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Tuesday, June 18 |
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6:00 PM |
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Conference Registration |
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8:00 PM |
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Welcome Reception and Dinner |
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Wednesday, June 19 |
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7:30 AM |
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Breakfast |
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8:20 AM |
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Welcome and Opening Remarks |
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SESSION I |
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Systems biology of ncRNAs Chair: Joan Steitz |
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8:30 AM |
1 |
The enigma of viral noncoding RNAs Joan Steitz |
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9:00 AM |
2 |
Single-Cell RNA analysis in space and time Nikolaus Rajewsky |
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9:30 AM |
3 |
Genome regulation by long noncoding RNAs Howard Chang |
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10:00 AM |
4 |
Ribothrypsis Zissimos Mourelatos |
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10:30 AM |
5 |
A new tool for in vivo RNA structure analysis reveals HIV-1 genome-wide heterogeneity and alternative conformations that regulate viral RNA splicing Phillip Tomezsko, Vincent Corbin, Paromita Gupta, Harish Swaminathan, and Silvia Rouskin |
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10:45 AM |
6 |
Dinucleoside polyphosphates: new class of 5’-RNA caps in bacteria Hana Cahova |
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11:00 AM |
7 |
Deep Learning for intra- and inter-species mining for small RNAs Georgios Georgakilas, Andrea Grioni, Konstantinos Liakos, Eliska Malanikova, Fotis Plessas, and Panagiotis Alexiou |
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11:15 AM |
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Coffee Break and Poster Viewing |
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SESSION II |
Short RNA biogenesis and regulation Chair: Richard Gregory |
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11:45 AM |
8 |
The Perlman Syndrome Dis3l2 exonuclease as guardian of ER-associated translation Richard Gregory |
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12:15 PM |
9 |
An unexpected role for a prokaryotic argonaute protein in DNA replication Samson Jolly, Ildar Gainetdinov, Han Zhang, and Phillip Zamore |
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12:45 PM |
10 |
MIWI Prevents Aneuploidy during Meiosis Chia-Ling Hsieh, Jing Xia, and Haifan Lin |
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1:15 PM |
11 |
Towards a comprehensive understanding of primary microRNA processing S. Chan Baek, Kijun Kim, Boseon Kim, Il-Soo Park, Dal-Hee Min, Kevin Weeks, and V. Narry Kim |
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1:45 PM |
12 |
Crosstalk between canonical and Ago2-dependent miRNA processing Daniel Cifuentes, Dmitry Kretov, and Simon Moxon |
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2:00 PM |
13 |
Structural and biochemical analyses reveal the mechanism of circRNA biogenesis Xueni Li, Shiheng Liu, Z. Hong Zhou, and Rui Zhao |
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2:15 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Thursday, June 20 |
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7:30 AM |
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Breakfast |
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SESSION III |
lncRNAs in development & disease 1 Chair: Myriam Gorospe |
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8:30 AM |
14 |
Role of lncRNA OIP5-AS1 in human myogenesis Jen-Hao Yang and Myriam Gorospe |
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9:00 AM |
15 |
Nucleolus-enriched repeat-containing noncoding RNA regulates rDNA transcription. Qinyu Hao and Kannanganattu Prasanth |
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9:30 AM |
16 |
SPARCLE, a p53-induced lincRNA that controls apoptosis after genomic stress Karla Meza-Sosa, Francisco Navarro, and Judy Lieberman |
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10:00 AM |
17 |
The role of non-coding transcription in compartmentalization Kees Murre, Takeshi Isoda, Vivek Chandra, and Zhaoren He |
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10:30 AM |
18 |
The lncRNA Xist establishes a phase-separated compartment required for the maintenance of gene silencing Amy Pandya-Jones, Yolanda Markaki, Jacques Serizay, Tsotne Chitiashvili, Walter Mancia, Andrey Damianov, Costantinos Chronis, Bernadett Papp, Robin McKee, Anthony Chau, Heinrich Leonhardt, Sika Zheng, Mitchell Guttman, Douglas Black, and Kathrin Plath |
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10:45 AM |
19 |
Nuclear lncRNA Cyrano modulates expression of OIP5 oncogene Elzbieta Wanowska, Michal Szczesniak, Magdalena Kubiak, and Izabela Makalowska |
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11:00 AM |
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Coffee Break and Poster Viewing |
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SESSION IV |
mRNA metabolism Chairs: Lynne E Maquat |
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11:45 AM |
20 |
3'UTR SINE-directed mRNA metabolism Lynne Maquat |
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12:15 PM |
21 |
Functional characterization of an ER-localized Nonsense-mediated decay (NMD) pathway Javier Caceres |
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12:45 PM |
22 |
Alternative splicing in leukemia: mechanisms and consequences Andrei Thomas-Tikhonenko |
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1:15 PM |
23 |
Regulation of 3′UTR-mediated protein-protein interactions Christine Mayr |
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1:45 PM |
24 |
Regulating the Terminator: Interaction of small non-coding RNA SraL regulates the terminator by preventing premature transcription termination of rho mRNA Ines Silva, Susana Barahona, Alex Eyraud, David Lalaouna, Nara Figueroa-Bossi, Eric Massé, and Cecilia Arraiano |
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2:00 PM |
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Cell-to-cell variability in Nonsense-mediated mRNA decay Hanae Sato and Robert Singer |
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2:15 PM |
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Lunch and Informal Discussions |
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7:30 PM |
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Dinner and Informal Discussions Buses depart from the hotel lobby at 7:30 PM |
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Friday, June 21 |
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7:30 AM |
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Breakfast |
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SESSION V |
lncRNAs in development & disease 2 Chair: Stewart Shuman |
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8:30 AM |
26 |
lncRNA synthesis and phosphate homeostasis in fission yeast Beate Schwer, Ana Sanchez, Angad Garg, and Stewart Shuman |
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9:00 AM |
27 |
piRNA-directed DNA Methylation Dónal O'Carroll |
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9:30 AM |
28 |
The gut microbiota regulates white adipose tissue inflammation and obesity via a highly conserved family of non-coding RNAs Jorge Henao-Mejia |
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10:00 AM |
29 |
sxRNA: Modulating mRNA regulatory motifs through the binding of structurally interacting, microRNA Scott Tenenbaum |
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10:15 AM |
30 |
The core tertiary structure of long non-coding RNA MEG3 is essential for stimulation of the p53 pathway Tina Uroda, Eleni Anastasakou, Jean-Marie Teulon, Jean-Luc Pellequer, Paolo Annibale, Alberto Inga, Isabel Chillon, and Marco Marcia |
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10:30 AM |
31 |
Regulation of CHD2 expression by the Chaserr long noncoding RNA is essential for viability Aviv Rom |
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10:45 AM |
32 |
Non-coding RNAs in motor neuron differentiation and degeneration Andrea Carvelli, Beatrice Salvatori, Silvia Biscarini, Irene Bozzoni, and Pietro Laneve |
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11:00 AM |
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Coffee Break and Poster Viewing |
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SESSION VI
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short RNAs in development & disease Chair: David Bartel |
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11:45 AM |
33 |
MicroRNAs David Bartel |
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12:15 PM |
34 |
MicroRNA regulation of early mammalian development Robert Blelloch |
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12:45 PM |
35 |
miRNAs and retrotransposons, seeking treasures in the non-coding genome Yongjin Choi, Andrew Modzelewski, Martin Kinisu, Paul Lin, and Lin He |
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1:15 PM |
36 |
Gene regulation by RNA modifications Ramesh Pillaiand Mateusz Mendel |
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1:45 PM |
37 |
Probing and targeting motor neuron subtype differential vulnerability in ALS via Mir-17~92 Jun-An Chen |
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2:00 PM |
38 |
microRNA degradation in human physiology and pathology Francesco Nicassio, Ines Simeone, Carmela Rubolino, and Matteo Marzi |
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2:15 PM |
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Lunch and Informal Discussions |
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3:30 PM |
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City Tour Buses depart from hotel lobby at 3:00 PM |
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7:30 PM |
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Dinner and Informal Discussions Please note that buses do not pick-up at the hotel prior to dinner. Dinner proceeds right after the tour |
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Saturday, June 22 |
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7:30 AM |
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Breakfast |
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SESSION VII |
Long and short ncRNAs in cancer Chair: Iannis Aifantis |
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8:30 AM |
39 |
Targeting RNA-binding protein networks in Acute Leukemia Iannis Aifantis |
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9:00 AM |
40 |
Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis Douglas Hanniford, Alejandro Ulloa, Beatriz Sánchez-Sendra, Alcida Karz, Rana S. Moubarak, Tommaso Tabaglio, Maria Gabriela Berzoti-Coelho, Veronica Davalos, Pamela Wu, Varshini Vasudevaraja, Karin Lilja, Jochen Imig, Andreas Kloetgen, Carlos Monteagudo, Ernesto Guccione, Iman Osman, Iannis Aifantis, and Eva Hernando |
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9:30 AM |
41 |
New paradigms for lncRNA functions and mechanisms in cancer metastasis Li Ma |
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10:00 AM |
42 |
A message from a putative lncRNA in colorectal cancer Ashish Lal |
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10:30 AM |
43 |
Circular RNAs drive oncogenic chromosomal translocations through R-loop-mediated genome instability Vanessa Conn, John Toubia, Gokhan Cildir, Shashikanth Marri, and Simon Conn |
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10:45 AM |
44 |
p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis Nadya Dimitrova and Christiane Olivero |
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11:00 AM |
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Coffee Break and Poster Viewing |
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SESSION VIII |
Genome editing and RNA therapeutics Chair: Adrian Krainer |
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11:45 AM |
45 |
Targeted antisense therapeutics for modulation of splicing or NMD Adrian Krainer |
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12:15 PM |
46 |
Modeling and treating BRAF-driven pediatric brain cancers using ex vivo and in vivo chromosomal engineering Andrea Ventura |
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12:45 PM |
47 |
Interrogating the effects of cancer-associated alternative splicing Peter Choi |
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1:15 PM |
48 |
Delivering on the promise of RNAi therapeutics Vasant Jadhav |
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1:45 PM |
49 |
Discovery of cancer-emergent orphan non-coding RNAs as neo-regulators in cancer progression Hani Goodarzi, Lisa Fish, and Steven Zhang |
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2:00 PM |
50 |
Anti-HIV-1 replicative effect of small molecule Enoxacin by modulation of pro-viral miR-132 Jochen Imig, Helen Lightfoot, Verena Schlösser, Christine Leemann, Valentina Vongrad, Andreas Brunschweiger, Jonathan Hall, and Karin Metzner |
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2:15 PM |
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Closing Remarks |
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2:20 PM |
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Lunch and Informal Discussions |
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8:00 PM |
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Farewell Dinner |
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Sunday, June 23 |
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8:00 AM |
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Breakfast |
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Departure |
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POSTERS |
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51 |
Establishing the role of miR-150 in Multiple Sclerosis and experimental autoimmune encephalomyelitis Eliane Piket, Lara Kular, and Maja Jagodic |
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52 |
CRISPR/Cas9 screen for functional MYC binding sites in K562 cells reveals an essential MYC-regulated cluster on chromosome 22 Marta Kazimierska, Magdalena Zurawek, Marta Podralska, Joost Kluiver, Anke van den Berg, and Agnieszka Dzikiewicz-Krawczyk |
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53 |
Dlk1-Dio3 locus-derived LncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity Ya-Ping Yen, Wen-Fu Hsieh, Ya-Yin Tsai, Ya-Lin Lu, Ee Shan Liau, Ho-Chiang Hsu, Yen-Chung Chen, Ting-Chun Liu, Mien Chang, Joye Li, Shau-Ping Lin, Jui-Hung Hung, and Jun-An Chen |
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54 |
ADAR1-mediated RNA editing promotes thyroid cancer tumorigenesis Julia Ramírez-Moya, Allison Backer, Frank Slack, and Pilar Santisteban |
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55 |
“Glucocorticoids selectivity enhances microRNAs production by modulating lncRNAs transcription” Julia Liz, Lisa Öberg, John Cole, Carl Goodyear, and Rose Maciewicz |
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56 |
Epigenetic mediators of acquired Erlotinib-resistance in Non-Small Cell Lung Cancer (NSCLC) Arpita Pal, Alejandra Agredo, Manvir Bains, Kayla Gates, and Andrea Kasinski |
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57 |
The long ncRNA LINP1 interacts with the Ku heterodimer in a multifunctional protein complex “lnc-ing” RNA To DNA repair with cancer implications Roopa Thapar, Michal Hammel, Ruiqiong Ye, Miaw-Sheue Tsai, John Tainer, and Susan Lees-Miller |
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58 |
Disturbed flow induces aortic valve calcification by activating the HIF-1α Pathway triggered by loss of miR-483-3p, leading to increased UBE2C and degradation of pVHL. Joan Fernandez Esmerats, Nico Villa-Roel, Tausif Salim, Ajit Yoganathan, and Hanjoong Jo |
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59 |
Dissecting the molecular mechanism of Meg3 in motor neuron development Hung Lo, Kuan-Wei Chen, Ya-Ping Yen, Ya-Yin Tsai, Wen-Fu Hsieh, Yen-Chung Chen, Jui-Hung Hung, and Jun-An Chen |
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60 |
Destroying nonsense mutation harboring transcripts Yarden Shor, Michal Caspi, and Rina Rosin-Arbesfeld |
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61 |
Use of therapeutic miRNAs for the treatment of chondrosarcoma Clément Veys, Abderrahim Benmoussa, Romain Contentin, Amandine Duchemin, Emilie Brotin, Yannick Saintigny, Christophe Denoyelle, Magali Demoor, Florence Legendre, and Philippe Galéra |
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62 |
Circ_Lrp6, a circular RNA enriched in vascular smooth muscle cells, acts as a sponge regulating miRNA-145 function Ignacio Hall, Monserrat Climent, Manuela Quintavalle, Floriana Farina, Tilo Schorn, Stefania Zani, Pierluigi Carullo, Paolo Kunderfranco, Efrem Civilini, Gianluigi Condorelli, and Leonardo Elia |
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63 |
Regulatory functions of nested retrocopies derived from protein-coding genes Magdalena Kubiak, Elzbieta Wanowska, Magdalena Przybylinska, and Izabela Makalowska |
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64 |
Identification of lncRNAs involved in Diffuse Large B-cell Lymphoma Joost Kluiver, Gerben Duns, Melanie Winkle, Lauren Chong, Daisuke Ennishi, Arjan Diepstra, David Scott, Anke van den Berg, and Christian Steidl |
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65 |
Functional role of miR-16 in platelets Neetu Dahiya and Chintamani Atreya |
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66 |
Role of DINO lncRNA in cell-to-cell variation of the p53 tumor suppressor transcriptional program Julia Garcia, Jin Xu, Laura Attardi, and Howard Chang |
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67 |
Identifying critical genes and microRNAs that potentiate KRAS;p53-driven lung tumorigenesis Chennan Li, Nadia Lanman, and Andrea Kasinski |
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68 |
A CRISPRi-based approach to identify long noncoding RNAs with roles in senescence Filipa Marques and Igor Ulitsky |
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69 |
Expression profiles and functional analysis of circRNAs in primary and secondary gliomas Konrad Kuczynski, Zaneta Zarebska, Dariusz Wawrzyniak, Anna-Maria Barciszewska, Rafał Piestrzeniewicz, and Katarzyna Rolle |
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70 |
Differential expression pattern of circular RNA in prostate cancer cells after single and fractionated radiation Moly Aryankalayil, Iris Eke, Sunita Chopra, Shannon Martello, and Norman Coleman |
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71 |
The role of ZDHHC11 in the oncogenic MYC/miR-150/MYB network in Burkitt Lymphoma Lotteke Swier, Agnieszka Dzikiewicz-Krawczyk, Yichen Liu, Annika Seitz, Joost Kluiver, and Anke van den Berg |
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72 |
Characterization of lincRNAs potentially involved with sexual maturation induced by pairing in Schistosoma mansoni Gilbert Silveira, Lucas Maciel, Murilo Amaral, and Sergio Verjovski-Almeida |
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73 |
LincRNA regulators of adaptive immunity to chronic infection James Hewitson, Kylie James, Katie West, Nidhi Dey, Naj Brown, Sarah Teichmann, Paul Kaye, and Dimitris Lagos |
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74 |
DICIER: A fine-tuned bioinformatics pipeline to detect microRNA chimeric reads Andrea Grioni, George Georgakilas, Andrea Biodi, Eliska malanikova, and Panagiotis Alexiou |
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75 |
The role of long non-coding RNAs in the regulatory landscape of plastic breast cancer cells Matteo Marzi, Chiara Tordonato, Montserrat Climent, Paola Bonetti, Ines Simeone, and Francesco Nicassio |
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76 |
A miRNAs family involved in breast normal and cancer stem cells connects cellular metabolism with pharmacological resistance Chiara Tordonato, Matteo Marzi, Francesco Nicassio, and Pier Paolo Di Fiore |
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77 |
Identification of blood plasma microRNA by Next-generation sequencing: a comparative methodical study with special focus on library preparation technique Karolína Trachtová, Táňa Macháčková, Natalia Gablo, and Ondřej Slabý |
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78 |
Functional Study of MiR-215 as Tumor Suppressor in Colorectal Cancer Tana Machackova, Kamila Souckova, Petra Vychytilova, Dominika Brchnelova, Tomas Loja, Natalia Anna Gablo, Karolina Trachtova, and Ondrej Slaby |
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79 |
Small RNA sequencing of preoperative blood plasma identifies microRNA signature enabling to find pancreatic cancer patients who will not benefit from surgical resection Natalia Gablo, Tana Machackova, Karolina Trachtova, Vladimir Prochazka, Jan Hlavsa, Igor Kiss, Josef Srovnal, Zdenek Kala, and Ondrej Slaby |
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80 |
Non-coding RNAs as markers and determinants of Epigenetic and Transcriptional plasticity in breast cancer Bianca Giuliani, Paola Bonetti, Chiara Tordonato, Ines Simeone, Matteo Marzi, and Francesco Nicassio |
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81 |
Determining the role for lincRNA-Cox2 in host defense within the lung Elektra Robinson, Allyson Capili, and Susan Carpenter |
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82 |
Stress-induced regulatory RNAs derived from tRNA Pavel Ivanov |
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83 |
IL6 signaling and long non-coding RNAs in liver cancer Nadège Minoungou, Florence Servais, Mélanie Kirchmeyer, Tony Kaoma, Petr Nazarov, and Iris Behrmann |
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84 |
The DNMT1-Associated lincRNA DACOR1 Reprograms Genome-Wide DNA Methylation in Colon Cancer Sai Somasundaram, Sanford Markowitz, Thomas LaFramboise, and Ahmad Khalil |
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85 |
Production, purification and delivery of recombinant pre-miR-29 Patrícia Pereira, Sandra Viegas, Fani Sousa, and Cecília Arraiano |
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86 |
More than a million experimentally supported entries of microRNA interactions with coding and non-coding transcripts Spyros Tastsoglou, Dimitra Karagkouni, Maria Paraskevopoulou, Ioannis Vlachos, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, and Artemis Hatzigeorgiou |
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87 |
LncRNA PVT1 mediates a transcriptional repression program in LNCaP prostate cancer cells Alexandre Videira, Felipe Beckedorff, and Sergio Verjovski-Almeida |
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88 |
microRNA-34b modulation can potentiates chemotherapy-induced apoptosis in Burkitt lymphoma cells Marcela Cristina Robaina, Amanda Leonel, Luciano Mazzoccoli, and Claudete Klumb |
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89 |
Identification of new class of 5’-RNA caps in E. coli using LC-MS Roberto Benoni, Oldřich Hudeček, and Hana Cahová |
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90 |
microCLIP introduces a new era of CLIP-Seq-guided characterization of miRNA targetome Dimitra Karagkouni, Maria Paraskevopoulou, Ioannis Vlachos, and Spyros Tastsoglou |
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91 |
The long non-coding RNA HOTAIRM1 mediates radioresistance in glioblastoma Ulvi Ahmadov, Daniel Picard, Manuela Silginer, Marlen Melcher, Alina Winkelkotte, Marija Trajkovic-Arsic, Nan Qin, Maike Langini, Anna Kaufhold, Jasmin Bartl, Lara Kleinesudeik, Simone Fulda, Felix Distelmaier, Jens Siveke, Kai Stühler, Arndt Borkhardt, Michael Weller, Patrick Roth, Guido Reifenberger, and Marc Remke |
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92 |
Network-based integration of multi-omics data enables the identification of the most critical determinants of a miRNA effects: the example of miR-491-5p in ovarian cancer Matthieu Meryet-Figuiere, Mégane Vernon, Mamy Andrianteranagna, Bernard Lambert, Jean-Paul Issartel, Audrey Guttin, Pascal Gauduchon, Emilie Brotin, Florent Dingli, Damarys Loew, Nicolas Vigneron, Anaïs Wambecke, Emmanuel Barillot, Laurent Poulain, Loredana Martignetti, and Christophe Denoyelle |
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93 |
Long Noncoding RNAs mediate the effect of childhood maltreatment on PTSD Guia Guffanti, Torsten Klengel, Claudia Klengel, Kerry Ressler, and Murray Stein |
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94 |
Profile of small non-coding RNAs and their machinery during Xenopus Laevis oocytes meiotic maturation. Rafah Mackeh, Tomoshige Kino , Njoud Al-Naama, Shahina Hayat, and Khaled Machaca |
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95 |
MicroRNA-31: a double-edged sword regulating cancer cell sensitivity to chemotherapy and radiation Stephen Maher, Niamh Lynam-Lennon, Hannah Moody, Jason McGrath, Becky Bibby, Michael Lind, and John Reynolds |