Monday, June 19

6:00 PM

Conference Registration

8:00 PM

Welcome Reception and Dinner

Tuesday, June 20

8:00 AM

Breakfast

SESSION I

Infection and innate immunity I

Chairs: George  Cotsarelis and Mihai Netea

9:15 AM

1

How does the immune system discriminate virulent vs commensal Staphylococcus aureus in the epidermis

Gabriel Nunez

9:40 AM

2

A cell autonomous stress response to bacterial viability

Julie  Magarian Blander

10:05 AM

3

Intracellular DNA sensing during infection and beyond

Andrea Ablasser

10:30 AM

4

Entamoeba histolytica invasion in the gut is dependent on NLRP3 inflammasome activation

Kris Chadee and France Moreau

10:45 AM

5

Dengue virus NS2B targets cGAS for degradation and prevents mtDNA sensing during infection

Sebastian Aguirre, Priya Luthra, Maria Sanchez-Aparicio, Ana Maestre, Tongtong Zhu, Jessica Pintado Silva, Laurece Webb, Dabeiba Bernal-Rubio, Alexander Solovyov, Benjamin Greenbaum, Viviana Simon, Christopher Basler, Lubbertus Mulder, Adolfo Garcia-Sastre, and Ana Fernandez-Sesma

11:00 AM

Coffee Break and Poster Session

SESSION II

Infection and innate immunity II

Chairs: Alberto Mantovani and Niki Moutsopoulos

12:00 PM

6

Mechanisms of innate sensing and signaling by RIG-I-like receptors

Michaela Gack

12:25 PM

7

E3 ligases in antiviral innate immunity

Sun Hur

12:50 PM

8

Novel mode of innate recognition to trigger antiviral IFN response

Akinori Takaoka

1:15 PM

9

Interferon-λ mediates non-redundant front line antiviral protection in the lung without compromising host fitness

Evangelos Andreakos

1:30 PM

10

Ex vivo innate immune profiling of dengue virus and Zika virus infections in human primary immune cells

Irene Ramos, Rebecca  Hamlin, Dabeiba  Bernal-Rubio, Rafael Fenutria, Adeeb Rahman, Jeffrey Johnson, Theodore Pak, Uma  Potla, Daniela  Michlmayr, Kevin  Maringer, Miriam  Merad, Nevan  Krogan, Andrew  Kasarkis, Eva Harris, and Ana Fernandez-Sesma

1:45 PM

11

Research funding by the National Institute of Allergy and Infectious diseases (NIAID/NIH)

Wolfgang Leitner

2:10 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

Wednesday, June 21

8:00 AM

Breakfast

SESSION III

Inflammation and disease

Chairs: Triantafyllos Chavakis and Dimitris Kontoyiannis

9:00 AM

12

Therapeutic complement inhibition at the level of C3: microconceptions, myths, and novel insight

John Lambris

9:25 AM

13

Maternal factors promote autism-like behaviors in offspring

Jun Huh

9:50 AM

14

CNS innate immune responses to flaviviruses impair learning and memory

Robyn Klein, Charise Garber, Michael Vasek, Lauren Vollmer, Kristen Funk, and Jasmine Brown

10:15 AM

15

Fibrin in CNS Innate Immunity and Repair

Katerina Akassolgou

10:40 AM

16

Microglial / macrophage Neuropilin 1 signaling in glioma

Jeremy  Miyauchi, Michael Caponegro, and Stella Tsirka

11:05 AM

Coffee Break and Poster Sessione

SESSION IV

Inflammation and homeostasis at mucosal surfaces

Chairs: Giorgio Trinchieri and Mariusz Ratajczak

12:00 PM

17

Role of Del-1 in inflammation resolution

Tetsuhiro Kajikawa, Ioannis Kourtzelis, Dayo Yuh, Xiaofei Li, Kavita Hosur, Baomei  Wang, Triantafyllos Chavakis, and George Hajishengallis

12:25 PM

18

Tissue specific factors regulated the induction of oral mucosal Th17 responses

Niki Moutsopoulos

12:50 PM

19

Control of intestinal immune homeostasis by group 3 innate lymphoid cells

Matthew Hepworth

1:15 PM

20

Intestinal Bacteria - The Good, The Bad and The Ugly: The Role of Dysbiosis in the Pathogenesis of IBD

Nobuhiko Kamada

1:40 PM

21

Host-microbe interaction in the inflamed gut

Manuela Raffatellu

2:05 PM

22

Investigations on intelectin-1, an abundant secreted lectin of Paneth cells

Eric Nonnecke, Patricia Castillo, Stephanie Goley, Charles Bevins, and Bo Lönnerdal

2:20 PM

Lunch and Informal Discussions

7:30 PM

Dinner and Informal Discussions

Thursday, June 22

8:00 AM

Breakfast

SESSION V

Cancer

Chairs: Lorenzo Moretta and 

9:00 AM

23

Innate immune pathways and the tumor microenvironment

Alberto  Mantovani

9:25 AM

24

Cancer as a Disease of the Symbiont/Metaorganism

Giorgio Trinchieri

9:50 AM

25

Genetic dissection of innate immunity in a malleable genetic models of cancer

Peter Murray

10:15 AM

26

Complement in cancer: untangling an intricate relationship

Edimara Reis

10:40 AM

27

Endothelial RhoA mediates trans-endothelial cancer cell migration and metastasis

Sanaullah Sajib, Fatema Zahra, Jee Hyun Park, Paul Tullar, Sanjay Srivastava, Ulrich Bickel, and Constantinos Mikelis

10:55 AM

28

Human BDCA3high dendritic cells infiltrate breast and ovarian tumors and can be reactivated to secrete type III interferons

Margaux HUBERT, Anne-Claire DOFFIN, Estelle VERRONESE, Isabelle DURAND, Nathalie BENDRISS-VERMARE, Christophe CAUX, and Jenny VALLADEAU-GUILEMOND

11:10 AM

Coffee Break and Poster Session

SESSION VI

Cell plasticity and reprogramming

Chairs: Laurie Dempsey and George Hajishengallis

11:40 AM

29

Uric acid priming in human monocytes is driven by the Akt-PRAS40 autophagy pathway causing epigenetic reprogramming

Leo Joosten

12:05 PM

30

Immunometabolic circuits involved in the induction of trained immunity

Mihai Netea

12:30 PM

31

Ioannis  Mitroulis, Lan-Sun Chen, Rashim Pal Singh, Ioannis Kourtzelis, Matina Economopoulou, Tetsuhiro Kajikawa, Ben Wielockx, George Hajishengallis, and Triantafyllos Chavakis

12:55 PM

32

Wound myofibroblasts convert to adipocytes through BMP signaling initiated by neogenic hair follicles

George Cotsarelis, Maksim Plikus, Mayumi Ito, Ying Zheng, Denise Gay, Christian Guerrero-Juarez, Patrick Seale, Warren Pear, and Mitch Lazar

1:20 PM

33

Central and Local Adaptations Sustain Innate Exhaustion During Chronic Viral Infection

Elina Zuniga

1:45 PM

34

Viral vaccine-Trained Innate Immunity (TII) enhances host defense against heterologous pneumococcal infection in the lung

Zhou Xing

2:00 PM

Lunch and Informal Discussions

3:30 PM

City Tour

7:30 PM

Dinner and Informal Discussions

Friday, June 23

8:00 AM

Breakfast

SESSION VII

Regulation of host immune responses

Chairs: Peter Murray and Katerina Akassoglou

9:00 AM

35

Molecular regulation of transendothelial migration

William Muller

9:25 AM

36

An additional CCR1-binding chemokine produced by neutrophils: CCL23

Marco Cassatella, Nicola Tamassia, Fabio Arruda e Silva, Francisco Bianchetto Aguilera, and Sara Gasperini

9:50 AM

37

Immune regulatory programs and apoptosis in myeloid-derived suppressor cells

Vincenzo Bronte

10:15 AM

38

Selective functions of RNA regulators of the hnRNP family in innate immunity

Niki  Lourou, Margarita Chatzimike-Levidi, and Dimitris Kontoyiannis

10:40 AM

39

Innate Immunity as a Pivotal Player in Mobilization of Hematopoietic Stem Cells from Bone Marrow Into Peripheral Blood. 

Mariusz Ratajczak

11:05 AM

40

Opal1, a novel transmemrane adaptor protein regulates immune cell traffiking

Šimon Borna, Ales Drobek, Jarmila  Kralova, Matej Fabisik, and Tomáš Brdička

11:20 AM

Coffee Break and Poster Session

SESSION VIII

Innate immunity and disease mechanisms

Chairs: Marco Cassatella and Enzo Bronte

12:00 PM

41

Human NK cells. From bench to bedside.

Lorenzo Moretta, Franco Locatelli, and Alessandro Moretta

12:25 PM

42

Innate sensing of Toxoplasma gondii
Felix Yarovinsky

12:50 PM

43

Structural recognition of Nectin2 by the natural killer cell receptor TIGIT

Felix Deuss, Benjamin Gully, Richard Berry, and Jamie Rossjohn

1:05 PM

44

The atypical ubiquitin E2 conjugase UBE2L3 is an indirect caspase-1 target and controls IL-1beta secretion by inflammasomes

Matthew Eldridge, Julia Sachez-Garrido, Gil Hoben, Phillipa Goddard, and Avinash Shenoy

1:20 PM

45

Metabolic dysregulation of cell-intrinsic innate immunity in a disease of systemic inflammation

Rekha Dhanwani, Mariko Takahashi, Ian Mathews, Yongjian Yu, Mohit Jain, and Sonia Sharma

1:35 PM

46

The role of Formyl Peptide Receptor 1 in the development of Non-alcoholic Steatohepatitis

Marina Nati, Kyoung-Jin  Chung, Lan-Sun  Chen, Ales Neuwirth, Jochen  Hampe, Oliver  Söhnlein, Antonios  Chatzigeorgiou, and Triantafyllos  Chavakis

1:50 PM

47

A Novel PINK1- and PARK2-dependent Protective Neuroimmune Pathway in Lethal Sepsis

Jian-xin Jiang

2:05 PM

Lunch and Informal Discussions

8:00 PM

Farewell Dinner

Saturday, June 24

8:00 AM

Breakfast

10:00 AM

Departure

POSTERS

48

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Zheng-guo Wang

49

FOXP3+ T regulatory cell mediated microvascular repair in mouse airway allografts.

Mohamamd Khan, Fatimah  Alanazi, Hala  Ahmed, Falah  Al-Mohanna, Abdullah  Assiri, and Dieter Broering

50

MicroRNA-223 suppresses inflammation by down regulating NF-kB activation in epithelial cells

Qing Deng

51

Poor mobilization in T cell-deficient nude mice is explained by defective activation of granulocytes and monocytes

Janina Ratajczak

52

The transcriptional response to adversity is conserved throughout vertebrate evolution.

Alexander Rebl, Tomáš Korytář, Mareen Nipkow, Simone  Altmann, Bernd Köllner, and Tom Goldammer

53

Early events differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers immune-dampening and host cell invasion immediately after udder infection

Juliane Günther, Wolfram Petzl, Isabel Bauer, Siriluck Ponsuksili, Holm Zerbe, Hans-Joachim Schuberth, Ronald Brunner, and Hans-Martin Seyfert

54

The endogenous homeostatic factor Del-1 promotes efferocytosis and the emergence of a pro-resolving macrophage phenotype

Ioannis Kourtzelis, Ioannis  Mitroulis, Anne Kathrin  Tausche, Tetsuhiro  Kajikawa, Daniel  Grosser, Janusz  von Renesse, Maria  Troullinaki, Christian  Doreth, Anaisa  Ferreira, Klara  Ruppova, Kavita  Hosur, Lan-Sun  Chen, Michal  Grzybek, Antonio  Castrillo, Ünal  Coskun, George  Hajishengallis, and Triantafyllos  Chavakis

55

Epigenetic modifiers alter the innate immune response in bovine udder tissues

Wolfram Petzl, Laura Macias Niemeyer, Hans-Joachim Schuberth, and Holm Zerbe

56

Innate Immune Recognition: Signaling Windows Concept

Klara Kubelkova, Zuzana Krocova, Milota Benuchova, and Ales Macela

57

Association of Human Mannose receptor (hMR) in Sexual Transmission and Pathogenesis HIV Subtype C virus in Serodiscordants couples

Shivaji Jadhav and A  Bandivdekar

58

Anti-CD69 mAb treatment increases the capacity of NK cells to eliminate hyper-reactive allogenic T cells and prevents acute graft versus host disease

Katerina Tsilingiri, Marta Relaño, Sandra Lasarte, Raquel Sánchez-Díaz, and Pilar Martín

59

The long pentraxin PTX3 has a non-redundant role in the control of Streptococcus pneumoniae invasive infections

Rémi Porte, Raffaella Parente, Marina Sironi, Fabio Pasqualini, Maria Luisa Barbagallo, Rita Silva-Gomes, Sadaf  Davoudian, Tom van der Poll, Cecilia Garlanda, Barbara Bottazzi, and Alberto Mantovani

60

Role of endosomal adaptor TAPE in RIG-I signaling and antiviral immunity

Kuan-Ru  Chen, Li-Chun Wang, Chia-Yu  Yang, Chun-Yang  Lin, Wan-Ying  Lin, Yin-Chiu  Lo, Huai-Chia  Chuang, Tse-Hua  Tan, and Pin  Ling

61

Human bronchial epithelial cells inhibit A. fumigatus growth                                                                   

Viviane Balloy, Jean Paul Latgé, Harriet Corvol, Loïc Guillot, and Michel Chignard

62

A novel functional cooperation between complement factor H and the long pentraxin PTX3 in the immune response to Aspergillus fumigatus.

Raffaella Parente, Francesca Petroni, Remi Porte, Marina Sironi, Marco Gobbi, Sonia Valentino, Barbara Bottazzi, Alberto Mantovani, and Antonio Inforzato

63

Proteasoma inhibitors and cannabinoids regulate inflammatory and chemotactic signals in multiple myeloma.

Massimo Nabissi

64

Molecule 1, a new marker for M2-polarization affecting monocytes motility

Tamara Gulic, Ilaria Laface, Antonio Inforzato, Maria Jose Oliveira, Marina Sironi, Roberto Leone, Andrea Doni, Barbara Bottazzi, Paola Allavena, Daniel Rukavina, and Alberto Mantovani

65

Fowl adenovirus infection and the avian innate immune response

Li Deng, Peter Krell, and Eva Nagy

66

Opsonization of dead cells by complement and IgM as a novel mechanism for generating the interferon signature in lupus

Haoyang Zhuang, Shuhong Han, Stepan  Shumyak, Lijun Yang, and Westley Reeves

67

Characterisation of Dendritic Cell Immune Profile in Models of Transfusion

Melinda Dean, Katrina Ki, Helen Faddy, Lacey Johnson, Denise Marks, and Robert Flower

68

Patient monocyte responses modulated following cardiac surgery

Melinda Dean, Alexis Perros, Arlanna Esguerra-Lallen, Kelly Rooks, Fenny Chong, Sanne Pederson, Rishendran Naidoo, John-Paul Tung, John Fraser, Marc Ziegenfuss, Susan Smith, Donalee OBrien, and Robert Flower

69

The role of Litopenaeus vannamei p38 in White Spot Syndrome Virus infection

Hong Shi

70

the atypical ubiquitin E2 conjugase UBE2L3 is an indirect caspase-1 target and controls IL-1β secretion by inflammasomes

Matthew Eldridge, Julia Sanchez-Garrido, Gil Ferreira Hoben, Philippa Goddard, and Avinash Shenoy

71

Comparison of innate immunity genes expression in sub-clinical and clinical cases of bovine mastitis

R Lakshmi and K. K Jayavardhanan

72

Alarmin HMGB1 in the Ileum of Gnotobiotic Piglets Infected with Salmonella Typhimurium or its Isogenic rfaL Mutant

Alla Splichalova, Vera Slavikova, and Igor Splichal

73

Impact of E. coli Nissle 1917, Lactobacillus amylovorus and Salmonella Typhimurium on Transcriptions of NLRP3 Inflammasome, NOD1 and NOD2 and Induction of IL-1 beta, IL-10 and IL-12/23 p40 in Ileum of Gnotobiotic Piglets

Igor Splichal, Vera Slavikova, and Alla Splichalova

74

Analysis of interactions between innate and adaptive immune cells in the tumour microenvironment in animal models of triple negative breast cancer.

Fabian Flores-Borja, Peter Gordon, Felix Wong, Ibrahim Sheriff, Purnank Aggarwal, Andrew Tutt, and Tony Ng

75

The role of transmembrane adaptor protein LST1 in dendritic cells and macrophages

Matej Fabisik, Jarmila Kralova, and Tomas Brdicka

76

The role of chromatin extracellular traps in phagocytes of Atlantic salmon (Salmo salar) against pathogens

Neila Alvarez de Haro, Adriano Rossi, Andrew Desbois, and Valerie Smith

77

CRTAM shapes the microbiota and enhances the severity of gut infection.

Araceli Perez-Lopez, Sean-Paul Nuccio, Robert Edwards, Irina Ushach, Albert Zlotnik, and Manuela Raffatellu

78

Organ-wide comprehensive lipidomic analysis of biomarkers linked to toll-like receptors 2 and 4 deficiency.  

Michal Grzybek, Tina Sartorius, Alessandra Palladini, Hans-Ulrich Häring, Carlo Cannistraci, and Ünal  Coskun

79

The expansion of heterotopic bone in Fibrodysplasia Ossificans Progressiva (FOP) is Activin A dependent.

Kalyan Nannuru, Lily Huang, Jaymin Upadhyay, Liqin Xie, Xialing Wen, Lili Wang, Nanditha Das, Andrew Murphy, Aris Economides, and Sarah Hatsell

80

Study of gene variants ADRB2 (β2-adrenergic receptor) in the predisposition to infection with Plasmodium vivax

Brenda Lopez and Mercedes Fernandez-Mestre

81

Dendritic cell response to neutrophil extracellular traps in type 1 diabetes

Zuzana Parackova, Irena  Zentsova, Jana Kayserova, Zdenek Sumnik, Stepanka Pruhova, and Anna Sediva

82

Identification of two subgroups of type I IFNs in perciforme fish large yellow croaker Larimichthys crocea provides novelinsights into function and regulation of fish type I IFNs

Jingqun  Ao

83

Influenza-derived peptides cross-react with allergens and provide asthma protection 

Chrysanthi Skevaki, Christoph   Hudemann, Mikhail   Matrosovich, Christian   Möbs,  Paul Sinu Paul, Andreas   Wachtendorf, Bilal  Alashkar Alhamwe, Daniel   Potaczek, Stefanie  Hagner, Diethard Gemsa, Holger Garn, Alessandro   Sette, and Harald  Renz

84

Antibody blockade of IL-1α markedly ameliorates Crohn’s Disease-like ileitis by a mechanism altering gut microbiome composition

Paola Menghini, Daniele Corridoni, Charles Dinarello, Natalia  Aladyshkina, Kalidip  Choudhury, Sushma Shivaswamy, Alexander Rodriguez-Palacios, and Fabio Cominelli

85

Role of NOD2 in the development and expansion of IL-33-responsive ILC2s that mediate chronic intestinal inflammation in ileitis-prone mice

Katherine  Buela, Chiara Cominelli, Carlo  De Salvo, Fabio Cominelli, and Theresa  Pizarro

86

Monocolonization of germ-free mice with Lactobacillus plantarum WCFS1 does not trigger the Imiquimod-induced skin inflammation in mice

Zuzana Stehlikova, Zuzana Jiraskova Zakostelska, Klara Klimesova, Pavel Rossmann, Tomas Hudcovic, Katerina Juzlova, Jana Herzogova, Helena Tlaskalova-Hogenova, and Miloslav Kverka