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Sunday, June 23 |
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7:00 PM |
Conference Registration |
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8:00 PM |
Welcome Reception and Dinner |
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Monday, June 24 |
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7:30 AM |
Breakfast |
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8:30 AM |
Welcome and Opening Remarks |
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SESSION I |
Systems Medicine Chair: Ellen Rothenberg |
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8:40 AM |
1 |
An update on the clinical development of the compstatin based drug candidate AMY-101 John Lambris |
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9:05 AM |
2 |
Diverse Approaches to Novel Gene Discovery in Founder and Special Populations at the Regeneron Genetics Center Nehal Gosalia, Claudia Gonzaga-Jauregui, Cristopher Van Hout, Alan Shuldiner, and Aris Economides |
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9:30 AM |
3 |
Investigating the role of CD28 in enhancing CAR-mediated signaling in T cells using systems biology Jennifer Rohrs, Pin Wang, and Stacey Finley |
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9:55 AM |
4 |
Microbiomes over time and space Rob Knight |
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10:20 AM |
5 |
Mapping pathways for Biliary atresia, a developmental disease, with Integrative analysis of multiomics data Rakesh Sindhi, Donghun Shin, and Shankar Subramaniam |
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10:45 AM |
6 |
Noisy biological systems Joe Nadeau |
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11:10 AM |
Coffee Break and Poster Viewing |
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SESSION II |
Single Cell and Technologies Chair: Stacey Finley |
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11:45 AM |
7 |
Single-cell dissection of the gene regulatory network controlling entry into the T-cell developmental pathway Ellen Rothenberg, Wen Zhou, and Xun Wang |
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12:10 PM |
8 |
single-cell measurement and control to unravel yeast gene expression heterogeneity Megan McClean, Kieran Sweeney, and Audrey Gasch |
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12:35 PM |
9 |
Mapping trajectories of drug-induced tumor evolution “one cell at-a-time” Ramanuj Dasgupta |
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1:00 PM |
10 |
ToppCell: A workbench for the analysis, modeling and prediction of transcriptional networks responsible for the development and function of cells and tissues based on single cell atlas datasets Alexis Mitelpunkt, Jake Wang, Eric Bardes, Kang Jin, Balaji Iyer, Saif Alimohamed, Scott Tabar, and Bruce Aronow |
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1:25 PM |
11 |
Founder populations for discovery and therapeutic development Nehal Gosalia, Bin Ye, Cristopher Van Hout, and Alan Shuldiner |
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1:50 PM |
12 |
Perturbation of the metabolic phenotypes of vaccination by the gut microbiome in humans Thomas Hagan, Mario Cortese, Nadine Rouphael, Mohan Maddur, Jun Zou, Andrew Gewirtz, Surender Khurana, Hana Golding, Shuzhao Li, and Bali Pulendran |
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2:15 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Tuesday, June 25 |
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7:30 AM |
Breakfast |
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SESSION III |
Neuronal Systems Chair: Gabriel Haddad |
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8:30 AM |
13 |
Identifying gene modules that remodel multiple components of the cellular machinery during developmental state transitions in embryonic stem cells Noel Buckley and Shankar Subramaniam |
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8:55 AM |
14 |
Role of chromatin remodeling in mechanisms associated with Familial Alzheimer’s Disease Andrew Caldwell, Qing Liu, Douglas Galasko, Shauna Yuan, Steven Wagner, and Shankar Subramaniam |
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9:20 AM |
15 |
A systems biology approach to understanding ALS pathogenesis in iPSC-derived motor neurons Leslie M Thompson and the NeuroLINCS and Answer ALS Consortia
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9:45 AM |
16 |
Cell state reprogramming and oncogene-induced plasticity in glioblastoma Dinorah Friedmann-Morvinski, Inbar Angel, Ori Pilo Kerman, and Liat Rousso-Noori |
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10:10 AM |
17 |
Mechanisms Impairing Neural Development in Schizophrenia (MINDS) Francis Szele, Yichen LI, Anthony James, Istvan Adorjan, Angela Russell, and Abeer Al-Shammari |
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10:35 AM |
18 |
Histone acetylome-wide association studies: autism spectrum disorder and tuberculosis Shyam Prabhakar |
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11:00 AM |
Coffee Break and Poster Viewing |
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SESSION IV |
Cancer Biology Chair: Raimond Winslow |
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11:45 AM |
19 |
Systems biology approach to early detection of biologically aggressive cancers Victoria Seewaldt, Jerneja Tomsic, Joseph Geradts, Long Cai, and Lihong Wang |
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12:10 PM |
20 |
Biological Markers for Colorectal Cancer Kavitha Mukund, Natalia Syulyukina, Shankar Subramaniam, and Sonia Ramamoorthy |
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12:35 PM |
21 |
Understanding and exploiting Cancer Mechanobiology Adam Engler |
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1:00 PM |
22 |
Dissecting the molecular basis of Marfanoid Progeroid Lipodystrophy Syndrome by multi-omics approach. Giusy Della Gatta, Christopher Schoenherr, Lawrence Miloscio, Trikaldarshi Persaud, Gannie Tzoneva, Silvia Smaldone, Erika Troy, and Aris Economides |
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1:25 PM |
23 |
Co-phosphorylation networks and their application in predicting kinase-substrate associations and cancer subtyping Mehmet Koyuturk, Marzieh Ayati, and Mark Chance |
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1:50 PM |
24 |
Recombination and Repair at Stalled Mammalian Replication Forks |
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2:15 PM |
Lunch and Informal Discussions |
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7:30 PM |
Dinner and Informal Discussions |
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Wednesday, June 26 |
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7:30 AM |
Breakfast |
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SESSION V |
Metabolism Chair: Noel Buckley |
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8:30 AM |
25 |
Using lipidomics to identify therapeutic targets. Michael Wakelam, An Nguyen, Qifeng Zhang, and Andrea Lopez-Clavijo |
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8:55 AM |
26 |
Dysregulation of the lysophospholipid/autotaxin axis defines the cardiovascular risk SNP rs10757274 on chromosome 9p21 Valerie O'Donnell |
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9:20 AM |
27 |
Amino acid metabolism and lipid diversity link cancer and neuropathy Christian Metallo |
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9:45 AM |
28 |
Metabolic crosstalk between mammalian cells and Clostridium difficile bacteria Alexander Heinz, Jasmin Hanke, Kerstin Schmidt-Hohagen, and Karsten Hiller |
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10:10 AM |
29 |
Nuclear one-carbon metabolism in embryonic development and disease. Patrick Stover, Martha Field, and Eunice Awuah |
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10:35 AM |
30 |
Advances In Obesity Metabolic Surgery Santiago Horgan |
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11:00 AM |
Coffee Break and Poster Viewing |
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SESSION VI |
Cardiac & Muscle Chair: Joe Nadeau |
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11:30 AM |
31 |
Re-introducing the Patient Context into Cardiac Drug Discovery using iPSC Disease Models Mark Mercola |
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11:55 AM |
32 |
Transcriptional Dysregulation in Muscle From Children with Cerebral Palsy Richard Lieber |
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12:20 PM |
33 |
Longitudinal Analysis of Myogenic Differentiation Mechanisms Priya Nayak, Shyni Varghese, and Shankar Subramaniam |
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12:45 PM |
34 |
Computational Cardiology: From the Molecule to the Patient Natalia Trayanova |
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1:10 PM |
35 |
FSTL1 Post-Transcriptional Modifications (or mechanisms to regulate cardiac regeneration) Pilar Ruiz-Lozano |
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1:35 PM |
Lunch and Informal Discussions |
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3:30 PM |
City Tour |
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7:30 PM |
Dinner and Informal Discussions |
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Thursday, June 27 |
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7:30 AM |
Breakfast |
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SESSION VII |
Disease and Systems Biology Chair: Christian Metallo |
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8:30 AM |
36 |
Genomic and signaling pathway analysis of high altitude hypoxia-induced excessive erythropoiesis in subjects with Monge’s disease Priti Azad, Arya Iranmehr, Dan Zhou, Vineet Bafna, and Gabriel Haddad |
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8:55 AM |
37 |
Predicting Patient Risk in Septic Shock Raimond L Winslow, Joseph Greenstein, and Ran Liu |
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9:20 AM |
38 |
Integration of genetic, transcriptomic, proteomic and metabolomic analysis to understand the basis of cardiometabolic health. Charles Burant |
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9:45 AM |
39 |
Tackling the diseases of ageing: from chemistry to stem cells and regenerative medicine Angela Russell |
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10:10 AM |
40 |
Epigenetic regulation of metabolic disease heterogeneity Andrew Pospisilik |
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10:35 AM |
41 |
Bridging the gap: connecting biochemical and mechanical activators of tissue gap repair Allyson Sgro |
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11:00 AM |
Coffee Break and Poster Viewing |
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SESSION VIII |
Development and Disease Chair: Aris Economides |
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11:30 AM |
42 |
Therapeutic strategies via genome engineering: new approaches and new challenges. Prashant Mali |
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11:55 AM |
43 |
Epigenetic inheritance in mammals Anne Ferguson-Smith |
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12:20 PM |
44 |
Genome-wide Analysis of Enhancers in Development and Disease Bing Ren |
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12:45 PM |
45 |
Blood Cell Fate Decisions: insights from single-cell RNA-seq Merav Socolovsky |
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1:10 PM |
46 |
Mechanical cues coordinating cell behaviors during morphogenesis Karen Kasza |
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1:35 PM |
47 |
Interaction of membrane cholesterol with G protein-coupled receptors: a multidimensional approach Amitabha Chattopadhyay |
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2:00 PM |
Closing Remarks |
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2:05 PM |
Lunch and Informal Discussions |
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8:00 PM |
Farewell Dinner |
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Friday, June 28 |
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7:30 AM |
Breakfast |
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10:00 AM |
Departure |
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POSTERS |
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48 |
Fuzzy Inferred Kalman Filter (FIKF): An efficient parameter estimation approach in biochemical pathway modeling Abhisek Bakshi, Abhijit Dasgupta, and Rajat De |
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49 |
In silico modeling of integrated biochemical pathways: A three-timescale system Abhijit Dasgupta, Abhisek Bakshi, and Rajat De |
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50 |
5LOX is associated with high metabolic activity and poor overall survival in oesophageal adenocarcinoma, and this pathway represents a novel target in OAC Zivile Useckaite, Vinod Malik, Aoife Maguire, John Reynolds, and Graham Pidgeon |
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51 |
Constructing regulatory networks from transcriptional data to explore the pathways controlled by miR-96 Morag Lewis, Miguel Moreno-Pelayo, and Karen Steel |
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52 |
Transcription factor Irf6 is a critical mediator of the ErbB2/Her2 signalling pathway Iman Khan, Byong Yoo, Michael McPhee, Olivier Masson, Alexi Surette , Kelly Dakin-Hache, Tallal Younis, Gillian Bethune, and Kirill Rosen |
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53 |
Macroecological dynamics of gut microbiota Dennis Vitkup |
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54 |
The Microsetta Initiative: Creating a Map of the Global Gut Microbiome Daniel McDonald, Justin Shaffer, Jordan Bisanz, Gregor Reid, Maria Gloria Dominguez-Bello, Emily Vogtmann, Mathilde Poyet, Mathieu Groussin, Eric Alm, and Rob Knight |
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55 |
Development of a non-invasive biosensor for diagnosis of circadian clock disorders Silvana Papagerakis, Nikos Chronis, and Petros Papagerakis |