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Sunday, June 3 |
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6:00 PM |
Conference Registration |
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8:00 PM |
Welcome Reception and Dinner |
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Monday, June 4 |
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8:00 AM |
Breakfast |
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9:00 AM |
Welcome and Opening Remarks |
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SESSION I |
Bone Marrow Niches Chairs: TBA |
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9:15 AM |
1 |
Regulation of immune cell bias by aging HSC niches Paul Frenette |
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9:45 AM |
2 |
Bone marrow niches, inflammatory hematopoiesis and osteoclasts Claudine Blin-Wakkach |
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10:15 AM |
3 |
The role of MyoD Family Inhibitor (Mdfi) in the maintenance of hematopoietic stem cells and lineage commitment Jeremy Houser, Marta Onopuik, Vasyl Nesin, Leo Tsiokas, and Mary Beth Humphrey |
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10:30 AM |
4 |
Macrophages are key effectors of neurogenic heterotopic ossification following spinal cord injuries Jean-Pierre Levesque |
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11:00 AM |
Coffee Break and Poster Viewing |
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SESSION II |
Bone and Tumor Microenvironment Chairs: TBA |
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12:00 PM |
5 |
The bone marrow stromal niche: An instigator and a therapeutic target of hematological myeloid malignancies Stavroula Kousteni |
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12:30 PM |
6 |
Using accelerator mass spectrometry to study bone metastasis and tumor microenvironment Gabriela Loots |
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1:00 PM |
7 |
Regulation of Macrophage-Osteoclast Polarization Yihong Wan |
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1:30 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Tuesday, June 5 |
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8:00 AM |
Breakfast |
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SESSION III |
Osteoclast Differentiation Chairs: TBA |
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9:00 AM |
8 |
MicroRNAs control osteoclastogenesis and bone remodeling Baohong Zhao |
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9:30 AM |
9 |
A combination of key transcription factors defines the chromatin landscape during RANKL-induced osteoclastogenesis Sakae Tanaka |
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10:00 AM |
10 |
STAT1/3 signaling in osteoclastogenesis and the process of corticalisation Natalie Sims |
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10:30 AM |
11 |
The C-type lectin receptor Mincle controls osteoclast-induced bone remodeling by sensing necrotic osteocytes Darja Andreev, Barbara Killy, Maria Faas, Ulrike Harre, Wolfgang Baum, Gerhard Krönke, Roland Lang, Georg Schett, and Aline Bozec |
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10:45 AM |
Coffee Break and Poster Viewing |
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SESSION IV |
Osteoimmunology and Joint Disease Chairs: TBA |
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11:45 AM |
12 |
The role of the IL-23/IL-17 immune pathway in structural damage in inflammatory arthritis Erik Lubberts |
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12:15 PM |
13 |
NK cells have distinct roles in the joint and gut pathology of ankylosing spondylitis Lynett Danks, Sarah Wythe, Adel Ersek, Thibault Griseri, Fiona McCann, and Nicole Horwood |
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12:45 PM |
14 |
Bone-damaging T cells and host defense Hiroshi Takayanagi |
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1:15 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Wednesday, June 6 |
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8:00 AM |
Breakfast |
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SESSION V |
New Concepts Chairs: TBA |
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9:00 AM |
15 |
Novel mechanisms in Innate Immunity Richard Flavell |
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9:30 AM |
16 |
Osteoblast production of SLIT3 controls skeletal CD31hiEMCNhi vascular endothelium and bone formation Ren Xu, Baohong Zhao, Jason Butler, Laurie Glimcher, and Matthew Greenblatt |
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9:45 AM |
17 |
Targeting fundamental aging mechanisms to treat osteoporosis Sundeep Khosla |
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10:15 AM |
Coffee Break and Poster Viewing |
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SESSION VI |
Microbiota and Bone Chairs: TBA |
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11:15 AM |
18 |
The microbiota, a novel regulator of bone health and disease. Roberto Pacifici |
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11:45 AM |
19 |
IGF-1: connecting microbiome and bone Julia Charles |
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12:15 PM |
20 |
Diabetes increases IL-17 to alter the oral microbiome and increase periodontal bone loss Dana Graves |
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12:45 PM |
21 |
The microbiome influences bone strength and tissue material properties Christopher Hernandez |
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1:15 PM |
Lunch and Informal Discussions |
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3:30 PM |
City Tour |
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7:30 PM |
Dinner and Informal Discussions |
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Thursday, June 7 |
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8:00 AM |
Breakfast |
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SESSION VII |
New Developments in Innate Immunity Chairs: TBA |
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9:00 AM |
22 |
Development and ageing of vascular niches in bone Anjali Kusumbe |
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9:30 AM |
23 |
Autophagy in bone marrow-resident immune cells Anna Katharina Simon |
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10:00 AM |
24 |
Origins of Osteoclasts Frederic Geissmann |
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10:30 AM |
25 |
TBD |
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11:00 AM |
Coffee Break and Poster Viewing |
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SESSION VIII |
Short Talks Chairs: TBA |
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11:45 AM |
26 |
The glucocorticoid receptor (GR) in stromal cells reduces inflammation in arthritis by steroid treatment, whereas GR in immune cells reduces osteophyte formation Jan Tuckermann, Mascha Koenen, Stephan Culemann, Sabine Vettorazzi, Wolfgang Baum, Gerhard Krönke, and Ulrike Baschant |
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12:00 PM |
27 |
PTH improved immunodeficiency through osteoblast activation Asuka Terashima, Kazuo Okamoto, and Hiroshi Takayanagi |
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12:15 PM |
28 |
Bifunctional role of Ostm1 in osteoclast maturation Monica Pata and Jean Vacher |
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12:30 PM |
29 |
miR-146a a key player in bone metabolism Victoria Saferding, Melanie Hofmann, Julia Brunner, Mihaela Militaru, Antonia Puchner, Silvia Hayer, Melanie Timmen, Richard Stange, Josef Smolen, and Stephan Blüml |
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12:45 PM |
30 |
Targeted depletion of mature B cells induces bone loss in young mice Albert Kolomansky, Naamit Deshet-Unger, Alina Ostrovsky, Nathalie Ben-Califa, Sahar Hiram-Bab, Tamar Liron, Howard Oster, Moshe Mittelman, Yankel Gabet, and Drorit Neumann |
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1:00 PM |
31 |
LIGHT/TNFSF14 deficiency impairs basal bone remodeling Giacomina Brunetti, Sara Bortolotti, Giuseppina Storlino, Graziana Colaianni, Paolo Pignataro, Lindsay Ward Kavanagh, Carl Ware, Janne Reseland, Silvia Colucci, and Maria Grano |
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1:15 PM |
32 |
Why do sex hormones control bone loss? Josef Penninger |
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1:45 PM |
Closing Remarks |
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1:50 PM |
Lunch and Informal Discussions |
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8:00 PM |
Farewell Dinner |
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Friday, June 8 |
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8:00 AM |
Breakfast |
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10:00 AM |
Departure |
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POSTERS |
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33 |
Association of Mitochondrial DNA Copy Number with Disease Activity in Rheumatoid Arthritis Jihyung Yoo, Mi-kyoung Lim, Donghyuk Sheen, and Soon Kim |
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34 |
The stability of rheumatoid factor and anti-ccp antibody in archived samples of blood |
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35 |
Serum exosomal microRNA-1915-3p is correlated with disease activity of rheumatoid arthritis Jihyung Yoo, Mi-Kyoung Lim, Jukyoung Song, and Soon Ae Kim |
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36 |
Efficacy of Human Monoclonal Antibody (Denosumab) On Bone Mineral Density in Postmenopausal Osteoporosis Corina Galesanu |
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37 |
Corylifol C inhibits RANKL-induced osteoclast differentiation Jung Yun Kang, Inik Chang, and Dong Min Shin |
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38 |
Diagnostic and prognostic value of presepsin as marker of post-operative orthopaedic joint prosthesis infection Emanuela Galliera, Monica Marazzi, Filippo Randelli, Marco Brioschi, Lorenzo Drago, Carlo Romanò, Giuseppe Banfi, Luca Massaccesi, Calogero Crapanzano, Franca Morelli, and Massimiliano Corsi Romanelli |
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39 |
Development of a fluorescence-based osteoclast fusion assay András Erdélyi, Dániel Csete, Edina Simon, Áron Pánczél, Simon Nagy, Gergő Bordács, Kristóf Csorba, Zoltán Jakus, and Attila Mócsai |
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40 |
Targeting fundamental aging mechanisms to treat osteoporosis Sundeep Khosla |
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41 |
Plasma High-Resolution Metabolomics identifies unique Metabolites and Metabolic Pathways associated with Bone Health and the Gut Microbiome Moriah Bellissimo, Thomas Ziegler, Roberto Pacifici, and Jessica Alvarez |
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42 |
Host defense system against bacterial infection by the osteoimmune crosstalk Masayuki Tsukasaki, Noriko Komatsu, Warunee Pluemsakunthai, Toshihiko Suzuki, and Hiroshi Takayanagi |
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43 |
Hypoxia-sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Osteoclast Precursors and Suppresses Osteoclastogenesis Koichi Murata, Chikashi Terao, Hiromu Ito, Koichiro Ohmura, Tsuneyo Mimori, Shuichi Matsuda, Kyung-Hyun Park-Min, and Lionel Ivashkiv |
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44 |
Blocking of OCL activity reverses systemic inflammation and reduces myeloid skewing in inflammatory bowel disease Lidia báñez, Agathe Boucoiran, Matthieu Rouleau, Claudine Blin-Wakkach, and Abdelilah Wakkach |
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45 |
RANKL, a Disease Modifier in inflammatory Arthritis Maria Papadaki, Vagelis Rinotas, Foteini Violitzi, Martina Samiotaki, George Panayotou, and Eleni Douni |
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46 |
Bone Marrow Adipose Tissue (BMAT) in modeled Osteoporosis Vagelis Rinotas, Efthymios Tzortzis, Panagiota Siatra, Anthi Kolokotroni, Maria Papadaki, and Eleni Douni |
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47 |
Role of innate immune signaling adapter protein DAP12 in high fat diet induced osteoarthritis in mice Evangelia Kalaitzoglou, Erika Barboza, Yao Fu, Jacquelyn Herron, Josiah Flaming, Elise Donovan, Adrian Filiberti, Timothy Griffin, and Mary Beth Humphrey |
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48 |
TRPC1 ion channel regulates calcium sensing receptor and PTH receptor responses Marta Onopuik, Bonnie Eby, Vasyl Nesin, Peter Ngo, Maria Luisa Brandi, Wenhan Chang, Kai Lau, Leonidas Tsiokas, and Mary Beth Humphrey |
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49 |
Non-clonal elevation of serum immunoglobulin total free light chains is predictive of hip fracture in both women and men Shreyasee Amin, Elizabeth Atkinson, Sara Achenbach, Angela Dispenzieri, Robert Kyle, and S. Vincent Rajkumar |
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50 |
Pasteurized Akkermansia muciniphila induces bone-loss in the femur of gonadal intact mice. Lina Lawenius, Julia Scheffler, Petra Henning, Karin Gustafsson, Karin Nilsson, Hannah Colldén, Ulrika Islander, Willem de Vos, Patrice Cani, Hubert Plovier, Claes Ohlsson, and Klara Sjögren |
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51 |
New Approach for Cell Sorting and FACS Analysis on Osteoclasts Maria-Bernadette Madel, Lidia Ibáñez, Matthieu Rouleau, Abdelilah Wakkach, and Claudine Blin-Wakkach |
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52 |
Vector-mediated TCIRG1 expression rescues resorptive capacity of osteoclasts derived from autosomal recessive osteopetrosis patients Valentina Capo, Sara Penna, Elena Draghici, Lucia Sergi Sergi, Eleonora Palagano, Erika Zonari, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, and Anna Villa |
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53 |
Phosphorylation of S122 in ERα is dispensable for the physiological regulation of the Skeleton or the Immune System in Female Mice Karin Gustafsson, Helen Farman, Petra Henning, Vikte Lionikaite, Sofia Movéare-Skrtic, Klara Sjögren, Annica Andersson, Ulrika Islander, Angelina Bernardi, Claes Ohlsson, and Marie Lagerquist |
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54 |
Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1 Eleonora Palagano, Giulia Zuccarini, Paolo Prontera, Stefano Mantero, Ciro Menale, Antonella Forlino, Paolo Uva, Paolo Vezzoni, Anna Villa, Giorgio Merlo, and Cristina Sobacchi |
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55 |
Chondrogenically primed paediatric MSCs are immunomodulatory and do not exhibit immunogenic properties in vitro in an inflammatory micro-environment Virginia Palomares Cabeza, Janneke Witte-Bouma, Eppo Wolvius, Pieter Brama, Martin Hoogduijn, and Eric Farrell |
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56 |
Autophagy and Immune Aging Hanlin Zhang |
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57 |
Pasteurella multocida toxin manipulates the osteoclast metabolism Sushmita Chakraborty, Bianca Kloos, Florian Uhle, and Katharina Kubatzky |
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58 |
Osteoporosis in murine lupus Jauquline Nordqvist, Marie Lagerqvist, Louise Grahnemo, Ulrika Islander, and Hans Carlsten |
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59 |
Which cytokines affect periarticular bone loss? Cecilia Engdahl, Julia Scheffler, Karin Gustafsson, Louise Grahnemo, and Marie Lagerqvist |
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60 |
Longitudinal intravital imaging of the bone marrow (LIMB) - A window to bone regeneration and cellular dynamics in bone tissue Jonathan Stefanowski, David Reismann, Robert Günther, Asylkhan Rakhymzhan, Romano Matthys, Reto Nützi, Sandra Zehentmeier, Katharina Schmidt-Bleek, Georg Petkau, Hyun-Dong Chang, Sandra Naundorf, York Winter, Fritz Melchers, Georg Duda, Raluca Niesner, and Anja Hauser |
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61 |
Role of interleukin-9 on Synovial Regulatory T cells in Rheumatoid Arthritis Sushmita Chakraborty, Ranjan Gupta, Rinkee Kumari, and Dipendra Kumar Mitra |
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62 |
Modulation of arthritis by type 2 innate lymphoid cells Yasunori Omata |
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63 |
Preconditioning mesenchymal stem cells with factors secreted from macrophages regulates their osteogenic potential Gema Vallés, Francisco Mancebo, Fatima Bensiamar, Nuria Vilaboa, and Laura Saldaña |
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64 |
Immunomodulatory properties of mesenchymal stem cells primed with factors secreted from macrophages Laura Saldaña, Fátima Bensiamar, Francisco Mancebo, Gema Vallés, and Nuria Vilaboa |
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65 |
Lentiviral-mediated gene transfer of TCIRG1 to correct osteoclast function in Autosomal Recessive Osteopetrosis Sara Penna, Valentina Capo, Elena Draghici, Lucia Sergi Sergi, Eleonora Palagano, Erika Zonari, Francesca Ficara, Cristina Sobacchi, Bernhard Gentner, and Anna Villa |
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66 |
Phosphatidylserine exposure regulates osteoclast fusion and bone homeostasis Brenda Krishnacoumar, Carina Scherbel, Natacha Ipseiz, Martin Stenzel, Christina Böhm, Magdalena Czubala, Philip Taylor, Karl Kunzelmann, Martin Herrmann, Georg Schett, and Gerhard Krönke |
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67 |
Inhibitory effects of Puerariae radix extract on RANKL-mediated osteoclastogenesis Keun Ha Park, Dong Ryun Gu, Su Hyun Jin, Youn Chul Kim, and Seoung Hoon Lee |
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68 |
Alpha-Enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritis. Jae Seung Kang |
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69 |
Development of anti-inflammatory strategies for implant materials Hala Al-Khoury, Adrian Hautmann, Frank Erdmann, Guoying Zhou, and Thomas Groth |
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70 |
Dickkopf-1 (Dkk1) plays distinct pathogenic roles in estrogen-deficiency vs. glucocorticoid-induced bone loss Juliane Colditz, Sylvia Thiele, Ulrike Baschant, Lorenz Hofbauer, and Martina Rauner |
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71 |
Impact of the immune system on the development of osteochondromas Marie Wehenkel, Spencer Richardson, Peter Vogel, and Maureen McGargill |
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72 |
The Influence of L-Arginine Availability on Osteoclastogenesis Julia Brunner, Melanie Hofmann, Victoria Saferding, Alexander Lercher, Birgit Niederreiter, Paul Cheng, Gernot Schabbauer, and Stephan Blüml |
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73 |
Transcriptomic characterization of inflammatory and physiological osteoclasts emphasizes CX3CR1 as a marker of inflammatory osteoclasts Maria-Bernadette Madel, Lidia Ibáñez, Antoine Boutin, Christophe Hue, Matthieu Rouleau, Isabelle Duroux-Richard, Florence Apparailly, Gilles Chiocchia, Henri-Jean Garchon, Abdelilah Wakkach, and Claudine Blin-Wakkach |
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74 |
Effects of glucocorticoid excess on the osteohematopoietic niche Ulrike Baschant, Holger Henneicke, Martina Rauner, and Lorenz Hofbauer |
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75 |
Sustained effects of acute neonatal antibiotics on bone quantity and quality Damian Genetos and Melanie Gareau |
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76 |
Glucocorticoid treatment does not decrease bone mass in Wif1 knockout mice Julius Mühleisen, Michael Stock, Ann-Kristin Picke, Peng Liu, Baruch Frenkel, and Jan Tuckermann |
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77 |
Immune modulating scaffolds for bone tissue engineering Olwyn Mahon, David Browe, Pierluca Pitacco, Tomas Gonzalez-Fernandez, Daniel Kelly, and Aisling Dunne |
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78 |
Fine tuning of calcium oscillations by ITAM receptors is essential for RANKL-induced osteoclast differentiation Hiroyuki Okada, Hiroshi Kajiya, Jun Hirose, Takumi Matsumoto, Koji Okabe, Takeshi Miyamoto, and Sakae Tanaka |
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