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Tuesday, May 30 |
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6:00 PM |
Conference Registration |
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8:00 PM |
Welcome Dinner |
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Wednesday, May 31 |
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7:30 AM |
Breakfast |
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8:20 AM |
Welcome and Opening Remarks Leonidas Platanias |
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SESSION I |
Session 1 Oleg Demidov and Ourania Andrisani |
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8:30 AM |
1 |
Interferons, viruses and lung epithelia: How to balance antiviral with proliferative requirements Andreas Wack |
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8:50 AM |
2 |
Anti-viral versus anti-cancer: the importance of being on the good side of the innate immune response Ludmila Prokunina-Olsson |
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9:10 AM |
3 |
News on STAT1 isoforms Birgit Strobl |
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9:30 AM |
4 |
The C/EBPdelta transcription factor is a marker of good prognosis in breast cancer and also promotes cancer cell stemness and metastasis: a paradox of the IL-6 signaling pathway? Kuppusamy Balamurugan, Daniel Mendoza-Villanueva, Shikha Sharan, Glenn Summers, Randall Johnson, and Esta Sterneck |
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9:45 AM |
5 |
Positive and Negative Regulation of Interferon and Cytokine Signaling Curt Horvath |
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10:05 AM |
6 |
The Molecular Basis for Differential Activity of Type I Interferons Gideon Schreiber |
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10:25 AM |
7 |
Regulation and dysregulation of type I interferon signaling, from human disease to in vitro studies Françoise Vuillier, Zhi Li, Erminia Rubino, Frédérique Michel, Lasse Dynesen, Pierre-Henri Commere, Pascal Miesen, and Sandra Pellegrini |
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10:45 AM |
8 |
STAT3 activation by cytokines requite multiple posttranslational modifications within both C-terminal and N-terminal domains Eugene Chinn |
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11:00 AM |
Coffee Break and Poster Session |
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SESSION II |
Session II Chairs: Eleanor Fish and Esta Sterneck |
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11:30 AM |
9 |
Molecular assembly and signalling by the human IL-3 receptor and its role in disease Angel Lopez, Denis Tvorogov, Winnie Kan, Tim Hercus, Sophie Broughton, Urmi Dhagat, Tracy Nero, Karen Cheung Tung Shing, Jeff Babon, Jarrod Sandow, David Ross, Tim Hughes, and Michael Parker |
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11:50 AM |
10 |
Novel STAT2 functions in cytokine signaling Johnathan Ho, Andreas Begitt, and Uwe Vinkemeier |
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12:10 PM |
11 |
Molecular insights into regulation of JAK2 in cytokine signalling Olli Silvennoinen |
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12:30 PM |
12 |
Dyregulated Gab1-dependent signalling in cells expressing the myeloproliferative neoplasm-associated Jak2-V617F mutant Hannes Bongartz, Wiebke Hessenkemper, Christian Müller, Katharina Mandel, Iris Behrmann, Claude Haan, Fischer Thomas, Stephan Feller, and Fred Schaper |
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12:50 PM |
13 |
ULK1 in interferon signaling Diana Saleiro, Eleanor Fish, and Leonidas Platanias |
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SESSION III |
Keynote Presentation |
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1:05 PM |
Keynote speaker introduction Mathias Müller |
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1:10PM |
14 |
Negative regulation of inflammatory chemokines and IL-1 family members in cancer-related inflammation Alberto Mantovani |
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2:00 PM |
Lunch and Informal Discussion |
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7:30 PM |
Dinner and Informal Discussions |
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Thursday, June 01 |
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7:30 AM |
Breakfast |
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SESSION IV |
Session III Chair: Hasem Habelhah and Rumela Chakrabarti |
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8:30 AM |
15 |
Jak/STAT driven factors shape the pulmonary immune microenvironment Sylvia Knapp |
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8:50 AM |
16 |
Mitochondrial retrograde signaling-induced chromosomal damage and cancer progression in immortalized cells Narayan Avadhani |
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9:10 AM |
17 |
TGFβ/hnRNP E1-mediated epithelial-mesenchymal transition (EMT) Philip Howe |
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9:30 AM |
18 |
Il-33 promotes gastric tumour growth in a mast cell dependent manner Moritz Eissmann, Christine Dijkstra, Michael Buchert, Robert O’Donoghue, Jamina Brunnberg, Toby Phesse, Michele Grimbaldeston, Andrew Jarnicki, Frederick Masson, and Matthias Ernst |
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9:45 AM |
19 |
IGF2BP1 in melanoma metastasis Lucas Rodrigues, TaeWon Kim, Chethana Gowda, QingLi Lu, Katie Kokolus, Todd Schell, Irina Elcheva, Yaohui Xu, and Vladimir Spiegelman |
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10:05 AM |
20 |
Delineating and targeting chromatin vulnerabilities in hematopoietic tumors Panagiotis Ntziachristos |
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10:25 AM |
21 |
Mitochondrion dependent regulation of cytokine –driven tumor suppressionMitochondrion dependent regulation of cytokine –driven tumor suppression Dhan Kalvakolanu and Shreeram Nallar |
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10:45 AM |
22 |
Functional characteristics of hetIL-15-induced effector cytotoxic lymphocytes that infiltrate tumors, effector sites and lymph nodes George Pavlakis, Cristina Bergamaschi, Sinnie Ng, Dionysios Watson, Antonio Valentin, Eirini Moysi, Costas Petrovas, and Barbara Felber |
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11:00 AM |
23 |
Mechanisms of chronic inflammation regulation in oncogenic virus-mediated cancers Noula Shembade, Juan Carlos Ramos, Enrique Mesri, and Richard Hunte |
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11:15 AM |
Coffee Break and Poster Session |
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SESSION V |
Session IV Chairs: Tracy Putoczki and Dagmar Stoiber |
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12:00 PM |
24 |
Gp130/Stat3 signaling in cancer: A plethora of therapeutic opportunities Matthias Ernst, Mortiz Eissmann, Michael Buchert, Mariah Allorro, Ashwini Chand, Tracy Putoczki, and Frederic Masson |
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12:20 PM |
25 |
Interferon Signaling and Immune Checkpoints in Cancer Leonidas Platanias |
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12:40 PM |
26 |
CCL5 activation of CCR5 regulates cell metabolism in breast cancer Eleanor Fish |
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1:00 PM |
27 |
Lymphoid or Myeloid Blood Cancers Require Different Tyrosine Kinase Activities Wired to Specific pYSTAT5 Activity Levels Richard Moriggl |
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1:20 PM |
28 |
A novel role of DNA damage response regulating phosphatase Wip1 in anti-tumor immunity Oleg Demidov, Burhan Uyanik, Anastasia Goloudina, Bogdan Grigorash, Carmen Garrido, and Ettore Appella |
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1:35 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Friday, June 02 |
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7:30 AM |
Breakfast |
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SESSION VI |
Session V Chairs: Ludmila Prokunina-Olsson and Noula Shembade |
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8:30 AM |
29 |
Inflammation mediates profound changes to the immunopeptidome of melanoma and alters tumour recognition by T cells Katherine Woods, Ralf Schittenhelm, Anthony Purcell, Jonathan Cebon, and Andreas Behren |
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8:50 AM |
30 |
Cytokine-mediated organotropism of cancer metastasis Andreas Möller |
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9:10 AM |
31 |
KLF4 links cytokines to pancreatic transformation and progression Keping Xie |
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9:30 AM |
32 |
Downregulation of innate response genes in a subpopulation of HBV replicating hepatocytes with cancer stem cell (CSC) properties Zhibin Cui, Saravana Kumar Kalaisam Mani, Hao Zhang, Nadim Fares, Philippe Merle, and Ourania Andrisani |
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9:45 AM |
33 |
Inhibition of the UPR effector PERK by small molecule inhibitors sensitizes tumor cells to hypoxia and improves tumor response to radiotherapy via immune-related mechanisms Ioannis Verginadis, Joel Encarnación, Souvik Dey, and Constantinos Koumenis |
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10:05 AM |
34 |
The Janus-faced TYrosine Kinase 2 – tumor surveillant and oncogene Agnieszka Witalisz-Siepracka, Sabine Macho-Maschler, Natalija Simonović, Katrin Meissl, Caroline Lassnig, Veronika Sexl, Birgit Strobl, and Mathias Müller |
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10:25 AM |
35 |
Mesenchymal causalities in inflammation and cancer George Kollias |
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10:45 AM |
36 |
PFKFB3-mediated immunometabolic regulation in antiviral defense and beyond Hui Jiang, Hengfei Shi, Panpan Guo, Man Sun, Yafeng Wang, Qingzhou Meng, Yanlan Cao, Jiong Chen, Xiang Gao, Erguang Li, and Jianghuai Liu |
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11:00 AM |
Coffee Break and Poster Session |
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SESSION VII |
Session VI Chairs: Sandra Nicolson and Stephanie Watowich |
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12:00 PM |
37 |
Role of Interleukin-11 in cancer progression and therapeutic resistance Tracy Putoczki |
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12:20 PM |
38 |
Tumour inherent IFNs as key players in metastasis and therapeutic response Belinda Parker, Natasha Brockwell, Katie Owen, and Sandra O'Toole |
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12:40 PM |
39 |
The Ying and Yang of JAK signaling in: Loss of USP9X buffers JAK signaling and enhances survival of CRLF2-JAK-STAT expressing B cell precursor acute lymphoblastic leukemia Angela Savino, Omer Schwartzman, Michael Gombert, Chiara Palmi, Gunnar Cario, Martin Schrappe, Cornelia Eckert, Arend von Stackelberg , Jin-Yan Huang, Michal Hameiri-Grossman, Smadar Avigad, Geertruy te Kronnie, Ifat Geron, Yehudit Birger, Yehudit Birger, Avigail Rein, Giulia Zarfati, Ute Fischer, Martin Stanulla, Andrea Biondi, Gianni Cazzaniga, Bridget Wagner, Zhu Chen, Saijuan Chen, Amos Tanay, Arndt Borkhardt, and Shai Izraeli |
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12:55 PM |
40 |
Regulation of the oncogenic potential of CDKN1A by suppressor of cytokine signaling 1 (SOCS1) in hepatocytes Md Gulam Khan, Mehdi Yeganeh, Sheela Ramanathan, and Subburaj Ilangumaran |
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1:10 PM |
41 |
Viral Hepatitis Induced Inflammatory Cytokine Signaling in Hepatocellular Carcinoma Emmanuel Thomas |
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1:25 PM |
Lunch and Informal Discussion |
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3:00 PM |
City Tour |
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7:30 PM |
Dinner and Informal Discussions |
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Saturday, June 03 |
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7:30 AM |
Breakfast |
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SESSION VIII |
Session VII Chairs: Ana Gamero and Suyun Huang |
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8:30 AM |
42 |
The RNA helicase DDX3X is an essential mediator of innate immunity Daniel Szappanos, Thomas Perlot, Roland Tschismarov, Sandra Westermayer, Ekaterini Platanitis, Fabian Kallinger, Maria Novatchkova, Caroline Lassnig, Mathias Müller, Veronika Sexl, Keiryn Bennett, Josef Penninger, and Thomas Decker |
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8:50 AM |
43 |
Myeloid cell network in therapeutic regulation of tumor microenvironment Dmitry Gabrilovich |
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9:10 AM |
44 |
PTPs and STATs in Obesity and Cancer Tony Tiganis |
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9:30 AM |
45 |
TRAF2 is essential for the survival of breast cancer cells under conditions of chronic endoplasmic reticulum stress Hasem Habelhah, Yumei Fan, Ainiwaer Xialikaer, and Laiqun Zhang |
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9:45 AM |
46 |
Innate immune regulation in inflammation and cancer Haiyan Li, Taylor Chrisikos, Huiyuan Zhang, Emily Hillmer, Yifan Zhou, Natalie Slone, and Stephanie Watowich |
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10:05 AM |
47 |
SOCS protein regulation of NK cell-mediated tumor immunity Rebecca Delconte, Tatiana Kolesnik, Laura Dagley, Jai Rautela, Edmond Linossi, Eva Putz, Mark Smyth, Jeffrey Babon, Nicholas Huntington, and Sandra Nicholson |
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10:25 AM |
48 |
The role of Integrin-linked kinase in Innate Immunity and Cancer Bryan Williams and Afsar Ahmed |
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10:45 AM |
49 |
DNp63+ tumor initiating cells recruit chemokines to promote MDSCs infiltration to the triple negative breast cancer to promote metastasis Rumela Chakrabarti, Sushil Kumar, and David Wilkes |
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11:00 AM |
Coffee Break and Poster Session |
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SESSION IX |
Session VIII Chairs: Diana Saleiro and Birgit Strobl |
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12:00 AM |
50 |
STAT2 Becomes a Villain when p53 is Inactivated in Colorectal Cancer Ana Gamero, Kevin Kotredes, Sruti Gohimukkula, Aliza Abezis, Alexandra Afanassiev, and Brianna Thomas |
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12:20 PM |
51 |
The Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammasome Activation and Cytokine Secretion in Murine Macrophages Melpo Christofidou-Solomidou, Ralph Pietrofesa, and Steven Albelda |
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12:40 PM |
52 |
Downregulation of type I interferon receptor contributes to the establishment of a localized immune privileged niche Serge Fuchs |
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1:00 PM |
53 |
epigenetic modulation of cytokine responses and tumorigenesis Suyun Huang |
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1:20 PM |
54 |
The role of STAT3 isoforms in acute myeloid leukemia Dagmar Stoiber |
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1:35 PM |
Closing Remarks Serge Fuchs |
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1:45 PM |
Lunch and Informal Discussions |
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8:00 PM |
Farewell Dinner |
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Sunday, June 04 |
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8:00 AM |
Breakfast |
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10:00 AM |
Departure |
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POSTERS |
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55 |
Circulating cytokines/chemokines for diagnosis, prognosis and therapy monitoring in cutaneous melanoma Monica Neagu, Carolina Constantin, and Sabina Zurac |
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56 |
A novel antitumor activity of IL-27 by promoting IL-27 promotes the differentiation of HSCs to antitumorigenic M1-like antitumor macrophages in tumor-bearing mice and their mobilization into tumor. Yukino CHIBA, Izuru MIZOGUCHI, Mio OHASHI, Hideaki HASEGAWA, Toshiyuki OWAKI, and Takayuki YOSHIMOTO |
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57 |
Host factors in cell mediated immunity and cancer progression Jennifer Steel, David Geller, Wallis Marsh, Jessica Miceli, Keith Gray, and Allan Tsung |
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58 |
HTLV-1 Tax requires CADM1 for chronic activation of NF-κB Richard Hunte and Noula Shembade |
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59 |
USP2a positively regulates interferons signaling by deubiquitinating and stabilizing activated STAT1 in the nucleus Ying Ren, Peng Zhao, Jin Liu, Yukang Yuan, Qiao Cheng, Yibo Zuo, Sidong Xiong, and Hui Zheng |
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60 |
Distinct immune status in patients with adenocarcinoma and squamous cell carcinoma: implication for immunotherapy of non-small cell lung cancer Irena Adkins, Nada Hradilova, Ondrej Palata, Lenka Sadilkova, Dagmar Mysikova, Hana Mrazkova, Robert Lischke, and Radek Spisek |
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61 |
Decreased IFN-γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation Paige Kulling, Kristine Olson, Thomas Olson, Cait Hamele, Kathryn Carter, David Feith, and Thomas Loughran |
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62 |
Tag7 (PGLYRP1) induces antitumor cytotoxic activity in human lymphocytes via TREM-1 receptor Tatiana Sharapova, Olga Ivanova, Elena Romanova, Lidia Sashchenko, and Denis Yashin |
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63 |
Conditional gp130-JAK-STAT3 activation induces malignant transformation in vivo Anna Katharina Scherger, Markus Schick, Katja Steiger, Mona Al-Maarri, Frank-Thomas Wunderlich, Stefan Rose-John, Christian Peschel, and Ulrich Keller |
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64 |
Development of novel inhibitors of STAT3-mediated transcription Sander Busker, Iryna Kolosenko, Jianping Liu, Juan Astroga-Wells, Lars johansson, Brent Page, Weixing Qian, Per-Anders Enquist, Katja Pokrovskaja-Tamm, and Dan Grander |
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65 |
E3 Ubiquitin Ligase Smurf1 Represses the production of Tumor Necrosis Factor-alpha by Decreasing Levels of Ubiquitin-specific peptidase 5 Yukang Yuan |
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66 |
Mechanism of autophagy is dependent on EGF receptor signaling in melanoma cell lines Vincenzo De Iuliis, Antonio Marino, Sabria Capodifoglio, Gianfranco Vitullo, Sebastiano Ursi, Vincenzo Flati, Paola Lanuti, Marco Marchisio, Caludio Talora, Stefano Martinotti, and Elena Toniato |
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67 |
Systemic immune-inflammation index correlates with cytokine levels in testicular germ cell tumors patients. Daniela Svetlovska, Viera Miskovska, Patrik Palacka, Dana Cholujova, Paulina Gronesova, Michal Chovanec, Jana Obertova, Katarina Rejlekova, Zuzana Sycova-Mila, Katarina Kalavska, Vanda Usakova, Silvia Cingelova, Dalibor Ondrus, Stanislav Spanik, Jozef Mardiak, and Michal Mego |
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68 |
The Growth Hormone Receptor single nucleotide polymorphism GHRP495T promotes lung cancer by an impairment of SOCS2-mediated receptor degradation. Yash Chhabra, Ho Yi Wong, Louise Nikolajsen, Helena Steinocher, Andreas Papadopulos, Kathryn Tunny, Frederic Meunier, Aaron Smith, Birthe Kragelund, Michael Waters, and Andrew Brooks |
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69 |
Cell-to-cell contact triggers the expression of IRF9 and interferon-related DNA damage resistance signature in cancer cells through a soluble factor Elin Edsbäcker, Iryna Kolosenko, Angelo de Milito, Dan Grandér, and Katja Pokrovskaja Tamm |
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70 |
Cachexia-associated activation of mitogen-and stress-activated protein kinase-1 (MSK1/MAPK) in the tumor microenvironment and in the muscle Gabriela de Castro, Joanna Lima, Estefanía Simões, Raquel Figueredo, Ulrike Lenz, Silvio Gomes, Daniela Gonçalves, Emídio Matos-Neto, Fernanda Formiga, Fang Bin, Jose Otoch, Paulo Martins, and Marília Seelaender |
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71 |
chemo-protective effect of umbelliferone β-d-galactopyranoside via nf-κb pathway in den induced hepatocellular in rats Vikas Kumar and P Malairajan |
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72 |
MicroRNAs as modulators of cytokine responses in cancerous and non-cancerous cells Florence Servais, Mélanie Kirchmeyer, Aurélien Ginolhac, Petr Nazarov, Laurent Vallar, Markus Casper, Matthias Glanemann, Frank Lammert, Claude Haan, Stephanie Kreis, and Iris Behrmann |
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73 |
Functional studies of the FERM domain of TYK2 Zhi LI and Sandra Pellegrini |
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74 |
Information transmission in interleukin-6-induced signalling Ulrike Billing, Heike Rummel, Tomasz Jetka, Fred Schaper, Michal Komorowski, Steffen Waldherr, and Anna Dittrich |
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75 |
Tumour microenvironment and muscle opposing behaviour in MAPK signalling pathways in cancer cachexia Joanna Lima, Estefania Simões, Gabriela de Castro, Raquel Figueredo, Silvio Gomes, Daniela Gonçalves, Emídio Matos-Neto, Fernanda Formiga, Fang Bin, José Otoch, Paulo Martins, and Marília Seelaender |
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76 |
Mitochondrial STAT3 supports malignant transformation through metabolic reprogramming David Levy, Isabelle Marié, Lara Brambilla, and Tanaya Lahiri |
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77 |
STAT1 suppresses myeloproliferative neoplasia Isabelle Marié, Lara Brambilla, Luisa Cimmino, and David Levy |
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78 |
STAT1 isoform-specific function in NK cells Katrin Meissl, Natalija Simonović, Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, Veronika Sexl, Mathias Müller, and Birgit Strobl |
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79 |
Inflammatory status and cytokines profile in cachectic colorectal cancer patient Estefanía Simões, Joanna Lima, Raquel Figueredo, Emidio Matos-Neto, Gabriela De Castro, Fernada Formiga, Jose Otoch, Fang Bin, Paulo Martins, and Marília Seelaender |
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80 |
Role of KSHV-activated cytokine signaling in paracrine oncogenesis of Kaposi’s sarcoma Enrique Mesri |
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81 |
Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in Non-small cell lung cancer Jeong Yeon Jo and Dong Hoon Shin |
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82 |
Fabrication of single and bundled cell-laden hyaluronic acid derivative hydrogel hollow fiber through competitive enzyme catalyzed reaction Mehdi Khanmohammadi, Shinji Sakai, and Masahito Taya |
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83 |
Langerhans-cell histiocytosis – a signaling-driven epigenetic disease of monocytic origin Matthias Farlik, Florian Halbritter, Christoph Bock, and Caroline Hutter |
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84 |
MAPKAPK2 regulates multiple and distinct stromal-specific pathways to promote cancer progression in the intestine Ana Henriques, Vasiliki Koliaraki, and George Kollias |
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85 |
Knockouts reveal crucial contribution of the canonical type 1 interferon pathway Victoria Urin, Maya Shemesh, and Gideon Schreiber |
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86 |
TLR9-targeted oligonucleotide STAT3 inhibitors for prostate cancer therapy Marcin Kortylewski |
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87 |
Cytokines drive amoeboid migration of cancer cells Vladimir Cermak, Aneta Gandalovicova, Ladislav Merta, Daniel Rösel, and Jan Brabek |