There are 3 ways to get from Athens to Ioannina by plane, car, or bus

FLYING OPTION

Fly from Athens (ATH) to Ioannina (IOA) ATH - IOA •  1h

Aegean Airlines https://en.aegeanair.com

SkyExpress https://www.skyexpress.gr

DRIVING OPTION

Drive from Athens Int'l Airport (ATH) to Hotel Du Lac, Ioannina •  4h 20m PDF Driving Directions

Drive from Thessaloniki Int'l Airport to Hotel Du Lac, Ioannina •  3h 10m PDF Driving Directions

BUS OPTION 

Take the bus from Athens to Ioannina •  5h 30m

Take the bus from Thessaloniki to Ioannina •  3h 30m

Link to the Publis Bus KTEL http://ktelioannina.gr