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Thursday, June 29 |
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6:00 PM |
Conference Registration |
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8:00 PM |
Welcome Reception and Dinner |
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Friday, June 30 |
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7:30 AM |
Breakfast |
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8:30 AM |
Welcome and Opening Remarks |
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SESSION I |
Neurons and diseases Chair: Aris Economides |
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8:45 AM |
1 |
Gene regulatory networks underlying human neural induction Noel Buckley |
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9:15 AM |
2 |
What happens to neurons in disease? Shankar Subramaniam |
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9:45 AM |
3 |
Modelling disease through iPSCs: Heterogeneity, identifying new therapeutics and single-cell approaches Caleb Webber |
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10:15 AM |
4 |
Modeling human diseases using human organoid systems Huck Hui NG |
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10:45 AM |
5 |
Integrative 'omics to define mutant Wnt/β-catenin signalling networks Rob Ewing |
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11:15 AM |
Coffee Break and Poster Session |
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SESSION II |
Drugs, Proteins & Physiology Chair: Noel Buckley |
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12:00 PM |
6 |
Status of Complement Therapeutics John Lambris |
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12:30 PM |
7 |
Lessons from Genetic Diseases: from novel biology to drug discovery Aris Economides |
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1:00 PM |
8 |
Using bond graphs to provide a framework for computational physiology in the Physiome Project Peter Hunter, Soroush Safaei, and Alan Garny |
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1:30 PM |
9 |
Intrinsically disordered protein, alternative splicing, and post-translational modification: A toolkit for developmental biology Keith Dunker |
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2:00 PM |
10 |
Signal integration and signal insulation: a tale of the NF-kappaB system Soumen Basak |
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2:30 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Buses depart from the hotel lobby at 7:30 PM |
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Saturday, July 1 |
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7:30 AM |
Breakfast |
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SESSION III |
Metabolomics Chair: Raimond Winslow |
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8:30 AM |
11 |
Understanding the interplay between amino acid and lipid Metabolism Christian Metallo |
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9:00 AM |
12 |
Metabolic rewiring of macrophages during inflammation reveals new intervention points Karsten Hiller, Johannes Meiser, Yannic Nonnenmacher, Lisa Krämer, and Jenny Ghelfi |
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9:30 AM |
13 |
Learning from its mistakes: enhancing our understanding of hypoxic metabolism through the study of pseudohypoxic systems Daniel Tennant |
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10:00 AM |
14 |
Arsenic targets folate-dependent de novo thymidylate synthesis in the nucleus leading to neural tube defects Patrick Stover |
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10:30 AM |
15 |
Pathways to longevity and metabolic health Charles Burant, Chanisa Thonusin, and Charles Evans |
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11:00 AM |
Coffee Break and Poster Session |
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SESSION IV |
Extracellular Impact Chair: Peter Hunter |
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11:30 AM |
16 |
Physicochemical properties of extracellular matrix: Key to function, Clue to mechanism Shyni Varghese |
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12:00 PM |
17 |
Hypoxia tolerance in humans: Lessons from high altitude adaptation Prit Azad, Ali Akbari, Dan Zhou, Tsering Stobdan, Vineet Bafna, and Gabriel Haddad |
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12:30 PM |
18 |
Integrating the unexpected roles of T cells in cardiovascular and oncological pathology Marinos Kallikourdis |
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1:00 PM |
19 |
Conserved cancer cell migration and transcriptional responses encoded by 3D extracellular matrix architecture Stephanie Fraley |
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1:30 PM |
20 |
Biomarkers in maternal and child health Susan McRitchie |
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2:00 PM |
21 |
A systems approach to dietary intervention: A tale of twins Rosane Oliveira |
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2:20 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Buses depart from the hotel lobby at 7:30 PM |
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Sunday, July 2 |
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7:30 AM |
Breakfast |
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SESSION V |
Cancer Chair: Christian Metallo |
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8:30 AM |
22 |
Spatial systems biology of cancer Tyler Risom, Spencer Watson, Danielle Jorgens, Mark Dane, Claudia Lopez, Guillaume Thibault, Damir Sudar, Michel Nederlof, Young Hwan Chang, Rosalie Sears, James Korkola, Laura Heiser, Gordon Mills, and Joe Gray |
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9:00 AM |
23 |
A stromal lysophosphatidic acid signaling axis promotes pancreatic cancer progression Francesca Auciello, Vinay Bulusu, Jacqueline Tait-Mulder, Mara Sherman, and Jurre Kamphorst |
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9:30 AM |
24 |
Single cell tumor transcriptomics Shyam Prabhakar |
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10:00 AM |
25 |
Effects of targeting metabolic pathways in pancreatic cancer: Systems biology predictions Stacey Finley and Mahua Roy |
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10:30 AM |
26 |
Applications of neural network and deep learning models on cancer prognosis prediction Lana Garmire |
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11:00 AM |
Coffee Break and Poster Session |
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SESSION VI |
Chromosome & Transcription Chair: Ellen Rothenberg |
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11:30 AM |
27 |
Mining single cell datasets via gene module network projection analysis Yunguan Wang, Anil Jegga, Steve Potter, Jeffery Whitsett, and Bruce Aronow |
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12:00 PM |
28 |
Genetic variation in human transcription factors Martha Bulyk |
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12:30 PM |
29 |
Supercoiled chromatin: Conformation and twist propagation Gaurav Arya and Gi-Moon Nam |
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1:00 PM |
30 |
The reconstruction and evolutionary history of eutherian chromosomes: A basis for evolutionary systems biology Jaebum Kim, Marta Farre, Loretta Auvil, Boris Capitanu, Denis Larkin, Jian Ma, and Harris Lewin |
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1:30 PM |
Lunch and Informal Discussions |
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3:00 PM |
City Tour |
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Buses depart from the hotel lobby at 3:00 PM |
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7:30 PM |
Dinner and Informal Discussions |
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Please note buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour. |
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Monday, July 3 |
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7:30 AM |
Breakfast |
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SESSION VII |
Immunology Chair: Harris Lewin |
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8:30 AM |
31 |
Systems biology of genomic regulatory mechanisms that program T-cell identity in multipotent precursor cells Ellen Rothenberg, Hiroyuki Hosokawa, Jonas Ungerbäck, William Longabaugh, and Wen Zhou |
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9:00 AM |
32 |
Evolving patterns of lymphopoiesis from embryogenesis through senescence Encarnacion Montecino-Rodriguez, Michael Fice, David Casero, Ying Kong, Peter Pioli, and Kenneth Dorshkind |
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9:30 AM |
33 |
Systems networks controlling innate leukocyte memory and non-resolving inflammatory disease Shuo Geng and Liwu Li |
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10:00 AM |
34 |
Early prediction of pending onset of septic shock using patient physiological time-series and EHR data Raimond Winslow, Ran Liu, and Sridevi Sarma |
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10:30 AM |
35 |
Clonal dynamics of antibody affinity maturation Gabriel Victora |
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11:00 AM |
36 |
In silico specification of T-cell commitment – deferral and irreversibility Carsten Peterson, Victor Olariu, Pawel Krupinski, and Mary Yui |
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11:20 AM |
Coffee Break and Poster Session |
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SESSION VIII |
HEART & Vessels Chair: Gaby Haddad |
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11:45 AM |
37 |
High throughput screening as an omics approach to understand heart disease Mark Marcola |
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12:15 PM |
38 |
Long non-coding RNA-mediated chromatin remodeling regulate endothelial transcriptome Zhen Chen |
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12:45 PM |
39 |
The spatio-temporal role of HO-1 in orchestrating the oxidative stress response in HUVECs Sindhushree Raghunandan, Srinivasan Ramachandran, Ratnesh Lal, Zhen Chen, and Shankar Subramaniam |
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1:15 PM |
40 |
Of cardiac regeneration secretome (or why men are not fish) Pilar Ruiz-Lozano |
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1:45 PM |
41 |
Comprehensive representation of molecular mechanisms of the disease Alexander Mazein, Marek Ostaszewski, Inna Kuperstein, Mansoor Saqi, Bertrand De Meulder, Irina Balaur, Johann Pellet, Piotr Gawron, Stephan Gebel, Emmanuel Barillot, Andrei Zinovyev, Reinhard Schneider, Rudi Balling, and Charles Auffray |
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2:05 PM |
42 |
Metabolic and inflammatory factors underlying regenerative capacity of human skeletal muscle progenitor cells Anna Thalacker-Mercer, Emily Riddle, Jamie Blum, and Heather Roman |
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2:25 PM |
Discussions and Feedback |
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2:30 PM |
Lunch and Informal Discussions |
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8:00 PM |
Farewell Dinner |
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Tuesday, July 4 |
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8:00 AM |
Breakfast |
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10:00 AM |
Departure |
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POSTERS |
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43 |
The effect of folate on vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and neural tube defects Martha Field |
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44 |
Bond graph modeling of glucose uptake in small intestine using CellML Nima Afshar |
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45 |
Statistical analysis of cellular network structures in 2D and 3D Volker Schmidt |
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46 |
Molecular engineering for imaging and reprogramming in live cells Peter Yingxiao Wang |
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47 |
Therapeutic drug targets for ras-driven lung and colon tumors Daniela Gaglio, Marcella Bonanomi, Seth Parker, Anna Maria Colangelo, Christian Metallo, and Lilia Alberghina |
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48 |
Cardiac transcriptome analysis reveals a critical role for the COP9 signalosome in transcriptional regulation of the substrate receptors of cullin-RING ligases in mice Ammara Abdullah, Kathleen Eyster, Travis Bjordahl, Peng Xiao, Erliang Zeng, and Xuejun Wang |
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49 |
A quantitative view of tissue specificity of molecular pathways in humans Moran Sharon, Ruth Barshir, Omer Basha, and Esti Yeger-Lotem |
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50 |
Clearing in vitro interactomes through tissue-specific gene expression profiles Idan Hekselman and Esti Yeger-Lotem |
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51 |
Diverse Type 2 diabetes genetic risk factors functionally converge in a phenotype-focused gene network Cynthia Sandor, Nicola Beer, and Caleb Webber |
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52 |
Implications of circadian disruption in cancer and autoimmune disease: a system biology approach for precision medicine Silvana Papagerakis and Petros Papagerakis |