Wednesday, October 9, 2019
7:30 - 8:00 Breakfast
What Apollo Reveals: Innate Immune Response to Trauma /HS (Auditorium)
Chairs: Irshad Chaudry, USA / Frank Hildebrand, Germany
08:00 - 08:20 Welcome ESS/IFSS/Aegean Conf (M. Huber-Lang, Germany / S. Bahrami, Austria / J. Lambris, USA)
08:20 - 08:40 Barrier failure after trauma/ HS (M. Huber-Lang, Germany)
08:40 - 09:00 Cellular innate immune response (T. Billiar, USA)
09:00 - 09:20 Fluid phase immune response (T. Mollnes, Norway)
09:20 - 09:30 Metabolic systems analysis of shock-induced endotheliopathy (SHINE) in trauma – a new research paradigm (H. Henriksen, Denmark)
09:30 - 09:40 Immunosuppression is associated with concurrent inflammation, endothelial activation and loss of endothelial barrier function in patients with community-acquired pneumonia (X. Brands, Netherlands)
09:40 - 09:50 Temperature-dependent reprogramming of bacterial clearance by neutrophils versus macrophages (M. Fonseca, Brazil)
09:50 - 10:00 Alcohol drinking modulates coagulation, barrier function with subsequent inflammation and leukocyte functions in healthy volunteers (R. Sturm, Germany)
10:00 – 10:30 Coffee Break
Prometheus’ Bestowment: Novel Pathomechanisms and Therapeutics in Critical Care (Auditorium)
Chairs: Karim Brohi, UK / C. Szabo, Switzerland
10:30 - 10:50 Septic organ failure – Molecular mechanisms and translation (S. Coldewey, Germany)
10:50 - 11:10 Effects of the poly(ADP-ribose)polymerase inhibitor Olaparib in preclinical models of CLP-induced sepsis and in cerulein-induced pancreatitis: opportunities for therapeutic repurposing (C. Szabo, Switzerland)
11:10 - 11: 30 Potential mechanisms of how HAT therapy improves sepsis survival (D. Remick, USA)
11:30 - 11:40 Metabolic redundancy in the regulation of lipopolysaccharide induced cytokine production by human monocytes and macrophages (N. Otto, Netherlands)
11:40 – 11:50 Sodium thiosulfate protects swine against hemorrhagic shock-induced acute lung injury, which is associated with increased glucocorticoid receptor expression (M. Wepler, Germany)
11:50 - 12:00 Enteral gabexate mesilate preserves baroreceptor reflex in non-blood resuscitated experimental trauma/hemorrhagic shock (F. Dos Santos, USA)
12:00 - 12:10 Bruton’s tyrosine kinase inhibition attenuates cardiac dysfunction caused by cecal ligation and puncture in mice (O’Riordan, United Kingdom)
12:10 - 12:20 Methane treatment improves the renal function in a large animal model of cardiopulmonary bypass (D. Érces, Hungary)
12:20 - 12:30 TREM-1 pharmacological inhibition by LR12/nangibotide improves survival and controls vascular leakage during experimental endotoxic shock in mice (A. Boufenzer, France)
12:30 – 13:30 Lunch
13:30 - 14:30 Poster Session (Poster area)
(Organization: B. Relja, Germany / T. Skirecki, Poland)
Chairs: Borna Relja, Germany / Mihály Boros, Hungary / Inge Bauer, Germany / Andrey Kozlov, Austria / Evangelos Giamarellos-Bourboulis, Greece / T. Skirecki, Poland / Basilia Zingarelli, USA / Andrea Szabo, Hungary
Prometheus and Hephaestus counsel: Clinically Relevant Modelling of Critical Care Conditions (Auditorium)
Chairs: Borna Relja, Germany / Andrea Szabo, Hungary
14:30 - 14:50 Clinical relevance: Precision Medicine in Sepsis (T. van der Poll, Netherlands)
14:50 - 15:05 What about sepsis modelling? - Wiggers-Bernard report & outlook
(M. Osuchowski, Austria)
15:05 - 15:20 Anything new in hemorrhagic shock? (W. Martini, USA)
15:20 - 15:30 Methane delays mitochondrial permeability transition pore-mediated calcium-efflux and improves endogenous calcium release in a rat model of hypoxemic hypoxia (L. Juhász, Hungary)
15:30 - 15:40 Effects of adjuncts on muscle oxygenation, perfusion and permeability in rats subjected to prolonged hemorrhagic shock studied by using a noninvasive automated system (I. Torres Filho, USA)
15:40 - 15:50 Cardiac function and renal blood flow in two models of haemolytic-uraemic syndrome (C. Neu, Germany)
15:50 - 16:00 Adenosine and an adenosine A2A receptor agonist alleviate cardiac dysfunction in a trauma-haemorrhage mouse model (B.Praditsuktavorn, United Kingdom)
16:00 - 16:10 In vivo platelet function and coagulopathy of trauma studied by intravital microscopy: integration of systemic and local parameters (I. Torres Filho, USA)
16:10 - 16:20 Microbiological aspects of a rat model of sepsis meeting the Minimum Quality Threshold In Pre-clinical Sepsis Studies criteria (S. Tallósy, Hungary)
16:20 - 16:30 Tranexamic acid prevents irreversible damage to fibrinogen receptors, thereby improving platelet function (J. Zipperle, Austria)
16:30 – 17:00 Coffee Break
Hippocrates meets Plato: Consequences and Complications of Trauma / Sepsis - ESS/ESTES (Auditorium)
Chairs: Marc Maegele, Germany / Mihály Boros, Hungary
17:00 - 17:20 Clinical consequences after polytrauma (M. Maegele, Germany)
17:20 - 17:40 Translational research in hemorrhagic shock (M. van Griensven, Netherlands)
17:40 - 17:50 The intergenerational burden of bacterial sepsis - preclinical evidence for a hereditary immunodeficiency (F. Uhle, Germany)
17:50 - 18:00 Outcome-dependent leukocyte and cytokine differences in human and mouse compartments follow similar dynamics in septic humanized mice(T. Skirecki, Poland)
18:00 - 18:10 Structural and functional heart damage is prevented by sensory contact to the stressor following psychosocial trauma (M. Kalbitz, Germany)
18:10 - 18:20 Transkingdom analysis of the intestinal ecosystem of critically ill patients on the intensive care unit (B. Haak, Netherlands)
18:20 - 18:30 Peritoneal macrophages impair dendritic cell function through prostaglandin E2/E prostanoid 4 receptor interaction early during polymicrobial sepsis(S. Flohé, Germany)
18:30 - 18:40 Acute CLP nullifies pre-existing sex-related differences in the metabolomic profile in the blood (S. Drechsler, Austria)
18:40 - 18:50 Low doses of dexamethasone prevents intestinal epithelial barrier dysfunction in endotoxemic shock (R. Saia, Brazil)
18:50 - 19:00 Pentraxin-3 is involved in defense against klebsiella pneumoniae infection (F. Asgari, Italy)
19:30 - 23:00 Dinner / Informal Discussions
Parallel Session (Seminar Room)
13:30 – 14:30 IFSS Board Meeting
Chairs: Soheyl Bahrami, Austria / Basilia Zingarelli, USA (IFSS Secretary)
14:30 – 18:30 ROTEM-Workshop
14:30-14:45 Welcome and Introduction by the Workshop Chairs
Marc Maegele, Germany
14:45-15:15 Thromboelastometry Basics
Klaus Görlinger, Essen/Munich, Germany
15:15-15:45 Ratio-driven MTPs versus Goal-directed PBM in Trauma
Klaus Görlinger, Essen/Munich, Germany
15:45-16:15 European Trauma Guidelines: Update 2019
Marc Maegele, Cologne, Germany
16:15-16:45 Coffee break
16:45-18:00 Hands-on Simulation Goal-directed Therapy of TIC
Marc Maegele, Klaus Görlinger, Nikos Simos (Antisel), Poonam Rao (Werfen EEMEAI)
Faculty:
Prof. Marc Maegele, MD, Department for Traumatology and Orthopaedic Surgery, Cologne- Merheim Medical Centre, University of Witten/Herdecke, Cologne, Germany.
Klaus Görlinger, MD, Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, Germany, and Medical Director TEM Innovations, Munich, Germany.
Sponsored by CSL Behring, ANTIΣEΛ and Werfen