4th International Conference on Model Hosts

Program

Friday, September 22

     

7:00 PM

 

Conference Registration

     

8:00 PM

 

Welcome Reception and Dinner

     

Saturday, September 23

     

8:00 AM

 

Breakfast

 

8:55 AM

 

 

Welcome and Opening Remarks

 

SESSION I

 

Immune response pathways in model hosts
Chair: Frederick M Ausubel

9:00 AM

1

A bacterial live/dead accumulation assay in the C. elegans intestinal lumen identifies GPCRs and a micro RNA involved in the C. elegans defense response
Hakkim Rahamathullah, Martin Newman, Rajamohammed Khader, Sakthimala Jagadeesan, Gary Ruvkun, and Frederick Ausubel

9:20 AM

2

Nuclear hormone receptor-mediated innate immune activation in C. elegans
Hilary Cheesman, Kyle Foster, Nicholas Peterson, Richa Chhaya, Sarah Anderson, and Read Pukkila-Worley

9:40 AM

3

Signaling damage in the worm epidermis
Clara Taffoni, Jola Polanoska, Shizue Omi, Jean-Christophe Lone, Didier  Marguet, Jonathan  Ewbank, and Nathalie Pujol

10:00 AM

4

Extracellular actin serves as an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila
Oliver Gordon, Naren Srinivasan, and Caetano Reis e Sousa

10:20 AM

5

C. elegans as a new tractable host to study animal infections by oomycetes
Michalis Barkoulas, Michael Fasseas, and Guled Osman

     

10:40 AM

 

Coffee Break

   

SESSION II

Whole animal responses to microbial infections
Chair: Alejandro Aballay

11:10 AM

6

Neuronal basis of the adrenergic receptor OCTR-1 in regulating the innate immune response of Caenorhabditis elegans
Xiou Cao and Alejandro Aballay

11:30 AM

7

Indoles derived from the microbiota limit Graft-versus-Host-Disease
Alyson Swimm, Cynthia Giver, Edmund Waller, and Daniel Kalman

11:50 AM

8

Rapid induction of apoptosis as an innate immune mechanism against viral infection
Lei Zhou

12:10 PM

9

Molecular dissection of a tripartite interaction among model organisms
Ioannis Eleftherianos

12:30 PM

10

The commensal microbiota influences intestinal stem cell differentiation to regulate stress tolerance.
Domonica Powell and Daniel Kalman

     

SESSION III

Host–Pathogen Evolution
Chair: Nathalie Pujol

12:50 PM

11

Systemic microsporidian infection+environment=back to enterocytes
Adrien Franchet, Louise Basmacyan, Marie Diogon, Frédéric Delbac, Frédéric Dalle, and Dominique Ferrandon

1:10 PM

12

Symbionts and genes: the coevolution of Drosophila and it’s viruses
Francis Jiggins

1:30 PM

13

C. elegans strain-specific defense against pathogens mediated by the GATA transcription factor ELT-2
Alejandra Zarate-Potes, Wentao Yang, Hinrich Schulenburg, and Katja Dierking

1:50 PM

14

Chemical bucket brigade: Heritable effects of acute-pesticide poisoning on the microbiome across host generations
Robert Brucker

2:10 PM

15

Experimental evolution of resistance against Bacillus thuringiensis in the insect model host Galleria mellonella results in epigenetic modifications
Ekaterina Grizanova, Krishnendu  Mukherjee, Ruediger Lehmann, Ekaterina Chertkova, Ivan Dubovskiy, and Andreas Vilcinskas

     

2:30 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

     

Sunday, September 24

     

8:00 AM

 

Breakfast

   

SESSION IV

Model hosts in drug and probiotic discovery and development
Chairs: Eleftherios Mylonakis and Andreas Vilcinskas

9:00 AM

16

Identification of new probiotic strains from the oral microbiome: recent study using invertebrate model host
Rodnei Rossoni, Beth Fuchs, Patrícia Barros, Marisol Velloso, Antonio Olavo Jorge, Juliana Junqueira, and Eleftherios Mylonakis

9:20 AM

17

Antibiotic Discovery and Development in Academia: A Medicinal Chemist's Perspective
Michael Kelso

9:40 AM

18

Galleria mellonella as a model host for assessment of acute toxicity of chemicals
Olivia Champion, Enrico Allegra, Leslie Ackhurst, John Carter, and Richard Titball

10:00 AM

19

C. elegans in antimicrobial drug discovery: Identification of agents effective against MRSA persisters
W Kim, AL Conery, R Rajamuthiah, BB Fuchs, GL Hendricks, K Lee, FM Ausubel, and Eleftherios Mylonakis

10:20 AM

20

Development of insect-derived antimicrobial peptides for medical applications
Andreas Vilcinskas

     

10:40 AM

 

Coffee Break

   

SESSION V

The diversity of host systems
Chair: Arturo Casadevall

11:10 AM

21

Mi casa es su casa: how an intracellular symbiont manipulates host biology
Irene Newton

11:30 AM

22

The Hawaiian bobtail squid: a model host for studying multiple interactions with beneficial bacteria
Spencer Nyholm

11:50 AM

23

Host modification of a bacterial quorum sensing signal induces a phenotypic switch in bacterial symbionts
Sebastian Fraune

12:10 PM

24

Amoeba-Cryptococcus neoformans interactions in the presence and absence of divalent cations
Man Shun Fu  and Arturo Casadevall

12:30 PM

25

Immuno-physiological adaptations confer wax moth Galleria mellonella resistance to Bacillus thuringiensis
Ivan Dubovskiy, Ekaterina Grizanova, Andreas Vilcinskas, and Tariq Butt

12:50 PM

26

CARD9: A critical molecule for mammalian antifungal host defense
Michail Lionakis

     

1:10 PM

 

Lunch and Informal Discussions

     

7:30 PM

 

Dinner and Informal Discussions

     

Monday, September 25

     

8:00 AM

 

Breakfast

   

SESSION VI

Functional genomics of host/microbe interactions
Chair: Michael Gilmore

9:00 AM

27

Use of mammalian models for cholera vaccine and phage therapy development
Andrew Camilli

9:20 AM

28

Origins of Enterococci - Ideal model for studying host microbe interactions in just about any system
Michael Gilmore, Ashlee Earl, and Francois Lebreton

9:40 AM

29

Pseudomonas aeruginosa transcriptome during human infection
Marvin Whiteley

10:00 AM

30

Co-infecting microbes impact pathogen gene essentiality in vivo
Carolyn Ibberson, Apollo Stacy, Derek Fleming, Justine Dees, Kendra Rumbaugh, Michael Gilmore, and Marvin Whiteley

10:20 AM

31

Defining the calling distance of quorum signals using micro-3D printed P. aeruginosa communities  
Sophie Darch, Mignon Fitzpatrick, Olja Simoska, Roger Bonnecaze, Jason Shear, and Marvin Whiteley

10:40 AM

32

Improved methods for RNA-Seq profiling of bacterial and mammalian transcriptomes help unravel the complexities of E. coli urovirulence
Jessica Alexander, Lu Yu, Henry Schreiber IV, Wen-Chi Chou, Abigail Manson, Ashlee Earl, Thomas Hannan, Scott Hultgren, and Jonathan Livny

   

11:00 AM

 

Coffee Break

   

SESSION VII

Roles of ROS in Host Response
Chair: Danielle A Garsin

11:30 AM

33

Mouse strains reveal novel mechanism for resistance/susceptibility to vulvovaginal candidiasis: role of heparin sulfate in vaginal neutrophil dysfunction
Paul Fidel

11:50 AM

34

The roles of a dual oxidase and heme Peroxidases in C. elegans innate immunity
Yi Liu and Danielle Garsin

12:10 PM

35

Non-traditional role for ROS in immune recruitment to fungal infection revealed by intravital imaging in zebrafish
Robert Wheeler

12:30 PM

36

Identifying Host Cell and Microbe interactions using the Drosophila animal model 
Rheinallt Jones

12:50 PM

37

C5ar1-dependent phagocyte effector functions protect against systemic candidiasis
Jigar Desai and Michail Lionakis

     

1:10 PM

 

Lunch and Informal Discussions

     

3:30 PM

 

City Tour

     

7:30 PM

 

Dinner and Informal Discussions

     

Tuesday, September 26

     

8:00 AM

 

Breakfast

   

SESSION VIII

Microbial communities and their interactions with their hosts I
Chair: Danielle A Garsin

9:00 AM

38

Spatiotemporal analysis of virulence gene regulation during food-borne infection with Escherichia coli O157:H7 within a live host
Anne-Marie Krachler

9:20 AM

39

Rules of engagement: how Drosophila interacts with its gut microbial community
Angela Douglas

9:40 AM

40

Human fecal minibioreactor arrays to study the functions of intestinal microbial communities.
Robert Britton, Jennifer Auchtung, and James Collins

10:00 AM

41

Induction of protective innate immunity against lethal polymicrobial intra-abdominal infection with Candida albicans and Staphylococcus aureus
Mairi Noverr

10:20 AM

42

A bacteriocin from Enterococcus faecalis attenuates Candida albicans in multiple virulence models
Michael Lorenz, Carrie Graham, Melissa Cruz, and Danielle Garsin

10:40 AM

43

Translocation of pyoverdine into host cells mediates iron removal and activates a distinct host immune response
Natasha Kirienko

     

11:00 AM

 

Coffee Break 

   

SESSION IX

Microbial communities and their interactions with their hosts II
Chair: Alejandro Aballay

11:30 AM

44

Intrinsic and extrinsic properties that shape Drosophila-microbiome interactions
Nichole Broderick

11:50 AM

45

Flies to humans - humans to flies: A virtuous circle of colorectal cancer prevention
Elena Kamilari, Vasilia Tamamouna, Myrofora Panagi, Savvas Teloni, Chrysoula Pitsouli, and Yiorgos Apidianakis

12:10 PM

46

Do the larvae of G. mellonella serve as an alternative model host to study gut commensals?
Anna Lange, Andrea Schaefer, Alexander Steimle, and Julia-Stefanie Frick

     

SESSION X

Oral Abstracts Session
Chairs: MichaelLorenz and Read Pukkila-Worley

12:20 PM

47

Investigating mechanism of Clostridium difficile colonization resistance in human fecal minibioreactor arrays (MBRAs)
Jennifer Auchtung and Robert Britton

12:30 PM

48

An important question: Which LPS do you use?
Raphael Parusel, Alexander Steimle, Anna Lange, and Julia Frick

12:40 PM

49

RAGE deficiency impairs bacterial clearance in murine staphylococcal sepsis, but has no significant impact on staphylococcal septic arthritis
Majd Mohammad

12:50 PM

50

Baseline regenerative signaling drives intestinal tumorigenesis in Drosophila
Myrofora Panagi, Vasilia Tamamouna, Antria Theophanous, Maria Dimosthenous, Maria Michail, Markella Papadopoulou, Chrysoula Pitsouli, and Yiorgos Apidianakis

1:00 PM

 

Closing Remarks

 

     

1:10 PM

 

Lunch and Informal Discussions

     

8:00 PM

 

Farewell Dinner

     

Wednesday, September 27

     

8:00 AM

 

Breakfast

     

10:00 AM

 

Departure