The prevalence of obesity and obesity-related diseases (diabetes, metabolic syndrome, cancer etc.) has reached epidemic proportions globally. The interplay between underlying genetic predisposition and environmental factors drives pathogenic weight gain and makes lifestyle interventions difficult to successfully implement broadly. Exciting new therapies for weight loss such as the glucagon-like peptide-1 receptor (GLP-1R) agonist class of drugs which elicit ~15-25% body weight loss have reinvigorated interest in exploring the biology of body weight regulation for other innovative therapeutic solutions. The multifactorial and polygenic nature of energy homeostasis means that such research efforts must consider broader physiological regulation of multiple tissue and organ systems. Therefore this meeting proposes to bring together experts in several different tissue/organ systems known to regulate components of energy utilization or intake (i.e., CNS, adipose tissue, muscle function). Cutting edge concepts around the biological processes of energy intake regulation, energy metabolism, lipid homeostasis and adipocyte dys/function, and muscle biology will be discussed. Updates on potential innovative or combination therapeutic approaches for the treatment of obesity will also be reviewed. Such cross-fertilization of ideas and experiences will lead to outside-the-box collaborative approaches and concepts to further push the frontiers of obesity research and make novel discoveries.