|
May 27 |
|
|
Conference Registration |
6:30PM - 7:30 PM |
|
Welcome Reception and Dinner |
7:30PM - 10:30 PM |
|
|
|
|
May 28 |
|
|
Breakfast |
8:00AM-9:00 AM |
|
|
|
|
Session I： Stromal osteoimmunology Chairs: Hiroshi Takayanagi & Iannis Adamopoulos |
9:00AM-11:00 AM |
|
|
|
|
9:00AM-9:30AM: Vascular Regulation of Immune System Aging Anjali Kusumbe 9:30AM-10:00AM:Regulation of bone turnover and hematopoiesis by bone marrow adipoprogenitors Ling Qin 10:00AM-10:30AM: TBA Adam P Croft 10:30AM-11:00AM: Gas or Brake: Inflammatory bone resorption and a novel osteoclastic niche Baohong Zhao |
|
|
|
|
|
Coffee Break / Poster Viewing |
11:00AM-11:30 AM |
|
|
|
|
Session II :Diversity in the bone marrow and stem cells Chairs: Hiroshi Takayanagi & Iannis Adamopoulos |
11:30AM-1:20PM |
|
|
|
|
11:30AM-12:00PM: Skeletal stem cells governing site-specific pathology in the spine and beyond Matthew Greenblatt 12:00 PM -12:20 PM: The stromal defense against cancer invasion by the periosteum Masayuki Tsukasaki 12:20 PM -12:40 PM: Clec3b+ fibroadipogenic progenitors in fracture healing and heterotopic ossification Ugur Ayturk 12:40PM-1:00PM: Bone marrow endosteal stem cells coordinate active osteogenesis and tumorigenesis in young bones Yuki Matsuhita 1:00PM-1:20PM: Clearing human bone marrow reveals spatial heterogeneity of the stromal niche Tsz Long Chu |
|
|
|
|
|
Lunch and Informal Discussions |
1:30 PM |
|
Dinner and Informal Discussions |
7:30 PM |
|
|
|
|
May 29 |
|
|
Breakfast |
8:00AM-9:00 AM |
|
|
|
|
Session III : Big data-driven deconvolution Chairs: Natalie Sims & Georg Schett |
9:00AM-11:00 AM |
|
|
|
|
9:00AM-9:30AM: Identification of Age-associated T (ThA) cells that increase with aging and possess both cytotoxic activity and B cell helper function Keishi Fujio 9:30AM-10:00AM:Tissue resident monocytic cells act as guardian for the synovium Harris Perlman 10:00AM-10:20AM:Quantification of the escape from X chromosome inactivation with the million cell-scale human single-cell omics datasets reveals heterogeneity of escape across cell types and tissues Yoshihiko Tomofuji 10:20AM-10:40AM: Characterization of the secretory lysosome reveals new regulators of osteoclast function and endolysosomal homeostasis Nathan Pavlos 10:40AM-11:00AM: Can AI be used to write credible scientific review articles? Melissa Kacena |
|
|
|
|
|
Coffee Break / Poster Viewing |
11:00AM-11:30 AM |
|
|
|
|
Session IV: New discoveries in disease pathogenesis Chairs: Natalie Sims & George Schett |
11:30AM-2:00PM |
|
|
|
|
11:30AM-12:00PM: Role of cytosolic DNA sensing pathways in autoimmunity and bone Ellen Gravallese 12:00PM-12:30PM: The role of macrophages and dendritic cells in shaping tissue niches during joint homeostasis, inflammation and disease remission Mariola Kurowska-Stolarska 12:30PM-12:50PM: Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis Aline Bozec 12:50PM-1:10PM: Advances in imaging approaches to study cell biology in bone Karl Lewis 1:10PM-1:30PM: Differential effects of the PTH-responsive citrate transporter SLC13A5 during growth and aging Naomi Dirckx |
|
|
|
|
|
Lunch and Informal Discussions |
13:30 PM |
|
Dinner and Informal Discussions |
7:30 PM |
|
|
|
|
May 30 |
|
|
Breakfast |
8:00AM-9:00 AM |
|
|
|
|
Session V: Aging and rejuvenating the osteoimmune system-1 |
9:00AM-11:00 AM |
|
|
|
|
9:00AM-9:30AM: Immune cell-mediated age-related osteoporosis Brendan F. Boyce 9:30AM-10:00AM:Preosteoclast-Secreted PDGF-BB in Skeletal Aging and Vascular Aging Mei Wan 10:00AM-10:30AM:Bone marrow-based inflammatory memory as a mechanistic basis for the comorbidity of arthritis and periodontitis George Hajishengallis 10:30AM-11:00AM:Use of medicinal secretory cells to alleviate pain and increase function in OA Hischam Drissi |
|
|
|
|
|
Coffee Break |
11:00AM-11:30 AM |
|
|
|
|
Session VI: Cutting edge |
11:30AM-1:00PM |
|
|
|
|
11:30PM-11:45PM: How does OPG limit vascular calcification? Yutaro Ando 11:45PM-12:00PM: A novel macrophage subset promotes bone regeneration through the activation of Wnt signals in mesenchymal stromal cells. Zhifeng He 12:00PM-12:15PM: The osteoimmunology of bone metastasis: the roles of osteoblasts in regulation of anti-tumoral immunity Serkin Park 12:15PM-12:30PM: Novel Role of Megakaryocytes in Bones Anabolic Response to Loading Amy Creecy 12:30PM-12:45PM: Emerging roles of the long pentraxin PTX3 in Staphylococcus aureus-dependent osteomyelitis Valentina Possetti 12:45PM-1:00PM: Memory T cells impair progenitor and endothelial cell behavior during fracture healing via secretion of interleukin 5 Christian Bucher |
|
|
|
|
|
Informal Discussions / Lunch |
1:00 PM-3:00PM |
|
City Tour |
3:00 PM |
|
Dinner and Informal Discussions |
7:30 PM |
|
|
|
|
May 31 |
|
|
Breakfast |
8:00AM-9:00 AM |
|
|
|
|
Session VII: Aging and rejuvenating the osteoimmune system-2 |
9:00AM-11:00 AM |
|
|
|
|
9:00AM-9:30AM;Barriers to immune defense against new infections with aging Janko Ž. Nikolich 9:30AM-10:00AM:Targeting energy metabolic pathways as therapeutic intervention for osteoporosis Ha-Neui Kim 10:00AM-10:20AM: Type 2 inflammation and associated diseases Yihong Wan 10:20AM-10:40AM: Inflammation and osteoblastic differentiation govern the commitment of hBMSCs toward bone regeneration Nathalie Chevallier 10:40AM-11:00AM: De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis David Sandor Gyori |
|
|
|
|
|
Coffee Break / Poster Viewing |
11:00AM-11:30 AM |
|
|
|
|
Session VIII: Upcoming |
11:30AM-1:30PM |
|
|
|
|
11:30AM-11:45PM:Biomaterial-modulated osteoclastogenesis in bone regeneration Liline Fermin 11:45PM-12:00PM: Osteoimmunology: why peri-implantitis should be regarded as an immune disease Joseph Choukrou 12:00PM-12:15PM: B cells regulate bone remodeling in a Fra-2/AP-1 dependent manner Bettina Groetsch 12:15PM-12:30PM: Estrogen loss postpartum activates low grade chronic inflammation: Implications and consequences Rajeev Aurora 12:30PM-12:45PM:The NLRP3 inflammasome is tightly regulated in the osteoclast cell lineage to avoid unnecessary osteolysis Khushpreet Kaur 12:45PM-1:00PM:Immunization-induced immune experience leads to altered local peptide patterns in bone and modulates fracture healing Ann-Kathrin Mess 1:00PM-1:15PM: Retrotransposon-derived dsRNAs trigger osteoblast mineralization via a paracrine, PKR-mediated, sterile inflammatory response Arianna Mangiavacchi 1:15PM-1:30PM:Notch signaling modulates human osteoclast progenitor differentiation and activity in patients with rheumatoid arthritis Danka Grcevic |
|
|
|
|
|
Lunch and Informal Discussions |
1:30 PM |
|
Farewell Dinner |
8:00 PM |
|
|
|
|
June 1 |
|
|
Breakfast |
7:30 AM |
|
Departure |
|
Poster
1. Evidence for accelerated immune aging in sclerostin-deficient mice
Nastaran Abbasizadeh, Christian Burns, Joel Spencer, and Jennifer Manilay
2. How the adaptive immunity change the differentiation capacity of mesenchymal stromal cells
Radost Sass,Christian Bucher, Georg Duda, and Katharina Schmidt-Bleek
3. Reduced DNA content of virus-derived genetic elements as a novel biomarker for osteoporosis
Arianna Mangiavacchi, Gabriele Morelli, Sjur Reppe, Alfonso Saera-Vila, Kaare Gautvik, and Valerio Orlando
4. Thrombotic events in inflammatory rheumatological diseases
Antigoni Soufla
5. Infection with SARS-CoV-2 differentially impacts bone loss and subsequent bone gain based on site examined and sex
Olatundun Awosanya, Christopher Dalloul, Tyler Hesselbrock, Sarah Mostardo, Rachel Blosser, Sonali Karnik, Karen Boschen, Michael Klemsz, Nancy Johnston, Alexandru Movila, and Melissa Kacena
6. CD31+ immune cells from peripheral blood a cell therapeutic approach to boost bone healing
Marie Mohn, Sevim Yanc, Katharina Schmidt-Bleek, and Georg Duda
7. Sex- and age-dependent effects of megakaryocyte secreted factors on endothelial cell properties
Rachel Blosser, Murad Nazzal, Hanisha Battina, Nikhil Tewari, Sarah Mostardo, Rohit Nagaraj, Donghui Zhou, Olatundun Awosanya, Saveda Majety, Sue Samson, Patrick Mulcrone, Ushashi Dadwal, and Melissa Kacena
8. The Role of FOXO3a in Odontogenic Differentiation of Human Dental Pulp Cells
Su-Kyung Son, Jung-Sun Moon, Jihye Kang, Nari Cheong, Sun-Hun Kim, and Min-Seok Kim
9. Modulating Notch signaling alters osteoclast activity and differentiation in murine collagen-induced arthritis: Insights into arthritis-induced bone loss
Maša Filipović, Alan Šućur, Darja Flegar, Sara Aničić, Ozana Jakšić, Pavao Planinić, Tomislav Kelava, Sanja Novak, Katerina Zrinski Petrović, Ivo Kalajzić, Nataša Kovačić, and Danka Grčević
10. Stimulation of NCAM1-14.3.3.ζδ-derived Peptide Interaction Fuels Angiogenesis and Osteogenesis in Ageing
Taha Yesin and Anjali Kusumbe
11. Calcium phosphate with submicron topography influences primary human macrophage response, enhancing downstream angiogenesis and osteogenesis in vitro
Lukas van Dijk, Lizette Utomo, Huipin Yuan, Florence Barrère -De Groot, Debby Gawlitta, Antoine Rosenberg, and Joost De Bruijn
12. Consequences of total body irradiation on immune-skeletal axis in mice
Tibor Sághy, Priti Gupta, Karin Horkeby, Ifrah Samater, Petra Henning, Hans Carlsten, Andrei Chagin, and Cecilia Engdahl
13. Investigation of the Hyaluronan-rich Matrix in Bone Marrow Adipose Tissue during the development and progression of Type 2 Diabetes Mellitus.
Katja Heller, Maren Döring, Laura-Marie Lahu, Oliver Steinhoff, Tim Seher, Stefan Lehr, Sonja Hartwig, Ulrich Flögel, Jens Fischer, and Maria Grandoch
14. Role of FOXO3a in LPS-induced inflammatory conditions in human dental pulp cells
Su-Kyung Son, Jung-Sun Moon, Jihye Kang, Nari Cheong, Min-Seok Kim, and Sun-Hun Kim
15. A Single Administration of High-Dose Erythropoietin Induces Bone Loss in Mice
Anton Gorodov, Albert (Alex) Kolomansky, Michelle Piper, Lior Lezerovich, Nathalie Ben-Califa, Yankel Gabet, and Drorit Neumann
16. Transcriptional Profiling reveals anti-anabolic Mechanisms of Progranulin Action on Bone Progranulin, macrophage, anti-anabolic mechanism, osteogenesis, Transcriptional profiling
Liping Wang, Vikrant Piprode, Mary Nakamura, and Robert Nissenson
17. Analysis of individual Osteoclasts reveals an elevated intrinsic Osteoclast Activity in RA Patients with inflamed Joints
Antonio Maccataio, Georg Schett, and Ulrike Steffen
18. Regulation of lysosomal trafficking in osteoclasts by RUFY4
Minhee Kim, Jihee Kim, Hana Park, and Soo Young Lee
19. Rapid immunostaining and high-resolution light-sheet imaging of intact calcified tissues
Hanyu Liu and Anjali Kusumbe
20. The effect of T cell mediated inflammation post estrogen loss on cortical bone porosity
Di Wu, Anna Cline-Smith, Deborah Veis, and Rajeev Aurora
21. Development of a combined deep learning-based segmentation and batch processing workflow for improved 3D bone microstructural assessment
Daniela Weidner, Oliver Aust, Tor Hildebrand, Peter Suter, Georg Schett, and Stefan Uderhardt
22. sCD14-ST and related osteoimmunological biomarkers: a new diagnostic approach to osteomyelitis
Emanuela Galliera, Luca Massaccesi, Elena DeVecchi, Antonio Pellegrini, and Massimiliano Corsi Romanelli
23. Phospholipase C beta 4 controls RANKL-mediated osteoclastogenesis through its interaction with MKK3 and p38
Hyun-Ju Kim, Dong-Kyo Lee, Xian Jin, Poo-Reum Choi, Ying Cui, Xiangguo Che, and Je-Yong Choi
24. Enhancing multi-modal bone imaging through correlative analysis: a unified approach
Sabrina Pechmann, Tor Hildebrand, Peter Suter, Dennis Possart, George Sarau, Stefan Udehardt, Oliver Aust, Andreas Maier, Georg Schett, Mareike Thies, and Silke Christiansen