Wed, Oct 11, 2023
6.30-7.30pm. Conference Registration
7.30-10.30pm. Welcome Reception and Dinner
Thu, Oct 12, 2023
8.00-9.00am. Breakfast
Session I: Novel approaches in liver biology and pathobiology
Chairs: Holger Willenbring and Carla Martinez Morant
9.00-9.30am. “Multimodal decoding of human liver regeneration”. Neil Henderson and Kylie Matchett, University of Edinburgh, UK
9.30-10am. “Efferocytosis regulates phenotypes of resident and recruited macrophages in distinct models of hepatic injury”. Charlotte Scott and Frederico De Ponti, VIB Ghent, Belgium
10.00-10.30am. “Spatial transcriptomics of the human liver”. Keren Bahar Halpern and Oran Yakubovsky, Weizman Institute, Rehovot, Israel
10.30am-10.45am. “Mechanosensitive self-fueling vascular Wnt controls liver function”. Ki Hong Lee, DKFZ, Heidelberg, Germany
10.45am-11.00am. “The niche map of ductular reaction-driven regeneration”. Rita Manco, Université catholique de Louvain, Brussels, Belgium
11.00-11.30 am. Coffee Break and Poster Viewing
Session II: Novel approaches in liver biology and pathobiology
Chairs: Rita Manco and Charlotte Scott
11.30-12pm. “Injury-induced hepatocyte dedifferentiation in liver regeneration and tumorigenesis.” Lijan Hui and Sun Chen, Chinese Academy of Science, China
12.00-12.30pm. "Visualizing Kupffer cell adaptations in liver fibrosis". Moritz Peiseler, Charité, Berlin, Germany
12.30-1pm. “Deep Learning-Based Phenotyping Reclassifies Combined Hepatocellular-Cholangiocarcinoma”. Narmin Ghaffari Laleh, TU Dresden, Germany
1.00-1.30pm. “Approaches to extending the reach of liver gene therapy”. Holger Willenbring, UCSF, USA
1.30pm-2.00pm. Poster session I (even posters)
2.00-3.00pm. Lunch and Informal Discussions
3.15pm-7pm. Informal Discussions
7:30pm - 10:30pm Dinner and Informal Discussions
Fri, Oct 13, 2023
8.00-9.00am. Breakfast
Session III: Transcriptional regulation, identity, cell-cell communication and connective tissue biology in hepatic health and disease
Chairs: Kirsten Sadler Edepli and Mikko Karpale
9.00-9.30am. "Epigenetic mechanisms of tissue aging.” Payel Sen, NIH, Bethesda, USA.
9.30-10.00am. „Game of zones: WNTer is coming.“ Jan Tchorz, Novartis, Switzerland
10.00-10.30am. “Regulation of hepatocyte functions by hepatic stellate cells in health and disease”. Robert Schwabe, Columbia University, and Aveline Filliol, MSKCC, New York, USA.
10.30am-10.45am. "Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies". Vincent Merens, Vrije Universiteit Brussel, Belgium
10.45am-11.00am. "Multicellular liver organoids recapitulate homeostatic and fibrotic peri-portal liver tissue architecture and cellular interactions in vitro". Anna Dowbaj, MPI-CBG Dresden, Germany
11.00pm-11.15pm. “Understanding the Role of HNF1B in the Transition of the Endoderm to a Hepatic Fate”. Carla Martinez Morant, MUSC, Charleston, USA
11.15-11.45 am. Coffee Break and Poster Viewing
Session IV: Transcriptional regulation, identity, cell-cell communication and connective tissue biology in hepatic health and disease
Chairs: Jan Tchorz and Anna Dowbaj
11.45-12.15pm. "Epigenetic regulation of liver development, cancer & regeneration". Kirsten Sadler, NYU-Abu Dhabi
12.15pm-12.45pm. "Translational control in liver disease". Mercedes Fernandez, IDIBAPS Biomedical Research Institute, Spain
12.45-1.15pm. "How programmed cell death and cell death responses control HCC development“. Tom Luedde and Anne Schneider, University of Düsseldorf, Germany
1.15-1.45pm. “Engineering human HCC tumour microenvironments“. Derek Mann and Amy Collins, Newcastle University, UK.
1.45pm-2pm. “The distinct effects of oxygen shortage, Roxadustat and HIF-P4H-2 inhibition on mouse embryonic fibroblasts and hepatic stellate cell activation”. Mikko Karpale, University of Oulu, Finland
2pm-2.15pm. “Disease-specific human ECM composition and bioactivity in NASH liver fibrosis”. Lisa Longato, Engitix, London, UK.
2.15pm-3.15pm. Lunch and Informal Discussion
3.15pm-7pm. Informal Discussions
7:30pm - 10:30pm Dinner and Informal Discussions
Sat, Oct 14, 2023
8.00-9.00am. Breakfast
Session V: Metabolic liver disease
Chairs: Vangelis Kondylis and Chantal Desdouets
9.00am-9.30am. “Maladaptive re-activation of morphogenic signaling in liver as causal to NASH-induced fibrosis”. Utpal Pajvani, Columbia University, USA
9.30-10.00pm. Correcting metabolic liver disease by gene therapy.” Karl-Dimiter Bissig, Duke University, USA
10.30am-10.45am. “Hepatic specific ablation of PGC-1a drives fibrosis in MASH model”. Maria Arconzo, University of Bari, Italy
10.45pm-11.00am. “Vascular Control of Liver Pathobiology”. Donato Inverso, Unit of Vascular Pathobiology, University San Raffaele. Milano, Italy
11.00-11.30 am. Coffee Break and Poster Viewing
Session VI: Metabolic liver disease
Chairs: Neil Henderson and Maria Arconzo
11.30am-12.00pm. “Polyploidy: DNA damage response driver or gatekeeper of chronic liver diseases?” Chantal Desdouets and Pierre Cordier, Centre de Recherche des Cordeliers, INSERM, France
12.00pm-12.30pm. “Somatic mutations in steatotic liver disease lead to hepatic metabolic remodelling”. Peter Campbell, and Natalia Brzozwoska, Welcome Sanger Institute, Cambridge, UK
12.30pm-1.00pm. “NASH has a tumor-suppressive effect through YAP-driven cell competition.” Georg Halder and Ana Alguero Nadal, KU Leuven, Belgium.
1.00pm-1.15pm. “A Mavs-dependent type I IFN pathway contributes to non-viral liver injury upon hepatic autophagy impairment”. Vangelis Kondylis, University of Cologne, Germany
1.15pm-1.45pm. “Multiancestry genome-wide studies in nonalcoholic fatty liver disease studies”. Marijana Vujkovic, UPenn, USA
1.45pm-2.15pm. Poster Session II (odd posters)
2.15pm-3.15pm. Lunch and Informal Discussion
3.15pm-7pm. Informal Discussions
7:30pm - 10:30pm Dinner and Informal Discussion
Sunday, Oct 15, 2023
8.00-9.00am. Breakfast
Session VII: Hepatic carcinogenesis and therapeutic vulnerabilities
Chairs: Jessica Zucman-Rossi and Amaia Lujambio
9.00-9.30am. "Genetic predisposition to liver cancer". Jessica Zucman-Rossi, Inserm Paris, France
9.30-10.00am. "Targeting senescence mechanisms in liver fibrosis and cancer". Scott Lowe, MSKCC, New York, USA
10.00-10.30am. "Novel mechanisms regulating cancer risk revealed by CRISPR screening in vivo“. Kirk Wangensteen and Alexandra Vazquez Salgado, Mayo Clinic, Rochester, Minnesota, USA
10.30am-10.45am. “Intermittent fasting promotes immune escape in hepatocellular carcinoma”. Anthony Lozano, Mount Sinai School of Medicine, New York, USA
10.45am-11.00am. “Novel pre-malignant hepatocyte state (daHep) accumulates in liver disease and predicts HCC risk”. Rodrigo Maron Carlessi, Curtin University, Australia
11.00am-11.15pm. “Diet-induced steatosis is a driver of liver metastasis from pancreatic cancer”. Changyu Zhu,MSKCC, New York, USA
11.15-11.45 am. Coffee Break and Poster Viewing
Session VIII: Hepatic carcinogenesis and therapeutic vulnerabilities
Chairs: Rodrigo Maron Carlessi and Changyu Zhu
11.45-12.15pm. "Development and characterization of kinase sparing TPX2-tethering Aurora Kinase A ligands for cancer therapy". Lars Zender and Athina Moschopoulou, University of Tübingen, Germany
12.15-12.45pm. USA. "Characterization of a novel Er stress inducing oncoprotein that restricts immunosurveillance". Mathias Heikenwälder, German Cancer Center, Heidelberg, Germany
12.45-1.15pm. “Notch1 promotes sexually dimorphic immune responses in HCC”. Amaia Lujambio, Mount Sinai School of Medicine, New York, USA
1.15pm-1.45pm. "Deciphering Mucosal-Associated Invariant T (MAIT) Cell Regulation Networks in Liver Cancer", Benjamin Ruf, Tübingen, Germany
1.45pm-2.15pm. The oncogenic function of Smyd3 histone methyltransferase in liver and colon cancer”. Iannis Talianidis, FORTH, Crete, Greece10
2.15pm-3.15pm. Lunch and Informal Discussion
3pm-7pm. Informal Discussions
7:30pm - 11pm Farewell Dinner
Monday, Oct 16, 2023
Breakfast
Departure
All remaining abstracts have been accepted as a poster presentation