7:30 - 8:00 Breakfast

Asklepios in Shock: Novel Therapies in Trauma / Sepsis

(IFSS – Japan Shock) (Auditorium)

Chairs: Hiroyuki Hirasawa, Japan / Mayuki Aibiki, Japan

08:00 - 08:13   Sepsis and aging induced persistent T cell exhaustion with impaired circadian rhythm of circulating T cells in mouse models of repeated sepsis  (S. Inoue, Japan)

08:13 - 08:26   Artificial blood (M. Kinoshita, Japan)

08:26 - 08:39   Hydrogen and resuscitation (K. Hayashida, Japan)

08:39 - 08:52   CHDF with cytokine-adsorbing hemofiltration for sepsis (H. Hirasawa, Japan)

08:52 - 09:05   Autophagy in sepsis-induced organ failure (E. Watanabe, Japan)

09:05 - 09:18   DIC in sepsis (S. Gando, Japan)

09:18 - 09:31   Pathogenesis of inflammatory thrombus in sepsis (T. Iba, Japan)

09:31 - 09:44   Immunothrombosis in inflammation - A unifying concept in the coagulopathy of critical illness? (M. Kutcher, USA)

09:44 - 09:57   Optimal patient selection for anticoagulant therapy in sepsis (K. Yamakawa, Japan)

09:57 - 10:00   Closing remarks (H. Hirasawa, Japan / M. Aibiki, Japan)

10:00 – 10:30  Coffee Break

Dionysus and Hebe: Obesity & Aging (IFSS – US Shock) (Auditorium)

Chairs: Basilia Zingarelli, USA / Elizabeth Kovacs, USA

10:30 - 10:50   Innate immunity in geriatric trauma patients in the ICU (P. Efron, USA)

10:50 - 11:10   Aging and fecal microbiome dysbiosis after burn injury (E. Kovacs, USA)

11:10 - 11:30   Age-dependent metabolic recovery in multiple organ failure (B. Zingarelli, USA)

11:30 - 11:50   Targeting white and brown adipose tissue in sepsis (J. Kaplan, USA)

11:50 - 12:10   The role of adipose tissue in the age-dependent severity of sepsis (H. Saito, USA)

12:10 - 12:20   Sepsis impairs physical, cognitive and mental function in aged mice - establishment of post-intensive care syndrome model after sepsis (M. Saito, Japan)

12:20 - 12:30   Polymyxin B hemoperfusion for septic shock: effect modification of age-related trends by disease severity (H. Nakata, Japan)

12:30 – 13:30 Lunch

13:30 - 14:30   Poster Session

(Organization: B. Relja, Germany / Tomasz Skirecki, Poland)

Chairs: Tomasz Skirecki, Poland / Olaf Picker, Germany / Stefanie Flohé, Germany / Andrea Szabo, Hungary / Federico Aletti, USA / W. Martini, USA / Borna Relja, Germany / Andreas Baratt-Due, Norway

13:30 - 14:30   Guided poster tours for the summer school attendees

            What is new in HS? (M. Maegele, Germany / M. van Griensven, Germany)

            What is new in MODS? (C. Thiemermann, UK, M. Wepler, Germany)

Olympus Meeting: European New Investigator Award Competition (Auditorium)

(Organization: M. Osuchowski, Austria)

Chairs: Markus Huber-Lang, Germany / Evangelos Giamarellos-Bourboulis, Greece

Reviewer Board: tba

14:30 - 14:45   Early cardiovascular dysfunction drives in-hospital trauma deaths (R. Carden, United Kingdom)

14:45 - 15:00   Unfolded protein response in traumatic hemorrhagic shock improved blood circulation and relieved organ injury (A. Luís, Austria)

15:00 - 15:15   Does metabolic endotoxemia play a role in the insulin-resistance, steatohepatitis and proteinuria caused by high-fat diet in mice? (S. Mohammad, United Kingdom)

15:15 - 15:30   Abdominal sepsis is associated with stronger host response aberrations when compared with sepsis caused by community-acquired pneumonia (H. Peters-Sengers, Netherlands)

15:30 - 15:45   Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis (L. Tian, China; presented by Xiao-yuan Ma, off scoring)

16:00 – 20:00 City Tour

20:00 – 23:30 Dinner / Informal Discussions