and Informal Discussions

     

SESSION VI

Radiotherapy, the TME & metastasis

Chair: Albert Koong

3:00 PM

21

A novel small molecule inhibitor of MRCK prevents radiation driven invasion of glioblastoma cells and extends survival in an orthotopic xenograft model

Anthony Chalmers, Joanna Birch, Lesley Gilmour, Laura McDonald, Justin Bower, Heather McKinnon, Mari Sime, and Michael Olson

3:25 PM

22

Assessment of metastasis targeting agents in the laboratory and the clinic

Veronica Hughes and Dietmar Siemann

3:50 PM

23

Polyamine-mediated epigenetic gene regulation and radiation response in glioblastoma.

Scott Welford

     

7:30 PM

 

Dinner and Informal Discussions

     

Monday, June 11

     

7:30 AM

 

Breakfast

     

SESSION VII

The Unfolded Protein Response and Integrated Stress Response in cancer I

Chair: Andrew Thorburn

8:30 AM

24

Escape of endoplasmic reticulum chaperones to the cell surface: mechanisms and consequences

Amy Lee, Yuan-Li Tsai, Dat Ha, and Anthony Carlos

8:55 AM

25

Mapping the functional interplay between PERK and Sphingolipids

J. Alan Diehl and Dariusz Pytel

9:20 AM

26

The ISR effector ATF4 is a critical regulator of Myc-dependent translational program and tumorigenesis

Costas Koumenis

9:45 AM

27

Protein synthesis in cancer: when too much of a good thing is bad

Davide Rugerro

10:10 AM

28

PKR-dependent eIF2α serine 51 phosphorylation suppresses HER2-mediated  breast tumorigenesis and increases the potency of Trastuzumab therapy.

Cedric Darini, Shuo Wang, Catherine Chabot, Gloria Assaker, Jothilala Krishnamoorthy, Siham  Sabri, Giuseppina  Ursini-Siegel, Mark Basik, and Antonis Koromilas

10:35 AM

29

A critical role for the ISR effector ATF4 in the tumor stroma in primary and metastatic tumor growth

Ioannis Verginadis, Brett Bell, Sravya Koduri, Nektaria Maria Leli, Frank Chinga, and Constantinos Koumenis

     

10:45 AM

 

Coffee Break and Poster Viewing

     

SESSION VIII

The Unfolded Protein Response and Integrated Stress Response II

Chair: Serge Fuchs

11:30 AM

30

Complexity of IRE1 signaling in tumor development and therapeutic opportunities

Eric Chevet

11:55 AM

31

Targeting IRE1alpha/XBP1 for Promoting Immunogenic Cell Death in Triple-Negative Breast Cancer Treatment

Chih-Chien Chou, Dadi Jiang, Zhifen Yang, and Albert Koong

12:20 PM

32

Activation of a Major Arm of the UPR Proteotoxic Stress Response by Lipid Signaling

Arvin  Tam, Lindsay  Roberts, Daniel  Nomura, and Maho Niwa

12:45 PM

33

IRE1 as a potential therapeutic target in cancer

Afshin Samali

1:10 PM

34

Translational regulation of stem cell factors underpins the stress-induced plasticity of breast cancer cells

Lynne-Marie Postovit, Michael Jewer, Laura Lee, Scott  Findlay, Guihua Zhang, and Jiahui Liu

1:20 PM

35

Targeting IRE1alpha/XBP1 for Promoting Immunogenic Cell Death in Triple-Negative Breast Cancer Treatment

Chih-Chien Chou, Dadi Jiang, Zhifen Yang, and Albert Koong

     

1:30 PM

 

Lunch and Informal Discussions

     

3:30 PM

 

City Tour

     

7:30 PM

 

Dinner and Informal Discussions

Tuesday, June 12

     

7:30 AM

 

Breakfast

     

SESSION IX

Tumor hypoxia- Impact on tumor progression

Chair: Amit Maity

8:30 AM

36

Understanding and exploiting the hypoxia-induced DNA damage response

Ester Hammond

8:55 AM

37

Hypoxic Tumor Microenvironment, Tumor Cell Fate Regulation, and Therapy Response

Qun Lin, Hoon Kim, Peter Glazer, and Zhong Yun

9:20 AM

38

Metabolic adaptation of VHL-deficient and/or HIF-expressing cancer cells to glutamine deprivation.

Danos Christodoulou, Evmorfia Konstantakou, Junyoung Park, Tianjin Yi, Ravi Sundaram, Gregory Stephanopoulos, Lee Zou, and Othon Iliopoulos

9:45 AM

39

Microenvironmental inhibition of triglyceride hydrolysis supports tumor growth

Matthew  VandeKopple, Soumen Karmahapatra, Jinghai Wu, and Ioanna  Papandreou

10:10 AM

40

Hypoxia-mediated repression of the DDX5 RNA helicase - a crucial factor in DNA replication of cancer cells

Katarzyna Leszczynska and Ester Hammond

10:20 AM

41

Repurposing papaverine as a metabolic radiosensitizer

Nic Denko

     

SESSION X

Meet the experts

Chairs: Alexia-Ileana Zaromytidou

10:30 AM

42

NIH grant system and NCI Division of Cancer Biology

Konstantin Salnikow

11:00 AM

43

Reproducibility in basic and translational research

Alexia-Ileana Zaromytidou

     

11:30 AM

 

Coffee Break and Poster Viewing

     

SESSION XI

Clinical-Therapeutic implications

Chair: Fei-Fei Liu

12:15 PM

44

Proton Radiation in the setting of combined modality therapy

James Metz

12:40 PM

45

Hypoxia imaging: HX4 and Radiomics, the “rich” vs “poor” man approaches – Towards multifactorial predictive algorithms

Philippe Lambin, Sebastian Sanduleanu, Henry Woodruff, Ala Yaromina, Jan Theys, Ludwig Dubois, and Arthur Jochems

1:05 PM

46

Improving radiotherapy by targeting hypoxia: will it ever become routine clinical practice

Michael Horsman

1:30 PM

47

Discovery of the plasma membrane reductase responsible for the activation of the cell-excluded hypoxia-activated prodrug Tarloxotinib

Shevan Silva, Chris Guise, Matt Bull, Cris Print, Jeff Smaill, and Adam Patterson

     

1:40 PM

 

Closing Remarks

     

1:45 PM

 

Lunch and Informal Discussions

     

8:00 PM

 

Farewell Dinner

     

Wednesday, June 13

     

8:00 AM

 

Breakfast

     

10:00 AM

 

Departure

POSTERS

48

Improving treatment decisions in colon cancer. The tumor-stroma ratio (TSR) additional to the TNM classification

Wilma Mesker

49

TRIM44 promotes quiescent multiple myeloma cell occupancy and survival in the osteoblastic niche via HIF-1a stabilization

Nami McCarty

50

Identification of functionally distinct subtypes of cancer-associated fibroblasts in high grade serous ovarian cancer and their impact on survival

Ali Hussain, Veronique Voisin, Stephanie Poon, Jalna Meens, Gary Bader, Benjamin Neel, and Laurie Ailles

51

Identifying compensatory responses to autophagy inhibition in autophagy-dependent cancer cells

Christina Towers, Michael Morgan, and Andrew Thorburn

52

Synthetic lethal screens to identify treatments for CREB3L1-deficient breast cancers

Deborah Anderson, Paul Mellor, Shari Smith, Stephanie Kendall, and Dielle Whitecross

53

Novel roles of the endocytic protein Rab5 in hypoxia-dependent tumor cell migration, invasion and metastasis

Patricio Silva, Solange Rivas, Pablo Mendoza, Jorge Diaz, and Vicente Torres

54

MicroRNA-21 inhibitor potentiates anti-tumor effect of radiation therapy in vitro and in vivo

David Lee, Hans  Kim, Bong  Cho, Yeo Hyun  Hwang, and In Ah Kim

55

A Radiosensitivity Gene Signature and PD-L1 Status Predict Clinical Outcome of Patients with Glioblastoma

Bum Sup  Jang and In Ah Kim

56

Response to Stress by the Tumor Microenvrionment

Kerry  Roby, Bang-Jin Kim, Allyson Lieberman, Minhyeong Kim, Sandra Ryeom, Donita Brady, and Costas Koumenis

57

WSB1 regulation of DNA repair in the tumour microenvironment: a novel 'BRCAness' marker?

Merce Gomez-Merchan, Flore-Anne Poujade, Patrícia Grácio, and Isabel Pires

58

Radiosensitization capacities of a novel estradiol analogue assessed on a bone metastasis model

Jolene Helena

59

Cathepsin L and K inhibition by small molecule KGP94 suppresses pulmonary metastasis in murine osteosarcoma

Henrietta  Fasanya , Christine Pampo, Lori Rice , and Dietmar Siemann

60

Effects of Exercise on the Breast Tumor Microenvironment in hyperlipidemic Mice

Linda Buss, Margaret Currie, Abel Ang, and Gabi Dachs

61

Vitamin C administration in colorectal cancer patients: a clinical trial aimed at determining biological efficacy

Gabi Dachs, Jamish Gandhi, Helen Morrin, Christina Wohlrab, Simone Bayer, Anitra Carr, Timothy Eglinton, Bridget Robinson, and Margreet Vissers

62

CP-506, a next generation hypoxia-activated prodrug, as a promising novel anti-cancer therapeutic

Sofie Deschoemaeker, Sophie Thiolloy, Julie Gilissen, Ludwig Dubois, Ala Yaromina, Jan Theys, Amir Ashoorzadeh, Chris Guise, Maria Abbattista, Mathew Bull, Jeff Smaill, Adam Patterson, Philippe Lambin, and Arne Heyerick

63

Ovarian cancer cell lines grown in a three dimensional collagen model respond differentially to Lysophosphatidic acid and Tumour Necrosis Factor-alpha.

Alexandria Tino, Gabi Dachs, Peter Sykes, John Evans, and Kenny Chitcholtan

64

Divergent roles of fibroblasts on the radiation-response of cancer cells

Alizée Steer, Sara Sofia  Deville, Nils  Cordes, Verena  Jendrossek, and Diana Klein

65

PPT1 promotes tumor growth and is the molecular target of chloroquine-derivatives in cancer

Cynthia Chude, Vito Rebecca, Michael Nicastri, Colin Fennelly, Julie Barber-Rotenberg, Rani Ojha, Amruta Ronghe, Quentin McAfee, Noel McLaughlin, Gao Zhang, Shengfu Piao, Phyllis Gimotty, Meenhard Herlyn, Xiaowei Xiao, Ronen Marrmorstein, David Speicher, Jeffrey Winkler, and Ravi Amaravadi

66

Hypoxia tumour targeting with Tarloxotinib to improve clinical outcomes for patients with EGFR-dependent malignancies

Victoria Jackson-Patel, Kevin Hicks, Shevan Silva, Christopher Guise, Matthew Bull, Maria Abbattista, Amir Ashoorzadeh, Jeff Smaill, and Adam Patterson

67

Distinct immune status in patients with adenocarcinoma and squamous cell carcinoma: implication for immunotherapy of non-small cell lung cancer

Irena Adkins, Nada Hradilova, Ondrej Palata, Lenka  Sadilkova, Lenka Palova Jelinkova, Klara Danova, Dagmar Mysikova, Robert Lischke, and Radek Spisek

68

Inactivation of type I interferon signaling by tumor-derived factors promotes the generation of the pre-metastatic niche in the lungs

Jun  Gui, Farima Zahedi, and Serge Fuchs

69

Axl signaling under hypoxia persists in the absence of its ligand Gas6

Mai Tanakaand Dietmar Siemann

70

The role of cathepsin L in macrophage-driven breast cancer progression and dissemination

Samantha Dykes and Dietmar Siemann

71

Diet impacts mammary gland unfolded protein response signaling and mitochondrial metabolism to modulate breast tumorigenesis

David Soto-Pantoja, Adam  Wilson, and Katherine Cook

72

Design, discovery and preclinical antitumour activity of SN38080, a novel hypoxia-activated irreversible FGFR1-3 inhibitor

Jeff Smaill, Amir Ashoorzadeh, Xueqiang Li, Christopher Guise, Maria Abbattista, Angus Grey, Matthew Bull, Swarna Gamage, Maria Kaliukina, Yuliana Yosaatmadja, Rana Taghipouran, Huai-Ling Hsu, Woo-Kyong Paik, Jinfeng Luo, Shuang Jiang, Zheng-Chao Tu, Yong Xu, Robert Anderson, Xiaomei Ren, Christopher Squire, Ke Ding, and Adam Patterson

73

Ovarian cancer stem cells are maintained by fibroblastic niche and have constitutively active stress-response signaling.

TOSHIHIKO TORIGOE, YOSHIHIKO HIROHASHI, KAZUYO YASUDA, and TSUYOSHI SAITO

74

Innate immune signaling regulates microbiota, immune infiltrates and tumor development in a TAK1-deficient mouse model

Rongfu Wang

75

ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex.

Marina Stantic, Johanna  Wolfsberger, Habib  Sakil, and Margareta  Wilhelm

76

The role of Lcn-2 in determining the macrophage iron phenotype and its impact on cancer progression

Michaela Jung, Christina Mertens, Claudia Rehwald, Matthias  Schnetz, and Bernhard Brüne

77

Translational and HIF1alpha -dependent metabolic reprograming underpin oncometabolome plasticity.

Ivan Topisirovic

78

SCF/CD117 signaling axis drives prostate cancer aggressiveness and metastasis

Bethany Kerr, Lihong Shi, Koran Harris, Brittni Foster, Aleksander Skardal, and Mary Mobley

79

Deficiency of CD47 regulates metabolism and hypoxia in the tumor microenvironment

Katherine  Cook, Tiffany Newman, Adam Wilson, Yismeilin Feliz-Mosquea, Elizabeth Stirling , Lilya Yamaleyeva, and David Soto Soto-Pantoja

80

Angiotensin-(1-7) reduces pediatric sarcoma growth through regulation of tumor cell proliferation and angiogenesis

Patricia Gallagher and E. Ann Tallant

81

Prevention of Breast Tumor Growth by a Muscadine Grape Extract through Alteration of the Tumor Microenvironment

E. Ann Tallant and Patricia Gallagher

82

Prevention of Breast Tumor Growth by a Muscadine Grape Extract through Alteration of the Tumor Microenvironment

E. Ann Tallant and Patricia Gallagher

83

Hypoxia-mediated regulation of APOBEC expression

Sam Bader and Ester Hammond

84

Identifying novel regulators of UPR by utilizing genome-scale CRISPR-Cas9 knockout screens

Nektaria Maria Leli, Souvik Dey, Lauren  Brady, Ioannis Verginadis, Carlo Salas Salinas, and Constantinos Koumenis

85

The identification of a new subtype of myeloid cells in tumor microenvironment by lineage-tracing.

Oleg DEMIDOV, Bogdan Grigorash, Burhan Uyanik, Elena Kochetkova, Evgeniy Eruslanov, and Ettore Appella

86

Targeting IRE1alpha/XBP1 for Triple-Negative Breast Cancer Therapy

Dadi Jiang, Zhifen Yang, Chih-Chien Chou, Rakesh Bam, and Albert Koong

87

GAS6/AXL signaling mediates hypoxia-induced epithelial-mesenchymal transition and invasiveness in hepatocellular carcinoma

Anne Ernst

88

Molecular Analysis of Hemangioblastoma tumors of the Central Nervous System

Eumorphia Konstantakou, Ana Metelo, Nicholas Haradhvala, Atanas Kamburov, Jean-Valery Coumans, Frederick Barker, Brian Nahed, Anat Stemmer-Rachamimov, Gad  Getz, and Othon Iliopoulos

89

Stress signaling in breast cancer cells induces matrix components of stem cell niches that promote chemotherapy-resistant metastasis

Jacob Insua-Rodríguez, Maren  Pein, Tsunaki  Hongu, Jasmin  Meier, Arnaud  Descot, Camille Lowy, Etienne De Braekeleer, Hans-Peter  Sinn, Saskia  Spaich, Marc  Sütterlin, Andreas  Schneeweiss, and Thordur Oskarsson

90

TAp73 loss results in elevated levels of CCL2 and higher macrophage infiltration into the tumor microenvironment

Johanna Wolfsberger, Habib Sakil, Marina  Stantic, Margareta  Wilhelm, Tatjana  Wallmann, and Charlotte Rolny

91

Pyruvate dehydrogenase kinase 1 (PDHK1) and carbonic anhydrase IX (CAIX) regulation and targeting in hypoxic tumors

Martin Kery, Silvia Radenkovic, Nina Oravcova, Maria Bartosova, and Tereza Golias

92

Molecular basis of transient therapy resistance in colorectal cancer liver metastasis

Theodora Fifis, Linh Nguyen, George Kastrappis, and Christopher Christophi

93

Intra- and extracellular signalling pathways activated in cancer cells by microtubule disruptors structurally modified to bind preferentially to carbonic anhydrase IX

Anne  Mercier, Laurence Lafanechère, Michael Pepper, and Annie Joubert

94

The role of neuropilin-1 and VEGF isoforms and their potential as predictive biomarkers of response to vascular-targeted therapies

Ruth Thomas, Chryso  Kanthou, William English, and Gillian Tozer

95

Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation

Yongjoon Suh, Ki-Chun  Yoo, Mi-Young  Choi, and Su-Jae Lee

96

Inhibiting C5a-C5aR pathway to improve radiation response

Monica Olcina, Stavros Melemenidis, Ryan Kim, Edward Graves, and Amato Giaccia

97

Intercellular communication of tumour cells and macrophages drives tumour cell migration and immunosuppression

Annamaria Gal, Dammar Thapa, Thaneswari Karpanasamy, and Chelsea Street

98

Chloroquine or autophagy inhibition in endothelial cells distinctly reshape intercellular signaling in the tumor vasculature

Marco Schaaf, Diede Houbaert, Hannelore Maes, Odeta Mece, San Kit To, and Patrizia Agostinis

99

force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma

Jae-Hyeok  Kang, Eun-Jung  Lim, Yongjoon  Suh, Seungmo  Kim, and Su-Jae  Lee

100

Investigating the role of radiation in tumor cell recruitment to the lungs

Luis Soto, Stavros Melemenidis, and Edward Graves

101

Migrastatics—anti-metastatic and anti-invasion drugs: promises and challenges

Aneta Gandalovičová, Daniel Rosel, Michael Fernandes, Pavel Veselý, Victoria Sanz Moreno, and Jan Brábek

102

Quantitative phase imaging as a tool for analyzes of cancer cell invasion

Ondrej Tolde, Aneta Gandalovicova, Aneta Krizova, Pavel Vesely, Radim Chmelik, Jan Brabek, and Daniel Rosel

103

Foxn1 expression in keratinocytes is stimulated by hypoxia: further evidence of its role in skin wound healing

Anna Kur-Piotrowska, Joanna Bukowska, Marta Kopcewicz, Mariola Dietrich, Joanna Nynca, Mariola Slowinska, and Barbara Gawronska-Kozak

104

Cancer Invasion in Organ-Specific ExtraCellular Matrices

Ninna Rossen