12th International Conference on Pathways, Networks, and Systems Medicine

Preliminary Program

Thursday, June 29

     

6:00 PM

 

Conference Registration

     

8:00 PM

 

Welcome Reception and Dinner

Friday, June 30

     

7:30 AM

 

Breakfast

     

8:30 AM

 

Welcome and Opening Remarks

     

SESSION I

 

Neurons and diseases

Chair: Aris Economides

8:45 AM

1

Gene regulatory networks underlying human neural induction

Noel Buckley

9:15 AM

2

What happens to neurons in disease?

Shankar Subramaniam

9:45 AM

3

Modelling disease through iPSCs: Heterogeneity, identifying new therapeutics and single-cell approaches

Caleb Webber

10:15 AM

4

Modeling human diseases using human organoid systems

Huck Hui NG

10:45 AM

5

Integrative 'omics to define mutant Wnt/β-catenin signalling networks

Rob Ewing

     

11:15 AM

 

Coffee Break and Poster Session

     

SESSION II

 

Drugs, Proteins & Physiology

Chair: Noel Buckley

12:00 PM

6

Status of Complement Therapeutics

John Lambris

12:30 PM

7

Lessons from Genetic Diseases: from novel biology to drug discovery

Aris Economides

1:00 PM

8

Using bond graphs to provide a framework for computational physiology in the Physiome Project

Peter Hunter, Soroush Safaei, and Alan Garny

1:30 PM

9

Intrinsically disordered protein, alternative splicing, and post-translational modification: A toolkit for developmental biology

Keith Dunker

2:00 PM

10

Signal integration and signal insulation: a tale of the NF-kappaB system

Soumen Basak

     

2:30 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

   

Buses depart from the hotel lobby at 7:30 PM

     

Saturday, July 1

     

7:30 AM

 

Breakfast

     

SESSION III

Metabolomics

Chair: Raimond Winslow

8:30 AM

11

Understanding the interplay between amino acid and lipid Metabolism

Christian Metallo

9:00 AM

12

Metabolic rewiring of macrophages during inflammation reveals new intervention points

Karsten Hiller, Johannes Meiser, Yannic Nonnenmacher, Lisa Krämer, and Jenny Ghelfi

9:30 AM

13

Learning from its mistakes: enhancing our understanding of hypoxic metabolism through the study of pseudohypoxic systems

Daniel Tennant

10:00 AM

14

Arsenic targets folate-dependent de novo thymidylate synthesis in the nucleus leading to neural tube defects

Patrick Stover

10:30 AM

15

Pathways to longevity and metabolic health

Charles Burant, Chanisa Thonusin, and Charles Evans

     

11:00 AM

 

Coffee Break and Poster Session

     

SESSION IV

Extracellular Impact

Chair: Peter Hunter

11:30 AM

16

Physicochemical properties of extracellular matrix: Key to function, Clue to mechanism

Shyni Varghese

12:00 PM

17

Hypoxia tolerance in humans: Lessons from high altitude adaptation

Prit Azad, Ali Akbari, Dan Zhou, Tsering Stobdan, Vineet  Bafna, and Gabriel Haddad

12:30 PM

18

Integrating the unexpected roles of T cells in cardiovascular and oncological pathology

Marinos Kallikourdis

1:00 PM

19

Conserved cancer cell migration and transcriptional responses encoded by 3D extracellular matrix architecture

Stephanie Fraley

1:30 PM

20

Biomarkers in maternal and child health

Susan McRitchie

2:00 PM

21

A systems approach to dietary intervention: A tale of twins

Rosane Oliveira

     

2:20 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

   

Buses depart from the hotel lobby at 7:30 PM

     

Sunday, July 2

     

7:30 AM

 

Breakfast

     

SESSION V

Cancer

Chair: Christian Metallo

8:30 AM

22

Spatial systems biology of cancer

Tyler Risom, Spencer Watson, Danielle Jorgens, Mark Dane, Claudia Lopez, Guillaume Thibault, Damir Sudar, Michel Nederlof, Young Hwan Chang, Rosalie Sears, James Korkola, Laura Heiser, Gordon Mills, and Joe Gray

9:00 AM

23

A stromal lysophosphatidic acid signaling axis promotes pancreatic cancer progression

Francesca Auciello, Vinay Bulusu, Jacqueline Tait-Mulder, Mara Sherman, and Jurre Kamphorst

9:30 AM

24

Single cell tumor transcriptomics

Shyam Prabhakar

10:00 AM

25

Effects of targeting metabolic pathways in pancreatic cancer: Systems biology predictions

Stacey Finley and Mahua Roy

10:30 AM

26

Applications of neural network and deep learning models on cancer prognosis prediction

Lana Garmire

     

11:00 AM

 

Coffee Break and Poster Session

     

SESSION VI

Chromosome & Transcription

Chair: Ellen Rothenberg

11:30 AM

27

Mining single cell datasets via gene module network projection analysis

Yunguan Wang, Anil Jegga, Steve Potter, Jeffery Whitsett, and Bruce Aronow

12:00 PM

28

Genetic variation in human transcription factors

Martha Bulyk

12:30 PM

29

Supercoiled chromatin: Conformation and twist propagation

Gaurav Arya and Gi-Moon Nam

1:00 PM

30

The reconstruction and evolutionary history of eutherian chromosomes: A basis for evolutionary systems biology

Jaebum Kim, Marta Farre, Loretta Auvil, Boris Capitanu, Denis Larkin, Jian Ma, and Harris Lewin

     

1:30 PM

 

Lunch and Informal Discussions

     

3:00 PM

 

City Tour

   

Buses depart from the hotel lobby at 3:00 PM

     

7:30 PM

 

Dinner and Informal Discussions

   

Please note buses do not pick-up at the hotel prior to dinner.

Dinner proceeds right after the tour.

     
       

Monday, July 3

     

7:30 AM

 

Breakfast

     

SESSION VII

Immunology

Chair: Harris Lewin

8:30 AM

31

Systems biology of genomic regulatory mechanisms that program T-cell identity in multipotent precursor cells

Ellen Rothenberg, Hiroyuki Hosokawa, Jonas Ungerbäck, William Longabaugh, and Wen Zhou

9:00 AM

32

Evolving patterns of lymphopoiesis from embryogenesis through senescence

Encarnacion Montecino-Rodriguez, Michael Fice, David Casero, Ying Kong, Peter Pioli, and Kenneth Dorshkind

9:30 AM

33

Systems networks controlling innate leukocyte memory and non-resolving inflammatory disease

Shuo Geng and Liwu Li

10:00 AM

34

Early prediction of pending onset of septic shock using patient physiological time-series and EHR data

Raimond Winslow, Ran Liu, and Sridevi Sarma

10:30 AM

35

Clonal dynamics of antibody affinity maturation

Gabriel Victora

11:00 AM

36

In silico specification of T-cell commitment – deferral and irreversibility

Carsten Peterson, Victor Olariu, Pawel Krupinski, and Mary Yui

     

11:20 AM

 

Coffee Break and Poster Session

     

SESSION VIII

HEART & Vessels

Chair: Gaby Haddad

11:45 AM

37

High throughput screening as an omics approach to understand heart disease            

Mark Marcola

12:15 PM

38

Long non-coding RNA-mediated chromatin remodeling regulate endothelial transcriptome

Zhen Chen

12:45 PM

39

The spatio-temporal role of HO-1 in orchestrating the oxidative stress response in HUVECs

Sindhushree Raghunandan, Srinivasan Ramachandran, Ratnesh Lal, Zhen Chen, and Shankar Subramaniam

1:15 PM

40

Of cardiac regeneration secretome (or why men are not fish)

Pilar Ruiz-Lozano

1:45 PM

41

Comprehensive representation of molecular mechanisms of the disease

Alexander Mazein, Marek Ostaszewski, Inna Kuperstein, Mansoor Saqi, Bertrand De Meulder, Irina Balaur, Johann Pellet, Piotr Gawron, Stephan Gebel, Emmanuel Barillot, Andrei Zinovyev, Reinhard Schneider, Rudi Balling, and Charles Auffray

2:05 PM

42

Metabolic and inflammatory factors underlying regenerative capacity of human skeletal muscle progenitor cells

Anna Thalacker-Mercer, Emily Riddle, Jamie Blum, and Heather Roman

     

2:25 PM

 

Discussions and Feedback

     

2:30 PM

 

Lunch and Informal Discussions

     

8:00 PM

 

Farewell Dinner

     

Tuesday, July 4

     

8:00 AM

 

Breakfast

     

10:00 AM

 

Departure

         

POSTERS

43

The effect of folate on vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and neural tube defects

Martha Field

44

Bond graph modeling of glucose uptake in small intestine using CellML

Nima Afshar

45

Statistical analysis of cellular network structures in 2D and 3D

Volker Schmidt

46

Molecular engineering for imaging and reprogramming in live cells

Peter Yingxiao Wang

47

Therapeutic drug targets for ras-driven lung and colon tumors

Daniela Gaglio, Marcella  Bonanomi, Seth Parker, Anna Maria Colangelo, Christian Metallo, and Lilia Alberghina

48

Cardiac transcriptome analysis reveals a critical role for the COP9 signalosome in transcriptional regulation of the substrate receptors of cullin-RING ligases in mice

Ammara Abdullah, Kathleen Eyster, Travis Bjordahl, Peng Xiao, Erliang Zeng, and Xuejun Wang

49

A quantitative view of tissue specificity of molecular pathways in humans

Moran Sharon, Ruth Barshir, Omer Basha, and Esti Yeger-Lotem

50

Clearing in vitro interactomes through tissue-specific gene expression profiles

Idan Hekselman and Esti Yeger-Lotem

51

Diverse Type 2 diabetes genetic risk factors functionally converge in a phenotype-focused gene network

Cynthia Sandor, Nicola Beer, and Caleb Webber

52

Implications of circadian disruption in cancer and autoimmune disease: a system biology approach for precision medicine

Silvana Papagerakis and Petros Papagerakis