Tuesday, October 8, 2019
Summer School (Lecture hall)
14:00 - 14:05 Welcome & aims (M. Huber-Lang, Germany/ S. Bahrami, Austria)
14:05 - 14:15 Hand-out: Hemorrhagic shock (HS): as old as human (J-M Cavaillon, France)
14:15 - 14:35 HS-induced circulatory changes (M. Wepler, Germany)
14:35 - 14:55 HS-induced immunological changes (M. Huber-Lang, Germany)
14:55 - 15:15 Strategies to reduce MODS in HS ( C. Thiemermann, UK)
15:15 - 15:30 HS modelling (M. Osuchowski, Austria)
15:30 - 16:15 Hands-on: Clinical simulation of shock (M. Wepler, Germany)
16:15 – 16:30 Coffee Break
16:30 - 18:00 Hands-on: coagulatory changes / ROTEM
(M. Maegele, Germany / J. Zipperle, Austria / L. Rodewald, Germany)
18:00 – 20:00 ESS Board Meeting
20:00 – 23:00 Welcome Reception ESS/IFSS
Wednesday, October 9, 2019
What Apollo Reveals: Innate Immune Response to Trauma /HS(Auditorium)
Chairs: Irshad Chaudry, USA / Frank Hildebrand, Germany
08:00 - 08:20 Welcome ESS/IFSS/Aegean Conf (M. Huber-Lang, Germany / S. Bahrami, Austria / J. Lambris, Greece)
08:20 - 08:40 Barrier failure after trauma/ HS (M. Huber-Lang, Germany)
08:40 - 09:00 Cellular innate immune response (T. Billiar, USA)
09:00 - 09:20 Fluid phase immune response (T. Mollnes, Norway)
09:20 - 09:30 #20 Metabolic systems analysis of shock-induced endotheliopathy (SHINE) in trauma – a new research paradigm (H. Henriksen, Denmark)
09:30 - 09:40 #90 Immunosuppression is associated with concurrent inflammation, endothelial activation and loss of endothelial barrier function in patients with community-acquired pneumonia (X. Brands, Netherlands)
09:40 - 09:50 #70 Temperature-dependent reprogramming of bacterial clearance by neutrophils versus macrophages (M. Fonseca, Brazil)
09:50 - 10:00 #19 Alcohol drinking modulates coagulation, barrier function with subsequent inflammation and leukocyte functions in healthy volunteers (R. Sturm, Germany)
10:00 – 10:30 Coffee Break
Prometheus’ Bestowment: Novel Pathomechanisms and Therapeutics in Critical Care (Auditorium)
Chairs: Karim Brohi, UK / Fabienne Venet, France
10:30 - 10:50 Novel pathomechanisms in MODS (C. Thiemermann, UK)
10:50 - 11:10 #38 Effects of the poly(ADP-ribose)polymerase inhibitor Olaparib in preclinical models of CLP-induced sepsis and in cerulein-induced pancreatitis: opportunities for therapeutic repurposing (C. Szabo, Switzerland)
11:10 - 11: 30 Potential mechanisms of how HAT therapy improves sepsis survival (D. Remick, USA)
11:30 - 11:40 #62 Metabolic redundancy in the regulation of lipopolysaccharide induced cytokine production by human monocytes and macrophages (N. Otto, Netherlands)
11:40 – 11:50 #50 Sodium thiosulfate protects swine against hemorrhagic shock-induced acute lung injury, which is associated with increased glucocorticoid receptor expression (M. Wepler, Germany)
11:50 - 12:00 #48 Enteral gabexate mesilate preserves baroreceptor reflex in non-blood resuscitated experimental trauma/hemorrhagic shock (F. Dos Santos, USA)
12:00 - 12:10 #68 Bruton’s tyrosine kinase inhibition attenuates cardiac dysfunction caused by cecal ligation and puncture in mice (O’Riordan, United Kingdom)
12:10 - 12:20 #80 Methane treatment improves the renal function in a large animal model of cardiopulmonary bypass (D. Érces, Hungary)
12:20 - 12:30 #102 TREM-1 pharmacological inhibition by LR12/nangibotide improves survival and controls vascular leakage during experimental endotoxic shock in mice (A. Boufenzer, France)
12:30 – 13:30 Lunch
13:30 - 14:30 Poster Session (Poster area)
(Organization: B. Relja, Germany / F. Venet, France / T. Skirecki, Poland)
Chairs: Borna Relja, Germany / Mihály Boros, Hungary / Inge Bauer, Germany / Andrey Kozlov, Austria / Evangelos Giamarellos-Bourboulis, Greece / T. Skirecki, Poland / Basilia Zingarelli, USA / Fabienne Venet, France
Prometheus and Hephaestus counsel: Clinically Relevant Modelling of Critical Care Conditions (Auditorium)
Chairs: Borna Relja, Germany / Andrea Szabo, Hungary
14:30 - 14:50 Clinical relevance: Precision Medicine in Sepsis (T. van der Poll, Netherlands)
14:50 - 15:05 What about sepsis modelling? - Wiggers-Bernard report & outlook
(M. Osuchowski, Austria)
15:05 - 15:20 Anything new in hemorrhagic shock? (W. Martini, USA)
15:20 - 15:30 #67 Methane delays mitochondrial permeability transition pore-mediated calcium-efflux and improves endogenous calcium release in a rat model of hypoxemic hypoxia (L. Juhász, Hungary)
15:30 - 15:40 #16 A single dose of the nonsteroidal anti-inflammatory drug (NSAID, meloxicam) causes duodenal bleeding, acute kidney injury (AKI) and papillary necrosis in a rabbit model of hemorrhagic shock and hypotensive (prehospital) resuscitation (B. Kheirabadi, USA)
15:40 - 15:50 #52 Cardiac function and renal blood flow in two models of haemolytic-uraemic syndrome (C. Neu, Germany)
15:50 - 16:00 #92 Adenosine and an adenosine A2A receptor agonist alleviate cardiac dysfunction in a trauma-haemorrhage mouse model (B.Praditsuktavorn, United Kingdom)
16:00 - 16:10 #10 In vivo platelet function and coagulopathy of trauma studied by intravital microscopy: integration of systemic and local parameters (I. Torres Filho, USA)
16:10 - 16:20 #66 Microbiological aspects of a rat model of sepsis meeting the Minimum Quality Threshold In Pre-clinical Sepsis Studies criteria (S. Tallósy, Hungary)
16:20 - 16:30 #88 Tranexamic acid prevents irreversible damage to fibrinogen receptors, thereby improving platelet function (J. Zipperle, Austria)
16:30 – 17:00 Coffee Break
Hippocrates meets Plato: Consequences and Complications of Trauma / Sepsis - ESS/ESTES (Auditorium)
Chairs: Christoph Joosten, Germany / Mihály Boros, Hungary
17:00 - 17:20 Clinical consequences after polytrauma (C. Joosten, Germany)
17:20 - 17:40 Translational research in hemorrhagic shock (M. van Griensven, Netherlands)
17:40 - 17:50 #135 The intergenerational burden of bacterial sepsis - preclinical evidence for a hereditary immunodeficiency (F. Uhle, Germany)
17:50 - 18:00 #133 Outcome-dependent leukocyte and cytokine differences in human and mouse compartments follow similar dynamics in septic humanized mice(T. Skirecki, Poland)
18:00 - 18:10 #81 Structural and functional heart damage is prevented by sensory contact to the stressor following psychosocial trauma (M. Kalbitz, Germany)
18:10 - 18:20 #89 Transkingdom analysis of the intestinal ecosystem of critically ill patients on the intensive care unit (B. Haak, Netherlands)
18:20 - 18:30 #126 Peritoneal macrophages impair dendritic cell function through prostaglandin E2/E prostanoid 4 receptor interaction early during polymicrobial sepsis(S. Flohé, Germany)
18:30 - 18:40 #109 Acute CLP nullifies pre-existing sex-related differences in the metabolomic profile in the blood (S. Drechsler, Austria)
18:40 - 18:50 #32 Low doses of dexamethasone prevents intestinal epithelial barrier dysfunction in endotoxemic shock (R. Saia, Brazil)
18:50 - 19:00 #138 Pentraxin-3 is involved in defense against klebsiella pneumoniae infection (F. Asgari, Italy)
Thursday, October 10, 2019
Asklepios in Shock: Novel Therapies in Trauma / Sepsis
(IFSS – Japan Shock) (Auditorium)
Chairs: Hiroyuki Hirasawa, Japan / Mayuki Aibiki, Japan
08:00 - 08:13 #76 Aging and immune response (S. Inoue, Japan)
08:13 - 08:26 Artificial blood (M. Kinoshita, Japan)
08:26 - 08:39 Hydrogen and resuscitation (K. Hayashida, Japan)
08:39 - 08:52 CHDF with cytokine-adsorbing hemofiltration for sepsis(H. Hirasawa, Japan)
08:52 - 09:05 Autophagy in sepsis-induced organ failure (E. Watanabe, Japan)
09:05 - 09:18 DIC in sepsis (S. Gando, Japan)
09:18 - 09:31 Pathogenesis of inflammatory thrombus in sepsis (T. Iba, Japan)
09:31 - 09:44 Immunothrombosis in inflammation - A unifying concept in the coagulopathy of critical illness? (M. Kutcher, USA)
09:44 - 09:57 Optimal patient selection for anticoagulant therapy in sepsis(K. Yamakawa, Japan)
09:57 - 10:00 Closing remarks (H. Hirasawa, Japan / M. Aibiki, Japan)
10:00 – 10:30 Coffee Break
Dionysus and Hebe: Obesity & Aging (IFSS – US Shock)(Auditorium)
Chairs: Basilia Zingarelli, USA / Elizabeth Kovacs, USA
10:30 - 10:50 Innate immunity in geriatric trauma patients in the ICU (P. Efron, USA)
10:50 - 11:10 Aging and fecal microbiome dysbiosis after burn injury (E. Kovacs, USA)
11:10 - 11:30 Age-dependent metabolic recovery in multiple organ failure(B. Zingarelli, USA)
11:30 - 11:50 Targeting white and brown adipose tissue in sepsis (J. Kaplan, USA)
11:50 - 12:10 The role of adipose tissue in the age-dependent severity of sepsis(H. Saito, USA)
12:10 - 12:20 #77 Sepsis impairs physical, cognitive and mental function in aged mice - establishment of post-intensive care syndrome model after sepsis (M. Saito, Japan)
12:20 - 12:30 #39 Polymyxin B hemoperfusion for septic shock: effect modification of age-related trends by disease severity (H. Nakata, Japan)
12:30 – 13:30 Lunch
13:30 - 14:30 Poster Session
(Organization: B. Relja, Germany / F. Venet, France / Tomasz Skirecki, Poland)
Chairs: Fabienne Venet, France / Tomasz Skirecki, Poland / Olaf Picker, Germany / Stefanie Flohé, Germany / Andrea Szabo, Hungary / Federico Aletti, Italy / W. Martini, USA / Borna Relja, Germany
13:30 - 14:30 Guided poster tours for the summer school attendees
What is new in HS? (M. Maegele, Germany / M. van Griensven, Germany)
What is new in MODS? (C. Thiemermann, UK, M. Wepler, Germany)
Olympus Meeting: European New Investigator Award Competition (Auditorium)
(Organization: M. Osuchowski, Austria)
Chairs: Markus Huber-Lang, Germany / Evangelos Giamarellos-Bourboulis, Greece
Reviewer Board: tba
14:30 - 14:45 Early cardiovascular dysfunction drives in-hospital trauma deaths (R. Carden, United Kingdom)
14:45 - 15:00 Unfolded protein response in traumatic hemorrhagic shock improved blood circulation and relieved organ injury (A. Luís, Austria)
15:00 - 15:15 Does metabolic endotoxemia play a role in the insulin-resistance, steatohepatitis and proteinuria caused by high-fat diet in mice? (S. Mohammad, United Kingdom)
15:15 - 15:30 Abdominal sepsis is associated with stronger host response aberrations when compared with sepsis caused by community-acquired pneumonia (H. Peters-Sengers, Netherlands)
15:30 - 15:45 Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis (L. Tian, China; presented by Xiao-yuan Ma, off scoring)
Friday, October 11, 2019
Immune Dysfunction and Precision Modulation in Trauma and Sepsis (IFSS – China Shock) (Auditorium)
Chairs: Yong-Ming Yao, China / Timothy Billiar, USA
08:00 - 08:20 Host immunosuppression and its precision regulation in postburn sepsis (Y.-M. Yao, China)
08:20 - 08:40 Caspase-11-mediated pyroptosis promoted DIC in sepsis (B. Lu, China)
08:40 - 09:00 Copy number variation of DEFA1/DEFA3: how genetic background impacts sepsis development and its precision treatment (X.-M. Fang, China)
09:00 - 09:20 #33 Endotoxin inhibition of neutrophil chemotaxis: increased autocrine ATP signaling enhances myosin light chain phosphorylation (B.-W. Sun, China)
09:20 - 09:30 #17 Functional immune monitoring in severely injured patients - a pilot study (R. Halbgebauer, Germany)
09:30 - 09:40 #30 A novel insight into agmatine: multitasking in post-traumatic immunodysfunction, systemic inflammatory response and sepsis (H. Liang, China)
09:40 - 09:50 #60 Metabolic rewiring of airway epithelial cells modulates inflammatory responses to the bacterial component flagellin (I. Ramirez-Moral, Netherlands)
09:50 - 10:00 #115 Immunomodulatory therapy of necrotizing pancreatitis with beta-D-glucan (N. Koliakos, Greece)
10:00 – 10:30 Coffee Break
Hermes: Sepsis / Trauma Around the World
(IFSS – Latin America) (Auditorium)
Chairs: Reinaldo Salomao, Brazil / Stefanie Flohe, Germany
10:30 - 10:50 Sepsis in low and middle income countries: how to reduce the inequalities?
(R. Salomao, Brazil)
10:50 - 11:10 Sepsis in Europe (M. Bauer, Germany)
11:10 - 11:30 Is multi-organ failure protective? (M. Singer, United Kingdom)
11:30 - 11:40 #127 Pathogen- and damage-associated molecular patterns are immune modified by apoptotic cell adjuvant therapy for acute sepsis in a cecal ligation and puncture mice model, avoids multi-organ failure and improves survival (D. Mevorach, Israel)
11:40 - 11:50 #8 Inhibition of TLR4/MyD88/TAK1/NF-κB/COX-2 pathway activation contributes to protective effect of bexarotene, a RXR agonist, against lipopolysaccharide-induced inflammatory hyperalgesia (S. Senol, Turkey)
11:50 - 12:00 #21 Mitochondrial respiration and circulating mtDNA levels may help improve early diagnosis of sepsis in burn patients (B. Gomez, USA)
12:00 - 12:10 #100 Immune modulation and CMV reactivation in sepsis-induced immunosuppression (G. Lambe, India)
12:10 - 12:20 #40 Rational designed endogenous antimicrobial peptides in the treatment of sepsis (G. Luo, China)
12:20 - 12:30 #61 A spleen-liver axis drives TNF-alpha production in endotoxemia (A. Steiner, Brazil)
12:30 – 13:30 Lunch
13:30 - 14:30 General Assembly ESS (Auditorium)
Markus Huber-Lang, Germany / Evangelos Giamarellos-Bourboulis, Greece / Inge Bauer,
Germany / Marcin Osuchowski, Austria
European Collaborative Shock Research (Auditorium)
Chairs: Karim Brohi, UK / Federico Aletti, Italy
14:30 - 14:45 INTRIN / London (K. Brohi, UK)
14:45 - 15:00 CRC1149 Trauma (A. Ignatius, Germany)
15:00 - 15:15 Network Trauma Research (NTF) (B. Relja, Germany)
15:15 - 15:30 TREAT (K. Horst, Germany)
15:30 - 15:45 EGIS (European Group for Immunology of Sepsis) (J. Mermejo-Martin, Spain)
15:45 - 16:00 Center TBI (M. Maegele, Germany)
16:00 - 16:15 Hellenic Institute for the Study of Sepsis (E. Giamarellos-Bourboulis, Greece)
16:15 - 16:30 EU – Shockomics (F. Aletti, Italy)
16:30 – 17:00 Coffee Break
ESS 2030 / IFSS 2030: Hades or Olymp?
Past – Presence - Future (Auditorium)
Chairs: Inge Bauer, Germany / Heinz Redl, Austria
17:00 - 17:10 Past ESS (J.-M. Cavaillon, France / H. Redl, Austria)
17:10 - 17:20 Present ESS (I. Bauer, Germany)
17:20 - 17:30 Future ESS - Quo vadis? (M. Huber-Lang, Germany)
17:30 - 17:40 Past IFSS (I. Chaudry, USA)
17:40 17:50 Present IFSS (S. Bahrami, Austria)
17:50 - 18:00 Future IFSS - Quo vadis? (Y.M. Yao, China)
18:00 - 18:10 Discussion
18:10 - 18:20 Special Honors
18:20 - 18:30 Closing remarks (E. Giamarellos-Bourboulis, Greece)
Parallel Sessions (Seminar Room)
Wednesday, October 9, 2019
13:30 – 14:30
IFSS Board Meeting
Chairs: Soheyl Bahrami, Austria / Basilia Zingarelli, USA (IFSS Secretary)
14:30 – 18:30
ROTEM-Workshop
Chairs: Marc Maegele, Germany / Johannes Zipperle, Austria
Friday, October 11, 2019
Hellenic Sepsis Study Group Meeting (English)
Chairs: Iraklis Tsangaris, Greece / Charalombos Gogos, Greece
08:00 - 08:15 Platelets and anti-platelets in sepsis (K. Akinisoglou, Greece)
08:15 - 08:40 New antimicrobials to combat resistance (G. Dimopoulos, Greece)
08:40 - 09:00 The interaction between the immune response and the vascular endothelium in septic shock: a two-way street? (J. Bermejo-Martin, Spain)
09:00 - 09:20 How early vascular endothelium informs of the advent of sepsis? The PROUD study (E. Giamarollos-Bourboulis, Greece)
09:20 - 09:35 A randomized prospective clinical trial to assess the role of procalcitonin-guided antimicrobial therapy to reduce long-term infections sequelae: Results of the PROGRESS trial
(E. Kyriazopoulou, Greece)
09:35 - 09:50 Personalized immunotherapy in sepsis: how to study? (E. Giamarellos-Bourboulis, Greece)
09:50 - 10:00 #58 Institutional anticoagulation protocol for septic DIC is associated with differences in in-hospital mortality: J-SEPTIC DIC study (a nation-wide registry study) (K. Tanaka, Japan)
10:00 – 10:30 Coffee Break
IFSS - Russian Shock SSSR (Russian – English translation)
Chair: Vladimir Pisarev, Russia
10:30 - 10:55 # 73 Perfluorancarbones in critical care (V. Moroz, Russia)
10:55 - 11:20 Shock: clinical and anatomical analysis (A. Golubev, Russia)
11:20 - 11: 45 Septic shock: problems of pathogengesis, diagnosis, and treatment
(V. Kulabuchov, Russia)
11:45 - 11:55 Nosocomial pneumonia: role in septic shock development(A. Kuzovlev, Russia)
11:55 - 12:05 Metabolic alterations in traumatic shock: correction by deferoxamin(V. Dolgih, Russia)
12:05 - 12:15 #54 Microbiota as an organ and the role of its total dysfunction in septic shock (N. Beloborodova, Russia)
12:15 - 12:25 #120 Young scientist study: Specificity of gut microbiota in critically ill patients: quantity, quality and function (E. Chernevskaya, Russia)
12:25 - 12:30 Closing remarks (V. Pisarev, Russia)
12:30 – 13:30 Lunch
Friday, October 11, 2019
IFSS- Russian Shock SSSR (Russian – English translation)
Chairs: Artem N. Kuzovlev, Russia
14:30 - 14:55 #99 Genetic and immune regulation biomarkers in sepsis and shock patients
(V. Pisarev, Russia)
14:55 - 15:20 #104 Endotoxicosis as a course of shock development (A. Lodiagin, Russia)
15:20- 15:45 Critical illness in acute poisoning with narcotic drugs (G. Livanov, Russia)
15:45 - 15:55 Endotoxic shock in acute poisoning with the cauterizing substances
(B. Batocirenov, Russia)
15:55 - 16:05 Strategy of prevention of the intra-surgery massive hemorrhage in children
(E. Spiridonova, Russia)
16:05 - 16:15 Cardiogenic shock at a prehospital stage: management and prevention
(A. Zakcharova, Russia)
16:15 - 16:25 #106 Young scientist study: Microvascular alterations in rat skin during hemorrhagic shock and after resuscitation with autologous blood and crystalloids (I. Ryzhkov, Russia)
16:20 - 16:30 #7 The prescription of phosphocreatine in patients with septic shock improves parameters of hemodynamics and reduces the degree of hypoxia (V. Slepushkin, Russia)
Saturday, October 12, 2019
09:00 – 19:00 By invitation only
Wiggers-Bernard Conference
(Organization: Marcin Osuchowski, Austria)