8th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets

Preliminary Program

SCHEDULE

Each session will consist of invited talks (20+5 for Q&A) and some short talks (12+3 Q&A), selected from abstracts.

Day 1-Monday, September 26, 2022

Conference Registration:   6:00-8:00pm    Hotel Lobby

Welcome Reception: Dinner 8:00pm

Day 2-Tuesday, September 27, 2022

7:30am       Breakfast

9:00     Costas Koumenis, UPenn                                          Opening remarks

Session I (9:05am- 10:45 am): TME, Metastasis and Tumor Dormancy

Chair: Costas Koumenis/Ashi Weeratna

9:05     Ashani Weeratna, Johns Hopkins      “Age against the machine: how aging impacts tumor progression 

9:30      Julio Aguirre-Ghiso, Einstein    “Targeting Dormant Tumor Cells”

9:55      Soledad Sosa, Mt. Sinai   “NR2F1 and Maintenance of Tumor Dormancy”

10:20    Costas Koumenis, U. Penn   “The Integrated Stress response in tumor progression and    

                                                           metastasis”

Keynote lecture

Introduction: Sandra Ryeom

10:45  William Kaelin, DFCI       Oxygen sensing

11:30 Coffee Break-Discussions & Poster Viewing (11:30 am-12:20 pm)

Session II (12:20-1:35): Hypoxia, HIF and the TME

Chair: Sandra Ryeom

12:20 James Nathan, Cambridge University  “Regulation of HIF response at chromatin”    

12:45  Erinn Rankinn, Stanford   “Synthetic lethality between VHL and RNA demethylase FT0”

1:10 Kasper Rouschop, Maastricht University    “Hypoxia-derived EVs and angiogenesis”

1:35 pm      Lunch/informal discussions

7:30pm       Dinner/Informal Discussions

Day 3-Wednesday, September 28, 2022

7:30am     Breakfast

Session III (8:30-10:25 AM): Therapeutic Targeting, Immune Evasion and Plasticity

Chair: Soledad Sosa

8:30  Amir Abdollahi, U. Heidelberg    “Reprogramming the TME for an in-situ tumor vaccine”

8:55 Michael Horsman, Aarhus U. “Combination therapy: ICB, vascular disruption and hyperthermia”

9:20 Ravi Amaravadi, U. Penn       “Lysosomal targeting and resistance”

9:45 Shiv Singh, U Goettingen  “Pancreatic cancer and response to therapy”

10:10 Deyu Fang, Northwestern (short talk) “Deubiquitination and Tregs”

Coffee Break-Discussions & Poster Viewing (10:25 am-11:10 am)

Session IV (11:10-12:25): Genome Integrity

Chair:  Ester Hammond

11:10  Robert Bristow, U. Manchester “Hypoxia and Tumour Genomics” 

11:35 Martin Eilers, U. Wuerzburg     “MYC oncoproteins and genomic stability” 

12:00 PM  Lilie Lin, MDACC (short talk ) “PARP Expression in Patients with DNA Damage 

                                                                  Response Pathway Mutations” 

Session V (12:15-1:30): Novel Targets in the TME

Chair: Natasha Kyprianou

12:15 Sandra Ryeom, Columbia University   “Nervous system innervation in gastric cancer”

12:40 Artemis Hatzigeorgiou,  U. Thessaly    “miRNA functional analysis”

1:05 Katherine Cook, Wake Forest (short talk) “The microbiome and breast cancer”

1:20 Special Session:Alexia-Ileana Zaromytidou, Nature Cancer Editor

1:40 pm      Lunch/informal discussions

7:30pm       Dinner/Informal Discussions

Day 4-Thursday, September 29, 2022

7:30am   Breakfast

Session V (8:30am- 10:35pm) UPR and Stress Responses                      

Chair:  Ravi Amaravadi

8:30 Linda Hendershot, St. Jude’s  “Molecular Signature of Dilated Endoplasmic Reticulum in Osteosarcoma”

8:55 Ronald Wek, Indian University        “The eIF2 kinase GCN2 in translational control and stress adaptation”

9:20 Susan Logue, University of Manitoba  “Crosstalk between UPR Mediators”

9:45 Kirk Staschke, Indiana U  “GCN2, Prostate Cancer and preservation of amino acids”

10:10 Natasha  Kyprianou, Mt. Sinai  “Prostate cancer reprogramming and therapeutic resistance”

Coffee Break-Discussions & Poster Viewing (10:35 am-11:25 am)

Session VI (11:25-1:30) Metabolism, Epigenetics and the TME

Chair: Susan Logue

11:25 Ben Stanger, U Penn  “Metabolic Heterogeneity and therapeutic targets”

11:50 Colin Goding, Oxford    “Tumor Cell Plasticity and therapeutic responses”

12:15 Apostolos Klinakis, Athens Academy         “KMT2C loss and Bladder Cancer”

12:40 Joel Encarnacion Rosado, NYU (Short Talk)Glutamine dependencies in PDAC”

12:55 Dennis Vitkup, Columbia University (Short Talk) “The Role of environmental lipids when electron acceptors are limited in cancer”

1:10 pm      Lunch/informal discussions

CITY TOUR

7:30pm       Dinner/Informal Discussions

Day 5-Friday, September 30

7:30am       Breakfast

Session VII (8:30am- 10:40pm) Radiation Resistance and Sensitization

Chair: Michele Kim

8:30 Alexander Lin, U Penn “HIV protease inhibitor as Hypoxic Radiosensitizer in Head and Neck Cancer”

8:55 Ester Hammond, Oxford   “Hypoxia-induced ROS and R loop accumulation”

9:20 Ramesh Rengan, U. Washington  “Radiation and Immune modulation in Lung Cancer”

9:45 Chandan Guha, Einstein   “Immune Priming using low energy focused ultrasound (LOFU)” 

10:10 Jian-Jian Li  UC Davis (short talk)  TBD

10:25 Kyriakos Fotiou, Cyprus (Short talk)  “Lung Cancer and Proton Therapy”

Coffee Break-Discussions & Poster Viewing (10:40 am-11:20 am)

Session VIII (11:20-1:25 ) Latest developments in Radiotherapy-FLASH Radiation

Chair: Lilie Lin

11:20 Jim Metz, U Penn             “FLASH Radiation in the Clinics”

11:45  Michele Kim, U Penn    “In Vivo Proton FLASH Radiation”

12:10 Billy Loo, Stanford  “FLASH Abdominal Irradiation” 

12:35  Andrew Minchinton, U. British Columbia  “Flash Radiation and 3D spheroids”      

1:00 PM Closing remarks:  Ester Hammond, Oxford

1:10 pm     Lunch/informal discussions

7:30pm     Farewell Gala Dinner

Day 6–Saturday October 1

7:00am     Breakfast

9:00am     Departure

If your abstract is not listed above, then it has been accepted for a poster presentation