7:00 PM

Conference Registration

8:00 PM

Welcome Reception/Dinner

7:30 AM

Breakfast

9:00 AM

Welcome and Opening Remarks

Session I

Inflammation

Chairs: Peter Garred and Triantafyllos Chavakis

9:05 AM

1

Therapeutic regulation of thromboinflammation induced by biosurfaces

Bo Nilsson

9:35 AM

2

Natural and artificial biosurfaces as coagulation and complement crosstalk platforms

Markus Huber-Lang and Rebecca Wiegner

10:05 AM

3

Del-1, an inhibitor of intravascular inflammation

Triantafyllos Chavakis

10:35 AM

4

Generation of biomarkers in dialysis treatment – focus on blood cascade systems and microparticles

Bengt Fellström, Inga Soveri, PhilipdeLaval, Liina Vassil, Kristina Nilsson, and Bo Nilsson

11:05 AM

5

The lectin complement pathway in patients with necrotizing soft tissue infection

Marco Hansen, Lars Rasmussen, Katrine Pilely, Dorthe Hellemann, Estrid Hein, Martin Hansen, Ole Hyldegaard, and Peter Garred

11:35 AM

Coffee Break

Session II

Experimental models

Chairs: Marianne Jensen-Waern and Katarina LeBlanc

12:00 PM

6

Protection of the vascular wall in kidney transplantation

Sofia Nordling, Johan Brännström, Fredrik Carlsson, Bo Lu, Evelyn Salvaris, Alkwin Wanders, Sergio Estrada, Vladimir Tolmachev, Peter Cowan, Tomas Lorant, and Peetra Magnusson

12:30 PM

7

Complement involvement in experimental AMD

Camilla Mohlin, Kerstin Sandholm, and Kristina N Ekdahl

12:50 PM

8

Properdin binding to MPO, HUVECs and Neisseria meningitidis is mediated by initial C3b-deposition where modelling shows that properdin TSR5 binds C345C in the C3b moiety for stabilization of the alternative pathway complement convertase

Morten Harboe, Christina  Johnson, Stig Nymo, Karin Ekholt, Camilla Schjalm, Julie Lindstad, Anne Pharo, Bernt Christian Hellerud, Kristina Ekdahl, Tom Eirik Mollnes, and Per Nilsson

1:20 PM

9

Pigs in transplantation research

Marianne Jensen-Waern

1:50 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

7:30 AM

Breakfast

Session III

Surfaces 1

Chairs: Ian Nicholls and Duncan Sutherland

9:00 AM

10

The functional link between protein adsorption and hemocompatibility

Kristina Ekdahl

9:30 AM

11

Role of nanoscale ligand distribution on monocyte adhesion to ICAM1 presenting surfaces

Duncan Sutherland, Andreas Andersen, and Xingyu Jiang

10:00 AM

12

Gene silencing and immune activation

Jons Hilborn, Oommen Varghese, and Oommen Podiyan

10:30 AM

13

Modulating acute immune responses to biomaterial-induced inflammation

John Hayball

11:00 AM

14

Towards hierarchical biomaterial architectures: synthetic polymer-based biomimetic materials and biohybrids

Ian Nicholls

11:30 AM

Coffee Break

Session IV

Transplantation

Chairs: Peter Cowan and Yuji Teramura

12:00 PM

15

Bringing mesenchymal stem cells into the clinic

Katarina Le Blanc

12:30 PM

16

Multicomponent microcapsules for islets transplantation – tuning their properties towards a low-inflammatory surface by assessments in a human whole blood model

Anne Mari Rokstad, Abba Elisabeth  Coron, Duzana Trelova, Filip Ràzga, Veronica Nemethova, Petra Mazancova, Zuzana Kronekova, Enza Marchese, James McGarrigle, Mustafa Omami, Igor Lacìk, and Jose Oberholzer

1:00 PM

17

Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation

Ioannis Kourtzelis, Klara Kotlabova, Jong-Hyung Lim, Ioannis Mitroulis, Anaisa Ferreira, Lan-Sun Chen, Bettina  Gercken, Anja Steffen, Elisabeth Kemter, Anne Klotzsche-von Ameln, Claudia Waskow, Kavita Hosur, Antonios  Chatzigeorgiou, Barbara Ludwig, Eckhard Wolf, George  Hajishengallis, and Triantafyllos Chavakis

1:20 PM

18

Different approaches to neutralizing complement in transplantation

Peter Cowan

1:50 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

7:30 AM

Breakfast

Session V

Surfaces 2

Chairs: Kristina Nilsson Ekdahl and Dimitris Mastellos

9:00 AM

19

Hydrogels based on gelatin and hyaluronic acid derivatives for monocyte encapsulation and phenotype control

Nihal Vrana, Philippe Lavalle, Lucie Wolfova, Julie Bystronova, Ivana Ščigalková, Martin Pravda, and Vladimir Velebny

9:20 AM

20

Nanoengineered plasma polymer films for controlling physiological processes including immune response

Krasimir Vasilev

9:50 AM

21

Immunomodulation of monocytes by self-crosslinked PLL/HA-Aldehyde derivative polyelectrolyte multilayer based coatings

Helena Knopf-Marques, Sonali Singh, Lucie Wolfova, Radovan Buffa , Amir Ghaemmaghami, Nihal Vrana, and Philippe Lavalle

10:11 AM

22

Heparinization of human MSC and hepatocyte with a short peptide-conjugated PEG-lipid for regulation of thromboinflammation

Yuji Teramura, Sana Asif, Kristina Ekdahl, Elisabet Gustafson, Katarina Le Blanc, and Bo Nilsson

10:40 AM

23

Bioactive coating system with self-antimicrobial and immunomodulatory properties

Philippe Lavalle, Angela Mutschler, Hayriye Ozcelik, Schaaf Pierre, and Engin Nihal Vrana

11:10 AM

24

Design of biointerphase responses of venous access devices by the Bactiguard® coating

Javier Sanchez, Erika Södergren, and Mattias Ohrlander

11:40 AM

25

Keep quiet! – Preventing endothelial activation in ischemia/reperfusion injury and xenotransplantation

Robert Rieben

12:10 PM

Lunch and Informal Discussions

3:00 PM

City tour

7:30 PM

Dinner and Informal Discussions

7:30 AM

Breakfast

Session VI

Nanoparticles

Chairs: Moein Moghimi and Jöns Hilborn

9:00 AM

26

The art of nanoparticle engineering: Taming innate immunity

Moein Moghimi

9:30 AM

27

Chondroitin Sulfate derived nanoparticles: Overcoming challenges of cancer nanomedicine

Oommen Oommen and Jöns Hilborn

10:00 AM

28

Assembly and activation of complement pathways on nanoparticle surface: lessons from iron oxides

Dmitri Simberg, Guankui  Wang, Nirmal Banda, Fangfang  Chen, and S Moein Moghimi

10:30 AM

Coffee Break

Session VII

Drugs/Mechanism

Chairs: Peetra Magnusson and Oomen Oomen

11:00 AM

29

Generation of an alternative pathway convertase by contact-activated C3 on a material surface is dependent on the conformation of C3 and on the binding of properdin

Karin Fromell, Yi Yang, Mattias Berglin, Hans Elwing, Kristina Ekdahl, and Bo Nilsson

11:20 AM

30

Targeting Factor XIIa – potential for safe anticoagulation

Magnus Larrson, Veronika  Rayzman, Marc Nolte, Katrin Nickel, Jenny Bjorkqvist, Anne Jamsa, Matthew Hardy, Marion Fries, Stefan  Schmidbauer, Patricia Hedenqvist, Michael Broome, Ingo Pragst, Gerhard Dickneite, Michael Wilson, Andrew Nash, Con Panousis, and Thomas Renne

11:50 AM

31

Compstatin CP40 (AMY-101): A C3-targeted complement inhibitor reaching its prime for bedside intervention

John Lambris, Edimara Reis, Hongbin Wang, Markus Huber-Lang, Martijn van Griensven, Bo Nilsson, Kristina  Nilsson-Ekdahl, Richard Smith, Dimitrios Mastellos, Margaret Lindorfer, Ronald Taylor, Laura Evgin, Evlambia  Hajishengallis, George Hajishengallis, Despina Yancopoulou, Antonio Risitano, and Daniel Ricklin

12:20 PM

32

NN from the Swedish MPA Legislation 

TBD

12:50 PM

Closing Remarks

1:00 PM

Lunch and Informal Discussions

9:00 PM

Farewell Dinner and Informal Discussions

7:30 AM

Breakfast

10:00 AM

Departure