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Wednesday, June 13 |
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6:00 PM |
Conference Registration |
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8:00 PM |
Welcome Reception and Dinner |
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Thursday, June 14 |
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7:30 AM |
Breakfast |
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8:25 AM |
Welcome & Opening Remarks |
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SESSION I |
Cell types, mechanisms, and therapeutic targets in lung repair and fibrosis Chair: Robert Martinez |
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8:30 AM |
1 |
Fibroblasts drive inflammation and monocyte recruitment in damaged tissue via an IL-1R1/JunD/CCL2 dependant signalling pathway Lauren Davison, Ben Barksby, Jack Leslie, Saimir Luli, Fiona Oakley, Andrew Fisher, Derek Mann, and Lee Borthwick |
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8:55 AM |
2 |
Understanding endotypes of progressive pulmonary fibrosis? Gisli Jenkins |
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9:20 AM |
3 |
The impact of aging on fibrosis Melanie Königshoff |
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9:45 AM |
4 |
CCN2-mediated activation of cancer-associated fibroblasts is required for metastasis and tumor neovascularization in a murine model of melanoma James Hutchenreuther, Krista Vincent, Chris Norley, David Holdsworth, Lynne-Marie Postovit, and Andrew Leask |
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10:10 AM |
Coffee Break and Poster Viewing |
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SESSION II |
Cell types, mechanisms, and therapeutic targets in lung repair and fibrosis Chair: Neil Henderson |
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11:10 AM |
5 |
Novel mechanisms driving rapid progression in IPF Cory Hogaboam |
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11:35 AM |
6 |
Targeting the ADAM10-sEphrin-B2 pathway in lung injury and fibrosis David Lagares |
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12:00 PM |
7 |
SREBP2 drives late-phase TNF-α inflammatory circuitry in macrophages and suppresses tissue repair program Anthony Kusnadi, Lionel Ivashkiv, Kyung-Hyun Park-Min, Sung-ho Park, Ruoxi Yuan, Tania Pannellini, Orla O'Shea, David Oliver, and Eugenia Giannopoulou |
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12:15 PM |
8 |
Clinically validated markers of the extracellular matrix remodelling are modulated by anti-fibrotic compounds in a human lung fibrosis ex vivo model Diana Julie Leeming, Jannie Sand, Christina Hesse, Sebastian Konzok, Katherina Sewald, Sarah Rønnow, Armin Braun, Morten Karsdal, Sarah Brockbank, and Simon Cruwys |
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12:30 PM |
9 |
Inhibition of autotaxin reduces the desmoplastic response and decreases growth of pancreatic adenocarcinoma Bryan Fuchs |
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12:55 PM |
10 |
understanding heterogeneity in IPF and its pre-clinical translation Andy Blanchard, Adam Taylor, Gisli Jenkins, and Morten Karsdal |
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1:20 PM |
11 |
Mechanistic insights from clinical trials in fibrotic disorders Joseph Arron |
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1:45 PM |
12 |
Pharmacological inhibition of ROCK protects vascular integrity and ameliorates experimental pulmonary fibrosis Masha Poyurovsky, Rigen Mo, Sarah Lucas, Rafael Depetris, Ji-In Kim, Kevin Liu, Ed Skucas, Xiao-Jiang Feng, Jack Gaffney, and Jeegar Patel |
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2:00 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Friday, June 15 |
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7:30 AM |
Breakfast |
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SESSION III |
Stem cells in Development, Repair, and Fibrosis Chair: Randy Levinson |
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8:30 AM |
13 |
Building and re-building the lung: insights from human lung development Dawei Sun, Kyungtae Lim, Quitz Jeng, Marko Nikolic, Oriol Caritg, Jo-Anne Johnson, and Emma Rawlins |
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8:55 AM |
14 |
Perivascular progenitors in fibrotic disease Rafael Kramann |
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9:20 AM |
15 |
Adult liver cholangiocytes, organoid cultures and tissue regeneration Meritxell Huch |
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9:45 AM |
16 |
Modelling non-alcoholic fatty liver disease using human pluripotent stem cells Ludovic Vallier |
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10:10 AM |
17 |
Lung stem cells and their dynamic niche during regeneration and repair Joo-Hyeon Lee |
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10:25 AM |
Coffee Break and Poster Viewing |
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SESSION IV |
Cell types, mechanisms, and therapeutic targets in liver regeneration and fibrosis Chair: Ludovic Vallier |
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11:10 AM |
18 |
Using single cell RNA sequencing to investigate mechanisms of liver fibrosis and repair\ Neil Henderson |
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11:35 AM |
19 |
Evaluation of inflammatory mechanisms in nonalcoholic steatohepatitis (NASH) Franklin Schlerman, Zhiyong Yang, Martin Dowty, Christopher Taylor, Gabriel Sholder, Nicole Bodycombe, Evanthia Pashos, Tom Wynn, and Robert Martinez |
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12:00 PM |
20 |
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis Marina Nati, Antonios Chatzigeorgiou, Lan-Sun Chen, Ales Neuwirth, Jochen Hampe, Oliver Soehnlein, Kyoung-Jin Chung, and Triantafyllos Chavakis |
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12:15 PM |
21 |
Regulation of tissue fibrosis by galectin-3 and evaluation of inhibitors as anti-fibrotic therapies Alison Mackinnon, Fredrick Zetterberg, Neil Henderson, Anders Pederson, Ulf Nilsson Nilsson, Hakon Leffler, and Hans Schambye |
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12:30 PM |
22 |
A high-throughput microfluidic organ-on-chip system for screening of therapeutics Joseph Charest |
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12:55 PM |
23 |
When liver regeneration fails: identifying cellular and molecular targets for therapy Stuart Forbes |
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1:20 PM |
24 |
Development of liver fibrosis in mice reflects a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction. Michelle Boland, Stephanie Oldham, Boland Brandon, Silvia Guionaud, Jean-Martin Lapointe, Sarah Will, Christopher Rhodes, and James Trevaskis |
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1:45 PM |
25 |
Non-invasive high resolution and global assessment of biological processes in progressive liver fibrosis Anja Schmidt-Christensen, Julia Nilsson, Michael Gottschalk, René ´T Zandt, Rajmund Mokso, and Dan Holmberg |
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2:00 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Saturday, June 16 |
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7:30 AM |
Breakfast |
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SESSION V |
Imaging the matrix Chair: Bryan Fuchs |
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8:30 AM |
26 |
Live imaging inflammation and its consequences in wound healing and cancer Paul Martin |
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8:55 AM |
27 |
Imaging lesion repair in multiple sclerosis Daniel Reich |
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9:20 AM |
28 |
Control of the matrisome in tissue repair and cancer Sabine Werner |
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9:45 AM |
29 |
Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring Dongsheng, Donovan, Simon, Anna, Juan, Pushkar, Darcy, Yuval Jiang, Correa Gallegos, Christ, Stefanska, Liu, Ramesh, Wagner, Rinkevich |
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10:00 AM |
Coffee Break and Poster Viewing |
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SESSION VI |
Mechanisms of organ specific fibrosis Chair: Lynne Murray |
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11:00 AM |
30 |
Control of immune cell phenotype: an antifibrogenic strategy Lotersztajn |
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11:25 AM |
31 |
Macrophages in skin repair and fibrosis Sabine Eming |
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11:50 AM |
32 |
Identification of an IL-6 dependent CD64+ lung macrophage population driving fibrosis. Emma Doran, Darren Ruane, Alexander Abbas, Patrick Caplazi, Claire Emson, and Joseph Arron |
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12:05 PM |
33 |
REVERBalpha modifies pulmonary fibrosis through inhibition of myofibroblast differentiation Alicja Nazgiewicz, Peter Cuningham, Peter Meijer, Monika Lodyga, Hannah Durrington, Paul Mercer, David Bechtold, Julie Gibbs, Andrew Loudon, Karen Piper Hanley, Boris Hinz, David Ray, and John Blaikley |
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12:20 PM |
34 |
Kidney repair: mechanisms and trade-offs Paola Romagnani |
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12:45 PM |
35 |
Innate immune signaling driving fibrosis: novel therapeutic targets John Varga |
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1:10 PM |
36 |
A novel mouse model that spontaneously develops chronic inflammation and fibrosis Julia Nilsson, Anja Schmidt-Christensen, Nina Fransén Pettersson, and Dan Holmberg |
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1:25 PM |
37 |
Lack of fibrotic response to wounding in the adult spiny mouse, Acomys, permits the regeneration of many tissue types Malcolm Maden, Yanfei Qui, Carl Pepine, Mohan Raizada, Ketan Patel, Robert Mitchell, Henry Hollin-Cooper, Aaron Sandoval, and Jason Brant |
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1:40 PM |
Lunch and Informal Discussions |
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3:30 PM |
City Tour |
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7:30 PM |
Dinner and Informal Discussions |
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Sunday, June 17 |
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7:30 AM |
Breakfast |
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SESSION VII |
Inflammation and epigenetics in organ regeneration and fibrosis Chair: Jason Rock |
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8:30 AM |
38 |
Understanding skeletal muscle regeneration and decline with aging Pura Muñoz-Cánoves |
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8:55 AM |
39 |
Causes and effects of interstitial fibrosis in skeletal muscle Marcela Low, Elena Groppa, Hesham Soliman, Chihkai Chang, and Fabio Rossi |
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9:20 AM |
40 |
Type 3 inflammation in liver fibrosis and hepatocellular carcinoma (HCC) Naglaa Shoukry |
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9:45 AM |
41 |
The role of endothelial cells in driving tissue fibrosis Maria Trojanowska |
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10:10 AM |
42 |
Mechanisms of tubulointerstitial injury and fibrosis driven by discrete inflammatory signals in human kidney organoids Dario Lemos |
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10:25 AM |
Coffee Break and Poster Viewing |
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SESSION VIII |
Inflammation and epigenetics in organ regeneration and fibrosis Chair: Tom Wynn |
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11:00 AM |
43 |
Significance of epigenetics in liver fibrosis Jelena Mann |
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11:25 AM |
44 |
Mesenchymal-immune cell crosstalk in lung fibrosis Oliver Eickelberg |
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11:50 AM |
45 |
Recruited monocytes and type 2 immunity promote adult lung regeneration Jason Rock |
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12:15 PM |
46 |
Injury and defective regeneration of the epithelial basement membrane in myofibroblast-mediated corneal fibrosis: A paradigm for fibrosis in other organs? Steven Wilson |
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12:30 PM |
47 |
The M problem in fibrosis: myofibroblasts, macrophages, matrix, and mechanics Boris Hinz |
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12:55 PM |
Closing Remarks |
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1:10 PM |
Lunch and Informal Discussions |
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8:00 PM |
Farewell Dinner |
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Monday, June 18 |
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8:00 AM |
Breakfast |
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10:00 AM |
Departure |
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POSTERS |
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48 |
Long term restoration of fecal continence in a large animal model using BioSphincters TM Khalil Bitar, Jaime Bohl, Riccardo Tamburrini, and Prabhash Dadhich |
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49 |
Osteoconductive microarchitecture realized by additive manufacturing Franz Weber |
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50 |
The NOX1/4 inhibitor GKT-137831 reduces alpha-SMA and CCN2 protein overexpression and collagen gel contraction in lesional scleroderma fibroblasts Andrew Leask, Hannah Murphy-Marshman, Xu Shiwen, Richard Stratton, and Katherine Quensel |
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51 |
Lysosomes and volumes of the inflamed lung Petra Jacobson, Hans Lennart Persson, and Linda Vainikka |
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52 |
Efficacy of a hybrid system of hyaluronic acid and collagen loaded with prednisolone and TGF-β3 for cartilage regeneration in rats Farhad Mohammadi, Nader Tanideh, Soliman Mohammadi Samani, and Fatemeh Ahmadi |
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53 |
A new highly selective 5-Hydroxytryptamine 2B (5-HT2B) Receptor Antagonist ameliorating Fibrosis in preclinical Models of Systemic Sclerosis Christina Wenglén, Lars Pettersson, Helena Arozenius, and Gunilla Ekstrom |
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54 |
Wilms Tumor 1 - a cytokine-inducible component of normal and fibrotic connective tissue repair David O'Gorman, John Luo, Emmy Sun, Trisiah Tugade, Ana Maria Pena Diaz, Bing Siang Gan, Ruby Grewal, and Nina Suh |
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55 |
TGF-beta1 alters the epigenetic signature of histone marks during myofibroblast differentiation Timothy Hewitson, Belinda Wigg, Stephen Holt, and Edward Smith |
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56 |
Epithelial-Mesenchymal Homeostasis in lung organoids Qi Tan, Giovanni Ligresti, Jeffrey Meridew, and Daniel Tschumperlin |
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57 |
the anti-fibrotic effects of CB2 receptor agonist, JWH 133 on lungs affected by nicotine. Ewelina Wawryk-Gawda, Katarzyna Chłapek, Marta Lis-Sochocka, Patrycja Chylińska-Wrzos , Michał Zarobkiewicz, Mirosław Sławiński, Beata Budzyńska, Anna Boguszewska-Czubara , and Barbara Jodłowska-Jędrych |
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58 |
Collagen type IV degradation predicts mortality in the ECLIPSE COPD cohort Sarah Rønnow, Lasse Langholm, Morten Karsdal, Ruth Tal-Singer, Bruce Miller, Jørgen Vestbo, Jannie Sand , and Diana Leeming |
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59 |
Characterizing nuclear translocation of beta-catenin in palmar fascia fibrosis David O'Gorman, Kevin Ho, Ana Maria Pena Diaz, Nina Suh, Ruby Grewal, and Bing Siang Gan |
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60 |
Leukemia inhibitory factor induces cholangiocyte proliferation and corrects the impaired bile duct morphogenesis in sortilin-deficient mice following cholestatic liver injury Einav Hubel, Roy Avraham, Elise Lavoie, Jonathan Dranoff, Oren Shibolet, and Isabel Zvibel |
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61 |
Development of multiple rodent models of non-alcoholic steatosis and steatohepatitis (NASH) – a profile of a rodent NASH-CRN score Samuel Daniels, Diana Leeming, Maria Bruun, Sönke Detlefsen, Sara Hjuler, Morten Karsdal, Peter Hein, Sarah Brockbank, and Simon Cruwys |
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62 |
Evaluation of the Scar-in-a-Jar as an in vitro screening tool for anti-fibrotic therapies, using markers reflecting ECM remodelling Sarah Rønnow, Sarah Brockbank, Simon Cruwys, Morten Karsdal, Diana Leeming, and Jannie Sand |
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63 |
The ratio between von Willebrand factor and platelet count is highly correlated to the severity of Non-alcoholic fatty liver disease (NAFLD) histological parameters and can identify patients with advanced fibrosis Samuel Daniels, Diana Leeming, Lasse Langholm, Morten Karsdal, and Leon Adams |
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64 |
Collagen type III degradation is impaired in patients with IgA nephropathy and ANCA-associated vasculitis with high renal fibrotic burden Federica Genovese, Nadja Sparding, Morten Karsdal, Veronika Satrapova, Doubravka Frausova, Lenka Bartonova, Eva Honsova, Dita Maixnerova, Vladimir Tesar, and Zdenka Hruskova |
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65 |
A novel biomarker of type VI collagen formation measured in serum and urine of patients with CKD reflects the level of fibrosis in the kidneys Nadja Sparding, Federica Genovese, Morten Karsdal, Michaela Neprasova, Dita Maixnerova, Veronika Satrapova, Doubravka Frausova, Lenka Bartonova, Eva Honsova, Zdenka Hrušková, and Vladimír Tesař |
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66 |
Collagen is not just collagen – differential matrix expression induced by TGF-β and PDGFs Alexander Reese-Petersen, Morten Karsdal, and Federica Genovese |
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67 |
In search of the balance between increasing mesenchymal stem cell regenerative properties and potential risk of tumor transformation Katarzyna Drela, Luiza Stanaszek, Zuzanna Kuczynska, Sylwia Sarzyńska, and Barbara Lukomska |
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68 |
A novel Macrocyclic Compound reduces fully developed Pulmonary Fibrosis in the Mouse Bleomycin Model Snjezana Cuzic, Boska Hrvacic, Ines Glojnaric, Maja Antolic Klasnic, Dijana Pesic, Sanja Kostrun, and Martina Bosnar |
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69 |
predicting lung function decline in IPF using gene expression in peripheral blood mononuclear cells guiquan JIA, Alexander Abbas, Margaret Neighbors, Joseph Arron, and Thirumalai Ramalingam |
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70 |
The impact of age, sex and dietary regiment on the skin wound healing in C57BL/6J (B6) mice. Marta Kopcewicz, Katarzyna Walendzik, Joanna Bukowska, and Barbara Gawronska-Kozak |
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71 |
TGF-beta and IL-1 as yin and yang in fibrosis: Keratinocytes as coplayers with fibroblasts Mikael Ivarsson, Anita Koskela von Sydow, Chris Janbaz, and Matilda Skoglund |
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72 |
Long term dietary (ex vivo) and culture conditions (in vitro) effect on functional features of dermal fibroblasts (DF) Katarzyna Walendzik, Joanna Bukowska, Marta Kopcewicz, and Barbara Gawronska-Kozak |
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73 |
Actomyosin signalling via PAK1 controls mechanical signals toward the nucleus in liver fibrosis Aoibheann Mullan, Katherine Martin, James Pritchett, Elliot Jokl, Lindsay Birchall, Kara Simpson, Sayyid Raza, Varinder Athwal, Sara Wickstrom, Neil Hanley, and Karen Piper Hanley |
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74 |
Control of fibroblast behaviour by Nrf2-mediated microRNA expression and the potential impact on wound repair and regeneration Paul Hiebert, Mateusz Wietecha, Michael Cangkrama, Eric Haertel, Eleni Mavrogonatou, Michael Stumpe, Heiko Steenbock, Peter Angel, Jürgen Brinckmann, Dimitris Kletsas, Jörn Dengjel, and Sabine Werner |
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75 |
Calcium signaling and the immune response play important roles for spinal cord regeneration in zebrafish Ivar Dehnisch Ellström |
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76 |
Histatin-1: a salivary peptide that promotes endothelial cell migration and angiogenesis Pedro Torres |
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77 |
Immune profiling of human chronic wounds Antonella Pellicoro, Georgios Krilis, and Jenna Cash |
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78 |
Characterising the resolution network in acute and age-impaired skin healing Holly Rocliffe, Antonella Pellicoro, Jesmond Dalli, and Jenna Cash |
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79 |
Prostaglandin environment may favor collagen deposition in mare endometrium when challenged by neutrophil extracellular traps proteases Maria Rebordão, Ana Amaral, Carina Fernandes, Karolina Lukasik, Anna Szóstek-Mioduchowska, António Galvão, Pedro Pinto-Bravo, Dariusz Skarzynski, and Graça Ferreira-Dias |
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80 |
Activated interferon signaling in cultured BMSC from myelofibrosis patients: core finding of a proteomic study Maria Åström, Edvard Welander, Arvid Pourlotfi, Akram Abawi, Erik Ahlstrand, and Mikael Ivarsson |
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81 |
Noscapine inhibits elastase induced collagen transcription and prostaglandin secretion in mare endometrium Ana Amaral, Carina Fernandes, Karolina Lukasik, Anna Szóstek-Mioduchowska, Maria Rebordão, Sofia Morazzo, Pedro Pinto-Bravo, Dariusz Skarzynski, and Graça Ferreira-Dias |
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82 |
The role of interleukin-24 in the pathomechanism of IBD-associated tissue remodeling Apor Veres-Székely, Anna Ónody, Erna Sziksz, Domonkos Pap, Réka Rokonay, Rita Lippai, István Takács, Gábor Veres, Áron Cseh, Attila Szabó, and Ádám vannay |
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83 |
The Renin-Angiotensin-Aldosterone System inhibitors ameliorate hyperglycaemia induced tubulointerstitial fibrosis in Diabetic Kidney Disease Agnes Molnar, Sandor Koszegi, Lilla Lenart, Judit Hodrea, Dora Balogh, Edgar Szkibinszkij, Laszlo Wagner, Adam Vannay, and Andrea Fekete |
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84 |
Increased modulation of inflammation and fibrosis in experimental Chagas disease cardiomyopathy by G-CSF-overexpression in mesenchymal stem cells Daniela Silva, Bruno Souza, Juliana Vasconcelos, Carine Azevedo, Clarissa Valim, Bruno Paredes, Vinicius Rocha, Gisele Carvalho, Pamela Daltro, Simone Macambira, Carolina Nonaka, Ricardo Santos, and Milena Soares |
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85 |
Assays of evaluation of inflammasomes’ activity in alveolar macrophages in fibrotic lung diseases Athina Trachalaki, Eliza Tzitoura, Eirini Vasarmidi, Eleni Bibaki, George Margaritopoulos, Nikolaos Tzanakis, and Katerina Antoniou |
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86 |
Upregulation of Retinoic Acid-Related Orphan Receptor-alpha (RORa) in pulmonary fibrosis Eliza Tsitoura, Eleni Bibaki, Anastasios Koutsopoulos, Eleni Lagoudaki, Nikos Tzanakis, and Katerina Antoniou |